Wilfred Aniagyei, Sumaya Mohayideen, Osei Sarfo-Kantanka, Sarah Bittner, Monika M Vivekanandan, Joseph F Arthur, Agnes O Boateng, Augustine Yeboah, Hubert S Ahor, Shadrack O Asibey, Elizabeth Owusu, Diran Herebian, Maximilian Huttasch, Volker Burkart, Robert Wagner, Michael Roden, Ernest Adankwah, Dorcas O Owusu, Ertan Mayatepek, Marc Jacobsen, Richard O Phillips, Julia Seyfarth
BCG vaccination affects other diseases beyond tuberculosis by unknown-potentially immunomodulatory-mechanisms. Recent studies have shown that BCG vaccination administered during overt type 1 diabetes (T1D) improved glycemic control and affected immune and metabolic parameters. Here, we comprehensively characterized Ghanaian T1D patients with or without routine neonatal BCG vaccination to identify vaccine-associated alterations. Ghanaian long-term T1D patients ( n = 108) and matched healthy controls ( n = 214) were evaluated for disease-related clinical, metabolic, and immunophenotypic parameters and compared based on their neonatal BCG vaccination status...
April 24, 2024: Vaccines