S R Bornstein, K Guan, C Brunßen, G Mueller, V Kamvissi-Lorenz, R Lechler, R Trembath, M Mayr, L Poston, R Sancho, S Ahmed, E Alfar, B Aljani, T C Alves, S Amiel, C L Andoniadou, M Bandral, A Belavgeni, I Berger, A Birkenfeld, E Bonifacio, T Chavakis, P Chawla, P Choudhary, A M Cujba, L F Delgadillo Silva, T Demcollari, D M Drotar, S Duin, N N El-Agroudy, A El-Armouche, A Eugster, M Gado, A Gavalas, M Gelinsky, M Guirgus, S Hansen, E Hanton, M Hasse, H Henneicke, C Heller, H Hempel, C Hogstrand, D Hopkins, L Jarc, P M Jones, M Kamel, S Kämmerer, A J F King, A Kurzbach, C Lambert, Y Latunde-Dada, I Lieberam, J Liers, J W Li, A Linkermann, S Locke, B Ludwig, T Manea, F Maremonti, Z Marinicova, B M McGowan, M Mickunas, G Mingrone, K Mohanraj, H Morawietz, N Ninov, M Peakman, S J Persaud, J Pietzsch, E Cachorro, T J Pullen, I Pyrina, F Rubino, A Santambrogio, F Schepp, P Schlinkert, L D Scriba, R Siow, M Solimena, F M Spagnoli, S Speier, A Stavridou, C Steenblock, A Strano, P Taylor, A Tiepner, W Tonnus, T Tree, F Watt, M Werdermann, M Wilson, N Yusuf, C G Ziegler
Currently, we are experiencing a true pandemic of a communicable disease by the virus SARS-CoV-2 holding the whole world firmly in its grasp. Amazingly and unfortunately, this virus uses a metabolic and endocrine pathway via ACE2 to enter our cells causing damage and disease. Our international research training programme funded by the German Research Foundation has a clear mission to train the best students wherever they may come from to learn to tackle the enormous challenges of diabetes and its complications for our society...
March 2021: Hormone and Metabolic Research
Ching-Jen Chang, Chih-Hsueh Lin, Hui-Min Hsieh, Wen-Yann Lo, Yen-Hsun Lai, Li-Ning Peng, Liang-Kung Chen
BACKGROUND: The association between type 2 diabetes mellitus (T2DM) and sarcopenia has been reported before, but little was known regarding associations between albuminuria status in the development of sarcopenia. This study aimed to explore the associations between albuminuria status and sarcopenia among older patients with T2DM. METHODS: This cross-sectional study recruited T2DM patients aged 65 years and older from the DM shared care center in a regional hospital who were grossly absent from functional impairment...
February 5, 2021: Archives of Gerontology and Geriatrics
Song Yang, Ting Hu, He Liu, Ya-Li Lv, Wen Zhang, Han Li, Lingling Xuan, Li-Li Gong, Li-Hong Liu
Metabolic syndrome (MetS) is a complex, multifactorial disease which lead to an increased risk of cardiovascular disease, type 2 diabetes, and stroke. However, selective, and potent drugs for the treatment of MetS are still lacking. Previous studies have found that Akebia saponin D (ASD) has beneficial effects on metabolic diseases such as obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Therefore, our study was designed to determine the effect and mechanism of action of ASD against MetS in a high-fat diet (HFD) induced mouse model...
February 27, 2021: Biomedicine & Pharmacotherapy
Mohan Sreelekshmi, Kozhiparambil Gopalan Raghu
Glucokinase (GK), a key regulator of hepatic glucose metabolism in the liver and glucose sensor and mediator in the secretion of insulin in the pancreas, is not studied in detail for its therapeutic application in diabetes. Herein, we study the alteration in GK activity during hyperinsulinemia-induced insulin resistance in HepG2 cells. We also investigated the link between GK and Bcl-2-associated death receptor (BAD) during hyperinsulinemia. There are emerging demands for GK activators from natural resources, and we selected vanillic acid (VA) to evaluate its potential as GK activators during hyperinsulinemia in HepG2 cells...
March 2, 2021: Journal of Biochemical and Molecular Toxicology
Christina Kranc, Ryan Wagner, Nicole M Joy, Jerry Feldman, David C Reid
Amyloidosis consists of approximately 30 protein-folding disorders in which a specific soluble precursor protein aggregates to form the insoluble fibrils of amyloid. Insulin is the hypothesized precursor protein in localized cutaneous insulin-derived (AIns) amyloidosis. Amyloid deposition at insulin injection sites can interfere with absorption, leading to poor glucose control. Despite the increasing prevalence of diabetes mellitus and insulin use, there is a paucity of published cases of AIns amyloidosis and a lack of awareness of this condition among both dermatologists and general practitioners...
January 2021: Cutis; Cutaneous Medicine for the Practitioner
Yan Yi, Samar R El Khoudary, Jeanine M Buchanich, Rachel G Miller, Debra Rubinstein, Karen Matthews, Trevor J Orchard, Tina Costacou
OBJECTIVE: Evidence suggests that insulin deficiency and hyperglycemia may disrupt the female reproductive system's normal function, leading to delayed menarche and premature ovarian aging. We thus compared the length of the reproductive period of women with type 1 diabetes (T1D) to women without diabetes. METHODS: Women with childhood-onset T1D (diagnosed in 1950-80) from the prospective Epidemiology of Diabetes Complications (EDC) study and nondiabetic women from the Pittsburgh site of the Study of Women's Health Across the Nation (SWAN) were studied...
March 1, 2021: Menopause: the Journal of the North American Menopause Society
Philip Virgil Astillo, Gaurav Choudhary, Daniel Gerbi Duguma, Jiyoon Kim, Ilsun You
Advances of implantable medical devices (IMD) are transforming the tradition method of providing medical treatment, especially to patients under the most challenging condition. Accordingly, the IMD-enabled artificial pancreas system (APS) has now reached global market. It is helping many patients suffering from chronic disease, called diabetes mellitus, in monitoring and maintaining blood glucose level conveniently. However, this advancement is accompanied by various security threats that place the life of patients at risk...
March 2, 2021: IEEE Journal of Biomedical and Health Informatics
Thiago Santos Rosa, Hugo Luca Corrêa, Lysleine Alves de Deus, Whitley Stone, Andrea Lucena Reis, André Bonadias Gadelha, Thaís Branquinho de Araújo, Paulo Roberto Silva Junior, Milton Moraes, José Adeirton Bezerra Silva, Carmen Tzanno-Martins, Herbert Gustavo Simões, Jonato Prestes, Rodrigo Vanerson Passos Neves
To compare the effect of dynamic (DRT) and isometric (IRT) resistance training on glycemic homeostasis, lipid profile, and nitric oxide (NO) in hemodialysis (HD) patients. Patients were randomly distributed into three groups: control (CTL; n=65), DRT (n=65), and IRT (n=67). Patients were tested for fasting blood glucose, glycated hemoglobin, oral glucose tolerance test, insulin resistance, lipid profile, leptin, insulin, adiponectin, C-reactive protein, and NO were assessed pre- and post-intervention period...
March 2, 2021: Applied Physiology Nutrition and Metabolism
Fernando Gomez-Peralta, Ebaa Al-Ozairi, Edward B Jude, Xiaoying Li, Julio Rosenstock
Despite novel therapeutic options, many people with type 2 diabetes (T2D) do not achieve their HbA1c targets. Given the progressive nature of T2D, many individuals not controlled with oral therapy will require advancement to injectable therapy using either a glucagon-like peptide-1 receptor agonist (GLP-1 RA), recently recommended as a first option, or traditionally a basal insulin. However, premix insulins remain frequently used, either as initial injectable therapy or as intensification from basal insulin...
March 2, 2021: Diabetes, Obesity & Metabolism
Lunwen Rao, Chenhong Ren, Shan Luo, Chenghu Huang, Xuefeng Li
AIMS: The aim was to systematically review the efficacy and safety of sodium-glucose cotransporter inhibitor (SGLT2i) as an adjunct to insulin at different follow-up durations in randomized, double-blind clinical trials in patients with type 1 diabetes. METHODS: We conducted a search on Medline, Embase, and the Cochrane Library for relevant studies published before May 2020. According to the duration of follow-up, the subgroup analysis included four periods: 1-4, 12-18, 24-26, and 52 weeks...
March 2, 2021: Acta Diabetologica
Yasaman Ghorbani, Katherine J P Schwenger, Johane P Allard
PURPOSE: Increasing evidence suggests that the intestinal microbiome (IM) and bacterial metabolites may influence glucose homeostasis, energy expenditure and the intestinal barrier integrity and lead to the presence of systemic low-grade inflammation, all of which can contribute to insulin resistance (IR) and type 2 diabetes (T2D). The purpose of this review is to explore the role of the IM and bacterial metabolites in the pathogenesis and treatment of these conditions. RESULTS: This review summarizes research focused on how to modulate the IM through diet, prebiotics, probiotics, synbiotics and fecal microbiota transplant in order to treat IR and T2D...
March 2, 2021: European Journal of Nutrition
Riccardo Tamburrini, Jon S Odorico
PURPOSE OF REVIEW: The aim of the present review is to gather recent reports on the use of pancreas and islet transplantation and conventional insulin therapy for treating patients experiencing diabetes and its related complications. The present review directs attention to the current status, challenges and perspectives of these therapies and sheds light on potential future cellular therapies. RECENT FINDINGS: The risks and benefits of diabetes treatment modalities continue to evolve, altering the risk versus benefit calculation for patients...
April 1, 2021: Current Opinion in Organ Transplantation
Chloe B H Asato, Denise C Nelson-Hurwitz, Thomas Lee, Andrew Grandinetti
Background: Accurate prevalence measurement and diagnosis to prevent type 2 diabetes mellitus and cardiovascular disease cannot occur without consistent diagnostic criteria that can be applied to varying populations. Objective: The objective of this study was to determine the prevalence of metabolic syndrome in Caucasian, Filipino, Native Hawaiian, and Japanese populations utilizing different definitions. Methods: This study utilized cross-sectional study data from the Native Hawaiian/Multiethnic Health Research Project, collected from a population living in Kohala, Hawai'i...
March 1, 2021: Metabolic Syndrome and related Disorders
Lady Katerine Serrano Mujica, Carolina S Stein, Ligia Gomes Miyazato, Fernanda Valente, Melissa Orlandin Premaor, Alfredo Quites Antoniazzi, Rafael Noal Moresco, Fabio Vasconcellos Comim
Background: This study aims to evaluate metabolic and oxidative stress markers in a postmenopausal rat model of polycystic ovary syndrome (PCOS). Methods: Wistar rats were divided in four groups: control ovariectomized (OVX; n  = 9), control SHAM ( n  = 9), androgenized OVX ( n  = 10), and androgenized SHAM ( n  = 10). Female rats were androgenized during the neonatal period and compared with controls. Surgery (ovariectomy or SHAM procedure) was performed at day 100 and euthanasia at day 180 of life...
March 1, 2021: Metabolic Syndrome and related Disorders
Fazel Sahraneshin Samani, Marzieh Ebrahimi, Tahereh Zandieh, Reyhaneh Khoshchehreh, Mohamadreza Baghaban Eslaminejad, Nasser Aghdami, Hossein Baharvand
In this article which was published in Cell J, Vol 17, No 2, Summer 2015, on pages 211-220, the authors found that Figures 3 and 4 had some errors that accidentally happened during organizing figures as well as because of mislabeling of some images and saving them in an incorrect folder. The following figures are corrected. The authors would like to apologies for any inconvenience caused.
April 2021: Cell Journal
Anahita Oveisi, Akbar Vahdati, Maryam Shahhoseini, Raha Favaedi, Saman Maroufizadeh, Bahar Movaghar
Objective: Genomic imprinting is an epigenetic phenomenon that plays a critical role in normal development of embryo. Using exogenous hormones during assisted reproductive technology (ART) can change an organism hormonal profile and subsequently affect epigenetic events. Ovarian stimulation changes gene expression and epigenetic pattern of imprinted genes in the organs of mouse fetus. Materials and Methods: For this experimental study, expression of three imprinted genes H19, Igf2 (Insulin-like growth factor 2) and Cdkn1c (Cyclin-dependent kinase inhibitor 1C), which have important roles in development of placenta and embryo, and the epigenetic profile of their regulatory region in some tissues of 19-days-old female fetuses, from female mice subjected to ovarian stimulation, were evaluated by quantitative reverse-transcription PCR (qRT-PCR) and Chromatin immunoprecipitation (ChIP) methods...
April 2021: Cell Journal
Adele Chimento, Arianna De Luca, Marta Claudia Nocito, Sara Sculco, Paola Avena, Davide La Padula, Lucia Zavaglia, Rosa Sirianni, Ivan Casaburi, Vincenzo Pezzi
Adrenocortical cancer (ACC) is a rare tumour with unfavourable prognosis, lacking an effective treatment. This tumour is characterized by IGF-II (insulin-like growth factor II) overproduction, aromatase and ERα (oestrogen receptor alpha) up-regulation. Previous reports suggest that ERα expression can be regulated by sirt1 (sirtuin 1), a nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylases that modulates activity of several substrates involved in cellular stress, metabolism, proliferation, senescence, protein degradation and apoptosis...
March 2, 2021: Journal of Cellular and Molecular Medicine
Dong-Yan Guan, Hui-Wen Sun, Ji-Ting Wang, Zhen Wang, Yang Li, Hao-Jun Han, Xiang Li, Ting-Ting Fang
The study aimed to explore the effects of rosiglitazone on glucose metabolism of GIFT tilapia based on the PI3K/Akt signaling pathway. The experiment was divided into five groups: normal starch group (32%, LC), high starch group (53%, HC), high starch +rosiglitazone group 1 (10 mg/kg, R1), high starch + rosiglitazone group 2 (20 mg/kg, R2), and high starch + rosiglitazone group 3 (30 mg/kg, R3). The results showed that a high starch diet supplemented with 10-20 mg/kg rosiglitazone had a better specific growth rate and protein efficiency that was beneficial for the growth of the tilapia...
March 2021: Physiological Reports
Guang Ren, Robert L Bowers, Teayoun Kim, Alonzo J Mahurin, Peter W Grandjean, Suresh T Mathews
Fetuin-A (Fet-A), secreted by the liver and adipose tissue, inhibits insulin receptor tyrosine kinase activity and modulates insulin action. Numerous studies have shown association of elevated serum Fet-A concentrations with obesity, non-alcoholic fatty liver disease, and type 2 diabetes. Both moderate body weight loss (5%-10%) and significant body weight loss have been shown to decrease serum Fet-A and improve insulin sensitivity. Currently, there are no studies examining the effects of a single bout of exercise on serum Fet-A or Ser312-pFet-A (pFet-A) responses...
March 2021: Physiological Reports
Yasuyo Ando, Fumika Shigiyama, Takahisa Hirose, Naoki Kumashiro
INTRODUCTION: We investigated the potential use of canagliflozin, in comparison with liraglutide, as an alternative to bolus insulin in patients with well-controlled type 2 diabetes mellitus (T2DM) receiving multiple daily insulin injection therapy (MDI). MATERIALS AND METHODS: In 40 patients, with HbA1c level of <7.5% controlled by MDI, all bolus insulin was randomly switched to canagliflozin (100 mg/day) or liraglutide (0.3-0.9 mg/day) for 24 weeks. Basal insulin was continued with dose adjustment according to a predefined algorithm...
March 2, 2021: Journal of Diabetes Investigation
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