Yu-Yang Lin, Elias H Jbeily, Priscilla M Tjandra, Michael C Pride, Michael Lopez-Torres, Seif B Elmankabadi, Connor M Delman, Kristin K Biris, Heejung Bang, Jill L Silverman, Cassandra A Lee, Blaine A Christiansen
OBJECTIVE: People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA. The goal of this study was to determine how surgical restabilization of a mouse knee joint following non-invasive ACL injury affects PTOA progression. DESIGN: In this study, 187 mice were subjected to non-invasive ACL injury or no injury...
April 30, 2024: Osteoarthritis and Cartilage