Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Yu Zhang, Yuan-Jie Liu, Jia Mei, Zhao-Xu Yang, Xiao-Ping Qian, Wei Huang
Colorectal cancer (CRC) is the third most common malignant disease worldwide, and its incidence is increasing, but the molecular mechanisms of this disease are highly heterogeneous and still far from being fully understood. Increasing evidence suggests that fibrosis mediated by abnormal activation of fibroblasts based in the microenvironment is associated with a poor prognosis. However, the function and pathogenic mechanisms of fibroblasts in CRC remain unclear. Here, combining scrna-seq and clinical specimen data, DAZ Interacting Protein 1 (DZIP1) was found to be expressed on fibroblasts and cancer cells and positively correlated with stromal deposition...
February 9, 2024: Molecular Biotechnology
#2
REVIEW
Jasper Iske, Maximilian J Roesel, Nikola Cesarovic, Leonard Pitts, Annabel Steiner, Leonard Knoedler, Timo Z Nazari-Shafti, Serdar Akansel, Stephan Jacobs, Volkmar Falk, Joerg Kempfert, Markus Kofler
Mitral valve prolapse (MVP) is common among heart valve disease patients, causing severe mitral regurgitation (MR). Although complications such as cardiac arrhythmias and sudden cardiac death are rare, the high prevalence of the condition leads to a significant number of such events. Through next-generation gene sequencing approaches, predisposing genetic components have been shown to play a crucial role in the development of MVP. After the discovery of the X-linked inheritance of filamin A, autosomal inherited genes were identified...
November 30, 2023: Journal of Clinical Medicine
#3
JOURNAL ARTICLE
Qizhen Tang, Quanxin Su, Letian Wei, Kenan Wang, Tao Jiang
OBJECTIVE: The cause and mechanism of non-obstructive azoospermia (NOA) is complicated; therefore, an effective therapy strategy is yet to be developed. This study aimed to analyse the pathogenesis of NOA at the molecular biological level and to identify the core regulatory genes, which could be utilised as potential biomarkers. METHODS: Three NOA microarray datasets (GSE45885, GSE108886, and GSE145467) were collected from the GEO database and merged into training sets; a further dataset (GSE45887) was then defined as the validation set...
2023: Frontiers in Endocrinology
#4
JOURNAL ARTICLE
Bo Liu, Ling-Li Lv, Ping Liu, Yun-Yan Xu, Mian Guo, Jie Liu, Jing-Shan Shi
Senescence-accelerated mouse prone 8 (SAMP8) mice exhibit cognitive defects and neuron loss with aging, and were used to study anti-aging effects of Dendrobium nobile alkaloids (DNLA). DNLA (20 and 40 mg/kg) were orally administered to SAMP8 mice from 6 to 10 months of age. At 10-month of age, behavioral tests via Y-maze and Open-field and neuron damage via Nissl staining were evaluated. Protein was extracted and subjected to phosphorylated proteomic analysis followed by bioinformatic analysis. The cognitive deficits and neuron loss in hippocampus and cortex of aged SAMP8 mice were improved by DNLA...
May 6, 2023: Experimental Gerontology
#5
REVIEW
Constance Delwarde, Romain Capoulade, Jean Mérot, Solena Le Scouarnec, Nabila Bouatia-Naji, Mengyao Yu, Olivier Huttin, Christine Selton-Suty, Jean-Marc Sellal, Nicolas Piriou, Jean-Jacques Schott, Christian Dina, Thierry Le Tourneau
Mitral valve prolapse (MVP) is a common condition affecting 2-3% of the general population, and the most complex form of valve pathology, with a complication rate up to 10-15% per year in advanced stages. Complications include mitral regurgitation which can lead to heart failure and atrial fibrillation, but also life-threatening ventricular arrhythmia and cardiovascular death. Sudden death has been recently brought to the forefront of MVP disease, increasing the complexity of management and suggesting that MVP condition is not properly understood...
2023: Frontiers in Cardiovascular Medicine
#6
JOURNAL ARTICLE
Yi Yin, Yuanjie Liu, Yunya Wang, Jiepin Li, Shuo Liang, Wei Zhang, Zhibin Ma, Shenlin Liu, Xi Zou
The tumor microenvironment (TME) contains complex components, of which the most well-known one is the tumor-associated fibroblast (CAF) that participates in the development and progression of tumors. A high abundance of CAFs implies that tumor stroma is also abundant and often predicts a poor prognosis, especially in terms of immunotherapeutic resistance. In this study, DAZ interacting zinc finger protein 1 (DZIP1) was identified to be upregulated in CAFs and malignant epithelial cells based on single-cell sequencing...
February 17, 2023: International Immunopharmacology
#7
JOURNAL ARTICLE
Yuda Gong, Xuan Liu, Arvind Sahu, Abhinav V Reddy, Haiyu Wang
Background: Gastric cancer (GC) is the 5th most common cause of cancer in the world and the 3rd largest cause of cancer-related death. It is usually associated with a variety of cancers, of which cholangiocarcinoma (CCA) combined with GC accounts for about 1.6%. This study sought to examine the hub genes and role of lipid metabolism in the development and diagnosis of GC and CCA. Methods: To screen potential hub genes, The Cancer Genome Atlas (TCGA) data sets, including the GC (STAD, dataset of GC) and CCA (CHOL, dataset of CCA) data sets, were used to conduct a differentially expressed gene (DEG) analysis and an enrichment analysis of the DEGs...
August 2022: Annals of Translational Medicine
#8
REVIEW
Nicolò Azzola Guicciardi, Michele De Bonis, Chiara Di Resta, Guido Ascione, Ottavio Alfieri, Francesco Maisano, Pasquale Vergara
Mitral valve prolapse (MVP) has a prevalence of 2-3% among the population. It involves a heterogeneous group of patients with different expressions and according to the phenotype can be further divided into fibroelastic deficiency, which is mainly considered as a degeneration due to aging, and myxomatous disease, frequently associated with familiar clusters. Thus, MVP can be present in syndromic, when part of a well-defined syndrome, and non-syndromic forms. The latter occurs more often. To the second belong both familiar and isolated or sporadic forms...
March 12, 2022: Reviews in Cardiovascular Medicine
#9
JOURNAL ARTICLE
Jordan E Morningstar, Cortney Gensemer, Reece Moore, Diana Fulmer, Tyler C Beck, Christina Wang, Kelsey Moore, Lilong Guo, Franz Sieg, Yasufumi Nagata, Philippe Bertrand, Ricardo A Spampinato, Janiece Glover, Stephen Poelzing, Robert G Gourdie, Kelsey Watts, William J Richardson, Robert A Levine, Michael A Borger, Russell A Norris
Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP. Methods and Results We performed histopathologic analysis of left ventricular (LV) biopsies from peripapillary regions, inferobasal LV wall and apex on surgical patients with MVP, as well as in a mouse model of human MVP ( Dzip1S14R /+ )...
December 21, 2021: Journal of the American Heart Association
#10
JOURNAL ARTICLE
Yuan-Jie Liu, Jie-Pin Li, Shu-Hong Zeng, Mei Han, Shen-Lin Liu, Xi Zou
Purpose: Gastric cancer (GC) is a common type of cancer worldwide. It can relapse and metastasize even after standard treatment; therefore, it has a poor prognosis. Moreover, sensitive biomarkers for prognosis prediction in GC are lacking. In this study, using a bioinformatics approach, we aimed to examine the value of DAZ Interacting Protein 1 ( DZIP1 ) as a prognostic predictor and therapeutic target in GC. Methods: We explored the clinical relevance, function, and molecular role of DZIP1 in GC using MethSurv, cBioPortal, TIMER, Gene Expression Profiling Interactive Analysis, IMEx, ONCOMINE, MEXPRESS, and EWAS Atlas databases...
2021: Pharmacogenomics and Personalized Medicine
#11
JOURNAL ARTICLE
Lilong Guo, Tyler Beck, Diana Fulmer, Sandra Ramos-Ortiz, Janiece Glover, Christina Wang, Kelsey Moore, Cortney Gensemer, Jordan Morningstar, Reece Moore, Jean-Jacques Schott, Thierry Le Tourneau, Natalie Koren, Russell A Norris
BACKGROUND: Mitral valve prolapse (MVP) is a common and progressive cardiovascular disease with developmental origins. How developmental errors contribute to disease pathogenesis are not well understood. RESULTS: A multimeric complex was identified that consists of the MVP gene Dzip1, Cby1, and β-catenin. Co-expression during valve development revealed overlap at the basal body of the primary cilia. Biochemical studies revealed a DZIP1 peptide required for stabilization of the complex and suppression of β-catenin activities...
April 2, 2021: Developmental Dynamics
#12
JOURNAL ARTICLE
Zhimao Wu, Nan Pang, Yingying Zhang, Huicheng Chen, Ying Peng, Jingyan Fu, Qing Wei
Cilia play critical roles during embryonic development and adult homeostasis. Dysfunction of cilia leads to various human genetic diseases, including many caused by defects in transition zones (TZs), the "gates" of cilia. The evolutionarily conserved TZ component centrosomal protein 290 (CEP290) is the most frequently mutated human ciliopathy gene, but its roles in ciliogenesis are not completely understood. Here, we report that CEP290 plays an essential role in the initiation of TZ assembly in Drosophila...
December 28, 2020: PLoS Biology
#13
JOURNAL ARTICLE
Jean-André Lapart, Amélie Billon, Jean-Luc Duteyrat, Joëlle Thomas, Bénédicte Durand
Cilia play important signaling or motile functions in various organisms. In Human, cilia dysfunctions are responsible for a wide range of diseases, called ciliopathies. Cilia assembly is a tightly controlled process, which starts with the conversion of the centriole into a basal body, leading to the formation of the ciliary bud that protrudes inside a ciliary vesicle and/or ultimately at the cell surface. Ciliary bud formation is associated with the assembly of the transition zone (TZ), a complex architecture of proteins of the ciliary base which plays critical functions in gating proteins in and out of the ciliary compartment...
June 30, 2020: Biochemical Society Transactions
#14
JOURNAL ARTICLE
Aniek L van Wijngaarden, Yasmine L Hiemstra, Tamara T Koopmann, Claudia A L Ruivenkamp, Emmelien Aten, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Daniela Q C M Barge-Schaapveld, Nina Ajmone Marsan
PURPOSE: Although a familial distribution has been documented, the genetic aetiology of mitral valve prolapse (MVP) is largely unknown, with only four genes identified so far: FLNA , DCHS1 , DZIP1 and PLD1 . The aim of this study was to evaluate the genetic yield in known causative genes and to identify possible novel genes associated with MVP using a heart gene panel based on exome sequencing. METHODS: Patients with MVP were referred for genetic counselling when a positive family history for MVP was reported and/or Barlow's disease was diagnosed...
April 10, 2020: Journal of Medical Genetics
#15
JOURNAL ARTICLE
Mingrong Lv, Wangjie Liu, Wangfei Chi, Xiaoqing Ni, Jiajia Wang, Huiru Cheng, Wei-Yu Li, Shenmin Yang, Huan Wu, Junqiang Zhang, Yang Gao, Chunyu Liu, Caihua Li, Chenyu Yang, Qing Tan, Dongdong Tang, Jingjing Zhang, Bing Song, Yu-Jie Chen, Qiang Li, Yading Zhong, Zhihua Zhang, Hexige Saiyin, Li Jin, Yuping Xu, Ping Zhou, Zhaolian Wei, Chuanmao Zhang, Xiaojin He, Feng Zhang, Yunxia Cao
BACKGROUND: Asthenoteratospermia, one of the most common causes for male infertility, often presents with defective sperm heads and/or flagella. Multiple morphological abnormalities of the sperm flagella (MMAF) is one of the common clinical manifestations of asthenoteratospermia. Variants in several genes including DNAH1 , CEP135 , CATSPER2 and SUN5 are involved in the genetic pathogenesis of asthenoteratospermia. However, more than half of the asthenoteratospermia cases cannot be explained by the known pathogenic genes...
February 12, 2020: Journal of Medical Genetics
#16
JOURNAL ARTICLE
Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila .
Jean-André Lapart, Marco Gottardo, Elisabeth Cortier, Jean-Luc Duteyrat, Céline Augière, Alain Mangé, Julie Jerber, Jérôme Solassol, Jay Gopalakrishnan, Joëlle Thomas, Bénédicte Durand
Cilia and flagella are conserved eukaryotic organelles essential for cellular signaling and motility. Cilia dysfunctions cause life-threatening ciliopathies, many of which are due to defects in the transition zone (TZ), a complex structure of the ciliary base. Therefore, understanding TZ assembly, which relies on ordered interactions of multiprotein modules, is of critical importance. Here, we show that Drosophila Dzip1 and Fam92 form a functional module which constrains the conserved core TZ protein, Cep290, to the ciliary base...
December 10, 2019: ELife
#17
JOURNAL ARTICLE
Wangxiang Yan, Yun Deng, Yuhang Zhang, Jing Luo, Dunlang Lu, Quan Wan, Lijuan Mao, Yu Chen
BACKGROUND: DZIP1 is an oncogene involved in the progression and stemness of carcinoma through the Wnt/β-catenin pathway, and the potential mechanism of DZIP1 in oral squamous cancer remains unknown. The aim of this study was to uncover the effect and mechanism of DZIP1 in the progression of oral squamous carcinoma. METHODS: TCGA database scanning was applied to verify dysregulated genes in oral squamous carcinoma. quantitative real-time polymerase chain reaction, immunohistochemistry, and Western blotting assays were used to detect the expression of DZIP1 in tissues and cell lines...
August 23, 2019: Translational Oncology
#18
JOURNAL ARTICLE
Darawalee Wangsa, Rüdiger Braun, Christina H Stuelten, Markus Brown, Kerry M Bauer, Georg Emons, Leigh A Weston, Yue Hu, Howard H Yang, Maria Vila-Casadesús, Maxwell P Lee, Philip Brauer, Lidia Warner, Madhvi Upender, Amanda B Hummon, Jordi Camps, Thomas Ried
Chromosomal aneuploidy is a defining feature of epithelial cancers. The pattern of aneuploidies is cancer-type specific. For instance, the gain of chromosome 13 occurs almost exclusively in colorectal cancer. We used microcell-mediated chromosome transfer to generate gains of chromosome 13 in the diploid human colorectal cancer cell line DLD-1. Extra copies of chromosome 13 resulted in a significant and reproducible up-regulation of transcript levels of genes on chromosome 13 (P = .0004, FDR = 0.01) and a genome-wide transcriptional deregulation in all 8 independent clones generated...
July 2019: Neoplasia: An International Journal for Oncology Research
#19
JOURNAL ARTICLE
Katelynn A Toomer, Mengyao Yu, Diana Fulmer, Lilong Guo, Kelsey S Moore, Reece Moore, Ka'la D Drayton, Janiece Glover, Neal Peterson, Sandra Ramos-Ortiz, Alex Drohan, Breiona J Catching, Rebecca Stairley, Andy Wessels, Joshua H Lipschutz, Francesca N Delling, Xavier Jeunemaitre, Christian Dina, Ryan L Collins, Harrison Brand, Michael E Talkowski, Federica Del Monte, Rupak Mukherjee, Alexander Awgulewitsch, Simon Body, Gary Hardiman, E Starr Hazard, Willian A da Silveira, Baolin Wang, Maire Leyne, Ronen Durst, Roger R Markwald, Solena Le Scouarnec, Albert Hagege, Thierry Le Tourneau, Peter Kohl, Eva A Rog-Zielinska, Patrick T Ellinor, Robert A Levine, David J Milan, Jean-Jacques Schott, Nabila Bouatia-Naji, Susan A Slaugenhaupt, Russell A Norris
Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death, and to date, the causes of this disease are poorly understood. We now demonstrate that defects in primary cilia genes and their regulated pathways can cause MVP in familial and sporadic nonsyndromic MVP cases. Our expression studies and genetic ablation experiments confirmed a role for primary cilia in regulating ECM deposition during cardiac development...
May 22, 2019: Science Translational Medicine
#20
JOURNAL ARTICLE
Wenjia Qiang, Yunpeng Huang, Zhihui Wan, Bing Zhou
Metallothionein (MT) protein families are a class of small and universal proteins rich in cysteine residues. They are synthesized in response to heavy metal stresses to sequester the toxic ions by metal-thiolate bridges. Five MT family members, namely MtnA, MtnB, MtnC, MtnD and MtnE, have been discovered and identified in Drosophila. These five isoforms of MTs are regulated by metal responsive transcription factor dMTF-1 and play differentiated but overlapping roles in detoxification of metal ions. Previous researches have shown that Drosophila MtnB responds to copper (Cu), cadmium (Cd) and zinc (Zn)...
April 21, 2017: Biochemical and Biophysical Research Communications
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
