iodine uptake

Gui-Xiong Zhang, Yan-Lan Liu, Min Yang, Wen-Shan Huang, Jie-Hua Xu
Aptamers which are promising and effective molecular probes, can deliver either fluorescent materials or radionuclides to tumors. This study aimed to develop a novel both fluorescent and radionuclide dual-modality probe based on a truncated aptamer and evaluate its stability and binding affinities in vitro. The aptamer JHIT2 with binding specifically to HepG2 cells was previously generated by Cell-SELEX. Using mfold and RNAstructure software to predict the secondary structure folded by a middle random sequence to truncate the primer sequences at both ends of the aptamer JHIT2 to yield the aptamer JHIT2e, with a similar secondary structure to JHIT2 and the same specificity and affinity as JHIT2...
February 17, 2020: Biochimie
Tomohiro Sato, Masanao Hayashi
Specific binding ratio (SBR) is mainly used as a quantitative index of dopamine transporter scintigraphy, although it was reported that standardized uptake value (SUV) is useful for clinical diagnosis in recent years. The aim of this study is to evaluate whether xSPECT is useful for SUV in dopamine transporter scintigraphy. xSPECT is a recently developed, high-resolution image reconstruction technique that transforms single photon emission computed tomography (SPECT) to a computed tomography (CT) coordinate system...
2020: Nihon Hoshasen Gijutsu Gakkai Zasshi
Haruko Nakamura, Hiroshi Doi, Satomi Mitsuhashi, Satoko Miyatake, Kazutaka Katoh, Martin C Frith, Tetsuya Asano, Yosuke Kudo, Takuya Ikeda, Shun Kubota, Misako Kunii, Yu Kitazawa, Mikiko Tada, Mitsuo Okamoto, Hideto Joki, Hideyuki Takeuchi, Naomichi Matsumoto, Fumiaki Tanaka
Recently, a recessively inherited intronic repeat expansion in replication factor C1 (RFC1) was identified in cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS). Here, we describe a Japanese case of genetically confirmed CANVAS with autonomic failure and auditory hallucination. The case showed impaired uptake of iodine-123-metaiodobenzylguanidine and 123 I-ioflupane in the cardiac sympathetic nerve and dopaminergic neurons, respectively, by single-photon emission computed tomography...
February 18, 2020: Journal of Human Genetics
Giacomo Pirovano, Stephen A Jannetti, Lukas M Carter, Ahmad Sadique, Susanne Kossatz, Navjot Guru, Paula Demétrio De Souza França, Masatomo Maeda, Brian M Zeglis, Jason S Lewis, John L Humm, Thomas Reiner
PURPOSE: Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent decades. EXPERIMENTAL DESIGN: 123 I-MAPi (Iodine-123 Meitner-Auger PARP1 inhibitor) is a precise therapeutic tool composed of a PARP1 inhibitor radiolabeled with an Auger- and gamma-emitting iodine isotope. Here, the PARP inhibitor, which binds to the DNA repair enzyme PARP1, specifically targets cancer cells, sparing healthy tissue, and carries a radioactive payload within reach of the cancer cells' DNA...
February 17, 2020: Clinical Cancer Research
Paul Gaschen, Joehassin Cordero, Alan N Peiris
Total thyroidectomy for hyperthyroidism is usually curative. We report the unusual recurrence of thyrotoxicosis following a near-total thyroidectomy. The patient, a 27-year-old woman, elected to have a total thyroidectomy and began levothyroxine after the procedure. Approximately 2 years later, recurrent thyrotoxicosis was evident off levothyroxine. Vascularized thyroid tissue was noted on ultrasound, and a radioactive iodine scan indicated increased uptake in the right thyroid region. She began antithyroid medication and was subsequently treated with radioactive iodine once a euthyroid state was achieved...
January 2020: Proceedings of the Baylor University Medical Center
Junaid Zia Hashmi, Ammarah Ghafoor, Arifa Zia Hashmi, Shaheer Anwar, Zubair Siddiqui, Kanza Zia Hashmi
Ectopic lingual thyroid along with a normally located thyroid gland is an uncommon condition caused by an aberrant descent of thyroid during embryogenesis. It is more common among females and expresses during puberty, pregnancy and menopause. It is mostly associated with hypothyroidism. Patient usually presents with complaints of dysphagia, dysphonia and suffocation. Treatment of choice depends upon the primary complaint of the patient. We present the case of a young female who underwent tracheostomy to relieve respiratory tract obstruction during puberty and was later diagnosed as a case of ectopic lingual thyroid by radioactive iodine uptake and CT scan imaging...
February 2020: JPMA. the Journal of the Pakistan Medical Association
Zinat Changani, Amir Razmjou, Asghar Taheri-Kafrani, Majid Ebrahimi Warkiani, Mohsen Asadnia
The development of stable and effective iodine removal systems would be highly desirable in addressing environmental issues relevant to water contamination. In the present research, a novel iodine adsorbent was synthesized by self-polymerization of dopamine (PDA) onto inert polypropylene (PP) membrane. This PP/PDA membrane was thoroughly characterized and its susrface propeties was analyzed by various analytical techniques indcluding field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH), contact angle, and surface free energy measurement...
February 4, 2020: Chemosphere
Jessica J Miller, Anaïs Blanchet, Christophe Orvain, Lucienne Nouchikian, Yasmin Reviriot, Ryan M Clarke, Diego Martelino, Derek Wilson, Christian Gaiddon, Tim Storr
Protein misfolding and aggregation contributes to the development of a wide range of diseases. In cancer, over 50% of diagnoses are attributed to p53 malfunction due to missense mutations, many of which result in protein misfolding and accelerated aggregation. p53 mutations also frequently result in alteration or loss of zinc at the DNA-binding site, which increases aggregation via nucleation with zinc-bound p53. Herein, we designed two novel bifunctional ligands, LI and LH , to modulate mutant p53 aggregation and restore zinc binding using a metallochaperone approach...
December 14, 2019: Chemical Science
Márcia Faria, Rita Domingues, Francisca Paixão, Maria João Bugalho, Paulo Matos, Ana Luísa Silva
The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool, being RAI therapy the systemic treatment of choice for metastatic disease. Still, a significant proportion of patients with advanced TC lose the ability to respond to RAI therapy and no effective alternative therapies are available. Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to malignant transformation...
2020: PloS One
Takashi Kudo, Akihiro Inano, Sanae Midorikawa, Hitoshi Kubo, Kino Hayashi, Sawako Nakashima, Chizu Fukushima, Kazuya Maeda, Noboru Oriuchi, Shin Irie, Shunichi Yamashita, Hiroyuki Kusuhara
The purpose of this study was to evaluate the kinetic parameters that determine the uptake rate of radioiodide in the thyroid over 24 h after administration and to estimate thyroid volumes/masses of present-day Japanese. Methods: We determined the thyroid uptake rate of I in healthy male Japanese after oral administration (4.5-8.0 MBq) without iodine restriction. Masses of thyroid glands were collected in 2012-2016 during autopsies of 7,651 male and 3,331 female subjects. Volumes of thyroid glands were estimated by ultrasonography and magnetic resonance imaging in 52 male subjects...
February 3, 2020: Health Physics
Hideki Ishii, Tomoteru Yamasaki, Joji Yui, Yiding Zhang, Masayuki Hanyu, Masanao Ogawa, Nobuki Nengaki, Atsushi B Tsuji, Yuya Terashima, Kouji Matsushima, Ming-Rong Zhang
[Thiocarbonyl-11 C]disulfiram ([11 C]DSF) was synthesized via iodine oxidation of [11 C]diethylcarbamodithioic acid ([11 C]DETC), which was prepared from [11 C]carbon disulfide and diethylamine. The decay-corrected isolated radiochemical yield (RCY) of [11 C]DSF was greatly affected by the addition of unlabeled carbon disulfide. In the presence of carbon disulfide, the RCY was increased up to 22% with low molar activity (Am , 0.27 GBq/μmol). On the other hand, [11 C]DSF was obtained in 0.4% RCY with a high Am value (95 GBq/μmol) in the absence of carbon disulfide...
January 28, 2020: Bioorganic & Medicinal Chemistry Letters
Wen-Yuan Pei, Jin Yang, Hui Wu, Wei Zhou, Ying-Wei Yang, Jian-Fang Ma
Construction of large multi-component coordination cages becomes much more challenging as the number of building blocks increases. A giant hexameric calix[4]resorcinarene-based coordination cage (cage-1) was successfully designed through the precise tuning of ancillary rigid tetracarboxylic acid. Significantly, cage-1 exhibited reversible uptake of volatile iodine, suggesting that it could serve as a porous material for efficient capture and separation of radioactive iodine.
January 31, 2020: Chemical Communications: Chem Comm
Xinyue Yao, Zhihao Zha, Karl Ploessl, Seok Rye Choi, Ruiyue Zhao, David Alexoff, Lin Zhu, Hank F Kung
Radioligand therapy (RLT) using prostate-specific membrane antigen (PSMA) targeting ligands is an attractive option for the treatment of Prostate cancer (PCa) and its metastases. We report herein a series of radioiodinated glutamate-urea-lysine-phenylalanine derivatives as new PSMA ligands in which l-tyrosine and l-glutamic acid moieties were added to increase hydrophilicity concomitant with improvement of in vivo targeting properties. Compounds 8, 15, 19a/19b and 23a/23b were synthesized and radiolabeled with 125 I by iododestannylation...
January 20, 2020: Bioorganic & Medicinal Chemistry
Mehmet Celik, Buket Yılmaz Bulbul, Semra Ayturk, Yusuf Durmus, Hakan Gurkan, Nuray Can, Ebru Tastekin, Funda Ustun, Atakan Sezer, Sibel Guldiken
Aim BRAF mutation inhibits many tumour suppressor genes, increases pro-angiogenic molecules and reduces radioactive iodine uptake of tumour in papillary thyroid cancer (PTC), giving it more aggressive clinical characteristics. In this study, we aimed to evaluate the effect of BRAF V600E mutation on the clinicopathological features in patients with PTC. Methods The laboratory and clinical findings of 256 PTC patients who were referred to our clinic between 2007 and 2017 were assessed. Subjects involved in the study were divided into two groups depending on the presence of BRAF V600E mutation...
February 1, 2020: Medicinski Glasnik
Yuchen Zhang, Joanne Wang
Cancer cells reprogram their gene expression to promote growth, survival, proliferation, and invasiveness. The unique expression of certain uptake transporters in cancers and their innate function to concentrate small molecular substrates in cells make them ideal targets for selective delivering imaging and therapeutic agents into cancer cells. In this review, we focus on several solute carrier (SLC) transporters known to be involved in transporting clinically used radiopharmaceutical agents into cancer cells, including the sodium/iodine symporter (NIS), norepinephrine transporter (NET), glucose transporter 1 (GLUT1), and monocarboxylate transporters (MCTs)...
January 2020: Acta Pharmaceutica Sinica. B
Florian Rosar, Martin J Hügle, Martin Ries, Mark Bartholomä, Stephan Maus, Peter Fries, Fadi Khreish, Samer Ezziddin
BACKGROUND: Accuracy of 68Ga-PSMA-11 PET/CT may be hampered by ureter accumulation, mimicking lymph node metastases depending on localization and configuration. The benefit of CT urography for differentiation of lymph node metastasis from urinary tract activity was evaluated in a "PET/CT with low-dose CT" setting. METHODS: Retrospective analysis of PET/CT for primary staging, biochemical recurrence or local treatment planning in patients with prostate cancer...
January 24, 2020: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Reina Kayama, Takeshi Fukuda, Sho Ogiwara, Mami Momose, Tadashi Tokashiki, Yoshinori Umezawa, Akihiko Asahina, Kunihiko Fukuda
The aim of this study was to investigate the feasibility of quantitative assessment of the therapeutic response in psoriatic arthritis (PsA) by measuring iodine uptake using a Dual-energy CT (DECT) iodine map. The study included 74 symptomatic and 74 matching non-symptomatic joints of 26 consecutive PsA patients who underwent two contrast enhanced DECTs of the hand or foot, pre and post medical interventions. Symptomatic and matched non-symptomatic control joints were scored with the PsA DECT Scoring System (PsADECTS), which was derived by modifying the PsA MRI Scoring System (PsAMRIS), a recently validated scoring system that assesses PsA changes on MRI...
January 27, 2020: Scientific Reports
Robert C Moore, Carolyn I Pearce, Joseph W Morad, Sayandev Chatterjee, Tatiana G Levitskaia, Robert M Asmussen, Amanda R Lawter, James J Neeway, Nikolla P Qafoku, Mark J Rigali, Sarah A Saslow, Jim E Szecsody, Praveen K Thallapally, Guohui Wang, Vicky L Freedman
Radioiodine-129 (129 I) in the subsurface is mobile and limited information is available on treatment technologies. Scientific literature was reviewed to compile information on materials that could potentially be used to immobilize 129 I through sorption and redox-driven processes, with an emphasis on ex-situ processes. Candidate materials to immobilize 129 I include iron minerals, sulfur-based materials, silver-based materials, bismuth-based materials, ion exchange resins, activated carbon, modified clays, and tailored materials (metal organic frameworks (MOFS), layered double hydroxides (LDHs) and aerogels)...
June 12, 2019: Science of the Total Environment
Maha Hichri, Georges Vassaux, Jean-Marie Guigonis, Thierry Juhel, Fanny Graslin, Julien Guglielmi, Thierry Pourcher, Béatrice Cambien
(1) Background: We recently showed that iodinated contrast media (ICM) reduced thyroid uptake of iodide independently of free iodide through a mechanism different from that of NaI and involving a dramatic and long-lasting decrease in Na/I symporter expression. The present study aimed at comparing the response of the thyroid to ICM and NaI using a quantitative proteomic approach. (2) Methods: Scintiscans were performed on ICM-treated patients. Micro Single-Photon Emission Computed Tomography (microSPECT/CT) imaging was used to assess thyroid uptakes in ICM- or NaI-treated mice and their response to recombinant human thyroid-stimulating hormone...
January 23, 2020: Journal of Clinical Medicine
Su Woong Yoo, Md Sunny Anam Chowdhury, Subin Jeon, Sae-Ryung Kang, Sang-Geon Cho, Jahae Kim, Changho Lee, Young Jae Ryu, Ho-Chun Song, Hee-Seung Bom, Jung-Joon Min, Seong Young Kwon
We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and RAI therapy were included. Based on the presence/absence of focal uptake at the anterior midline of the neck above the thyroidectomy bed on RxWBS, patients were classified into positive and negative uptake groups...
January 22, 2020: Cancers
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