Baek-Lok Oh, Jeong Seok Lee, Eun Young Lee, Hee Young Lee, Hyeong Gon Yu
Purpose : To investigate the incidence and risk factors of blindness in uveitis. Methods : From a national sample cohort (n = 1,025,340), we selected 9,036 new-onset uveitis patients. Incidences of unilateral and bilateral blindness (visual acuities ≤20/400) were estimated and socioeconomic and clinical risk factors for unilateral blindness in uveitis patients were identified. Result : Incidence of unilateral and bilateral blindness was 2.93 and 0.42 per 1,000 person-years, respectively. The risk factors for unilateral blindness were age >40 (hazard ratio [HR], 2...
April 15, 2020: Ocular Immunology and Inflammation
Arnd Heiligenhaus, Jens Klotsche, Martina Niewerth, Gerd Horneff, Gerd Ganser, Johannes-Peter Haas, Kirsten Minden
BACKGROUND: To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome. METHODS: Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002 to 2016. Cross-sectional data from the years 2002 to 2016 were analyzed. Patients with JIA-associated uveitis and with ANA-positive idiopathic anterior uveitis were included and the disease manifestation investigated in terms of uveitis characteristics and disease course...
April 15, 2020: Arthritis Research & Therapy
C Ellis Wisely, Katy C Liu, Divakar Gupta, Alan N Carlson, Sanjay G Asrani, Terry Kim
PURPOSE: To describe the patient characteristics and clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil. DESIGN: Retrospective case series. METHODS: Case series at a single academic center wherein treatment with netarsudil produced a particular pattern of bullous epithelial corneal edema. RESULTS: 6 episodes of reticular bullous epithelial corneal edema were identified in 5 eyes of 5 patients treated with netarsudil...
April 11, 2020: American Journal of Ophthalmology
Ilknur Tugal-Tutkun, Sumru Onal, Miles Stanford, Mehmet Akman, Jos W R Twisk, Maarten Boers, Merih Oray, Pinar Çakar Özdal, Sibel Kadayifcilar, Radgonde Amer, Sivakumar R Rathinam, Rajesh Vedhanayaki, Moncef Khairallah, Yonca Akova, Fatime Nilüfer Yalcindag, Esra Kardes, Berna Basarir, Çigdem Altan, Yilmaz Özyazgan, Ahmet Gül
Purpose : To develop an algorithm for the diagnosis of Behçet's disease (BD) uveitis based on ocular findings. Methods : Following an initial survey among uveitis experts, we collected multi-center retrospective data on 211 patients with BD uveitis and 207 patients with other uveitides, and identified ocular findings with a high diagnostic odds ratio (DOR). Subsequently, we collected multi-center prospective data on 127 patients with BD uveitis and 322 controls and developed a diagnostic algorithm using Classification and Regression Tree (CART) analysis and expert opinion...
April 14, 2020: Ocular Immunology and Inflammation
Athimalaipet V Ramanan, Andrew D Dick, Catherine Guly, Andrew McKay, Ashley P Jones, Ben Hardwick, Richard W J Lee, Matthew Smyth, Thomas Jaki, Michael W Beresford
Background: Uveitis associated with juvenile idiopathic arthritis is a cause of major ocular morbidity. A substantial proportion of children are refractory to systemic methotrexate and TNF inhibitors. Our aim was to study the safety and efficacy of tocilizumab in children with juvenile idiopathic arthritis-associated uveitis refractory to both methotrexate and TNF inhibitors. Methods: This multicentre, single-arm, phase 2 trial was done following a Simon's two-stage design at seven tertiary hospital sites in the UK...
March 2020: The Lancet Rheumatology
Louisa P Thong, Sophie L Rogers, Colby T Hart, Anthony J Hall, Lyndell L Lim
IMPORTANCE: The epidemiology of episcleritis and scleritis in Australia is largely unknown. BACKGROUND: To determine the incidence, prevalence and clinical characteristics of episcleritis and scleritis in Melbourne. DESIGN: Retrospective longitudinal study. PARTICIPANTS: Patients aged ≥18 years with episcleritis or scleritis seen at the Royal Victorian Eye and Ear Hospital from November 2014 to October 2015. METHODS: Medical record review confirmed clinical diagnosis and characteristics...
April 12, 2020: Clinical & Experimental Ophthalmology
Sara J Haug, Doan Luong Hien, Gunay Uludag, Than Trong Tuong Ngoc, Sherin Lajevardi, M Sohail Halim, Yasir J Sepah, Diana V Do, Arshad M Khanani
Purpose: To describe retinal arterial occlusion and vasculitis following intravitreal brolucizumab administration in a patient with neovascular age-related macular degeneration (nAMD). Observation: An 88-year-old Caucasian woman with neovascular age-related macular degeneration (nAMD) complained of painless loss of vision with light sensitivity in both eyes (OU) four weeks after bilateral intravitreal brolucizumab. Upon examination, her visual acuity decreased to 20/40 in the right eye (OD) and 20/50 in the left eye (OS)...
June 2020: American Journal of Ophthalmology Case Reports
Michael B Green, Milhim I Aswad, Mary K Daly
Purpose: To report a case of anterior uveitis caused by migration of cosmetic "hair-building fibers" into the anterior chamber and discuss previous literature describing ocular disease caused by small foreign fibers. Observations: A 73 year old male presented with his first episode of acute anterior uveitis. He was found to have a white fiber penetrating through the cornea into the anterior chamber. This foreign body was removed. The patient identified the material as a being from the cosmetic hair-building fiber product he had been using called Toppik...
June 2020: American Journal of Ophthalmology Case Reports
Daniel J Lee, Sapna Desai, Emily Laurent, Laura J Kopplin
Purpose : To assess the spectrum and treatment outcomes of inflammatory eye disease (IED) in subjects with hidradenitis suppurativa (HS). Methods : We conducted a single center retrospective chart review of 236 patients with HS seen for ophthalmic examination between 2013 and 2018. Results : Of 236 subjects with HS, 22 subjects (9.3%) were found to have IED. Seven of 22 subjects had more than one IED diagnosis. Anterior uveitis was the most common type of IED (40.9% of subjects with IED). Episcleritis, optic neuritis, keratitis, scleritis, intermediate and posterior uveitis, trochleitis, and dacryoadenitis were also observed...
April 7, 2020: Ocular Immunology and Inflammation
Xiaoxuan Liu, Thomas W McNally, Sophie Beese, Laura E Downie, Ameenat L Solebo, Livia Faes, Syed Husain, Pearse A Keane, David J Moore, Alastair K Denniston
Purpose : Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures for AC flare. Methods : In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability. Results : Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique...
April 7, 2020: Ocular Immunology and Inflammation
Mingzhi Lu, Xiaoran Wang, Lei Lei, Yang Deng, Tinglong Yang, Ye Dai, Yonghao Li, Xiaoliang Gan, Yixin Hu, Hui Chen, Meng Li, Lishi Su, Jin Yuan, Wei Chi
PURPOSE: We evaluated the clinical utility of a novel anterior segment optical coherence tomography (AS-OCT) device, CASIA2, to evaluate parameters indicative of anterior chamber (AC) inflammation severity in uveitis, including AC cell number, flare, and keratic precipitates (KPs). DESIGN: Prospective evaluation of a diagnostic device. METHODS: Uveitis eyes were classified into active and inactive groups. The number of hyper-reflective dots representing AC cells and optical density ratio (aqueous-to-air relative intensity [ARI] index) for flare qualification were calculated from AS-OCT images...
April 3, 2020: American Journal of Ophthalmology
Rupesh Agrawal, Ilaria Testi, Sarakshi Mahajan, Yew Sen Yuen, Aniruddha Agarwal, Andres Rousselot, Dhananjay Raje, Dinesh Visva Gunasekeran, Onn Min Kon, Talin Barisani-Asenbauer, John H Kempen, Amod Gupta, Douglas A Jabs, Justine R Smith, Bahram Bodaghi, Manfred Zierhut, Marc DeSmet, Peter Mc Cluskey, Mamta Agarwal, Manisha Agarwal, Kanika Aggarwal, Mukesh Agrawal, Hassan Al-Dhibi, Sofia Androudi, Fatma Asyari, Manohar Babu Balasundaram, Kalpana Babu Murthy, Edoardo Baglivo, Alay Banker, Reema Bansal, Soumyava Basu, Digamber Behera, Jyotirmay Biswas, Ester Carreño, Laure Caspers, Soon Phaik Chee, Romi Chhabra, Luca Cimino, Luz Elena Concha Del Rio, Emmett T Cunningham, Andrè Luiz Land Curi, Dipankar Das, Ekaterina Denisova, Alastair K Denniston, Marie-Hélène Errera, Alejandro Fonollosa, Amala George, Debra A Goldstein, Yan Guex Crosier, Avinash Gurbaxani, Alessandro Invernizzi, Hazlita M Isa, Shah Md Islam, Nicholas Jones, Deeksha Katoch, Moncef Khairallah, Amit Khosla, Michal Kramer, Amitabh Kumar, Atul Kumar, Rina La Distia Nora, Richard Lee, Careen Lowder, Saurabh Luthra, Padmamalini Mahendradas, Dorine Makhoul, Shahana Mazumdar, Salil Mehta, Elisabetta Miserocchi, Manabu Mochizuki, Oli S Mohamed, Cristina Muccioli, Marion R Munk, Somasheila Murthy, Shishir Narain, Heloisa Nascimento, Piergiorgio Neri, Myhanh Nguyen, Annabelle A Okada, Pinar Ozdal, Alan Palestine, Francesco Pichi, S R Rathinam, Ariel Schlaen, Shobha Sehgal, H Nida Sen, Aman Sharma, Kusum Sharma, Samir S Shoughy, Nirbhai Singh, Ramandeep Singh, Masoud Soheilian, Sudharshan Sridharan, Jennifer E Thorne, Christoph Tappeiner, Stephen Teoh, Maria Sofia Tognon, Ilknur Tugal-Tutkun, Mudit Tyagi, Harvey Uy, Daniel Vitor Vasconcelos Santos, Natasa Vidovic Valentincic, Mark Westcott, Ryoji Yanai, Bety Yanez Alvarez, Rahman Zahedur, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
An international, expert led consensus initiative was set up by the Collaborative Ocular Tuberculosis Study (COTS) group to develop systematic, evidence, and experience-based recommendations for the treatment of ocular TB using a modified Delphi technique process. In the first round of Delphi, the group identified clinical scenarios pertinent to ocular TB based on five clinical phenotypes (anterior uveitis, intermediate uveitis, choroiditis, retinal vasculitis, and panuveitis). Using an interactive online questionnaires, guided by background knowledge from published literature, 486 consensus statements for initiating ATT were generated and deliberated amongst 81 global uveitis experts...
April 6, 2020: Ocular Immunology and Inflammation
Haya H Al-Ani, Joanne L Sims, Oren Tomkins-Netzer, Susan Lightman, Rachael L Niederer
AIMS: To evaluate the long-term risk of permanent vision loss in subjects with anterior uveitis. METHODS: Retrospective study of subjects attending uveitis clinic at Auckland District Health Board and Moorfields Eye Hospital between 2008 and 2018. Main outcome measures were: best corrected visual acuity (BCVA); moderate vision loss (MVL ≤20/50); and severe vision loss (SVL ≤20/200). RESULTS: 2526 eyes of 1814 subjects were included with a mean follow-up of 6...
April 3, 2020: British Journal of Ophthalmology
Rachel L Davis, Christopher M Reilly, Phillip A Moore
OBJECTIVE: To report the surgical excision of an iridociliary adenoma and iridal melanocytoma using a postero-anterior cyclo-iridectomy in two dogs. PROCEDURE: A 7 year old neutered male English springer spaniel (case 1) and a 7 year old neutered male Labrador mix (case 2) were presented for evaluation of an intrairidal mass OS. RESULTS: Complete ophthalmic examination revealed a large, dorsonasal, well-demarcated, intrairidal mass OS. A tan to pink intrairidal mass extending into the iridocorneal angle (case 1) and a pigmented intrairidal mass (case 2) were present...
April 1, 2020: Veterinary Ophthalmology
Mariana M Flores, Fabio Del Piero, Perry L Habecker, Ingeborg M Langohr
Ocular diseases are an important category in equine medicine; however, most articles regarding histologic ocular lesions in horses are exclusive to a specific condition and do not provide a complete review of clinically significant ocular disease frequency in a diagnostic laboratory. We reviewed sections of equine eyes from 140 cases (98 enucleations [biopsies] and 42 autopsies) with clinically relevant ocular alterations at 2 diagnostic centers in the United States. The most common primary conditions were non-traumatic keratitis (36), equine recurrent uveitis (ERU; 31), traumatic injuries (22), ocular and periocular neoplasms (19), and uveitis and/or endophthalmitis resulting from sepsis (18)...
March 24, 2020: Journal of Veterinary Diagnostic Investigation
Marta Catarina Esteves Guedes, Maria Jorge Arroz, Catarina Martins, Miguel Angelo-Dias, Rui Daniel Proença, Luis Miguel Borrego
PURPOSE: Regulatory T cells (Tregs) have been intensively studied in a myriad of autoimmune diseases. As for noninfectious uveitis (NIU), results have been contradictory, and studies have failed to demonstrate a consistent reduction in Treg cell frequency in patients with active disease. The present study aims to characterize T lymphocyte subsets, including naïve and memory Tregs as well as their respective CD39 expression, in the peripheral blood of NIU patients. Inflammatory as well as suppressive cytokine profiles were also evaluated...
March 21, 2020: Graefe's Archive for Clinical and Experimental Ophthalmology
Gerard Espinosa, José M Herreras, Santiago Muñoz-Fernández, José M García Ruiz de Morales, Miguel Cordero-Coma
OBJECTIVE: To generate recommendations on the use of immunomodulators in patients with non-infectious, non-neoplastic intermediate uveitis (IU), posterior uveitis (PU) and panuveitis (PanU) based on best evidence and experience. METHODS: A multidisciplinary panel of 5 experts was established, who defined the scope, users, and sections of the document. A systematic literature review (SLR) was performed to assess the efficacy and safety of immunomodulatory drugs in patients with non-infectious, non-neoplastic, non-anterior uveitis...
March 19, 2020: Medicina Clínica
Anna H Brouwer, Gerard C de Wit, Ninette H Ten Dam, Ralph Wijnhoven, Maria M van Genderen, Joke H de Boer
PURPOSE: In uveitis, a prolonged implicit time of the cone b-wave is a characteristic electroretinogram (ERG) abnormality. We investigated whether this can improve or deteriorate over time and which clinical factors are associated with change. METHODS: Prospective cohort study. Patients with a non-infectious uveitis were included. An ERG was measured in the first year of uveitis onset and a follow-up ERG one year later. Changes in the implicit time of the cone b-wave were investigated in relation to clinical parameters including the following: demographics, uveitis characteristics, treatment, best-corrected visual acuity, optical coherence tomography parameters and fluorescein angiography scores...
March 19, 2020: Acta Ophthalmologica
Laraib Jumani, Deepak Kataria, Muhammad Umer Ahmed, Mir Ali Asghar Shah, Kunal Raja, Faizan Shaukat
Introduction Extra-intestinal manifestations (EIM) play an important role in the mortality, morbidity, and quality of life in patients with Crohn's disease (CD). Understanding the prevalence and clinical course of these manifestations is important to understand and manage CD. Materials and methods The hospital records of 103 patients diagnosed with CD between July 2016 and December 2019 at a tertiary care hospital in Pakistan were reviewed retrospectively. Baseline demographic and clinical characteristics including sex, age, follow-up duration, CD phenotype at diagnosis, clinical features, and course of EIMs were noted...
February 10, 2020: Curēus
X S Liu, F Gao, C Zhao, M F Zhang
Objective: To characterize the clinical features of patients with Behcet's uveitis. Methods: Retrospective case series study. Medical records of patients who were diagnosed as Behcet's uveitis in Peking Union Medical College Hospital between January 1998 and November 2015 were retrospectively reviewed. Information about the clinical manifestation, complication, best corrected visual acuity (logarithm of the minimum angle of resolution) and medication was collected. The correlation of visual acuity and the disease course, as well as inflammation relapse times before and after biological agents applied was analyzed...
March 11, 2020: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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