A Abitbol, L Merlini, E H Masmejean, T Gregory
The Wide-Awake Local Anesthesia No Tourniquet (WALANT) method is a recent anesthesia option for surgery of the upper limbs based on the injection of an anesthetic solution containing adrenaline at the surgical site, hence circumventing tourniquet use. In a prospective study, we compared the functional outcomes using this anesthesia technique with those of the regional anesthesia (RA) technique for the surgical care of distal radius fractures (DRF). From November 2019 to June 2020, a non-randomized, single-center study was conducted with a cohort of 41 patients suffering from a DRF and who received volar plate fixation at a university hospital center...
February 23, 2021: Hand Surgery and Rehabilitation
Yuangui Zhang, Qingqing Sun, Aixia Fan, Guimin Dong
Isoflurane was responsible for acute neuronal impairment, but its potential molecular mechanisms in damaging hippocampal neurons had not been clearly understood. This study aimed to explore the underlying mechanism of how isoflurane affected the cognitive function of aged rats by damaging the hippocampal neurons. Acute cognitive impairment was found in aged Wistar rats via Morris water maze test and Y-maze test after isoflurane anesthesia in a dose-dependent manner compared with the control group in vivo. Isoflurane also decreased the viabilities and strengthened the apoptotic potential of hippocampal neurons by damaging the mitochondria in a time-dependent manner compared with the control group which was reported by MTT, immunofluorescent assay, flow cytometry and western blot assay in vitro...
February 23, 2021: Behavioural Brain Research
Jane Tucker, Joanne Salas, Zidong Zhang, Richard Grucza, Jeffrey F Scherrer
The CDC Guideline for Prescribing Opioids for Chronic Pain cautioned against high dose prescribing but did not provide guidance on type of opioid for new pain episodes. We determined if new prescriptions for Schedule II opioids vs. tramadol decreased in the 18 months after vs. before the CDC guideline and if this decrease was associated with physician specialty. New opioid prescriptions, provider type and covariates were measured using a nationally distributed, Optum® de-identified Electronic Health Record (EHR) data base...
February 23, 2021: Preventive Medicine
Anu Kewlani, Nidhi Bhatia, Jeetinder Kaur Makkar, Vishal Kumar
BACKGROUND: The median effective dose of ropivacaine required for producing an effective costoclavicular block has not yet been determined. The authors conducted this dose-finding study with the objective of determining the median effective dose of 0.5% ropivacaine required to produce a successful costoclavicular block for surgical anesthesia in 50% of the patients (ED50) as well as the calculated dose required for effective blockade in 95% of the patients (ED95). METHODS: This single-armed prospective study was conducted on 40 American Society of Anesthesiologists physical status I or II patients, aged 18 to 60 yr, with a body mass index of 18 to 30 kg/m2, scheduled to undergo forearm and hand surgeries under ultrasound-guided costoclavicular block...
February 26, 2021: Anesthesiology
L Stan Leung, Liangwei Chu, Marco A M Prado, Vania F Prado
BACKGROUND: Cholinergic drugs are known to modulate general anesthesia, but anesthesia responses in acetylcholine-deficient mice have not been studied. It was hypothesized that mice with genetic deficiency of forebrain acetylcholine show increased anesthetic sensitivity to isoflurane and ketamine and decreased gamma-frequency brain activity. METHODS: Male adult mice with heterozygous knockdown of vesicular acetylcholine transporter in the brain or homozygous knockout of the transporter in the basal forebrain were compared with wild-type mice...
February 26, 2021: Anesthesiology
Dinesh Pal, George A Mashour
No abstract text is available yet for this article.
February 26, 2021: Anesthesiology
Angus Leung, Dror Cohen, Bruno van Swinderen, Naotsugu Tsuchiya
The physical basis of consciousness remains one of the most elusive concepts in current science. One influential conjecture is that consciousness is to do with some form of causality, measurable through information. The integrated information theory of consciousness (IIT) proposes that conscious experience, filled with rich and specific content, corresponds directly to a hierarchically organised, irreducible pattern of causal interactions; i.e. an integrated informational structure among elements of a system...
February 26, 2021: PLoS Computational Biology
Nishant Kumar
No abstract text is available yet for this article.
February 1, 2021: Anesthesia and Analgesia
Robert G Hahn
No abstract text is available yet for this article.
February 1, 2021: Anesthesia and Analgesia
Jean Gabriel Charchaflieh
No abstract text is available yet for this article.
February 1, 2021: Anesthesia and Analgesia
Nicholas D Sookhoo, Jie Zhou
No abstract text is available yet for this article.
February 1, 2021: Anesthesia and Analgesia
Rasa Mladenovic, Kristina Mladenovic, Pavle Milanovic, Dragica Selakovic
No abstract text is available yet for this article.
February 26, 2021: Journal of Dental Education
Sergio Lassola, Sara Miori, Andrea Sanna, Alberto Cucino, Sandra Magnoni, Michele Umbrello
PURPOSE: The COVID-19-related shortage of ICU beds magnified the need of tools to properly titrate the ventilator assistance. We investigated whether bedside-available indices such as the ultrasonographic changes in diaphragm thickening ratio (TR) and the tidal swing in central venous pressure (ΔCVP) are reliable estimates of inspiratory effort, assessed as the tidal swing in esophageal pressure (ΔPes). METHODS: Prospective, observational clinical investigation in the intensive care unit of a tertiary care Hospital...
February 26, 2021: Journal of Clinical Monitoring and Computing
L Eberhart, G Geldner, A Kowark, T-P Zucker, S Kreuer, M Przemeck, S Huljic, T Koch, T Keller, S Weber, P Kranke
No abstract text is available yet for this article.
February 26, 2021: Der Anaesthesist
Christina Scharf, Michael Zoller, Uwe Liebchen
No abstract text is available yet for this article.
February 26, 2021: Der Anaesthesist
Faisal Akhlaq Ali Khan, Moeez Fatima
BACKGROUND: Over the years, the techniques of performing abdominoplasty have been modified and altered. Some of these modifications include progressive tension suturing and preservation of sub-Scarpa fat. These alterations have been done to decrease the risk of postoperative seroma and hematoma formation. Abdominoplasty, without the use of drains, is well documented in the literature. Here, the authors describe that raising superficial flaps (in the sub-Scarpa fat plane) will reduce seroma formation risk...
February 26, 2021: Aesthetic Plastic Surgery
Orietta Agasaro, Georgette Munezero, Rex Wong, Aimé Hirwa, Abebe Bekele
BACKGROUND: Surgical interventions are cost-effective methods to save lives and prevent disabilities. Surgical delays and access to three Bellwether procedures are key monitoring indicators for universal access to safe and affordable surgical and anesthesia care and health system performance. This study assessed the delays in receiving surgical and anesthesia care for emergency surgical patients at a district hospital in Northern Rwanda. METHODS: A questionnaire was used to survey all emergency surgical patients who presented at the hospital between May and July 2020, to assess the delays in seeking (first) and reaching (second) care...
February 26, 2021: World Journal of Surgery
Ying Liang, Wei Wang, Xu Wang, Mingzheng Liu, Feilong Hei, Yulong Guan
PURPOSE: To examine key impacts of anesthesia on new-onset atrial fibrillation (AF) and acute kidney injury (AKI) in transcatheter aortic valve replacement (TAVR). METHODS: All consecutive patients who underwent transfemoral, transapical, and transaortic TAVR in Fuwai Hospital from 2012 to 2018 were retrospectively analyzed and dichotomized into 2 groups: TAVR under conscious sedation (CS) and under general anesthesia (GA). The primary endpoint was a composite of all-cause mortality, stroke, AF, permanent pacemaker implantation, myocardial infarction, heart failure, high-grade atrioventricular block, and AKI at 1 year...
February 8, 2021: Heart Surgery Forum
Zafer Cengiz Er, Kivanc Atilgan
OBJECTIVE: To evaluate the differences in neurocognitive abilities between the preoperative and postoperative periods following carotid endarterectomy (CEA), due to carotid artery stenosis, and to evaluate the effectiveness of CEA on neurocognitive abilities in the future. MATERIAL AND METHODS: Thirty-eight cases of CEA surgery at Bozok University Faculty of Medicine Research Hospital between January 2015 and June 2020 were examined. Neurocognitive tests were performed on carotid endarterectomy patients one day before the operation and on the 2nd, 4th, and 30th postoperative days...
February 16, 2021: Heart Surgery Forum
Michele Gaffuri, Pasquale Capaccio, Sara Torretta, Marco Daga, Gian Vincenzo Zuccotti, Lorenzo Pignataro
Testing for coronavirus disease 2019 is critical in controlling the pandemic all over the world. Diagnosis of severe acute respiratory syndrome coronavirus-2 infection is based on real-time polymerase chain reaction performed on nasopharyngeal swab. If not adequately performed, the viral specimen collection can be painful and lead to complications. We present a complication occurred during a nasopharyngeal swab collection performed in a noncooperative patient where the plastic shaft of the swab fractured during the procedure, resulting in swab tip retention deep into the nasal cavity...
February 26, 2021: Ear, Nose, & Throat Journal
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