Marie-Pierre Bonnet, Pauline L M de Vries, Solène Levet, Monica Saucedo, Estelle Morau, Michel Dreyfus, François Goffinet, Catherine Deneux-Tharaux
BACKGROUND: The aim of this study was to assess temporal trends in incidence and underlying causes of maternal deaths from obstetric hemorrhage in France and to describe clinical care before and after implementation of the first national guidelines published in 2004 and updated in 2014. METHODS: Data from all hemorrhage-related maternal deaths between 2001 and 2015 were extracted from the French Confidential Enquiry into Maternal Deaths. We compared the maternal mortality ratio (MMR), cause of obstetric hemorrhage, and death preventability by triennium...
May 23, 2024: Anesthesia and Analgesia
Carole Lin, Steven Abboud, Veronica Zoghbi, Ksenia Kasimova, Jonathan Thein, Kara D Meister, Douglas R Sidell, Karthik Balakrishnan, Ban C H Tsui
IMPORTANCE: Pain management following pediatric adenotonsillectomies is opioid-inclusive, leading to potential complications. OBJECTIVE: To investigate the use of suprazygomatic maxillary nerve (SZMN) blocks to reduce pain and opioid use after pediatric intracapsular adenotonsillectomy and to measure recovery duration and incidence of complications. DESIGN, SETTING, AND PARTICIPANTS: This was a randomized, blinded, prospective single-center tertiary pediatric hospital that included 60 pediatric patients (2-14 years old) scheduled for intracapsular adenotonsillectomy from November 2021 to March 2023...
May 23, 2024: JAMA Otolaryngology—Head & Neck Surgery
Mattias Renberg, Tomas Karlsson, Albin Dahlquist, Claire Luckhurst, Jenny Gustavsson, Ulf Arborelius, Mårten Risling, Mattias Günther
PURPOSE: Swine are one of the major animal species used in translational research, with unique advantages given the similar anatomic and physiologic characteristics as man, but the investigator needs to be familiar with important differences. This article targets clinical anesthesiologists who are proficient in human monitoring. We summarize our experience during the last two decades, with the aim to facilitate for clinical and non-clinical researchers to improve in porcine research. METHODS: This was a retrospective review of 337 swine with a mean (SD) weight 60 (4...
May 23, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Jessica Kreienbühl, Ladina Rüegg, Dalia Balsyte, Ladina Vonzun, Nicole Ochsenbein-Kölble
PURPOSE: Labor is shorter in multiparous women. However, there are no individualized data on differences in duration of labor for consecutive deliveries in the same parturient. METHODS: We conducted a retrospective data analysis from 2004 to 2021 at the University Hospital of Zurich and included all women with 2 or more vaginal deliveries of a singleton child in cephalic position, between 22 and 42 weeks of gestation. Descriptive statistics were performed with SPSS version 25...
May 23, 2024: Archives of Gynecology and Obstetrics
Teresa Herrmann, Peter Spieth, Torsten Richter
Surgical site infections (SSI) are the most frequent cause of impaired perioperative wound healing, lead to increased postoperative morbidity, mortality and length of hospital stay and are therefore a relevant perioperative complication. In addition to numerous measures taken by the surgical departments, there are anesthesiological options that can help to reduce the risk of SSI. In addition to heat, volume and transfusion management these include, for example, the use of antibiotics and the choice of the anesthesia procedure...
May 23, 2024: Anaesthesiologie
Michelle L Kloc, Gregory L Holmes, Jeremy M Barry
OBJECTIVE: Sex determines cognitive outcome in animal models of early life seizure, where males exhibit impaired hippocampal-dependent learning and memory compared with females. The physiological underpinnings of this sex effect are unclear. Cholinergic signaling is essential for the generation of hippocampal oscillations, and supplementation of cholinergic precursors prior to status epilepticus in immature male rats prevents subsequent memory deficits. We hypothesized that there are sex differences in acetylcholine circuits and their response to experimental febrile status epilepticus (eFSE)...
May 23, 2024: Epilepsia
Çömez Mehmet Selim, Sağlambilen Halide, Çelik Erkan Cem, Koyuncu Onur, Hakimoğlu Sedat, Urfalı Senem
BACKGROUND: This study aimed to evaluate the effectiveness of unilateral external oblique intercostal nerve block (EOIB) in laparoscopic cholecystectomy surgery. MATERIAL AND METHODS: After ethics committee approval, ASA I-II patients aged 18-70 who would undergo laparoscopic cholecystectomy surgery were included in the study. The patients were divided into two groups, external oblique intercostal nerve block (Group EOIB) and oblique subcostal transversus abdominis plane block (Group OSTAP)...
May 23, 2024: Surgical Innovation
Joaquín Cogo Pagella, María F Rodríguez, Fabricio Frisina, Claudio O Cervino
Melatonin (ML) and dexmedetomidine (DM) are used separately as anesthetic premedication or as an anesthetic in humans and laboratory animals. In this study, we aimed to investigate the anesthetic properties of both drugs combined. The anesthetic effects of several combinations of ML (50 and 100 mg/kg) and DM (50 and 100 μg/kg) were evaluated in rats by observing behavioral manifestations and recording the duration and depth of anesthesia. Five anesthetic intervals were established according to the loss and recovery of reflexes...
May 23, 2024: Laboratory Animals
Qianli Jia, Yiming Duan, Yaoyao Liu, Juntao Liu, Jinping Luo, Yilin Song, Zhaojie Xu, Kui Zhang, Jin Shan, Fan Mo, Mixia Wang, Ying Wang, Xinxia Cai
Precise assessment of wakefulness states during sevoflurane anesthesia and timely arousal are of paramount importance to refine the control of anesthesia. To tackle this issue, a bidirectional implantable microelectrode array (MEA) is designed with the capability to detect electrophysiological signal and perform in situ deep brain stimulation (DBS) within the dorsomedial hypothalamus (DMH) of mice. The MEA, modified with platinum nanoparticles/IrOx nanocomposites, exhibits exceptional characteristics, featuring low impedance, minimal phase delay, substantial charge storage capacity, high double-layer capacitance, and longer in vivo lifetime, thereby enhancing the sensitivity of spike firing detection and electrical stimulation (ES) effectiveness...
May 23, 2024: ACS Sensors
Sarah Oliveira, Adriana Prezado, Beatriz Soares, Miguel Ferreira
Morvan syndrome is a rare condition distinguished by hyperactivity within the central, autonomic, and peripheral nervous systems. Due to the limited number of cases, this presents clinical challenges stemming from the scarcity of published literature. We present a successful anesthetic approach for a patient diagnosed with Morvan syndrome scheduled for elective major intra-thoracic surgery to remove metastases from a thymoma. The patient had previously undergone thymectomy, with the syndrome being diagnosed only one year after the surgery...
April 2024: Curēus
Seong Min Han, So Young Kwon, Jang Hyeok In, Jin Deok Joo
BACKGROUND: Myringotomy with tympanostomy tube insertion (MTI) is a superficial surgical procedure used to prevent hearing loss in children with serous otitis media. Intravenous anesthesia, often ketamine, is preferred for this procedure because of its ability to induce sedation without compromising airway reflexes. However, ketamine alone may be insufficient and potentially lead to spontaneous movement during surgery. This study evaluated the effectiveness of midazolam and fentanyl as adjuvants to ketamine in reducing spontaneous movement during MTI and enhancing the quality of recovery...
May 23, 2024: J Yeungnam Med Sci
Li-Na Zhang, Yan-Ge Zhang, Yong-Quan Wu
OBJECTIVE: To investigate the effect of remote ischemic preconditioning (RIPC) on major adverse cardiovascular events (MACE) in elderly patients with hip fracture 1 year after operation. METHODS: Total of 314 elderly patients with hip fracture of gradeⅡand Ⅲ for American Society of Anesthesiologists (ASA) were treated by surgical operation from April 2015 to May 2020 including 116 males and 198 females, the age ranged from 60 to 76 years old. The subjects were divided into intervention group and control group according to whether received RIPC...
May 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Qianyu Wang, Águeda Molinero-Fernandez, Qikun Wei, Xing Xuan, Åsa Konradsson-Geuken, María Cuartero, Gastón A Crespo
Lactate is an important diagnostic and prognostic biomarker of several human pathological conditions, such as sepsis, malaria, and dengue fever. Unfortunately, due to the lack of reliable analytical decentralized platforms, the determination of lactate yet relies on discrete blood-based assays, which are invasive and inefficient and may cause tension and pain in the patient. Herein, we demonstrate the potential of a fully integrated microneedle (MN) sensing system for the minimally invasive transdermal detection of lactate in an interstitial fluid (ISF)...
May 22, 2024: ACS Sensors
Yazan Hassona, Dua'a Alqaisi, Asma Alkilani, Iyas AbuHijleh
BACKGROUND: Pitt-Hopkins syndrome (PTHS) is a rare neurodevelopmental disorder with physical, cognitive, and behavioral characteristics that is caused by heterozygous mutations in the TCF4 gene. Patients with PTHS might present a unique challenge for oral healthcare professionals because of the associated comorbidities. CASE REPORT: Here we describe a new case of PTHS in a 13-year-old girl with particular emphasis on oro-dental findings and oral healthcare management...
May 22, 2024: BMC Oral Health
Nancy Mohamed Metwally, Osama Abd Allah Ragab, Mostafa Shaaban Husseiny Kandil, Lamis Ahmed Elghareb
BACKGROUND: A change in professionals' perspectives on the value of general anesthesia (GA) for pediatric patients, including those with disabilities, medical conditions, severe oral issues, and challenging behaviors. Full-mouth rehabilitation under GA allows for the comprehensive treatment of all oral health problems in a single visit, without requiring the child's active participation. Extensive dental problems are often associated with severe dental pain, which can impact cognitive function, including perception, attention, memory, reasoning, language, communication, and executive functions...
May 23, 2024: BMC Oral Health
Wenjing Chen, Wenjuan Bao, Jing Shi, Lei Shi, Jianli Cui
This study delves into the effectiveness of combining remimazolam with low-dose propofol in pediatric fiberoptic bronchoscopy. Ninety children scheduled for fiberoptic bronchoscopy in our hospital were enrolled as research participants. Based on the intraoperative anesthetic drug regimen, the children were divided into three groups: group R (remimazolam 0.2-0.4 mg/kg), group P (propofol 1-3 mg/kg), and group RP (remimazolam0.2 mg/kg, propofol 0.5 mg/kg). Immediately post-anesthesia, group P exhibited lower blood pressure and heart rate (HR) compared to both group R and group RP (P < 0...
May 22, 2024: Scientific Reports
Qian Zhang, Xiaoting Wang, Yangong Chao, Lixia Liu
Oliguria is a clinical symptom characterized by decreased urine output, which can occur at any stage of acute kidney injury and also during renal replacement therapy. In some cases, oliguria may resolve with adjustment of blood purification dose or fluid management, while in others, it may suggest a need for further evaluation and intervention. It is important to determine the underlying cause of oliguria during renal replacement therapy and to develop an appropriate treatment plan. This review looks into the mechanisms of urine production to investigate the mechanism of oliguria during renal replacement therapy from two aspects: diminished glomerular filtration rate and tubular abnormalities...
May 22, 2024: Journal of Anesthesia
Gokcen Kulturoglu, Savas Altinsoy, Julide Ergil, Derya Ozkan, Yusuf Ozguner
PURPOSE: The objective of this study was to examine the hypothesis that the opioid consumption of patients who receive a rhomboid intercostal block (RIB) or a pectoral nerve (PECS) block after unilateral modified radical mastectomy (MRM) surgery is less than that of patients who receive local anesthetic infiltration. METHODS: Eighty-one female patients aged 18-70 years who underwent unilateral MRM surgery with general anesthesia were randomly allocated to three groups...
May 22, 2024: Journal of Anesthesia
Eun Jung Choi, David Levin, Amanda Robertson, Fenella J Kirkham, Prakash Muthusami, Pradeep Krishnan, Manohar Shroff, Mahendranath Moharir, Peter Dirks, Daune MacGregor, Elizabeth Pulcine, Ishvinder Bhathal, Andrea Kassner, Kirstin Walker, Warwick Allan, Gabrielle deVeber, William J Logan, Nomazulu Dlamini
BACKGROUND: Moyamoya is a progressive, non-atherosclerotic cerebral arteriopathy that may present in childhood and currently has no cure. Early diagnosis is critical to prevent a lifelong risk of neurological morbidity. Blood-oxygen-level-dependent (BOLD) MRI cerebrovascular reactivity (CVR) imaging provides a non-invasive, in vivo measure of autoregulatory capacity and cerebrovascular reserve. However, non-compliant or younger children require general anesthesia to achieve BOLD-CVR imaging...
May 23, 2024: Pediatric Radiology
Min-Yi Tsai, Shun-Ming Chan, Nan-Kai Hung, Hou-Chuan Lai, Yao-Chia Liu, Wei-Lin Lin, Wei-Cheng Tseng, Chueng-He Lu
Liver transplantation (LT) is frequently complicated by coagulopathy associated with end-stage liver disease, which is often multifactorial and associated with hemostatic disturbances affecting both the procoagulant and anticoagulant systems. This rebalanced coagulation system may lead to bleeding diathesis or increased clot formation. Conventional coagulation tests cannot reflect these complex changes because they can only illustrate deficiencies in the procoagulant system. Viscoelastic tests such as rotational thromboelastometry (ROTEM) have been used in LT and have shown useful for detecting coagulopathy and guiding transfusions...
May 1, 2024: Asian Journal of Anesthesiology
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