keyword
https://read.qxmd.com/read/38465638/electrocardiographic-proarrhythmic-changes-in-pregnancy-of-women-with-chd
#41
JOURNAL ARTICLE
Constance G Weismann, Frida Wedlund, Thuva Lindblad Ryd, Emma von Wowern, Joanna Hlebowicz
OBJECTIVES: Pregnancy-related physiological adaptations result in increased heart rate as well as electrocardiographic changes such as a mean QTc prolongation of 27 ms. Pregnant women with CHD are at increased risk for cardiovascular complications. The aim of this study was to identify risk factors for abnormally prolonged QTc interval-a risk factor for ventricular arrhythmias-in pregnant women with CHD. MATERIAL AND METHOD: Retrospective longitudinal single-centre study...
March 11, 2024: Cardiology in the Young
https://read.qxmd.com/read/38459752/protective-effect-of-thymoquinone-nanoemulsion-in-reducing-the-cardiotoxic-effect-of-5-fluorouracil-in-rats
#42
JOURNAL ARTICLE
Bardia Karim, Motahare Arabameri, Fatemeh Alimoradi, Razieh Mansoori, Ali A Moghadamnia, Sohrab Kazemi, Seyed M Hosseini
5-Fluorouracil (5-FU), which is one of the most widely used chemotherapy drugs, has various side effects on the heart. Thymoquinone (TMQ), the main bioactive component of Nigella sativa, has antioxidant and protective effects against toxicity. In this study, we investigated the protective effect of thymoquinone against cardiotoxicity caused by 5-FU in vitro and in vivo models. H9C2 cells were exposed to 5-FU and TMQ, and cell viability was evaluated in their presence. Also, 25 male Wistar rats were divided into five control groups, 5-FU, 2...
April 2024: Drug Development Research
https://read.qxmd.com/read/38446445/deep-learning-augmented-ecg-analysis-for-screening-and-genotype-prediction-of-congenital-long-qt-syndrome
#43
JOURNAL ARTICLE
River Jiang, Christopher C Cheung, Marta Garcia-Montero, Brianna Davies, Jason Cao, Damian Redfearn, Zachary M Laksman, Steffany Grondin, Joseph Atallah, Carolina A Escudero, Julia Cadrin-Tourigny, Shubhayan Sanatani, Christian Steinberg, Jacqueline Joza, Robert Avram, Rafik Tadros, Andrew D Krahn
IMPORTANCE: Congenital long QT syndrome (LQTS) is associated with syncope, ventricular arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline-normal QT interval despite LQTS often being detected by QT prolongation on resting electrocardiography (ECG). OBJECTIVE: To develop a deep learning-based neural network for identification of LQTS and differentiation of genotypes (LQTS1 and LQTS2) using 12-lead ECG. DESIGN, SETTING, AND PARTICIPANTS: This diagnostic accuracy study used ECGs from patients with suspected inherited arrhythmia enrolled in the Hearts in Rhythm Organization Registry (HiRO) from August 2012 to December 2021...
April 1, 2024: JAMA Cardiology
https://read.qxmd.com/read/38432528/virtual-clinical-qt-exposure-response-studies-a-translational-computational-approach
#44
JOURNAL ARTICLE
Jazmin Aguado-Sierra, Paula Dominguez-Gomez, Ani Amar, Constantine Butakoff, Michael Leitner, Stefan Schaper, Jan M Kriegl, Borje Darpo, Mariano Vazquez, Georg Rast
BACKGROUND AND PURPOSE: A recent paradigm shift in proarrhythmic risk assessment suggests that the integration of clinical, non-clinical, and computational evidence can be used to reach a comprehensive understanding of the proarrhythmic potential of drug candidates. While current computational methodologies focus on predicting the incidence of proarrhythmic events after drug administration, the objective of this study is to predict concentration-response relationships of QTc as a clinical endpoint...
March 1, 2024: Journal of Pharmacological and Toxicological Methods
https://read.qxmd.com/read/38417598/expedited-loading-with-intravenous-sotalol-is-safe-and-feasible-primary-results-of-the-prospective-evaluation-analysis-and-kinetics-of-iv-sotalol-peaks-registry
#45
JOURNAL ARTICLE
Benjamin A Steinberg, Richard Holubkov, Thomas Deering, Christopher A Groh, Suneet Mittal, Robert Kennedy, Parash Pokharel, Marco Perez, Salvatore Savona, Nishant Verma, Kevin Watt, Jonathan P Piccini, T Jared Bunch
BACKGROUND: Loading of oral sotalol for atrial fibrillation requires 3 days, frequently in the hospital, to achieve steady state. The Food and Drug Administration approved loading with intravenous (IV) sotalol through model-informed development, without patient data. OBJECTIVE: We present results of the first multicenter evaluation of this recent labeling for IV sotalol. METHODS: The Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry was a multicenter observational registry of patients undergoing elective IV sotalol load for atrial arrhythmias...
February 28, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38409566/evaluation-of-electrocardiogram-parameters-and-heart-rate-variability-during-blood-pressure-elevation-by-phenylephrine-in-cirrhotic-rats
#46
JOURNAL ARTICLE
Farzaneh Ketabchi, Mohammadreza Khoram, Amirreza Dehghanian
Cirrhotic cardiomyopathy is a myocardial disease that may go undetected in the early stages due to peripheral vasodilatation. The aim of the study was to evaluate the electrocardiogram (ECG) and heart rate variability (HRV) after raising blood pressure by phenylephrine injection in rats with liver cirrhosis. Twenty male Sprague-Dawley rats were divided into the Sham and common bile duct ligation (CBDL) groups. After 44 days, animals were anesthetized and the right femoral artery and vein catheterized. After a steady-state period, a bolus injection of phenylephrine (PHE, 10 μg/μl/IV, baroreflex maneuver) was followed by a slow injection of PHE (100 μg/ml/5 min/IV, sustained maneuver)...
February 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38404005/cyclin-dependent-kinase-4-6-inhibitors-in-the-treatment-of-advanced-or-metastatic-breast-cancer
#47
REVIEW
John P Micha, Mark A Rettenmaier, Randy D Bohart, Bram H Goldstein
OBJECTIVE: Despite the relatively high cure rates in early-stage breast cancer, advanced and metastatic breast cancer cases are associated with more inauspicious patient outcomes. Fortunately, with the advent of cyclin-dependent kinase (CDK)4/6 inhibitors (e.g. palbociclib, ribociclib, and abemaciclib) with endocrine therapy, survival in advanced and metastatic breast cancer has appreciably improved. In the current review, we discuss these distinctions and the concomitant implications associated with the individual CDK4/6 inhibitors...
February 25, 2024: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/38395523/characterization-of-cardiovascular-profile-of-anti-influenza-drug-peramivir-a-reverse-translational-study-using-the-isoflurane-anesthetized-dog
#48
JOURNAL ARTICLE
Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Atsushi Sugiyama
An injectable anti-influenza drug peramivir has been reported to induce QT-interval prolongation in some phase III studies, although its thorough QT/QTc study was negative. We investigated the discrepancy among those clinical studies using isoflurane-anesthetized beagle dogs (n = 4). Peramivir in doses of 1 mg/kg/10 min (sub-therapeutic dose) followed by 10 mg/kg/10 min (clinically-relevant dose) was intravenously administered. Peramivir prolonged QT interval/QTcV and Tpeak -Tend , and tended to delay ventricular repolarization in a reverse-frequency dependent manner, indicating IKr inhibition in vivo...
March 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38392605/developing-a-model-for-quantifying-qtc-prolongation-risk-to-enhance-medication-safety-assessment-a-retrospective-analysis
#49
JOURNAL ARTICLE
Luis Giovannoni, Gerd A Kullak-Ublick, Alexander Jetter
There are currently no established methods to predict quantitatively whether the start of a drug with the potential to prolong the QTc interval poses patients at risk for relevant QTc prolongation. Therefore, this retrospective study aimed to pave the way for the development of models for estimating QTc prolongation in patients newly exposed to medications with QTc-prolonging potential. Data of patients with a documented QTc prolongation after initiation of a QTc-prolonging drug were extracted from hospital charts...
January 31, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38384983/a-case-report-of-qtc-prolongation-drug-induced-or-myocarditis-in-severe-acute-respiratory-syndrome-coronavirus-2
#50
Mahboobeh Gholipour, Pirooz Samidoost, Mani Moayerifar, Golshan Ghasemzadeh
Remdesivir is a nucleotide prodrug of an adenosine analog. It binds to the viral Ribonucleic Acid (RNA)-dependent RNA polymerase and inhibits viral replication by terminating RNA transcription prematurely. Remdesivir has demonstrated in vitro and in vivo activity against Severe Acute Respiratory Syndrome Coronavirus 2; it also acts in vitro neutralization activity against the Omicron variant and its subvariants. We reported a 54-years-old woman admitted with Coronavirus disease 2019. Considering to require a high fraction of inspired oxygen therapy (⩾0...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38379810/impact-of-an-inpatient-pharmacist-driven-renal-dosing-policy-on-order-verification-time-and-patient-safety
#51
JOURNAL ARTICLE
Kayla Berry, Laura Postlmayr, Dane Shiltz, Jessi Parker, Calvin Ice
Research regarding pharmacist-driven renal dosing policies has focused on cost savings or prevention of adverse drug events. However, little is known about how these policies influence time from order signature to order verification or how this efficiency may reduce the incidence of adverse outcomes. Objectives: The primary endpoint compared time from prescriber electronic order signature to pharmacist electronic order verification between pre- and post-renal dosing policy implementation. The secondary endpoint evaluated electrocardiogram QTc prolongation attributed to fluconazole accumulation in renal impairment...
2024: SAGE Open Medicine
https://read.qxmd.com/read/38362953/scientific-review-of-the-proarrhythmic-risks-of-oligonucleotide-therapeutics-are-dedicated-ich-s7b-e14-studies-needed-for-low-risk-modalities
#52
JOURNAL ARTICLE
Yusheng Qu, Kim A Henderson, Tod A Harper, Hugo M Vargas
Oligonucleotide therapeutics (ONTs) represent a new modality with unique pharmacological and chemical properties that modulate gene expression with a high degree of target specificity mediated by complementary Watson-Crick base pair hybridization. To date, the proarrhythmic assessment of ONTs has been influenced by International Conference on Harmonization (ICH) E14 and S7B guidance. To document current hERG/QTc evaluation practices, we reviewed US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) Approval Packages (source: PharmaPendium...
February 16, 2024: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38361715/adverse-cardiovascular-events-associated-with-kopi-jantan
#53
Mohd Khairi Othman, Zurkurnai Yusof, Nur Imani Mohd Rossli, Mohd Hafizazham Mohd Fauzi, W Yus Haniff W Isa
Energy drinks (EDs) are widely accessible worldwide. In Malaysia, it is common for EDs to be premixed with sexual stimulants. ED consumption has been shown to have an association with cardiac arrest, myocardial infarction, spontaneous coronary artery dissection, and coronary vasospasm. In addition to this, EDs are associated with arrhythmias, which significantly prolong the QTc interval. Myocardial infarction with no obstructive coronary artery disease (MINOCA) is defined as a patient presenting with myocardial infarction with no obstructive coronary artery disease or ≤50% stenosis...
January 2024: Curēus
https://read.qxmd.com/read/38355047/medical-and-psychiatric-features-of-patients-hospitalized-for-severe-restrictive-eating-disorders-analysis-of-545-consecutive-patients-with-severe-anorexia-nervosa-or-avoidant-restrictive-food-intake-disorder
#54
JOURNAL ARTICLE
Kara Leach, Maryrose Bauschka, Ashlie Watters, Philip S Mehler
BACKGROUND: People with severe eating and feeding disorders regularly require hospitalization due to complications inherent to their disease, though formal training regarding this care is limited. METHODS: This retrospective study included 545 patients with severe anorexia nervosa (AN) or avoidant restrictive food intake disorder hospitalized in a medical stabilization unit between 2018 and 2021. Biometrics were obtained throughout hospitalization. Nutrition was increased until patients were gaining 0...
February 13, 2024: Journal of the Academy of Consultation—Liaison Psychiatry
https://read.qxmd.com/read/38348899/proceed-with-caution-standard-protocol-exercise-stress-tests-fail-to-replicate-the-diagnostic-utility-of-supine-stand-tests-for-long-qt-syndrome
#55
JOURNAL ARTICLE
Alexa M Pinsky, Veda K Kulkarni, J Martijn Bos, Raquel Neves, Thomas G Allison, Michael J Ackerman
BACKGROUND: Long QT syndrome (LQTS) is a sudden death predisposing condition characterized by ECG-derived prolongation of the QT interval. Previous studies have demonstrated that the supine-stand test may aid in the diagnosis of LQTS as patients fail to shorten their QT interval in response to standing up. The aim of this study was to evaluate the diagnostic accuracy of ECG data derived from standard protocol, clinically performed treadmill exercise stress tests (TESTs) in their ability to mimic the formal supine-stand test...
February 13, 2024: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/38348789/elevated-interleukin-6-levels-are-associated-with-an-increased-risk-of-qtc-interval-prolongation-in-a-large-cohort-of-us-veterans
#56
JOURNAL ARTICLE
Pietro Enea Lazzerini, Michael Cupelli, Alessandra Cartocci, Iacopo Bertolozzi, Viola Salvini, Riccardo Accioli, Fabio Salvadori, Tommaso Marzotti, Decoroso Verrengia, Gabriele Cevenini, Stefania Bisogno, Maurizio Bicchi, Giovanni Donati, Sciaila Bernardini, Franco Laghi-Pasini, Maurizio Acampa, Pier Leopoldo Capecchi, Nabil El-Sherif, Mohamed Boutjdir
BACKGROUND: Although accumulating data indicate that IL-6 (interleukin-6) can promote heart rate-corrected QT interval (QTc) prolongation via direct and indirect effects on cardiac electrophysiology, current evidence comes from basic investigations and small clinical studies only. Therefore, IL-6 is still largely ignored in the clinical management of long-QT syndrome and related arrhythmias. The aim of this study was to estimate the risk of QTc prolongation associated with elevated IL-6 levels in a large population of unselected subjects...
February 13, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38348658/evaluation-of-global-dystonia-rating-scale-as-a-predictor-of-unfavorable-outcomes-among-acute-antipsychotics-poisoned-patients
#57
JOURNAL ARTICLE
Asmaa Fady Sharif, Zahraa Khalifa Sobh, Sanaa Abd El-Fatah Abdo, Osama M Alahmadi, Hatem A Alharbi, Mohannad Saif Awaji, Faris A Alabdullatif, Abdullah M Baghlaf, Ahmad F Alanazi, Manar Maher Fayed
Worldwide, acute antipsychotic poisoning results in high morbidities and mortalities. Though extrapyramidal syndromes are commonly associated, the extent of extrapyramidal syndromes in relation to the severity of antipsychotic poisoning has not been addressed yet. Thus, this study aimed to assess the Global Dystonia Rating Scale (GDRS) as an unfavorable outcomes predictive tool in acute antipsychotic poisoning. A cross-sectional study included 506 antipsychotic-poisoned patients admitted to Tanta University Poison Control Center, Egypt, over three years was conducted...
February 13, 2024: Drug and Chemical Toxicology
https://read.qxmd.com/read/38348531/electrocardiographic-abnormalities-in-patients-with-sickle-cell-disease-a-systematic-review-and-meta-analysis
#58
REVIEW
Erfan Taherifard, Hamed Movahed, Ehsan Taherifard, Alireza Sadeghi, Niloofar Dehdari Ebrahimi, Alireza Ahmadkhani, Fatemeh Kheshti, Hossein Movahed
BACKGROUND: Previous studies have documented that electrocardiography (ECG) can reveal a range of abnormalities, offering valuable insights into the cardiac evaluation of patients with sickle cell disease (SCD). The objective of this study is to assess the patterns of ECG abnormalities observed in these patients with SCD, and to determine their prevalence. METHOD: We systematically reviewed the literature using online databases of PubMed, Scopus, Web of Science, Embase, and Google Scholar to identify original studies that reported findings of standard ECG assessments in patients with SCD...
February 13, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38340331/ivosidenib-significantly-reduces-triazole-levels-in-patients-with-acute-myeloid-leukemia-and-myelodysplastic-syndrome
#59
JOURNAL ARTICLE
Ashley Dinh, J Michael Savoy, Dimitrios P Kontoyiannis, Koichi Takahashi, Ghayas C Issa, Hagop M Kantarjian, Courtney D DiNardo, Caitlin R Rausch
BACKGROUND: Ivosidenib is primarily metabolized by CYP3A4; however, it induces CYP450 isozymes, including CYP3A4 and CYP2C9, whereas it inhibits drug transporters, including P-glycoprotein. Patients with acute myeloid leukemia are at risk of invasive fungal infections, and therefore posaconazole and voriconazole are commonly used in this population. Voriconazole is a substrate of CYP2C9, CYP2C19, and CYP3A4; therefore, concomitant ivosidenib may result in decreased serum concentrations...
February 10, 2024: Cancer
https://read.qxmd.com/read/38337498/long-qt-syndrome-and-wpw-syndrome-a-very-rare-association-between-two-causes-of-sudden-cardiac-death-in-a-young-patient
#60
Radu Gabriel Vătășescu, Silvia Deaconu, Corneliu Nicolae Iorgulescu, Gabriela Marascu, Bogdan Oprita, Alexandru Deaconu
Long QT syndrome (LQT) and WPW syndrome are causes of sudden cardiac death (SCD) in the young, and their association has been rarely reported. A 26-year-old woman presented with recurrent syncope. Her ECG showed a short PR interval, wide QRS (150 ms) due to a delta wave, and QT prolongation (QT 580 ms, QTc 648 ms). ECG monitoring documented recurrent salvos of a self-terminating wide QRS tachycardia, generally slightly polymorphic, sometimes with "torsade des pointes" (TdP) appearance, which were linked to the syncopal/presyncope episodes...
January 30, 2024: Journal of Clinical Medicine
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