Laurent Schmied, Thuy T Luu, Jonas N Søndergaard, Sophia H Hald, Stephan Meinke, Dara K Mohammad, Sunitha B Singh, Corinna Mayer, Giovanna Perinetti Casoni, Michael Chrobok, Heinrich Schlums, Giorgia Rota, Hieu M Truong, Lisa S Westerberg, Greta Guarda, Evren Alici, Arnika K Wagner, Nadir Kadri, Yenan T Bryceson, Mezida B Saeed, Petter Höglund
Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating receptors, recognizing products from tumors or viruses, and inhibitory receptors (such as KIR/Ly49), which recognize major histocompatibility complex class I (MHC-I) molecules. KIR/Ly49 signaling preserves tolerance to self but also conveys reactivity toward MHC-I-low target cells in a process known as NK cell education. Here, we found that NK cell tolerance and education were determined by the subcellular localization of the tyrosine phosphatase SHP-1...
April 11, 2023: Science Signaling