Kirsten L van Bokhorst, Sara Galac, Hans S Kooistra, Chiara Valtolina, Federico Fracassi, Dan Rosenberg, Björn P Meij
BACKGROUND: Successful treatment of cats with hypersomatotropism by transsphenoidal hypophysectomy is described in small numbers of cats. OBJECTIVES: To describe the endocrine profile, survival, and remission rates of hypersomatotropism and diabetes mellitus in a cohort of cats with hypersomatotropism that underwent hypophysectomy between 2008 and 2020. ANIMALS: Twenty-five client-owned cats with spontaneous hypersomatotropism. METHODS: Retrospective study...
February 23, 2021: Journal of Veterinary Internal Medicine
Antonia Sambola, Francisco Javier Elola, Irene Buera, Cristina Fernández, José Luis Bernal, Albert Ariza, Ralph Brindis, Héctor Bueno, Luis Rodríguez-Padial, Francisco Marín, José Antonio Barrabés, Renee Hsia, Manuel Anguita
BACKGROUND: There are limited data on sex-specific outcomes and management of cardiogenic shock complicating ST-segment elevation myocardial infarction (CS-STEMI). We investigated whether any sex bias exists in the admission to revascularization capable hospitals (RCH) or intensive cardiac care units (ICCU) and its impact on in-hospital mortality. METHODS: We used the Spanish National Health System Minimum Basic Data from 2003 to 2015 to identify patients with CS-STEMI...
February 23, 2021: European Journal of Clinical Investigation
Ghada M A Ajabnoor, Suhad Bahijri, Aliaa Amr Alamoudi, Rajaa Al Raddadi, Jawaher Al-Ahmadi, Hanan Jambi, Anwar Borai, Jaakko Toumilehto
Population specific associations between cardiovascular disease with various risk factors including pre-hypertension and hypertension were reported. We aimed to investigate the association of higher than optimal blood pressure with measures of dysglycemia, dyslipidemia, and markers of inflammation in non-diabetic Saudi adults hoping to improve current Saudi guidelines to prevent cardiovascular disease. Volunteers were recruited randomly from public healthcare centers in Jeddah. Demographic information, blood pressure (BP), and anthropometric measurements were taken...
2021: PloS One
Krystle Kq Yu, Stephanie Fischinger, Malisa T Smith, Caroline Atyeo, Deniz Cizmeci, Caitlin R Wolf, Erik D Layton, Jennifer K Logue, Melissa S Aguilar, Kiel Shuey, Carolin Loos, Jingyou Yu, Nicholas M Franko, Robert Y Choi, Anna Wald, Dan H Barouch, David M Koelle, Douglas Lauffenburger, Helen Y Chu, Galit Alter, Chetan Seshadri
Comorbid medical illnesses, such as obesity and diabetes, are associated with more severe COVID-19, hospitalization, and death. However, the role of the immune system in mediating these clinical outcomes has not been determined. We used multi-parameter flow cytometry and systems serology to comprehensively profile the functions of T cells and antibodies targeting spike, nucleocapsid, and envelope proteins in a convalescent cohort of COVID-19 subjects who were either hospitalized (n=20) or not hospitalized (n=40)...
February 23, 2021: JCI Insight
Huiming Liu, Rui Yan, Luqun Liang, Huifang Zhang, Jiayi Xiang, Lingling Liu, Xiaohuan Zhang, Yanwen Mao, Wei Peng, Ying Xiao, Fan Zhang, Yuxia Zhou, Mingjun Shi, Yuanyuan Wang, Bing Guo
Renal tubules are vulnerable targets of various factors causing kidney injury in diabetic kidney disease (DKD), and the degree of tubular lesions is closely related to renal function. Abnormal renal tubular epithelial cells (RTECs) differentiation and depletion of cell junction proteins are important in DKD pathogenesis. Caudal-type homeobox transcription factor 2 (CDX2), represents a key nuclear transcription factor that maintains normal proliferation and differentiation of the intestinal epithelium. The present study aimed to evaluate the effects of CDX2 on RTECs differentiation and cell junction proteins in DKD...
February 17, 2021: Aging
Wenjun Sha, Meizhi Liu, Dusang Sun, Junhui Qiu, Bilin Xu, Lin Chen, Tian Shen, Cheng Chen, Hongping Wang, Cuiping Zhang, Tao Lei
BACKGROUND: Resveratrol improves cell apoptosis and tissue damage induced by high glucose, but the specific mechanism is unknown. METHODS: This is a basic research. We performed cell transfection, real-time fluorescence quantitative PCR (qPCR), flow cytometry, immunofluorescence, western blot, enzyme linked immunosorbent assay (ELISA) and cell viability assay to analyze cell viability, cell cycle, cellular oxidative stress, intracellular inflammatory factors and autophagy activities in vitro ...
February 17, 2021: Aging
M Albertelli, E Nazzari, A Dotto, L F Grasso, S Sciallero, R Pirchio, A Rebora, M Boschetti, R Pivonello, S Ricci Bitti, A A L Colao, D Ferone
Context: Colonic polyps occur in 30-40% of acromegalic patients, increasing the risk of colon carcinoma. Although debated, there is emerging evidence that metformin may play a protective role in diabetic and non-diabetic patients with colonic polyps and its use in chemoprevention is currently explored. Objective: Evaluate the prevalence of colonic polyps in acromegalic patients treated or not with metformin and explore its possible protective role. Design: Exploratory cross-sectional study in two tertiary Italian referral centres...
March 2021: European Journal of Endocrinology
Michael T Kryshtalskyj, Mili Roy
Purpose : To characterize presentations, characteristics and outcomes of uveitis in Vogt-Koyanagi-Harada (VKH) syndrome in a North American First Nations (FN) population. Methods : Charts of 27 Canadian FN patients with VKH uveitis were retrospectively reviewed to characterize demographics, disease characteristics, management, complications and visual outcomes. Results : Average age at uveitis onset was 30.9 ± 13.8 years. Twenty-six patients 10 (96.3%) were female. Nine patients (33.3%) demonstrated complete VKH, 8 (29...
February 23, 2021: Ocular Immunology and Inflammation
Suwhan Kim, Wonyang Kang, Seunghyeon Cho, Dae-Young Lim, Yeongjae Yoo, Ryoung Jin Park, Byung Chan Lee, Jai-Dong Moon, Won-Ju Park
BACKGROUND: Lead exposure is a risk factor for increased blood pressure and cardiovascular disease, even when blood lead levels (BLLs) are within the normal range. OBJECTIVE: This study aimed to investigate the association between BLL and coronary artery stenosis (CAS) in asymptomatic adults using 128-slice dual-source coronary computed tomography (CT) angiography. METHODS: We analyzed medical records data from 2,193 adults (1,461 men and 732 women) who elected to complete a screening health examination, coronary CT angiography, and BLL measurement during 2011-2018 and had no history of CAS symptoms, cardiovascular disease, or occupational exposure to lead...
February 2021: Environmental Health Perspectives
Jiska van Schaik, Ichelle M A A van Roessel, Netteke A Y N Schouten-van Meeteren, Laura van Iersel, Sarah C Clement, Annemieke M Boot, Hedi L Claahsen-van der Grinten, Marta Fiocco, Geert O Janssens, Dannis G van Vuurden, Erna M Michiels, Sen K S Han, Paul A S P van Trotsenburg, Peter W P Vandertop, Leontien C M Kremer, Hanneke M van Santen
PURPOSE: Childhood brain tumor survivors (CBTS) are at risk for developing obesity, which negatively influences cardiometabolic health. The prevalence of obesity in CBTS may have been overestimated in previous cohorts because of inclusion of children with craniopharyngioma. On the contrary, the degree of weight gain may have been underestimated because of exclusion of CBTS who experienced weight gain, but were neither overweight nor obese. Weight gain may be an indicator of underlying hypothalamic-pituitary (HP) dysfunction...
February 23, 2021: Journal of Clinical Oncology
Hongwei Chen, Haixia Yang, Jianjun Deng, Daidi Fan
Obesity-induced colonic inflammation-stimulated colitis is one of the main causes of colorectal cancer. Dietary phytochemicals are considered to be an effective strategy for relieving obesity-induced inflammatory diseases such as diabetes and colitis. Ginsenoside Rk3 (Rk3) is the main bioactive component of ginseng. Our previous study has demonstrated that Rk3 can effectively alleviate obesity-induced type 2 diabetes, but whether it plays a beneficial role in obesity-induced colitis remains poorly understood...
February 23, 2021: Journal of Agricultural and Food Chemistry
Gabriel Monzón Daza, Carolina Meneses Macías, Abel M Forero, Jaime Rodríguez, Marcela Aragón, Carlos Jiménez, Freddy A Ramos, Leonardo Castellanos
The leaves of Passiflora ligularis Juss (known as sweet granadilla for its edible fruits) are a crop byproduct that is discarded. With the aim of contributing to give value-added products from these crop by-side products to farmers of Colombian Andes, we carried out a 1 H-NMR-metabolomics analysis of polar extracts from leaves collected in three locations and stored in two conditions in order to identify glucosyl-hydrolase inhibitors. Variations in the metabolic profile and the bioactivity among samples were analyzed by orthogonal partial least square discriminant analysis...
February 23, 2021: Journal of Agricultural and Food Chemistry
Leonardo L Monteiro, Rodrigo Skowronski, Fadi Brimo, Paulo da C Carvalho, Romulo A L Vasconcelos, Charley R C V Pacheco, Adriano A Calado, Wassim Kassouf
PURPOSE: To evaluate the erectile function in patients who underwent partial penectomy and identify factors associated with penile functional status. MATERIALS AND METHODS: We identified patients who underwent partial penectomy due to penile cancer between 2009 and 2014. Clinical and pathological characteristics included patient age at the time of diagnosis, obesity, hypertension, dyslipidemia, diabetes, smoking, metabolic syndrome, Eastern Cooperative Oncology Group (ECOG) status, penile shaft length, tumor size, primary tumor stage (pT), clinical nodal status, and local recurrence...
May 2021: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Alexandre Assi, Ziad Khoueir
PURPOSE: To evaluate the prevalence and extent of vitreous cortex remnants (VCR) on the surface of the retina in eyes with primary rhegmatogenous retinal detachment (RRD) and posterior vitreous detachment. MATERIALS AND METHODS: Triamcinolone acetonide was injected in the vitreous cavity of 100 consecutive cases of acute primary RRD undergoing pars plana vitrectomy. A multivariate regression analysis was performed to determine any association between the presence and pattern of stained VCR on the surface of the retina and the following variables: age, diabetes, axial length (AL), phakic status, extent of RRD and macular status...
November 25, 2020: Retina
Ofelia Poblano-Verástegui, Arturo Cuauhtémoc Bautista-Morales, Omar Acosta-Ruíz, Patricia María Gómez-Cortez, Pedro Jesús Saturno-Hernández
OBJECTIVE: To analyze the prevalence of polypharmacy, as well as the factors that identify the groups with higher risk, in population study in Mexico. MATERIALS AND METHODS: Descriptive analysis of the Encuesta Nacional de Salud y Nutrición 2018-19 (Ensanut 2018-19), Utilization of services (medicine section) and Household questionnaires, to obtain prevalence of polypharmacy (simultaneous consumption ≥5 medicines). A logistic regression model was used to estimate the association of polypharmacy with sociodemographic and health care factors...
November 2020: Salud Pública de México
Lizbeth Tolentino-Mayo, Janine Sagaceta-Mejía, Carlos Cruz-Casarrubias, Víctor Ríos-Cortázar, Alejandra Jauregui, Simón Barquera
OBJECTIVE: Evaluate the use, subjective and objective under-standing of the GDA frontal labeling to assist the population towards making healthy decisions regarding the products they consume. MATERIALS AND METHODS: The use of nu-tritional information contained in products ́ packages (GDA, nutritional information table, and list of ingredients), as well as the subjective and objective comprehension of the GDA. RESULTS: A total of 43 157 people were interviewed...
November 2020: Salud Pública de México
Aremis Villalobos, Carlos A Aguilar-Salinas, Martín Romero-Martínez, Rosalba Rojas-Martínez
OBJECTIVE: We describe the profile of the population aged 20 years and over, who go for a diabetes and hypertension screening test. MATERIALS AND METHODS: Based on the information from Ensanut 2018-19, two multiple logistic regression models were obtained with variables associated with the detection of diabetes and hypertension. Profiles were generated based on combinations of the variables included in the model. Increases in probabilities were plotted according to profiles...
November 2020: Salud Pública de México
Sergio Flores-Hernández, Omar Acosta-Ruiz, María Isidra Hernández-Serrato, Sheila Delgado-Rodríguez, Hortensia Reyes-Morales
OBJECTIVE: To estimate changes in the quality of process of care and its association with glycaemic control in adults with type 2 diabetes. MATERIALS AND METHODS: Changes in compliance of 14 process of care indicators for 9 038 adults with type 2 diabetes and glycaemic control in a subsample were estimated. Averages, weighted changes and associations without or controlling for other factors were estimated us-ing statistical weights for the combined data (Ensanut 2012 and Ensanut 2018-19)...
November 2020: Salud Pública de México
Jie Wen, Xiaoxia Bai
Gestational diabetes mellitus (GDM) is a type of diabetes that occurs during pregnancy due to abnormal maternal glucose metabolism. This study aimed to investigate the effect of miR-520h and its potential target gene on the progression of GDM. The blood samples were taken from healthy pregnant women and GDM patients. Human villous trophoblasts HTR-8/SVNEO cells were treated with 25 mM glucose and were considered as the GDM cell model. The miR-520h level was detected using qRT-PCR in the serum and GDM cell model...
February 23, 2021: Acta Biochimica Polonica
Marcus V Ortega, Marie Bangura, Elnaz Ayati, Kaitlyn James, Caroline Mitchell, Milena M Weinstein, Emily Von Bargen
OBJECTIVE: We aimed to evaluate the association between hemoglobin A1c (HbA1c) levels and midurethral sling (MUS) complications. METHODS: This was a multihospital, retrospective cohort study from 2010 to 2020. We included all women with diabetes mellitus who underwent a synthetic mesh MUS procedure and had a preoperative HbA1c within 3 months of surgery. The primary outcome was a composite of complications, including MUS mesh exposure, surgical site granulation tissue or infection, urinary tract infection, surgical site pain beyond 6 weeks postoperatively, and MUS failure...
March 1, 2021: Female Pelvic Medicine & Reconstructive Surgery
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