M Harrison Snyder, David T Asuzu, Dawn E Shaver, Mary Lee Vance, John A Jane
OBJECTIVE: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common problem during the postoperative course after pituitary surgery. Although treatment of this condition is well characterized, prevention strategies are less studied and reported. The authors sought to characterize outcomes and predictive factors of SIADH after implementation of routine postoperative fluid restriction for patients undergoing endoscopic transsphenoidal surgery for pituitary adenoma. METHODS: In March 2018, routine postoperative fluid restriction to 1000 ml/day for 7 days was instituted for all patients who underwent surgery for pituitary adenoma...
July 30, 2021: Journal of Neurosurgery
Arvind K Sharma, Vaseem Naheed Baig, Jitendra Ahuja, Sonali Sharma, Raja Babu Panwar, Vishwa Mohan Katoch, Rajeev Gupta
AIMS: Efficacy of mobile-phone based intervention for reducing cardiovascular risk in metabolic syndrome (MetSyn). METHODS: We screened adults 20-60 years in 10 villages in India for MetSyn using stratified cluster sampling. Lifestyle and biochemical risk factors were assessed. International Harmonized Criteria were used for diagnosis. Villages were randomized with 5 each in control and intervention groups. Interactive voice response system (IVRS) in Hindi was developed...
June 21, 2021: Diabetes & Metabolic Syndrome
Asirvatham Alwin Robert, Abdulghani Al Saeed, Mohamed Abdulaziz Al Dawish
BACKGROUND AND AIM: This review aims to report the current status of COVID-19 among people with diabetes, newly diagnosed diabetes, diabetic ketoacidosis, and programmatic efforts including vaccinations. METHODS: We conducted a literature search using PubMed, Google, and Scopus until July 15, 2021. RESULTS: In Saudi Arabia, most studies have reported diabetes as one of the highly prevalent comorbidities among patients with COVID-19. Currently, there are limited studies from Saudi Arabia on the newly diagnosed diabetes and diabetic ketoacidosis caused by COVID-19...
July 24, 2021: Diabetes & Metabolic Syndrome
Jothydev Kesavadev, Anjana Basanth, Gopika Krishnan, Rebecca Vitale, Hari Parameswaran, Sajna Shijin, Sreelakshmi R, Sumesh Raj, Asha Ashik, Arun Shankar, Sameer Badarudeen, A V Raveendran, Indu Rajalakshmy, Geethu Sanal, Akhila Manoj, Remya Jose, Yaseen Unes, Sunitha Jothydev
AIM: Amidst COVID-19 pandemic, the health care delivery in India faces major challenges owing to the overwhelming hospitals, exhausted healthcare workers, and shortage of crucial medical supplies such as ventilators and oxygen. The study aims to propose a novel successful interventional home care model, the Virtual COVID In-Patient (VCIP) care for effective COVID management. METHODS: The Covid-19 positive patients enrolled in VCIP were chosen for the study. A 24/7 active multidisciplinary WhatsApp group was created for each patient, for remote monitoring of temperature, blood pressure, blood glucose, respiratory and pulse rate along with the symptoms...
July 23, 2021: Diabetes & Metabolic Syndrome
Tatsuma Sakaguchi, Daisuke Hashimoto, Sohei Satoi, Tomohisa Yamamoto, So Yamaki, Mitsugu Sekimoto
INTRODUCTION AND IMPORTANCE: Hepatic actinomycosis (HA) is a rare infection mimicking a malignancy. HA after total pancreatectomy for a pancreatic tumor has not been reported. CASE PRESENTATION: A 70-year-old woman with a history of gastrectomy and sigmoidectomy for benign lesions, underwent a total pancreatectomy for a non-invasive, intraductal papillary mucinous carcinoma (IPMC). She required partial resection of the transverse colon due to insufficient blood flow and had an anastomotic failure...
July 20, 2021: International Journal of Surgery Case Reports
Dg Marshitah Pg Baharuddin, Nang Kham Oo Leik, Firdaus Hayati, Mohd Nazri Mohd Daud, Edwin See, Siti Zubaidah Sharif, Nik Amin Sahid Nik Lah
INTRODUCTION: Obesity has been proven to have adverse effects on fertility and is one of the predisposing factors for delay in pregnancy even with the use of assisted reproductive technique. There are many pathways in which obesity can affect fertility such as anovulation, poor implantation and low-quality oocyte. CASE PRESENTATION: We report a case of a 40-year-old lady with primary infertility for six years with underlying polycystic ovary syndrome (PCOS) and BMI 45...
July 24, 2021: International Journal of Surgery Case Reports
Gui-Lin Jin, Li-Mian Hong, Hai-Ping Liu, Rong-Cai Yue, Zu-Cheng Shen, Jian Yang, Ying Xu, Hui-Hui Huang, Yi Li, Bo-Jun Xiong, Yan-Ping Su, Chang-Xi Yu
BACKGROUND: Diabetic neuropathic pain (DNP), a complication of diabetes, has serious impacts on human health. As the pathogenesis of DNP is very complex, clinical treatments for DNP is limited. Koumine (KM) is an active ingredient extracted from Gelsemium elegans Benth. that exerts an inhibitory effect on neuropathic pain (NP) in several animal models. PURPOSE: To clarify the anti-NP effect of KM on rats with DNP and the molecular mechanisms involving the Notch- Jκ recombination signal binding protein (RBP-Jκ) signaling pathway...
June 29, 2021: Phytomedicine
Kevin Callison, Cuiping Schiman, Jeffrey C Schiman
Cigarette smoking has long been viewed as a means to control body weight. However, studies on the association between smoking cessation and weight gain have reported mixed findings and, notably, there is limited evidence among the Chinese population - the world's largest smoker population. The extent to which smoking cessation is positively associated with body weight is of interest as excessive weight gain contributes to heart disease, diabetes, hypertension, musculoskeletal disorders, and some cancers. Additionally, concerns over weight gain may dissuade current smokers from quitting...
July 16, 2021: Economics and Human Biology
Ryo Shikimoto, Yoshihiro Noda, Hisashi Kida, Shinichiro Nakajima, Sakiko Tsugawa, Yu Mimura, Ryo Ochi, Midori Takayama, Hidehito Niimura, Masaru Mimura
BACKGROUND: Resilience is a crucial factor preventing the onset of mental illness and contributing to the well-being and healthy longevity, whose neural bases are not fully elucidated in older people. The present study aimed to identify the cortical thickness associating with resilience in older adults. METHODS: This is a part of the cross-sectional Arakawa geriatric cohort study for people aged 65 years or older, consisting of 1001 individuals. A Self-Reported Resilience Scale (RS), neuropsychological batteries, face-to-face interviews for diagnosis, and a three-dimensional T1-weighted magnetic resonance imaging were conducted...
July 20, 2021: Journal of Psychiatric Research
Shanshan Zhao, Dongyu Wang, Zhuyu Li, Shuqia Xu, Haitian Chen, Wenjing Ding, Juan Yang, Weihua Zhao, Bo Sun, Zilian Wang
INTRODUCTION: This study aimed to evaluate whether FGF19 can alleviate insulin resistance and change the expression of placental IRS1/GLUTs. METHODS: Mice transgenic for Fgf15 (the murine homologue of human FGF19) were constructed, and human recombinant FGF19 was administered to pregnant high-fat diet mice. Then, glycolipid metabolism parameters and the weight of foetus and placenta were observed. The expression levels of key molecules of the insulin signalling pathway and glucose transporters in placentae were detected by qRT-PCR and western blotting...
July 15, 2021: Placenta
Megan A Rech, Elisabeth Donahey, Joshua M DeMott, Laura L Coles, Gary D Peksa
BACKGROUND: Treatment of acute ischemic stroke (AIS) with intravenous alteplase within 4.5 h of symptom onset is associated with neurologic improvement. High baseline blood pressure (BP) and BP variability during the first 24 h of AIS is associated with increased early adverse events and death. The purpose of this study is to characterize the incidence of poor neurologic outcome in patients treated with alteplase for AIS who received antihypertensive medications prior to and within the first 24 h following alteplase administration compared with patients who did not...
July 22, 2021: American Journal of Emergency Medicine
Anju Prabha, Jyoti Yadav, Asha Rani, Vijander Singh
In this work, a non-invasive diabetes mellitus detection system is proposed based on the wristband photoplethysmography (PPG) signal and basic physiological parameters (PhyP) to enable easy detection of diabetes mellitus (DM). A dataset of 217 participants with diabetes, prediabetes and normal conditions is used to develop the system. The Mel frequency cepstral coefficients (MFCC) extracted from 5s PPG signal segments and the PhyP are used as input for the machine learning algorithms. The K-nearest neighbors, support vector machine, random forest and extreme gradient boost (XGBoost) classifiers are used for classification...
July 22, 2021: Computers in Biology and Medicine
M B Divakara, R Ashwini, M S Santosh, M Priyanka, C R Ravikumar, R Viswanatha, H C Ananda Murthy
The dysfunctioning of β-cells caused by the unspecific misfolding of the human islet amyloid polypeptide (hIAPP) at the membrane results in type 2 diabetes mellitus. Here, we report for the first time, the early-stage interaction of hIAPP oligomers on the DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) lipid membrane using electrochemical parameters. Electrochemical techniques are better than other techniques to detect hIAPP at significantly lower concentrations. The surface level interactions between the peptide (hIAPP) and lipid membrane (DMPC) were investigated using atomic force microscopy (AFM), confocal microscopy (CM) and electrochemical techniques such as Tafel polarization, cyclic voltammetry (CV), differential pulse voltammetry (DPV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS)...
July 28, 2021: Biomedicine & Pharmacotherapy
Zobair M Younossi, Maria Stepanova, Rebecca A Taub, Jordan Mark Barbone, Stephen A Harrison
BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with adverse clinical outcomes and impaired health-related quality of life (HRQL). METHODS: Patients with biopsy-proven non-cirrhotic NASH with hepatic fat fraction of ≥10% by MRI-proton density fat fraction (MRI-PDFF) were enrolled in a Phase 2, multicenter, double-blind, randomized, placebo-controlled study of resmetirom. HRQL was assessed using Short Form-36 (SF-36) throughout 36 weeks of treatment...
July 27, 2021: Clinical Gastroenterology and Hepatology
Fikret Altındağ, Murat Çetin Rağbetli, Uğur Özdek, Necat Koyun, Jamal Khalid Ismael Alhalboosi, Sadi Elasan
In the present study, we aimed to investigate the effect of individual and combined treatment of sinapic acid (SA) and ellagic acid (EA) in streptozotocin (STZ)-induced diabetic rats. Rats were divided into eight groups (n = 7): Normal Control, Diabetic Control, Diabetic + Sinapic Acid, Diabetic + Ellagic Acid, Diabetic + Sinapic Acid + Ellagic Acid, Sinapic Acid, Ellagic Acid and Sinapic Acid + Ellagic Acid. Diabetic groups were injected with a single dose of 50 mg/kg STZ intraperitoneally. Rats received 20 mg/kg/day SA and 50 mg/kg/day EA intragastrically for 28 days...
July 27, 2021: Food and Chemical Toxicology
Sarah Erem, Mohammed S Razzaque
This review examines the beneficial effects of ultraviolet radiation on systemic autoimmune diseases, including multiple sclerosis and type I diabetes, where the epidemiological evidence for the vitamin D-independent effects of sunlight is most apparent. Ultraviolet radiation, in addition to its role in the synthesis of vitamin D, stimulates anti-inflammatory pathways, alters the composition of dendritic cells, T cells, and T regulatory cells, and induces nitric oxide synthase and heme oxygenase metabolic pathways, which may directly or indirectly mitigate disease progression and susceptibility...
July 27, 2021: Journal of Steroid Biochemistry and Molecular Biology
Jinni Meng, Yafei Zhu, Huixia Ma, Xiaobo Wang, Qipeng Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic cognitive dysfunction (DCD) is mainly one of the complications of type 2 diabetes mellitus (T2DM) with complex and obscure pathogenesis. Extensive evidence has demonstrated the effectiveness and safety of traditional Chinese medicine (TCM) for DCD management. AIM OF THE STUDY: This review attempted to systematically summarize the possible pathogenesis of DCD and the current Chinese medicine on the treatment of DCD. MATERIALS AND METHODS: We acquired information of TCM on DCD treatment from PubMed, Web of Science, Science Direct and CNKI databases...
July 27, 2021: Journal of Ethnopharmacology
Pedro H O Borges, Sónia Pedreiro, Salete J Baptista, Carlos F G C Geraldes, M T Batista, Maria M C Silva, Artur Figueirinha
ETHNOPHARMACOLOGICAL RELEVANCE: Leaves extracts from Cymbopogon citratus (DC) Stapf. are widely used in traditional medicine exhibiting several in vivo biological activities, including antidiabetic. Several flavonoids, including aglycones and glycosides, were reported in this plant and previous studies suggested that flavonoids may interact with targets related to diabetes. AIM OF THE STUDY: Evaluated the hypoglycemic activity of C. citratus flavonoids through α-glucosidase inhibition and assess the structure-activity relationship using molecular docking studies...
July 27, 2021: Journal of Ethnopharmacology
Sujoy Majumdar, Binayak Sinha, Biswajit Ghosh Dastidar, Kalyan Kumar Gangopadhyay, Samit Ghoshal, Jagat Jyoti Mukherjee, Anirban Mazumdar, Subir Ray, Samir Dasgupta, Kingshuk Bhattacharjee
OBJECTIVES: Depression is common in diabetes and has significant impact on health outcomes. Suicidal ideation also forms a part of the spectrum of diabetes and coexistent depression. To assess the predictors of depression as well as its prevalence in Type 2 Diabetes Mellitus (T2DM) patients, we conducted a cross sectional study entitled "DEPression in DIABetes" (DEPDIAB). MATERIAL AND METHODS: A cohort of consecutive 1371 T2DM patients from Eastern India suffering from diabetes greater than 1 year was assessed in a cross- sectional survey in 9 different hospitals and medical polyclinics in Kolkata, India for depression by administering the 9-item PHQ - 9 and Beck depression scales...
July 27, 2021: Diabetes Research and Clinical Practice
Yan-Yan Li, Xu-Nan Wu, Xia Deng, Pan-Pan Zhang, Hao-Xiang Li, Ke Chen, Dan-Ping Wu, Tian Gu, Chen-Xi Wang, Li Zhao, Dong Wang, Ling Yang, Guo-Yue Yuan
AIMS: Tsukushi, a newly identified hepatokine, has been recently characterized as a potent modifier in lipid metabolism and energy homeostasis, but the role of Tsukushi in diabetes remains almost unknown. We detected for the first time the increased serum Tsukushi levels in newly diagnosed type 2 diabetes, exploring the relationship between Tsukushi and various metabolic parameters. METHODS: A total of 172 participants were recruited, including 86 patients with newly diagnosed type 2 diabetes and 86 subjects with normal glucose tolerance according to oral glucose tolerance test...
July 27, 2021: Diabetes Research and Clinical Practice
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