Bang-Sheng Wu, Ya-Ru Zhang, Liu Yang, Wei Zhang, Yue-Ting Deng, Shi-Dong Chen, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
BACKGROUND: Alzheimer's disease (AD) patients rank among the highest levels of comorbidities compared to persons with other diseases. However, it is unclear whether the conditions are caused by shared pathophysiology due to the genetic pleiotropy for AD risk genes. OBJECTIVE: To figure out the genetic pleiotropy for AD risk genes in a wide range of diseases. METHODS: We estimated the polygenic risk score (PRS) for AD and tested the association between PRS and 16 ICD10 main chapters, 136 ICD10 level-1 chapters, and 377 diseases with cases more than 1,000 in 312,305 individuals without AD diagnosis from the UK Biobank...
November 21, 2022: Journal of Alzheimer's Disease: JAD
Hui-Young Lee, Hye Rim Jang, Hui Li, Varman T Samuel, Karrie D Dudek, Anna B Osipovich, Mark A Magnuson, Jeffrey Sklar, Gerald I Shulman
Single-nucleotide polymorphisms in the human juxtaposed with another zinc finger protein 1 ( JAZF1 ) gene have repeatedly been associated with both type 2 diabetes (T2D) and height in multiple genome-wide association studies (GWAS); however, the mechanism by which JAZF1 causes these traits is not yet known. To investigate the possible functional role of JAZF1 in growth and glucose metabolism in vivo, we generated Jazf1 knockout (KO) mice and examined body composition and insulin sensitivity both in young and adult mice by using 1 H-nuclear magnetic resonance and hyperinsulinemic-euglycemic clamp techniques...
December 6, 2022: Proceedings of the National Academy of Sciences of the United States of America
Erum Mubashir Shariff, Fahd Ali Al Khmais, Saima Nazish, Noman Ishaque, Aishah Ibrahim Al Bakr, Reem S AlOmar, Danah Aljaafari, Mohammad AlShurem, Azra Zafar, Rizwana Shahid, Sari AlSuhaibani, Saeed Al-Jubran, Nehad M Soltan, Abdulaziz Mohammad Al-Sharydah, Majed Alabdali
Objective: Wake-up stroke (WUS) comprises a significant proportion of ischemic strokes. However, due to unclear onset, these patients are often not considered for reperfusion therapy. The objective of this study was to investigate the clinical and imaging differences between WUS patients and those with clear-onset stroke, documenting any sex, age, or risk factor predilection for WUS. Methods: This prospective observational cohort study used an ongoing stroke registry to identify patients with acute ischemic stroke admitted to a hospital in Saudi Arabia within 5 days of symptom onset from April 2018 to March 2020...
November 24, 2022: Primary Care Companion to CNS Disorders
Christine Schumacher
Background: Large cardiovascular outcomes trials in individuals with heart failure, with and without diabetes, have demonstrated a significant risk reduction in the composite outcome of cardiovascular death or hospitalizations for heart failure with SGLT2 inhibitor therapy. These positive outcomes have led to the recommendation that SGLT2 inhibitors serve as backbone therapy in patients with heart failure reduced ejection fraction (HFrEF). To date, there has not been enough participants in clinical trials on concomitant SGLT2 inhibitor and angiotensin receptor-neprilysin inhibitor therapy to evaluate the benefits and risks of combination therapy with these two agents outside of smaller subgroup analyses...
November 28, 2022: Journal of Pharmacy Practice
Eduardo Izquierdo, Marta López-Corrales, Diego Abad-Montero, Anna Rovira, Gemma Fabriàs, Manel Bosch, José Luís Abad, Vicente Marchán
Ceramides (Cer) are bioactive sphingolipids that have been proposed as potential disease biomarkers since they are involved in several cellular stress responses, including apoptosis and senescence. 1-Deoxyceramides (1-deoxyCer), a particular subtype of noncanonical sphingolipids, have been linked to the pathogenesis of type II diabetes. To investigate the metabolism of these bioactive lipids, as well as to have a better understanding of the signaling processes where they participate, it is essential to expand the toolbox of fluorescent sphingolipid probes exhibiting complementary subcellular localization...
November 28, 2022: Journal of Organic Chemistry
Crystal S Shin, Remya Ammassam Veettil, Tamil S Sakthivel, Aparna Adumbumkulath, Richard Lee, Mahira Zaheer, Elayaraja Kolanthai, Sudipta Seal, Ghanashyam Acharya
Diseases affecting the retina, such as age-related macular degeneration (AMD), diabetic retinopathy, macular edema, and retinal vein occlusions, are currently treated by the intravitreal injection of drug formulations. These disease pathologies are driven by oxidative damage due to chronic high concentrations of reactive oxygen species (ROS) in the retina. Intravitreal injections often induce retinal detachment, intraocular hemorrhage, and endophthalmitis. Furthermore, the severe eye pain associated with these injections lead to patient noncompliance and treatment discontinuation...
November 28, 2022: ACS Applied Bio Materials
Filmon Tsegay, Mohamed Elsherif, Fahad Alam, Haider Butt
Wound healing is a huge challenge worldwide causing enormous financial burden on healthcare systems. Although conventional wound dressings, such as hydrogels, bandages, and foams, facilitate wound healing, they lack the ability to monitor the wound healing process. Here, hydrogel wound dressings in the form of auxetic structures were developed by a digital light processing (DLP) printer. Paper-based colorimetric sensors were incorporated with the 3D printed auxetic hydrogel skin wound patches for monitoring the wound status through detecting pH levels and glucose concentrations...
November 28, 2022: ACS Applied Bio Materials
Ayinalem Alemu, Zebenay Workneh Bitew, Getachew Seid, Getu Diriba, Emebet Gashu, Nega Berhe, Solomon H Mariam, Balako Gumi
BACKGROUND: The emergence of COVID-19 overwhelmed tuberculosis (TB) prevention and control, resulting in a decrease in TB detection rate and an increase in TB deaths. Furthermore, the temporary immunosuppressive effects, lung inflammation, and the corticosteroids used to treat COVID-19, may play a direct role in immunosuppression, leading to reactivation of either previous infection or latent TB or the development of new TB. Thus, the aim of this study was to review TB incidence in individuals who recovered from COVID-19...
2022: PloS One
Nicolette Stogios, Laurie Hamel, Emily Smith, Marcos Sanches, Gary Remington, Aristotle Voineskos, Satya Dash, Ariel Graff-Guerrero, Margaret Hahn, Sri Mahavir Agarwal
Antipsychotics (APs) are the cornerstone of treatment for schizophrenia (SCZ) but are unfortunately associated with serious metabolic adverse effects including weight gain and type 2 diabetes. The pathophysiology of AP-induced metabolic dysfunction is largely undetermined. Brain insulin resistance has been posited to be at the cross-roads of many cognitive and metabolic disorders, and disruption of central insulin action has emerged as a possible explanatory mechanism underlying AP induced metabolic dysfunction...
2022: PloS One
Dewi Murdiyanti Prihatin Putri, Yoyo Suhoyo, Ariani Arista Putri Pertiwi, Christantie Effendy
The number of patients with diabetes in Indonesia reach 19,47 million in 2021, mostly is caused by the adoption of sedentary and unhealthy lifestyles. Continuous self-management is important in diabetes care. It requires optimal coordination and communication between patients, families, and health care provider. The use of communication technology could be solution to the problem. This study aims to initiate an android-based mobile apps technology as a tool for patient, family, and healthcare provider to optimize patient with T2DM treatment...
2022: PloS One
Makoto Hatano, Fumiaki Higashijima, Takuya Yoshimoto, Tadahiko Ogata, Manami Ohta, Yuka Kobayashi, Makiko Wakuta, Ryoji Yanai, Kazuhiro Kimura
Administration of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the first-line therapy for diabetic macular oedema (DME). However, some patients show no or insufficient response to repeated anti-VEGF injections. Therefore, it is necessary to identify factors that can predict this resistance against anti-VEGF treatment. Presence of microaneurysms (MAs) is a predictor of the development and progression of DME, but its relationship with the treatment response to the anti-VEGF agents is not well known...
2022: PloS One
Debby Syahru Romadlon, Hui-Chuan Huang, Yang-Ching Chen, Sophia H Hu, Faizul Hasan, Milton D Chiang Morales, Ollyvia Freeska Dwi Marta, Safiruddin Al Baqi, Hsiao-Yean Chiu
Patients with type 2 diabetes mellitus (T2DM) often experience fatigue. The Multidimensional Fatigue Inventory (MFI-20) is a valid tool for evaluating fatigue; however, its psychometric properties have not been examined in Indonesian-speaking patients with T2DM. This study assessed the psychometric properties of the Indonesian version of the Multidimensional Fatigue Inventory-20 (IMFI-20) in patients with T2DM and investigated fatigue in a health-care setting. A cross-sectional design was adopted. Two hundred patients with T2DM were interviewed in clinics...
2022: PloS One
Jason Gurney, James Stanley, Andrea Teng, Jeremy Krebs, Jonathan Koea, Chunhuan Lao, Ross Lawrenson, Ineke Meredith, Dianne Sika-Paotonu, Diana Sarfati
The number of new cases of cancer is increasing each year, and rates of diabetes mellitus are also increasing dramatically over time. It is not an unusual occurrence for an individual to have both cancer and diabetes at the same time, given they are both individually common, and that one condition can increase the risk of the other. In this manuscript, we use national-level diabetes (Virtual Diabetes Register) and cancer (New Zealand Cancer Registry) data on nearly five million individuals over 44 million person-years of follow-up to examine the occurrence of cancer amongst a national prevalent cohort of patients with diabetes...
2022: PloS One
Laila Aboulatta, Payam Peymani, Christine Vaccaro, Christine Leong, Kaarina Kowalec, Joseph Delaney, Jamie Falk, Silvia Alessi-Severini, Basma Aloud, Sherif Eltonsy
BACKGROUND: The COVID-19 pandemic has led the Canadian provincial governments to take unprecedented measures, including restrictions to healthcare services and pharmacists. Limited evidence exists on changes in prescription trends in Canada during the pandemic period. OBJECTIVES: To examine the trend of prescription medications' utilization before and during COVID-19, among incident and prevalent users in the general population. We examined 18 major classes of medications...
2022: PloS One
Jie Sun, Na Li, Min Xu, Li Li, Ji Lin Chen, Yong Chen, Jian Guo Xu, Ting Hua Wang
PURPOSE: To study the effects of Lu-tong Granules (LTG) in ICH etermine the underlying mechanism of molecular network. METHODS: Modern bioinformatics and network pharmacology methods were used to predict molecular network mechanisms between ICH and LTG. Animal experiments were carried out to verify the effect of LTG for the treatment of ICH, combined with behavior test and morphologic detection. RESULTS: Forty-three active components in LTG and involved 192 gene targets were identified successfully...
2022: PloS One
In Young Yoo, Woong Heo, Joo An Kwon, Miran Lee, Yeon-Joon Park
BACKGROUND: Diabetic foot infection is the most common complications of diabetes mellitus. Although most of the diabetic foot infections has been known to be caused by aerobic and anaerobic bacteria, mycotic diabetic foot infection caused by Candida species has also been reported recently. Here, we present the first case of diabetic foot infection caused by Cutaneotrichosporon debeurmannianum (previously known as Trichosporon debeurmannianum). METHODS: A 68-year-old diabetic male patient was admitted for management of the necrosis of the big toe...
November 28, 2022: Journal of Clinical Laboratory Analysis
Yuki Kawai, Kayo Waki, Satoko Yamaguchi, Tomomi Shibuta, Kana Miyake, Shigeko Kimura, Tsuguyoshi Toyooka, Ryo Nakajima, Kazushi Uneda, Hiromichi Wakui, Kouichi Tamura, Masaomi Nangaku, Kazuhiko Ohe
BACKGROUND: Making lifestyle changes is an essential element of abdominal obesity (AO) reduction. To support lifestyle modification and self-management, we developed an information and communication technology-based self-management system-DialBeticsLite-with a fully automated dietary evaluation function for the treatment of AO. OBJECTIVE: The objective of this study was to evaluate the preliminary efficacy and feasibility of DialBeticsLite among Japanese office workers with AO...
November 28, 2022: JMIR Diabetes
Andrew Chan, Rachel Cohen, Katherine-Marie Robinson, Devvrat Bhardwaj, Geoffrey Gregson, Jeffrey W Jutai, Jason Millar, Adriana Ríos Rincón, Atena Roshan Fekr
BACKGROUND: Home health monitoring shows promise in improving health outcomes; however, navigating the literature remains challenging given the breadth of evidence. There is a need to summarize the effectiveness of monitoring across health domains and identify gaps in the literature. In addition, ethical and user-centered frameworks are important to maximize the acceptability of health monitoring technologies. OBJECTIVE: This review aimed to summarize the clinical evidence on home-based health monitoring through a scoping review and outline ethical and user concerns and discuss the challenges of the current user-oriented conceptual frameworks...
November 28, 2022: JMIR aging
Cristina Cadenas-Sanchez, Rafael Cabeza, Fernando Idoate, Maddi Osés, María Medrano, Arantxa Villanueva, Lide Arenaza, Aritz Sanz, Francisco B Ortega, Jonatan R Ruiz, Idoia Labayen
IMPORTANCE: Excess abdominal fat is a major determinant in the development of insulin resistance and other metabolic disorders. Increased visceral adipose tissue (VAT) seems to precede the development of insulin resistance and is therefore a prime target of childhood lifestyle interventions aimed at preventing diabetes. OBJECTIVES: To examine the effect of added exercise to a family-based lifestyle intervention program designed to reduce VAT plus subcutaneous (ASAT), intermuscular (IMAAT), and pancreatic (PAT) adipose tissue in children with overweight or obesity and to explore the effect of changes in VAT on insulin resistance...
November 1, 2022: JAMA Network Open
Ki-Jin Ryu, Min Sun Kim, Ji Yoon Lee, Seunghyun Nam, Hye Gyeong Jeong, Tak Kim, Hyuntae Park
IMPORTANCE: The association of tamoxifen use with the risk of uterine diseases, such as endometrial cancer, in premenopausal women with breast cancer remains controversial. However, many studies have reported an increased risk of uterine disease among postmenopausal tamoxifen users. OBJECTIVE: To investigate the association of tamoxifen use with the risk of endometrial cancer and other uterine diseases in premenopausal women with breast cancer. DESIGN, SETTING, AND PARTICIPANTS: A nationwide, population-based, retrospective longitudinal cohort study with an 18-year study period was conducted using data obtained from the Korean National Health Insurance Service...
November 1, 2022: JAMA Network Open
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