Asil Musleh, Khaled Abbadi, Malvina Asbah, Mohammed Nofal, Mayar Abu Hilal, Abdellatif Khader
INTRODUCTION: Mucinous cystic neoplasm is a rare premalignant tumor of the pancreas typically affects middle aged women. Mostly it affects the body and the tail of the pancreas and in very rare cases it may affect the head. CASE PRESENTATION: A 56-year-old female patient, previously diagnosed with type 2 diabetes mellitus, and with an unremarkable medical and surgical history except for a laparoscopic cholecystectomy and multiple admissions due to colonic diverticular disease, which ultimately required a left hemicolectomy...
September 22, 2023: International Journal of Surgery Case Reports
Qingqing Guo, Xueyi Zhang, Siqin Sun, Xiaojun Tang, Wei Shen, Jun Liang, Genhong Yao, Linyu Geng, Shuai Ding, Hongwei Chen, Hong Wang, Bingzhu Hua, Huayong Zhang, Dandan Wang, Xuebing Feng, Lingyun Sun, Ziyi Jin
INTRODUCTION: The association between mycophenolate mofetil (MMF) and infection in patients with systemic lupus erythematosus (SLE) has not been clarified. This study evaluated the degree and factors in effect of MMF use on infection in patients with SLE. METHODS: A hospitalized-based observational study was conducted to collect medical records on patients with SLE during 2010-2021. A nested case-control study was performed among 3339 patients with SLE, including 1577 cases and 1762 controls by whether they developed any type of infection...
September 24, 2023: Rheumatology and Therapy
Zeyu Liu, Tamara Daniels, Matthew J Campen, Roberto Ivan Mota Alvidrez
INTRODUCTION: Atherosclerosis is prevalent globally, closely associated with dyslipidemia and other metabolic dysfunction. Early diagnosis of atherosclerosis is challenging due to limited diagnostic capabilities that need to be expanded with animal models with enhanced vascular biology like rats. Our previous research showed [111In] In-DANBIRT has potential as a diagnostic tool for detecting atherosclerosis in mice. The primary aim of the present study is to evaluate [111In] In-DANBIRT in a novel atherosclerotic rat with early- and late-stage atherosclerosis and metabolic disease...
September 24, 2023: Annals of Nuclear Medicine
Yusuf Omran Hasan, Jonathan Bourget-Murray, Piers Page, Jowan G Penn-Barwell, Robert Handley
AIM: This article describes the technique of tibiotalar nailing performed using an antegrade tibial nail for salvage of distal tibia and ankle fractures in elderly patients. MATERIALS AND METHODS: We report indications, surgical technique, and the clinical outcomes and complication rate in our series to date. A retrospective review was performed at our level 1 major trauma centre. Patient demographics, comorbidities, and 12-month post-operative course were collected...
September 24, 2023: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Weiyan Lai, Dan Luo, Yin Li, Yuanqing Li, Qianqian Wang, Zhaoyong Hu, Zengchun Ye, Hui Peng
Many studies have highlighted the importance of moderate exercise. While it can attenuate diabetic kidney disease, its mechanism has remained unclear. The level of myokine irisin in plasma increases during exercise. We found that irisin was decreased in diabetic patients and was closely related to renal function, proteinuria, and podocyte autophagy injury. Muscle-specific overexpression of PGC-1α (mPGC-1α) in a mouse model is known to increase plasma irisin levels. The mPGC-1α mice were crossed with db/m mice to obtain db/db mPGC-1α+ mice in the present study...
October 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
(no author information available yet)
No abstract text is available yet for this article.
September 24, 2023: Rheumatology
Pragya Malla, Madhav Prasad Khanal, Asmita Pokhrel, Bishesh Sah, Sonam Pathak, Anukul Subedi, Srijana Sapkota
BACKGROUND: Diabetes complication poses a new challenge in Nepal as the disease is becoming endemic. Identifying risk factor for diabetes can be an essential step in preventing complication related to diabetes. Abnormal Uric acid and lipid profile are the important risk indicators of diabetes mellitus complications, so the study was done to know the association between uric acid and lipid profile in type 2 diabetes. METHODS: A cross-sectional study was done from 118 patients with type 2 diabetes mellitus visiting Nepal Medical College and Teaching Hospital...
September 10, 2023: Journal of Nepal Health Research Council
Mahesh Raj Ghimire, Sumnima Acharya, Sundar Pandey, Deepak Aryal, Pooja Shah, Binita Soti, Sulochana Ghimire, Lekhjung Thapa
BACKGROUND: Out of many atherosclerotic complications, peripheral arterial disease (PAD) is also important one. To prevent morbidity and mortality related with PAD, early detection is must, and is possible by duplex screening. This study aims at screening for PAD in patients with type 2 Diabetes mellitus. METHODS: This study is single centered cross- sectional, observational study conducted in department of internal medicine of DMCRI- a tertiary care hospital. A total of 140, type 2 diabetes patients were screened for peripheral arterial disease by duplex ultrasound after taking informed consent and fulfilling inclusion and exclusion criteria...
September 8, 2023: Journal of Nepal Health Research Council
Erik H Serné, Jetty A Overbeek, Jan Palmen, Hilda J I de Jong, Coen D A Stehouwer
OBJECTIVE: Dutch diabetes guidelines have been updated to incorporate specific therapies with cardiovascular and kidney outcomes benefit in type 2 diabetes patients (T2D) at very high risk for cardiorenal complications. This is part of a comprehensive approach to reduce the risk of diabetes-related complications, including management of glycemia, blood pressure, and lipids. The current study examines the prevalence of T2D at very high cardiorenal risk and the deployment of evidence-based approaches to lower this risk...
September 19, 2023: Nederlands Tijdschrift Voor Geneeskunde
Erik H Serné
The provision of appropriate care is the cornerstone of the Integrated Care Agreement (IZA) in the Netherlands. Appropriate care is presented as a way of working together to ensure that everyone continues to have access to reimbursed and good quality health care in the future. A method that has been successfully used within the diabetes field since 2016 and has taken shape as the Round Table Diabetes Care. The current article describes this approach.
September 20, 2023: Nederlands Tijdschrift Voor Geneeskunde
Lucia Scisciola, Ugo Chianese, Vicky Caponigro, Manuela Giovanna Basilicata, Emanuela Salviati, Lucia Altucci, Pietro Campiglia, Giuseppe Paolisso, Michelangela Barbieri, Rosaria Benedetti, Eduardo Sommella
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors constitute the gold standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) has shown beneficial effects against heart failure. Because cardiovascular diseases (mainly diabetic cardiomyopathy) are the leading cause of death in diabetic patients, the use of EMPA could be, simultaneously, cardioprotective and antidiabetic, reducing the risk of death from cardiovascular causes and decreasing the risk of hospitalization for heart failure in T2DM patients...
September 23, 2023: Journal of Translational Medicine
Wei Luo, Yu He, Mao Gang Wei, Guang Bing Lu, Qun Yi
BACKGROUND: Transplant recipients are at high risk of coronavirus disease 2019, and a timely supply of antivirals should be prioritized for those patients. Complicated drug‒drug interactions limit the use of Paxlovid (nirmatrelvir/ritonavir) coadministered with tacrolimus. Here, we report a patient with a kidney transplant who received Paxlovid and reduced-dose tacrolimus at the same time and suffered a severe tacrolimus toxicity. CASE PRESENTATION: We present a 56-year-old man of Han ethnicity with a kidney transplant who suffered from coronavirus disease 2019 twice...
September 24, 2023: Journal of Medical Case Reports
Fereshte Attaran, Sepideh Emami, Masoudreza Sohrabi, Mojtaba Malek, Hossein Ajdarkosh, Mahmoodreza Khoonsari, Faramarz Ismail-Beigi, Mohammad E Khamseh
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a complex metabolic disorder that increases the risk for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Global longitudinal strain (GLS) is an indicator of left ventricular (LV) mechanics and can detect subclinical myocardial dysfunction. We compared the effects of pioglitazone and empagliflozin on GLS in patients with T2DM and NAFLD without established atherosclerotic cardiovascular disease. METHODS: This study was a 24-week randomized, single-blind, and parallel-group (1: 1 ratio) clinical trial...
September 23, 2023: BMC Gastroenterology
Mei Jin, Jing Liu, Kang Liu, Ziwei Zhao, Suzhen Sun
BACKGROUND: The morbidity of type 1 diabetes mellitus (T1DM) in children is increasing and diabetic peripheral neuropathy (DPN) is one of the main microvascular complications of T1DM. The aim of this study was to explore sympathetic skin response (SSR) characteristics in children with T1DM and analyze the value of early diagnosis and follow-up in T1DM complicated with DPN. METHODS: Our prospective study enrolling 85 participants diagnosed with T1DM and 30 healthy controls (HCs) in the Children's Hospital of Hebei Province from 2017 to 2020...
September 23, 2023: BMC Pediatrics
Yiyong Dou, Yuwei Zhang, Shuo Zhang, Shuo Ma, Hong Zhang
Flexible hydrogel sensors have expanded the applications of electronic devices due to their suitable mechanical properties and excellent biocompatibility. However, conventionally synthesized reduced graphene oxide (rGO) encounters limitations in reduction degree and dispersion, restricting the conductivity of graphene hydrogels and impeding the development of high-sensitivity flexible sensors. Moreover, hydrogels are susceptible to inflammation and bacterial infections, jeopardizing sensor stability over time...
September 23, 2023: Journal of Nanobiotechnology
Jesper Medom Vestergaard, Annett Dalbøge, Jens Peter Ellekilde Bonde, Anne Helene Garde, Johnni Hansen, Åse Marie Hansen, Ann Dyreborg Larsen, Mikko Härmä, Sadie Costello, Morten Böttcher, Henrik Albert Kolstad
BACKGROUND: Night work has been associated with coronary heart disease. The present study examined exposure-response relations between quantitative night work characteristics and coronary heart disease (angina pectoris or myocardial infarction) with the aim to contribute to evidence-based recommendations for low-risk night work schedules. METHODS: We followed 100 149 night workers (80% women) and 153 882 day workers (78% women), all health care workers in Denmark with day by day payroll information on night shifts from 2007 to 2015...
September 23, 2023: International Journal of Epidemiology
Basma Mahrous El-Fatatry, Sahar Mohamed El-Haggar, Osama Mohamed Ibrahim, Khaled Hamed Shalaby
PURPOSE: Diabetic kidney disease (DKD) is a devastating complication of diabetes mellitus. Inflammation and histamine are potentially involved in the disease progression. This study aimed to evaluate the role of fexofenadine in patients with DKD. METHODS: From January 2020 to February 2022, out of 123 patients screened for eligibility, 61 patients completed the study. Patients were randomized into two groups, the fexofenadine group (n = 30): received ramipril plus fexofenadine, and the control group (n = 31): received ramipril only for six months...
September 23, 2023: International Urology and Nephrology
Angelo Scuteri, Christopher H Morrell, Majd AlGhatrif, Marco Orru, Edoardo Fiorillo, Michele Marongiu, David Schlessinger, Francesco Cucca, Edward G Lakatta
AIMS: High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. METHODS: Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. RESULTS: Although high plasma glucose in diabetics, did not differ by G6DP status (178...
September 23, 2023: Acta Diabetologica
Thomas A Mavrakanas, Michael A Tsoukas, James M Brophy, Abhinav Sharma, Karim Gariani
The effect of sodium-glucose co-transporter-2 (SGLT-2) inhibitors on cardiovascular and renal outcomes has not been systematically reviewed across baseline kidney function groups. We conducted a systematic review and meta-analysis of randomized control trials (RCTs) with SGLT-2 inhibitors in patients with and without CKD. We performed a PubMed/Medline search of randomized, placebo-controlled, event-driven outcome trials of SGLT-2 inhibitors versus active or placebo control in patients with and without diabetes from inception to November 2022...
September 23, 2023: Scientific Reports
Xinke Li, Xixi Ning, Binqi Rui, Yushuang Wang, Zengjie Lei, Da Yu, Feitong Liu, Yanjie Deng, Jieli Yuan, Wenzhe Li, Jingyu Yan, Ming Li
Gestational diabetes mellitus (GDM) is an increasing public health concern that significantly increases the risk of early childhood allergic diseases. Altered maternal milk glycobiome may strongly affect gut microbiota and enteric-specific Treg cell-mediated development of immune tolerance in GDM infants. In this study, we found that, compared with healthy Chinese mothers, mothers with GDM had significantly lower levels of total and specific human milk oligosaccharides (HMOs) in their colostrum that subsequently increased with extension of lactation...
December 2023: Gut Microbes
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