Akihisa Imagawa
Fulminant type 1 diabetes is characterized by a markedly rapid onset of hyperglycemia (1). According to the "criteria for the definite diagnosis of fulminant type 1 diabetes mellitus (2012)" (2), fulminant type 1 diabetes mellitus is confirmed when all the following three findings are present: 1) occurrence of diabetic ketosis or ketoacidosis soon after (within approximately 7 days) the onset of hyperglycemic symptoms (elevation of urinary and/or serum ketone bodies at first visit), 2).
October 24, 2020: Journal of Diabetes Investigation
Bedowra Zabeen, Bulbul Ahmed, Jebun Nahar
Our aim was to report our telemedicine experience with type 1 diabetes patients on insulin pumps who fasted during Ramadan 2020 at COVID 19 pandemic time. The routine diabetes outpatient care in our CDiC Paediatric Diabetes Center in BIRDEM hospital was closed as there was lock down since March 26 in Bangladesh. The diabetes team in our center started tele medicine care for routine follow up of patients. Nine patients contacted our diabetes team over phone who wished to fast this Ramadan. Mean age was 19.3 ± 5...
October 24, 2020: Journal of Diabetes Investigation
Ingun Toftemo, Anne Karen Jenum, Line Sletner
AIM: Independent effects of gestational diabetes (GDM), maternal prepregnant obesity and gestational weight gain on offspring BMI and obesity are scarcely documented. We examined associations between GDM and children's BMI trajectories from birth to 4-5 years age, and effects of prepregnant obesity and gestational weight gain not mediated through GDM. METHODS: We included 734 children from a population-based, multi-ethnic cohort of women and their offspring followed from early pregnancy...
October 24, 2020: Acta Paediatrica
Haytham Ali, Husam Salama, Nicola Robertson, Tawa Olukade, Sawsan Al-Obaidly, Mai Al-Qubaisi, Hilal Al Rifai
Objectives A recent discussion surrounding the extension of antenatal corticosteroid (ACS) use beyond 34 weeks of gestation did not include the subgroup of infants of diabetic mothers (IDM). We aimed to examine the association between ACS exposure and outcomes in neonates born at term and at near-term gestation in a large cohort of IDMs. Methods We selected 13976 eligible near-term and term infants who were included in the PEARL-Peristat Perinatal Registry Study (PPS). We assessed the association of ACS exposure with neonatal outcomes in a multivariate regression model that controlled for diabetes mellitus (DM) and other perinatal variables...
October 26, 2020: Journal of Perinatal Medicine
Keneth Iceland Kasozi, Dorothy Nakimbugwe, Herbert Izo Ninsiima, Josephine Kasolo, Kevin Matama, Abass Alao Safiriyu, Elna Owembabazi, Fred Ssempijja, Alfred Omachonu Okpanachi, Miriela Betancourt Valladares
Objectives Calcium deregulation in diabetes mellitus (DM) is central to the brain-heart axis pathology. This has led to the use of medical plants in complementary medicine such as Amaranthus hypochondriacus (GA). The objective of the study was to establish the effects of grain amaranth feed supplementation on calcium, s100al protein and antioxidant levels on the brain-heart axis in diabetic male Wistar rats. Methods The study involved six groups (n=5) with DM being induced in 20 rats. To the diabetic rats, Group I received mixtard®, Group II was positive control, Groups III and IV received GA feed supplementation at 25 and 50%...
October 12, 2020: Journal of Basic and Clinical Physiology and Pharmacology
Zi Li, Maki Murakoshi, Saki Ichikawa, Takeo Koshida, Eri Adachi, Chigure Suzuki, Seiji Ueda, Tomohito Gohda, Yusuke Suzuki
Trials on cardiovascular and renal outcomes in patients with type 2 diabetes have consistently demonstrated that sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of diabetic kidney disease (DKD) progression. However, their renal protective mechanisms have yet to be completely understood and the effect on albuminuria reduction in animal models is controversial. Here, we investigated these issues using KK and KK-Ay mice as a control (CTRL) and as a model for type 2 diabetes (DKD), respectively...
October 24, 2020: FEBS Open Bio
Kumiko Taguchi, Nozomu Kaneko, Kanami Okudaira, Takayuki Matsumoto, Tsuneo Kobayashi
AIMS: Diabetes impairs insulin-induced endothelium-dependent relaxation by reducing nitric oxide (NO) production. GLP-1, an incretin hormone, has been shown to prevent the development of endothelial dysfunction. In this study, we hypothesized that GLP-1 would improve the impaired insulin-induced relaxation response in diabetic mice. We also examined the underlying mechanisms. METHODS: Using aortic rings from ob/ob mice, an animal model of obesity and type 2 diabetes, and lean mice, vascular relaxation responses and protein expressions were evaluated using insulin, GLP-1, and pathway-specific inhibitors to elucidate the mechanisms of response...
October 24, 2020: Acta Physiologica
Masaya Koshizaka, Ko Ishikawa, Ryoichi Ishibashi, Sho Takahashi, Kenichi Sakamoto, Hidetaka Yokoh, Yusuke Baba, Shintaro Ide, Kana Ide, Takahiro Ishikawa, Shunichiro Onishi, Kazuki Kobayashi, Minoru Takemoto, Takuro Horikoshi, Ryota Shimofusa, Yoshiro Maezawa, Koutaro Yokote
INTRODUCTION: To compare the effects of ipragliflozin, a sodium-glucose transporter 2 inhibitor, with those of metformin on visceral fat (as well as muscles and bones) in Japanese elderly patients with type 2 diabetes (T2D), we conducted a sub-analysis of a prospective, multicenter, blinded-endpoint randomized-controlled study. METHODS: In total, 103 patients with T2D (body mass index ≥ 22 kg/m2 ; glycated hemoglobin, 7-10%) and being treated with sitagliptin (a dipeptidyl peptidase-4 inhibitor) were included and randomized to receive ipragliflozin or metformin...
October 24, 2020: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Eu Jeong Ku, Dong-Hwa Lee, Hyun Jeong Jeon, Frank Park, Tae Keun Oh
INTRODUCTION: A psychometric analysis on type 2 diabetic (T2D) patients was performed to assess whether glycated hemoglobin (HbA1c) levels were dependent upon either the psychologic or economic attitude toward the use of insulin as a treatment for their diabetic condition. METHODS: A cross-sectional study was designed using 271 patients with T2D who regularly visited a tertiary referral hospital in South Korea from June 2019 to December 2019. Each patient enrolled in this protocol was treated with insulin for at least 6 months, had recordings of their plasma HbA1c measurement, and completed validated questionnaires consisting of items focusing on patient attitudes toward insulin use [Insulin Treatment Appraisal Scale (ITAS)] and cost-related issues related to diabetic supply purchase...
October 24, 2020: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
K Uday Chandrika, Rekha Tripathi, Y Kameshwari, Nandini Rangaraj, J Mahesh Kumar, Shashi Singh
BACKGROUND: Tissue engineering centers on creating a niche similar to the natural one, with a purpose of developing an organ construct. A natural scaffold can replace none while creating a scaffold unique to each tissue in composition, architecture and cues that regulate the character of cells. METHODS: Whole pancreas from mouse was decellularized using detergent and enzymes, followed by recellularizing with MSC from human placenta. This construct was transplanted in streptozotocin induced diabetic mice...
October 24, 2020: Tissue Engineering and Regenerative Medicine
S V Ivanov, R U Ostrovskaya, A V Sorokina, S B Seredenin
Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we studied the effect of Afobazole on streptozotocin (STZ) model of type 2 diabetes in Wistar rats. Immunohistochemical analysis showed that the decrease in the number of β cells and a violation of their morphological structure caused by STZ were significantly alleviated by Afobazole administration (10 mg/kg orally for 28 days) to diabetic animals...
October 24, 2020: Bulletin of Experimental Biology and Medicine
Brittney L Blevins, Harry V Vinters, Seth Love, Donna M Wilcock, Lea T Grinberg, Julie A Schneider, Rajesh N Kalaria, Yuriko Katsumata, Brian T Gold, Danny J J Wang, Samantha J Ma, Lincoln M P Shade, David W Fardo, Anika M S Hartz, Gregory A Jicha, Karin B Nelson, Shino D Magaki, Frederick A Schmitt, Merilee A Teylan, Eseosa T Ighodaro, Panhavuth Phe, Erin L Abner, Matthew D Cykowski, Linda J Van Eldik, Peter T Nelson
Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC. Recent research indicates other and more complex risk factors and pathogenetic mechanisms. Here, we describe aspects of the unique architecture of brain arterioles, histomorphologic features of B-ASC, relevant neuroimaging findings, epidemiology and association with aging, established genetic risk factors, and the co-occurrence of B-ASC with other neuropathologic conditions such as Alzheimer's disease and limbic-predominant age-related TDP-43 encephalopathy (LATE)...
October 24, 2020: Acta Neuropathologica
Lucie Mourou, Valeria Vallone, Eleonora Vania, Silvia Galasso, Cécile Brunet, Florent Fuchs, Federico Boscari, Francesco Cavallin, Daniela Bruttomesso, Eric Renard
BACKGROUND: Pregnant women with type 1 diabetes (T1D) have high risk of complications despite improved care based on technology advancements. OBJECTIVE: To assess the effects of pregnancy planning on fetal and maternal outcomes in T1D women treated with continuous subcutaneous insulin infusion (CSII). STUDY DESIGN: We retrospectively assessed maternal and neonatal outcomes in T1D women using CSII who had planned or unplanned pregnancies between 2002 and 2018...
October 24, 2020: Acta Diabetologica
Xiayu Xu, Bin Gao, Wenxiang Ding, Qiong Wang, Maiye Zhang, Tao Tan, Fei Sun, Jianqin Lei, Qiuhe Ji, Feng Xu
AIMS: Retinal and renal microcirculations are known to share similar physiological changes during early diabetes because of abnormal glucose metabolism and other processes. The retinal vasculature therefore may serve as potential biomarker for the early identification of those at high risk of chronic kidney disease (CKD) in diabetes. METHODS: Data from 1925 patients (aged 49.0 ± 10.3) with type 2 diabetes were analyzed. Various retinal image measurements (RIMs) were collected using a validated fully automated computer program...
October 24, 2020: Acta Diabetologica
Christine P Limonte, Leila R Zelnick, John Ruzinski, Andrew N Hoofnagle, Ravi Thadhani, Michal L Melamed, I-Min Lee, Julie E Buring, Howard D Sesso, JoAnn E Manson, Ian H de Boer
AIMS/HYPOTHESIS: Interventions that reduce inflammation may delay progression of microvascular and macrovascular complications in diabetes. We examined the effects of vitamin D3 and/or n-3 fatty acid supplementation vs placebo on 5 year changes in serum inflammatory and cardiac biomarkers in adults with type 2 diabetes. METHODS: This study reports pre-specified secondary outcomes of the Vitamin D and Omega-3 Trial to Prevent and Treat Diabetic Kidney Disease, in which 1312 US adults with type 2 diabetes and without known cardiovascular disease, malignancy, or end-stage kidney disease were randomised using computer-generated random numbers in blocks of eight to vitamin D3 (2000 IU/day) vs placebo and n-3 fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]; 1 g/day) vs placebo in a 2 × 2 factorial design...
October 24, 2020: Diabetologia
Ronak Zarei, Parvaneh Nikpour, Bahman Rashidi, Nahid Eskandari, Roshanak Aboutorabi
Background: Mucin-1(Muc1) is one of the first molecules in the endometrium that confronts implanting embryos. There is insufficient knowledge about the impacts of diabetes and drugs developed for diabetes treatment on expression of this molecule at the time of implantation. Therefore, this study aimed to investigate the impacts of diabetes and insulin, metformin and pioglitazone on Muc1 expression at the time of implantation. Materials and Methods: This experimental study was conducted on a total of 63 female Wistar rats divided into 9 groups...
October 2020: International Journal of Fertility & Sterility
Gulay Simsek Bagir, Okan Sefa Bakiner, Filiz Eksi Haydardedeoglu, Filiz Araz, Melek Eda Ertorer, İlknur Kozanoglu
INTRODUCTION: The efficacy and safety of triglyceride (TG) apheresis in patients with type 2 diabetes mellitus (DM) is unclear. Diabetic complications may predispose patients to adverse events (AEs) associated with the apheresis procedure, and diabetic dyslipidemia may negatively affect the efficacy of therapeutic apheresis (TA). We investigated the effect of DM on the efficacy and complications of TA. METHODS: Patients with severe hypertriglyceridemia who underwent apheresis for treatment or for the prevention of acute pancreatitis were included in this retrospective study...
October 24, 2020: Therapeutic Apheresis and Dialysis
Habib Khoury, Nikhil Bellamkonda, Peyman Benharash, Jivianne T Lee, Marilene B Wang, Jeffrey D Suh
OBJECTIVES: To characterize the incidence, causes, risk factors, and costs of 30-day readmission after inpatient functional endoscopic sinus surgery (FESS) for patients with chronic rhinosinusitis. STUDY DESIGN: Retrospective cohort study. METHODS: The Nationwide Readmissions Database was used to characterize readmission after inpatient sinus surgery for chronic rhinosinusitis from 2015 to 2017. International Classification of Disease codes were used to identify the patient population, which included 5,644 patients...
October 24, 2020: Laryngoscope
Aekta Neel, Chris E Cunningham, Glyn R Teale
BACKGROUND: In response to the challenges of assessing fetal growth in obese women, guidelines recommend routine third trimester ultrasound scans. AIM: The aim of this study was to assess the diagnostic performance of this routine scan in obese women (body mass index (BMI) ≥ 35 kg/m2 ). METHODS: A retrospective cohort study of 1008 pregnancies with maternal BMI ≥ 35 kg/m2 born after 37 weeks gestation at a Victorian hospital from 2015 to 2017...
October 24, 2020: Australian & New Zealand Journal of Obstetrics & Gynaecology
Manuela Brüne, Silke Andrich, Burkhard Haastert, Matthias Kaltheuner, Andrea Icks
PURPOSE: To analyze the concordance of new prescription of antihyperglycemic agents between two data sources: patients' self-reports and statutory health insurance (SHI) data among patients with diabetes. METHODS: Within a cross-sectional study, 494 patients with diabetes were interviewed if and which new prescriptions of diabetes medication they received within the last three or six months. SHI data for 12 months were linked to cover these periods. For the agreement measurement, SHI data was set as reference, and kappa, positive predictive value (PPV), and sensitivity were calculated for single Anatomical Therapeutic Chemical (ATC) codes and cumulated code groups...
October 24, 2020: Pharmacoepidemiology and Drug Safety
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