Paola Rios, David Baidal, Joana Lemos, Stephanie S Camhi, Marco Infante, Nathalia Padilla, Ana M Alvarez Gil, Virginia Fuenmayor, Jonathan Ambut, Fatima A Qasmi, Alejandro M Mantero, Shari Messinger Cayetano, Phillip Ruiz, Camillo Ricordi, Rodolfo Alejandro
BACKGROUND: Allosensitization has been reported after discontinuation of immunosuppression following graft failure in islet transplantation (ITx) recipients, though duration of its persistence is unknown. METHODS: We evaluated 35 patients with type 1 diabetes who received ITx, including 17 who developed graft failure (ITx alone, n=13; ITx plus bone marrow-derived hematopoietic stem cells, n=4) and 18 with persistent graft function. Panel reactive antibody (PRA) was measured yearly for the duration of graft function within 1 year after graft failure at enrollment and yearly thereafter...
January 20, 2021: Transplantation