Hideaki Kuno, Takuya Fujimaru, Nozomi Kadota, Kasumi Konishi, Momoko Sekiguchi, Kimio Watanabe, Yugo Ito, Masahiko Nagahama, Fumika Taki, Toru Hifumi, Norio Otani, Masaaki Nakayama
Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported. Here we report a case of lactic acidosis and euDKA after metformin overdose. A 57-year-old female patient was transferred to our hospital with severe metabolic acidosis and acute kidney injury. She had type 2 diabetes mellitus and was on oral antidiabetic therapy of vildagliptin metformin hydrochloride daily. On the admission day, she had committed suicide by overdosing 50 tablets of vildagliptin metformin hydrochloride, which was equivalent to 25,000 mg of metformin and 2500 mg of vildagliptin...
March 19, 2023: CEN Case Reports