keyword
https://read.qxmd.com/read/38537095/-not-available
#1
JOURNAL ARTICLE
Eloy Salinas, María Cecilia De Pauw, María Fernanda Aguirre, María Jimena Marro, Christian Ballejo, Alejandro Félix Sturniolo, Alicia E B Lawrynowicz
El objetivo de este estudio fue estimar la prevalencia de diabetes mellitus (DM) y factores de riesgo cardiovascular en una población rural de la provincia de San Luis, Argentina. Estudio transversal desarrollado entre septiembre y noviembre de 2017 con habitantes de 18 años y más de cuatro localidades del departamento Juan Martín de Pueyrredón, San Luis. Los participantes respondieron preguntas por autorreporte sobre aspectos sociodemográficos, hábitos, factores psicosociales y de riesgo para enfermedades no transmisibles; se realizaron mediciones físicas, cuestionario FINDIRSC y extracción de muestras de sangre...
March 27, 2024: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#2
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536964/lessons-from-insulin-policy-prescriptions-for-affordable-diabetes-and-obesity-medications
#3
REVIEW
Kathryn E Nagel, Reshma Ramachandran, Kasia J Lipska
Escalating insulin prices have prompted public scrutiny of the practices of drug manufacturers, pharmacy benefit managers, health insurers, and pharmacies involved in production and distribution of medications. As a result, a series of policies have been proposed or enacted to improve insulin affordability and foster greater equity in access. These policies have implications for other diabetes and obesity therapeutics. Recent legislation, at both the state and federal level, has capped insulin out-of-pocket payments for some patients...
March 27, 2024: Diabetes Care
https://read.qxmd.com/read/38536962/acute-effects-of-vibrating-insoles-on-dynamic-balance-and-gait-quality-in-individuals-with-diabetic-peripheral-neuropathy-a-randomized-crossover-study
#4
JOURNAL ARTICLE
Giorgio Orlando, Steven Brown, Edward Jude, Frank L Bowling, Andrew J M Boulton, Neil D Reeves
OBJECTIVE: This study investigated the effects of vibrating insoles on dynamic balance and gait quality during level and stair walking and explored the influence of vibration type and frequency in individuals with diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS: Twenty-two men with DPN were assessed for gait quality and postural and dynamic balance during walking and stair negotiation using a motion capture system and force plates across seven vibratory insole conditions (Vcs) versus a control (Ctrl) condition (insole without vibration)...
March 27, 2024: Diabetes Care
https://read.qxmd.com/read/38536933/impact-of-type-2-diabetes-on-complications-after-primary-breast-cancer-surgery-danish-population-based-cohort-study
#5
JOURNAL ARTICLE
Kasper Kjærgaard, Jannik Wheler, Looket Dihge, Peer Christiansen, Signe Borgquist, Deirdre Cronin-Fenton
BACKGROUND: Knowledge is sparse on the impact of type 2 diabetes (T2D) on surgical outcomes after breast cancer surgery. This study investigated the association between T2D and risk of complications after primary breast cancer surgery, and evaluated the biological interaction between T2D and co-morbidities. METHODS: Using the Danish Breast Cancer Group clinical database, a cohort of all Danish women diagnosed with early-stage breast cancer during 1996-2022 was created...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38536878/increased-risk-of-diabetes-mellitus-and-hyperlipidemia-in-patients-with-differentiated-thyroid-cancer
#6
JOURNAL ARTICLE
Hwa Young Ahn, Jooyoung Lee, Jinmo Kang, Eun Kyung Lee
OBJECTIVE: This study aimed to assess the risk of cardiometabolic disease (CMD) in patients with differentiated thyroid cancer (DTC) using a population-based nationwide cohort in Korea. DESIGN: This was a population-based cohort study. METHODS: We selected 2649 patients with DTC and 7947 matched controls. The primary outcome was the composite of CMD including diabetes mellitus (DM), hypertension, hyperlipidemia, cerebrovascular disease, and ischemic heart disease...
March 2, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38536830/association-of-anti-diabetic-drugs-and-covid-19-outcomes-in-patients-with-diabetes-mellitus-type-2-and-chronic-kidney-disease-nationwide-registry-analysis
#7
JOURNAL ARTICLE
Jelena Dimnjaković, Tamara Buble, Pero Ivanko, Tamara Poljičanin, Sandra Karanović Štambuk, Hana Brborović, Ognjen Brborović
INTRODUCTION: Patients with diabetes mellitus type 2 and chronic kidney disease (T2DM-CKD) have a 5 times higher risk of developing severe SARS-CoV-2 infection than those without these 2 diseases. The goal of this study is to provide information on T2DM-CKD and COVID-19 outcomes, with an emphasis on the association with anti-diabetic medications. METHODOLOGY: Study is designed as a retrospective cohort analysis covering the years 2020 and 2021. Data from the National Diabetes Registry (CroDiab) were linked to hospital data, primary healthcare data, Causes of Death Registry data, the SARS-CoV-2 vaccination database, and the SARS-CoV-2 test results database...
2024: PloS One
https://read.qxmd.com/read/38536791/intrauterine-and-early-life-malnutrition-in-rats-disrupts-the-circadian-rhythm-programming-of-energy-metabolites-through-adulthood
#8
JOURNAL ARTICLE
Dulce Jocelyn Bustamante-Valdez, Martin Alejandro Fuentes-Cano, Jesus Salvador Gonzalez-Ruano, Alonso Martinez-Canabal, Rene Cardenas-Vazquez, Pilar Duran
Maternal malnutrition plays a crucial role in functional development, resulting in behavioral, cognitive, and metabolic abnormalities and disturbances. "Cafeteria diet" has been linked to obesity, metabolic syndrome, diabetes, and other metabolic disruptions in the mammalian lifespan. However, there are very few reports about the effect of intrauterine and early postnatal malnutrition on the circadian rhythm programming of energy metabolites. In mammals, circadian rhythm central control is fundamental for correct interaction with the environment and physiological regulation...
2024: PloS One
https://read.qxmd.com/read/38536787/multiple-cardiovascular-risk-factor-care-in-55-low-and-middle-income-countries-a-cross-sectional-analysis-of-nationally-representative-individual-level-data-from-280-783-adults
#9
JOURNAL ARTICLE
Alpha Oumar Diallo, Maja E Marcus, David Flood, Michaela Theilmann, Nicholas E Rahim, Alan Kinlaw, Nora Franceschini, Til Stürmer, Dessie V Tien, Mohsen Abbasi-Kangevari, Kokou Agoudavi, Glennis Andall-Brereton, Krishna Aryal, Silver Bahendeka, Brice Bicaba, Pascal Bovet, Maria Dorobantu, Farshad Farzadfar, Seyyed-Hadi Ghamari, Gladwell Gathecha, David Guwatudde, Mongal Gurung, Corine Houehanou, Dismand Houinato, Nahla Hwalla, Jutta Jorgensen, Gibson Kagaruki, Khem Karki, Joao Martins, Mary Mayige, Roy Wong McClure, Sahar Saeedi Moghaddam, Omar Mwalim, Kibachio Joseph Mwangi, Bolormaa Norov, Sarah Quesnel-Crooks, Abla Sibai, Lela Sturua, Lindiwe Tsabedze, Chea Wesseh, Pascal Geldsetzer, Rifat Atun, Sebastian Vollmer, Till Bärnighausen, Justine Davies, Mohammed K Ali, Jacqueline A Seiglie, Emily W Gower, Jennifer Manne-Goehler
The prevalence of multiple age-related cardiovascular disease (CVD) risk factors is high among individuals living in low- and middle-income countries. We described receipt of healthcare services for and management of hypertension and diabetes among individuals living with these conditions using individual-level data from 55 nationally representative population-based surveys (2009-2019) with measured blood pressure (BP) and diabetes biomarker. We restricted our analysis to non-pregnant individuals aged 40-69 years and defined three mutually exclusive groups (i...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536785/work-disability-and-employment-status-among-advanced-chronic-kidney-disease-patients
#10
JOURNAL ARTICLE
Shing Shen Bay, Lydia Kamaruzaman, Rozita Mohd, Shamsul Azhar Shah
INTRODUCTION: Chronic kidney disease (CKD) is a major public health issue with significant socioeconomic impacts. In Malaysia, the prevalence of CKD in 2018 was 15%. Complications of CKD such as anaemia, mineral bone disease, and infections led to frequent hospitalizations resulting in work disability and unemployment. To date, there is no data of employment status of CKD patients in Malaysia. METHODS: A cross-sectional study of patients with advanced CKD (stage 4 and 5 non-dialysis) treated in our centre...
2024: PloS One
https://read.qxmd.com/read/38536781/comparison-of-metabolic-risk-factors-lipid-indices-healthy-eating-index-and-physical-activity-among-premenopausal-menopausal-and-postmenopausal-women
#11
JOURNAL ARTICLE
Leila Moradi, Sayed Jalal Hashemi, Ferdos Zaman, Meysam Alipour, Zahra Farhangiyan, Maryam Sharifzadeh
INTRODUCTION: In this study, we aimed to compare metabolic risk factors, lipid indices, healthy eating index, and physical activity among premenopausal, menopausal, and postmenopausal women. METHODS: In this cross-sectional study, a total of 4,732 women participating in the Hoveyzeh Cohort Study were placed into three groups of premenopausal (n=736), menopausal (n=396), and postmenopausal (n=917) women, according to the inclusion and exclusion criteria . RESULTS: The prevalence of metabolic syndrome was 43...
March 27, 2024: Romanian Journal of Internal Medicine
https://read.qxmd.com/read/38536779/risk-factors-for-catheter-associated-bloodstream-infection-in-hemodialysis-patients-a-meta-analysis
#12
JOURNAL ARTICLE
Huajie Guo, Ling Zhang, Hua He, Lili Wang
OBJECTIVE: This meta-analysis aimed to elucidate the risk factors contributing to catheter-associated bloodstream infection in hemodialysis patients. METHODS: Comprehensive literature searches were conducted in both English and Chinese databases, which encompassed PubMed, Cochrane Library, Embase, CNKI, Wanfang Data, VIP Database and China Biomedical Literature Database. The search timeframe extended from each database's inception to March 8, 2023. Two independent researchers executed literature screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale...
2024: PloS One
https://read.qxmd.com/read/38536685/mcd-lightgbm-system-for-intelligent-analyzing-heterogeneous-clinical-drug-therapeutic-effects
#13
JOURNAL ARTICLE
Xiao-Hui Yang, Hao-Jie Liao, Pei- Yu Sun, Jing Ma, Bing Wang, Yan He, Liu-Gen Xue, Li-Min Su, Bin-Jie Wang
Causal effect estimation of individual heterogeneity is a core issue in the field of causal inference, and its application in medicine poses an active and challenging problem. In high-risk decision-making domain such as healthcare, inappropriate treatments can have serious negative impacts on patients. Recently, machine learning-based methods have been proposed to improve the accuracy of causal effect estimation results. However, many of these methods concentrate on estimating causal effects of continuous outcome variables under binary intervention conditions, and give less consideration to multivariate intervention conditions or discrete outcome variables, thus limiting their scope of application...
March 27, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38536671/evaluating-a-promising-methylcellulose-hydrogel-for-enhanced-diabetic-foot-ulcer-therapy-through-comprehensive-preclinical-studies
#14
JOURNAL ARTICLE
Priya Patel, Sanika Dongre, Alkesh Patel, Gayatri Patel
The present research focuses on formulating and evaluating hydrogels modified with crosslinking agents using methylcellulose to treat diabetic foot ulcers (DFU). Methylcellulose hydrogels are prepared and characterized for their crosslinking capacity through FTIR and degradation studies. The optimized hydrogel is further assessed for viscosity, gel strength, contact angle, in-vitro biodegradation, water-vapor transmission rate, anti-bacterial activity, and in-vivo efficacy. The results demonstrate that the developed hydrogel exhibits promising properties for DFU treatment, including increased wound healing percentage, improved ulcer morphology, reduced levels of proinflammatory cytokines, and enhanced tissue characteristics...
March 27, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38536666/non-cancerous-complications-in-htlv-1-carriers
#15
REVIEW
Akihiro Ohmoto, Shigeo Fuji
INTRODUCTION: Human T-cell leukemia virus type 1 (HTLV-1) carriers may develop adult T-cell leukemia (ATL), or HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The evidence is limited regarding other diseases potentially associated with HTLV-1, such as HTLV-1-associated autoimmune diseases. AREA COVERED: We summarized the available information on complications associated with HTLV-1 infection. EXPERT OPINION: Previous studies showed that HTLV-1 carriers have an increased incidence of collagen diseases including Sjögren's syndrome, as well as dysthyroidism, diabetes mellitus, and atherosclerosis...
March 27, 2024: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/38536658/development-of-diagnostic-algorithm-for-cushing-s-syndrome-a-tertiary-centre-experience
#16
JOURNAL ARTICLE
A Efthymiadis, H Loo, B Shine, T James, B Keevil, J W Tomlinson, A Pal, R Pofi
PURPOSE: No consensus exists as the gold standard for Cushing's Syndrome (CS) screening. This study aimed to evaluate the diagnostic accuracy and utility of late-night salivary cortisol (LNSC) and cortisone (LNSE), overnight dexamethasone suppression test (ODST), and urinary free cortisol (UFC) in developing a screening algorithm for CS. METHODS: A retrospective, single-centre analysis on 93 adult patients referred to the Oxford Centre for Diabetes, Endocrinology, and Metabolism for CS evaluation (2017-2022)...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536657/increased-risk-of-erythrocytosis-in-men-with-type-2-diabetes-treated-with-combined-sodium-glucose-cotransporter-2-inhibitor-and-testosterone-replacement-therapy
#17
JOURNAL ARTICLE
A R Gosmanov, D E Gemoets, K A Schumacher
PURPOSE: In clinical trials, sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and testosterone replacement therapy (TRT) were shown to stimulate red blood cell production. Little is known if combination therapy poses risk of erythrocytosis in real world clinical practice. METHODS: This was a retrospective nationwide cohort study of US Veterans with type 2 diabetes (T2D) and baseline hematocrit between 38 and 50% who were prescribed SGLT-2i and/or TRT between 3/2013 and 10/2022 and had adequate adherence based on the proportion of days covered > 80%...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536641/gut-microbiota-dynamics-in-kk-ay-mice-restoration-following-antibiotic-treatment
#18
JOURNAL ARTICLE
Jinni Hong, Tingting Fu, Weizhen Liu, Miao Yu, Yanshan Lin, Cunyun Min, Datao Lin
The primary aim of this study was to investigate the alterations in the microbial community of KK-Ay mice following antibiotic treatment. A comparative analysis of the gut microbiota was conducted between KK-Ay mice treated with antibiotics and those without treatment. The microbial community dynamics in antibiotic-treated KK-Ay mice were meticulously assessed over an eight-week period using 16S rDNA sequencing analysis. Simultaneously, dynamic renal function measurements were performed. The results demonstrated a marked decrease in bacterial DNA abundance following antibiotic intervention, coupled with a substantial reduction in bacterial diversity and a profound alteration in microbial composition...
March 27, 2024: Folia Microbiologica
https://read.qxmd.com/read/38536629/association-of-premorbid-glp-1ra-and-sglt-2i-prescription-alone-and-in-combination-with-covid-19-severity
#19
JOURNAL ARTICLE
Klara R Klein, Trine J Abrahamsen, Anna R Kahkoska, G Caleb Alexander, Christopher G Chute, Melissa Haendel, Stephanie S Hong, Hemalkumar Mehta, Richard Moffitt, Til Stürmer, Kajsa Kvist, John B Buse
INTRODUCTION: People with type 2 diabetes are at heightened risk for severe outcomes related to COVID-19 infection, including hospitalization, intensive care unit admission, and mortality. This study was designed to examine the impact of premorbid use of glucagon-like peptide-1 receptor agonist (GLP-1RA) monotherapy, sodium-glucose cotransporter-2 inhibitor (SGLT-2i) monotherapy, and concomitant GLP1-RA/SGLT-2i therapy on the severity of outcomes in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
March 27, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38536617/whole-transcriptome-mapping-reveals-the-lncrna-regulatory-network-of-tfp5-treatment-in-diabetic-nephropathy
#20
JOURNAL ARTICLE
Hongyan Luo, Lirong Yang, Guoqing Zhang, Xi Bao, Danna Ma, Bo Li, Li Cao, Shilu Cao, Shunyao Liu, Li Bao, Jing E, Yali Zheng
BACKGROUND: TFP5 is a Cdk5 inhibitor peptide, which could restore insulin production. However, the role of TFP5 in diabetic nephropathy (DN) is still unclear. OBJECTIVE: This study aims to characterize the transcriptome profiles of mRNA and lncRNA in TFP5-treated DN mice to mine key lncRNAs associated with TFP5 efficacy. METHODS: We evaluated the role of TFP5 in DN pathology and performed RNA sequencing in C57BL/6J control mice, C57BL/6J db/db model mice, and TFP5 treatment C57BL/6J db/db model mice...
March 27, 2024: Genes & Genomics
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