Juan E Tichauer, Gabriel Arellano, Eric Acuña, Luis F González, Nirmal R Kannaiyan, Paola Murgas, Concepción Panadero-Medianero, Jorge Ibañez-Vega, Paula I Burgos, Eileah Loda, Stephen D Miller, Moritz J Rossner, Peter J Gebicke-Haerter, Rodrigo Naves
Compelling evidence has shown that interferon (IFN)-γ has dual effects in multiple sclerosis and in its animal model of experimental autoimmune encephalomyelitis (EAE), with results supporting both a pathogenic and beneficial function. However, the mechanisms whereby IFN-γ may promote neuroprotection in EAE and its effects on central nervous system (CNS)-resident cells have remained an enigma for more than 30 years. In this study, the impact of IFN-γ at the peak of EAE, its effects on CNS infiltrating myeloid cells (MC) and microglia (MG), and the underlying cellular and molecular mechanisms were investigated...
2023: Frontiers in Immunology