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JOURNAL ARTICLE
Linlin Yan, Han Liu, Yuhui Wang, Lulu Zhang, Chao Ma, A M Abd El-Aty
Natural terpenoid carriers, such as oleanolic acid (OA), can enhance the water solubility and stability of hydrophobic compounds such as curcumin (Cur). However, improving the colloidal stability of nanoparticle emulsions and resolving the redispersion problem of freeze-dried nanoparticle powders remain significant challenges. In this study, we fabricated coassembled oleanolic acid-curcumin nanoparticles (OA/Cur NPs) and applied a polysaccharide surface coating method to improve their colloidal stability and water solubility...
April 25, 2024: Food Chemistry
#42
REVIEW
Kevin Bielamowicz, Peter Dimitrion, Oussama Abla, Simon Bomken, Patrick Campbell, Matthew Collin, Barbara Degar, Eli L Diamond, Olive S Eckstein, Nader El-Mallawany, Mark Fluchel, Gaurav Goyal, Michael M Henry, Michelle Hermiston, Michael Hogarty, Michael Jeng, Rima Jubran, Joseph Lubega, Ashish Kumar, Stephan Ladisch, Kenneth L McClain, Miriam Merad, Qing-Sheng Mi, D Williams Parsons, Erin Peckham-Gregory, Jennifer Picarsic, Zachary D Prudowsky, Barrett J Rollins, Peter H Shaw, Birte Wistinghausen, Carlos Rodriguez-Galindo, Carl E Allen
Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by lesions with CD1a-positive/Langerin (CD207)-positive histiocytes and inflammatory infiltrate that can cause local tissue damage and systemic inflammation. Clinical presentations range from single lesions with minimal impact to life-threatening disseminated disease. Therapy for systemic LCH has been established through serial trials empirically testing different chemotherapy agents and durations of therapy. However, fewer than 50% of patients who have disseminated disease are cured with the current standard-of-care vinblastine/prednisone/(mercaptopurine), and treatment failure is associated with long-term morbidity, including the risk of LCH-associated neurodegeneration...
April 30, 2024: Cancer
#43
JOURNAL ARTICLE
Răzvan Alexandru Radu, Vincent Costalat, Michele Romoli, Basel Musmar, James E Siegler, Sherief Ghozy, Jane Khalife, Hamza Salim, Hamza Shaikh, Nimer Adeeb, Hugo H Cuellar-Saenz, Ajith J Thomas, Ramanathan Kadirvel, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Robert W Regenhardt, Joshua D Bernstock, Aman B Patel, James D Rabinov, Christopher J Stapleton, Nicole M Cancelliere, Thomas R Marotta, Vitor Mendes Pereira, Kareem El Naamani, Abdelaziz Amllay, Stavropoula I Tjoumakaris, Pascal Jabbour, Lukas Meyer, Jens Fiehler, Tobias D Faizy, Helena Guerreiro, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Charbel Mounayer, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Takahiro Ota, Shogo Dofuku, Leonard L L Yeo, Benjamin Yq Tan, Anil Gopinathan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Lina M Chervak, Achala Vagal, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, Andrea M Alexandre, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Ymd, Jessica Jesser, Charlotte Weyland, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Cheng-Yang Hsieh, David S Liebeskind, Illario Tancredi, Robert Fahed, Boris Lubicz, Muhammed Amir Essibayi, Amanda Baker, David Altschul, Luca Scarcia, Erwah Kalsoum, Adam A Dmytriw, Adrien Guenego
BACKGROUND: Optimal anesthetic strategy for the endovascular treatment of stroke is still under debate. Despite scarce data concerning anesthetic management for medium and distal vessel occlusions (MeVOs) some centers empirically support a general anesthesia (GA) strategy in these patients. METHODS: We conducted an international retrospective study of MeVO cases. A propensity score matching algorithm was used to mitigate potential differences across patients undergoing GA and conscious sedation (CS)...
April 30, 2024: Clinical Neuroradiology
#44
JOURNAL ARTICLE
Alexandria P Eiken, Audrey L Smith, Sydney A Skupa, Elizabeth Schmitz, Sandeep Rana, Sarbjit Singh, Siddhartha Kumar, Jayapal Reddy Mallareddy, Aguirre A de Cubas, Akshay Krishna, Achyuth Kalluchi, M Jordan Rowley, Christopher R D'Angelo, Matthew A Lunning, R Gregory Bociek, Julie M Vose, Amarnath Natarajan, Dalia El-Gamal
Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within the tumor microenvironment (TME) driving activation of NF-κB signaling and the unfolded protein response (UPR). Malignant cells have higher basal levels of UPR posing a unique therapeutic window to combat CLL cell growth using pharmacological agents that induce accumulation of misfolded proteins. Frontline CLL therapeutics that directly target BCR signaling such as Bruton-tyrosine kinase (BTK) inhibitors (e...
April 30, 2024: Cancer Res Commun
#45
JOURNAL ARTICLE
Yiyou Gu, Teclegiorgis Gebremariam, Sondus Alkhazraji, Eman Youssef, Sabrina El-Gamal, Theresa Matkovits, Jenel Cobb, Raphael Mannino, Ashraf S Ibrahim
Invasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an orally administered lipid nanocrystal formulation of amphotericin B, which has been shown to be safe and effective against other fungal infections. We sought to compare the efficacy of MAT2203 to liposomal amphotericin B (LAMB) treatment in a neutropenic mouse model of IM due to Rhizopus arrhizus var. delemar or Mucor circinelloides f. jenssenii DI15-131. In R. arrhizus var. delemar -infected mice, 15 mg/kg of MAT2203 qd was as effective as 10 mg/kg of LAMB in prolonging median survival time vs placebo (13...
April 30, 2024: Antimicrobial Agents and Chemotherapy
#46
JOURNAL ARTICLE
Tatu Juvonen, Igor Vendramin, Giovanni Mariscalco, Mikko Jormalainen, Andrea Perrotti, Amélie Hervé, Enzo Mazzaro, Giuseppe Gatti, Matteo Pettinari, Sven Peterss, Joscha Buech, Francesco Nappi, Angel G Pinto, Javier Rodriguez Lega, Marek Pol, Jan Rocek, Petr Kacer, Andreas Rukosujew, Konrad Wisniewski, Daniela Piani, Till Demal, Lenard Conradi, Luisa Ferrante, Mauro Rinaldi, Eduard Quintana, Robert Pruna-Guillen, Sebastien Gerelli, Dario Di Perna, Antonio Fiore, Thierry Folliguet, Metesh Acharya, Zein El-Dean, Mark Field, Manoj Kuduvalli, Francesco Onorati, Alessandra Francica, Timo Mäkikallio, Angelo M Dell'Aquila, Caius Mustonen, Peter Raivio, Stefano Rosato, Fausto Biancari
BACKGROUND: The benefits and harms associated with femoral artery cannulation over other sites of arterial cannulation for surgical repair of acute Stanford type A aortic dissection (TAAD) are not conclusively established. METHODS: We evaluated the outcomes after surgery for TAAD using femoral artery cannulation, supra-aortic arterial cannulation (i.e., innominate/subclavian/axillary artery cannulation), and direct aortic cannulation. RESULTS: 3751 (96...
April 30, 2024: World Journal of Surgery
#47
JOURNAL ARTICLE
Menha Swellam, Mohamed K Khalifa, Amira M Nageeb, Lobna Ezz El-Arab, Manal El-Mahdy, Khaled El-Bahy, Magda Sayed Mahmoud
OBJECTIVES: Gliobalstoma is the most common primary brain tumor in adults with an extensive genetic and transcriptional heterogeneity, still identification of the role of DNA methylation, as one of epigenetic alterations, is emerged. Authors aimed to study the clinical role of N-myc downstream-regulated gene 2 (NDRG2) -based methylation among GBM patients versus benign neurological diseases (BND), investigate its prognostic role and its relation with survival outcomes. METHODS: A total of 78 FFPE specimens were recruited as follows: GBM ( n = 58) and BND ( n = 20) then analyzed for NDRG2 methylation using Methyl II quantitative PCR system...
2024: International Journal of Immunopathology and Pharmacology
#48
JOURNAL ARTICLE
Xiaoluo Peng, Peng Zou, Jiajie Zeng, Xing Wu, Dian Xie, Yan Fu, Dezhi Yang, Dongge Ma, Ben Zhong Tang, Zujin Zhao
Purely organic molecules with room-temperature phosphorescence (RTP) are potential luminescent materials with high exciton utilization for organic light-emitting diodes (OLEDs), but those exhibiting superb electroluminescence (EL) performances are rarely explored, mainly due to their long phosphorescence lifetimes. Herein, a robust purely organic RTP molecule, 3,6-bis(5-phenylindolo[3,2-a]carbazol-12(5H)-yl)-xanthen-9-one (3,2-PIC-XT), is developed. The neat film of 3,2-PIC-XT shows strong green RTP with a very short lifetime (2...
April 30, 2024: Angewandte Chemie
#49
JOURNAL ARTICLE
Mohammad Alomari, Magdy M El-Sayed Ahmed, Mostafa Ali, Ishaq J Wadiwala, Si M Pham, Basar Sareyyupoglu
Quadricuspid aortic valve is a rare congenital cardiac anomaly with an incidence of 0.008% to 0.043%. Its clinical course varies depending on cusp anatomy, function, and associated cardiac malformations. It frequently progresses to aortic valve regurgitation that may require surgical valve replacement. Detection has shifted from incidental discovery during autopsies or cardiac surgeries in the early 20th century to various cardiac imaging methods in recent decades. In addition to contributing to the literature, this report supports the use of transesophageal echocardiography more liberally to detect aortic valve abnormalities...
April 30, 2024: Texas Heart Institute Journal
#50
JOURNAL ARTICLE
Ahmad S Kodous, Mostafa A Abdel-Maksoud, Mohamed A El-Tayeb, Diana A Al-Sherif, Suzan Shawky Abuelkasem Mohamed, Mohamed Mohamady Ghobashy, Ayat M Emad, Shady M Abd El-Halim, Soheir A A Hagras, Samson Mani, Arunagiri Kuha Deva Magendhra Rao, Ahmed M Hussein, Helen N Saada
INTRODUCTION: Skin injuries represent a prevalent form of physical trauma, necessitating effective therapeutic strategies to expedite the wound healing process. Hesperidin, a bioflavonoid naturally occurring in citrus fruits, exhibits a range of pharmacological attributes, including antimicrobial, antioxidant, anti-inflammatory, anticoagulant, and analgesic properties. The main objective of the study was to formulate a hydrogel with the intention of addressing skin conditions, particularly wound healing...
2024: Frontiers in Immunology
#51
REVIEW
Shouki Bazarbashi, Heba Mohamed El Zawahry, Tarek Owaidah, Mohammad A AlBader, Ashraf Warsi, Mahmoud Marashi, Emad Dawoud, Hassan Jaafar, Sherif M Sholkamy, Fady Haddad, Alexander T Cohen
Venous thromboembolism is a leading cause of morbidity and mortality in patients with active cancer who require anticoagulation treatment. Choice of anticoagulant is based on careful balancing of the risks and benefits of available classes of treatment: vitamin K antagonists, low-molecular-weight heparin (LMWH), and direct oral anticoagulants (DOACs). Results from randomized controlled trials have shown the consistent efficacy of DOACs versus LMWH in the treatment of cancer-associated venous thromboembolism (VTE)...
2024: Journal of Blood Medicine
#52
JOURNAL ARTICLE
Bahija Rebbah, Abderrahim El Haib, Sara Lahmady, Issam Forsal, Maryse Gouygou, Sonia Mallet-Ladeira, Abdelouahid Medaghri-Alaoui, El Mostapha Rakib, Abdellah Hannioui
Semi-synthetic modifications of natural products have yielded numerous anti-cancer drugs, antimicrobials, and corrosion inhibitors. In this study, eugenol, a natural product, was synthetically modified to generate a novel heterocyclic compound: pyrrole, which forms crystals. The latter is the outcome of the condensation reaction between eugenol hydrazide and 2,5-hexanedione, conducted under reflux ethanol conditions, without a catalyst, achieving a 96% yield. This compound structure was characterized through spectroscopic methods, such as NMR and FTIR, and validated par the crystal's X-ray diffraction analysis...
April 25, 2024: RSC Advances
#53
COMPARATIVE STUDY
Hossam El Din H Abdelhafez, Amr A Abdallah, Reda K Abdel-Razik, Nadia A Hamed, Ahmed Elshatory, Walaa Awad, Abdel Azeim A Khalaf, Aya M Mekkawy
Abamectin (AB) is widely used in agriculture and has been employed as an insecticide, nematicide, and livestock pest control agent. However, it may also pose a serious threat to mammals. The primary purpose of this research was to compare the sex variations between male and female rats during exposure and to assess the risk of toxicity of abamectin, which are still largely unknown. The twenty albino rats were divided randomly into four groups (n = 5): 1) the male control group; 2) the male treatment group treated with AB (1 mg/kg B...
May 2024: Pesticide Biochemistry and Physiology
#54
JOURNAL ARTICLE
Ali D Abousoliman, Ateya Megahed Ibrahim, Hasan Abualruz, Hussein M Magdi, Donia Elsaid Fathi Zaghamir, Ahmed Alhowimel, Ahmed Hashem El-Monshed, Heba E El-Gazar, Mohamed A Zoromba
BACKGROUND: Climate change poses a worldwide challenge with anticipated exacerbation in the future, resulting in irreversible consequences. Nursing students may be vulnerable to experiencing psychological effects associated with climate change. AIM: The current study aimed to investigate the relationship between nursing students' knowledge and attitudes toward climate change and their psychological distress. METHOD: This descriptive cross-sectional study recruited 377 nursing students from three universities located in Saudi Arabia, Jordan, and Egypt in the Middle East...
April 29, 2024: BMC Nursing
#55
Adel I Alalawy, Mohamed Sakran, Fahad M Alzuaibr, Maeidh A Alotaibi, Mohamed E El-Hefnawy, Abdulelah Y Hazazi, Saad M El-Gendy, Esraa A Aidy, Heba Effat, Doha F Ismail, Mohamed Hessien
No abstract text is available yet for this article.
April 29, 2024: Scientific Reports
#56
JOURNAL ARTICLE
Jeffrey V Lazarus, Trenton M White, Katarzyna Wyka, Scott C Ratzan, Kenneth Rabin, Heidi J Larson, Federico Martinon-Torres, Ernest Kuchar, Salim S Abdool Karim, Tamara Giles-Vernick, Selina Müller, Carolina Batista, Nellie Myburgh, Beate Kampmann, Ayman El-Mohandes
It is unclear how great a challenge pandemic and vaccine fatigue present to public health. We assessed perspectives on coronavirus disease 2019 (COVID-19) and routine immunization as well as trust in pandemic information sources and future pandemic preparedness in a survey of 23,000 adults in 23 countries in October 2023. The participants reported a lower intent to get a COVID-19 booster vaccine in 2023 (71.6%), compared with 2022 (87.9%). A total of 60.8% expressed being more willing to get vaccinated for diseases other than COVID-19 as a result of their experience during the pandemic, while 23...
April 29, 2024: Nature Medicine
#57
Aksharkumar Dobariya, Tarek Y El Ahmadieh, Levi B Good, Ana G Hernandez-Reynoso, Vikram Jakkamsetti, Ronnie Brown, Misha Dunbar, Kan Ding, Jesus Luna, Raja Reddy Kallem, William C Putnam, John M Shelton, Bret M Evers, Amirhossein Azami, Negar Geramifard, Stuart F Cogan, Bruce Mickey, Juan M Pascual
No abstract text is available yet for this article.
April 29, 2024: Scientific Reports
#58
JOURNAL ARTICLE
Mohamed Tharwat Elabbasy, M A El-Morsy, Nasser S Awwad, Hala A Ibrahium, A A Menazea
Our study focused on the optical behavior, methylene blue (MB) dye degradation potential, antibacterial performance, and silver and trioxide mineral interaction with different bacterial species. We found that the addition of silver nanoparticles (Ag NPs) to neodymium oxide (Nd2 O3 ) resulted in a significant response, with an enlargement of the inhibition zone for bacterial species such as Staphylococcus aureus and Escherichia coli. Specifically, the inhibition zone for S. aureus increased from 9.3 ± 0...
April 30, 2024: Scientific Reports
#59
JOURNAL ARTICLE
A B Abdel-Aziz, F El-Taib Heakal, R M El Nashar, I M Ghayad
Dimensionally stable anodes of titanium (Ti) metal coated with mixed metal oxides (MMO) are widely used in several electrochemical applications, especially chloro-alkali electrolysis. Herein, we deposited MMO coatings on Ti substrates in different compositions, namely, (60%RuO2 -40%TiO2 ), (60%RuO2 -30%TiO2 -10%IrO2 ), and (60%RuO2 -20%TiO2 -15%IrO2 -5%Ta2 O5 ), where RuO2 has the same percentage ratio in all coatings. The aim was to use these electrodes for chlorine evolution reaction (CER) and oxygen evolution reaction (OER) applications...
April 29, 2024: Scientific Reports
#60
JOURNAL ARTICLE
Ashraf H F Abd El-Wahab, Rita M Borik, Al-Anood M Al-Dies, Ahmed M Fouda, Hany M Mohamed, Raafat A El-Eisawy, Mohamed H Sharaf, Abdullah Y A Alzahrani, Ahmed A Elhenawy, Ahmed M El-Agrody
The process of creating a series of 3-amino-1-aryl-8-methoxy-1H-benzo[f]chromene-2-carbonitriles (4a-q) involved reacting 6-methoxynaphthalen-2-ol (1), the appropriate aromatic aldehydes (2a-q), and malononitrile (3) in an absolute ethanol/piperidine solution under Ultrasonic irradiation. However, the attempt to create 3-amino-1-aryl-1H-benzo[f]chromene-2,8-dicarbonitrile (6a, d, e) was unsuccessful when 6-cyanonaphthalen-2-ol (5) was stirred at room temperature, reflux, Microwave irradiation, or Ultrasonic irradiation...
April 29, 2024: Scientific Reports
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