Shuyi Li, Qian Yuan, Minghui Yang, Xinyi Long, Jianwu Sun, Xin Yuan, Lang Liu, Wanting Zhang, Quanjiang Li, Zhujie Deng, Rui Tian, Renhao Xu, Lingna Xie, Jingna Yuan, Yue He, Yi Liu, Hongmei Liu, Zhengqiang Yuan
OBJECTIVE: Osteoarthritis (OA) is characterized by progressive cartilage degeneration and absence of curative therapies. Therefore, more efficient therapies are compellingly needed. Both mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) and Icariin (ICA) are promising for repair of cartilage defect. This study proposes that ICA may be combined to potentiate the cartilage repair capacity of MSC-EVs. MATERIALS AND METHODS: MSC-EVs were isolated from sodium alginate (SA) and hyaluronic acid (HA) composite hydrogel (SA-HA) cell spheroid culture...
November 23, 2023: Nanomedicine: Nanotechnology, Biology, and Medicine