Ana Canadas Sousa, Joana C Santos, Clara Landolt, Catarina Gomes, Patrícia Dias-Pereira, Cláudia S Baptista
BACKGROUND: The aetiology of pulmonary alveolar microlithiasis (PAM) in animals is still unknown. In humans, this pulmonary disorder is a rare autosomal recessive disorder triggered by a mutation in the gene SLC34A2, which causes deposition and aggregation of calcium and phosphate in the pulmonary parenchyma with formation of microliths. Although histopathological examination is required for a definite diagnosis, in humans, imaging modalities such as computed tomography can demonstrate typical patterns of the disease...
October 7, 2020: BMC Veterinary Research
Kiyomichi Mizuno, Mitsuhiro Isaka, Mototsugu Ono, Takamitsu Hayakawa, Yukihiro Terada, Yoshiyuki Yasuura, Hiroyuki Kayata, Hayato Konno, Hideaki Kojima, Tetsuya Mizuno, Takanori Kawabata, Yasuhisa Ohde
BACKGROUND: Positive pre-resection pleural lavage cytology (PLC+) is a poor prognostic factor of non-small cell lung cancer (NSCLC). We evaluated the prognosis of PLC+ for the different pathological stages (p-stage) of NSCLC. METHODS: Retrospective analysis of all staged 1293 patients who underwent curative resection for NSCLC to evaluate the impact of PLC+ on survival, specifically in p-stage I NSCLC patients. The survival rate between patients with and without PLC+ was compared using the Kaplan-Meier method with the log-rank test for comparison...
September 22, 2020: Annals of Thoracic Surgery
Muhammad Ali Niaz, Talal Almas, Leo Phelan, Maryam Ehtesham, David G Healy
 Empyema thoracis is a pleural space pathology that indicates accumulation of purulent material in the pleural space. It is often associated with an underlying infectious process, such as pneumonia, but can also be a ramification of a more sinister etiology, such as lung carcinoma, often warranting lung decortication surgery for prompt resolution. Although radiological imaging is used to form a preliminary diagnosis, its true predictive value remains questionable, and intraoperative microbiological, cytological, and histopathological samples are thus instrumental in yielding helpful diagnostic information...
June 26, 2020: Curēus
Alejandro Bejarano, Diego F Bautista, Luz F Sua, Bladimir Pérez, Juliana Lores, Marisol Aguirre, Liliana Fernández-Trujillo
RATIONALE: Polydimethylsiloxane, commonly referred as silicone, is an inert liquid compound used in esthetic procedures due to its durability and thermal stability, yet the application of non-pure silicone generates risks. One of the complications is systemic embolism syndrome which is presents with fever, hypoxemia, and progression to respiratory failure, diffuse alveolar damage and alveolar hemorrhage, as well as neurological alterations in one-third of the cases. Management is strictly supportive...
June 12, 2020: Medicine (Baltimore)
Ryoko Shibata, Tomomi Ozaki, Kazuhiro Tada, Takashi Aoyama, Maho Watanabe, Naoko Himuro, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Katsuhisa Miyake, Kosuke Masutani, Noriko Uesugi, Kazuki Nabeshima, Hitoshi Nakashima
Here, we present a 67-year-old Japanese man who developed insidious-onset nephrotic syndrome. He had a history of occupational asbestos exposure for about 8 years during his 30s, and was found to have pleural effusion 3 years before his present illness. At that time, repeated cytology testing of his pleural effusion found no malignant cells, and pleural biopsy found fibrous pleuritis without evidence of malignant mesothelioma. Percutaneous kidney biopsy found massive deposits of AA-type amyloid in the glomeruli, small arteries, and medulla...
June 13, 2020: CEN Case Reports
Thiyaphat Laohawetwanit, Kei Tanaka, Yoshiaki Zaizen, Kazuhiro Tabata, Kouji Ando, Hiroshi Ishimoto, Hiroshi Mukae, Yasushi Miyazaki, Andrey Bychkov, Junya Fukuoka
Amyloidosis is a rare condition in which tissue deposits of inert fibrillar protein result in organ damage and dysfunction. There are several types of amyloid fibrils. Some of the most common forms are AL (amyloid light chain) protein and AA (amyloid-associated) type of amyloid fibril protein. Pulmonary amyloidosis is relatively common but is usually asymptomatic. Thus, the diagnosis may be easily overlooked. A 78-year-old male with a history of multiple myeloma followed by systemic amyloidosis presented with abnormal chest CT showing diffuse interlobular thickening in the whole lung field with bilateral pleural effusion...
2020: Respiratory Medicine Case Reports
Kazuhiro Ueda, Junichi Murakami, Toshiki Tanaka, Tamami Nakamura, Sota Yoshimine, Kimikazu Hamano
BACKGROUND: Previous reports suggest that lung cancer arising in the lower lobe is associated with a poorer prognosis than upper lobe disease. However, the reason remains controversial. We evaluated the relationship among the affected lobe, postoperative infectious complications, and cancer recurrence in patients who underwent lobectomy for clinical stage I lung cancer. METHODS: We retrospectively reviewed 422 cases of resected lung cancer. We recorded the postoperative complications that developed within 30 days after surgery...
February 10, 2020: Annals of Thoracic Surgery
Mayra A Medina, Allison M Onken, Constance de Margerie-Mellon, Benedikt H Heidinger, Yigu Chen, Alexander A Bankier, Paul A VanderLaan
BACKGROUND: Tumor spread through air spaces (STAS), a significant prognostic indicator, has been described recently as a pattern of invasion in pulmonary carcinomas. However, questions remain regarding preoperative identification of STAS and whether it represents an in vivo phenomenon versus an ex vivo artifact. METHODS: We retrospectively reviewed 67 paired preoperative bronchoalveolar lavage (BAL) or bronchial washing (BW) cytology specimens with the subsequent lung adenocarcinoma surgical resection specimen to determine whether preoperative cytology could predict STAS...
February 3, 2020: Cancer Cytopathology
Jana Fassunke, Markus Ball, Marianne Engels
For lung carcinomas with certain molecular genetic alterations of the ALK, BRAF or EGFR gene, there are targeted therapies that are also approved as first-line therapy. Often, only limited sample material from biopsies is available for molecular pathological testing. In some cases, biopsies with standard and immunohistochemical staining have no or too low tumor content to be used for PCR-based examinations or fluorescence in situ hybridization (FISH) analyses. In such cases, cytological preparations such as bronchus brush smears, transbronchial needle aspiration (TBNA), bronchial lavage, puncture smears from lymph node or peripheral metastases, pleural effusion, ascites, and pericardial effusion can be used...
January 13, 2020: Der Pathologe
John G Edwards, Kari Chansky, Paul van Schil, Andrew G Nicholson, Souheil Boubia, Elisabeth Brambilla, Jessica Donnington, Françoise Galateau-Sallé, Hans Hoffman, Maurizio Infante, Mirella Marino, Edith Marom, Jun Nakajima, Marcin Ostrowski, William D Travis, Ming S Tsao, Yasushi Yatabe, Dorothy J Giroux, Lynn Shemanski, John Crowley, Marc Krasnik, Hisao Asamura, Ramón Rami-Porta
INTRODUCTION: To validate the prognostic relevance in NSCLC of potential residual tumor (R) descriptors, including the proposed International Association for the Study of Lung Cancer definition for uncertain resection -R(un). METHODS: 14,712 patients undergoing resection with full R status and survival were analyzed. The following were also evaluated: <3 N2 stations explored; lobe-specific nodal dissection (LSND); extra-capsular extension (ECE); highest lymph node station status; carcinoma in situ at bronchial resection margin (BRMcis); pleural lavage cytology (PLC)...
November 12, 2019: Journal of Thoracic Oncology
Le Yu Khine, Dong Won Kim, Omolola Olajide, Chelsey White, Yousef Shweihat, Henry Driscoll
Methimazole is a thionamide drug that inhibits the synthesis of thyroid hormones by blocking the oxidation of iodine in the thyroid gland. We report a case of methimazole-induced recurrent pleural effusion. A 67-year-old female with recently diagnosed Graves' disease on methimazole 20mg daily was admitted with dyspnea and new onset atrial fibrillation with rapid ventricular rate. Chest X-ray revealed a unilateral right pleural effusion, which was consistent with a transudate on thoracocentesis. She was managed as a case of congestive heart failure and methimazole dose was increased to 30 mg daily...
2019: Case Reports in Endocrinology
Ken Onodera, Akira Sakurada, Fumihiko Hoshi, Jiro Abe, Tohru Hasumi, Satomi Takahashi, Yasuki Saito, Yoshinori Okada
OBJECTIVE: The significance of clinicopathological features of pre- and post-resection pleural lavage cytology (PLC) for non-small cell lung carcinoma (NSCLC) currently remains unknown. METHODS: Between January 2010 and December 2012, pre- and post-resection PLC were performed for NSCLC in 565 patients at Tohoku University, Miyagi Cancer Center, or Sendai Medical Center. The relationship between the clinicopathological features and patient outcomes was analyzed...
February 2020: General Thoracic and Cardiovascular Surgery
Lei Yan, Prih Rohra, Lin Cheng, Paolo Gattuso
OBJECTIVE: Pleural effusion secondary to blastomycosis infection is an uncommon clinical manifestation of the disease. We undertook a retrospective study to assess the incidence and involvement of pleural effusion in patients with blastomycosis infection. STUDY DESIGN: Institutional cytology and surgical pathology records were searched from December 1995 to October 2017 for cases of blastomycosis. The cytologic, surgical pathology, and clinical pertinent information was reviewed in detail...
July 2, 2019: Acta Cytologica
Jasna Metovic, Luisella Righi, Luisa Delsedime, Marco Volante, Mauro Papotti
Pulmonary cytology is a challenging diagnostic tool, and it is usually evaluated considering medical history and radiological findings in order to reach an accurate diagnosis. Since the majority of lung cancer patients have an advanced stage at diagnosis, a cytological specimen is frequently the only material available for diagnosis and further prognostic/predictive marker determination. Several types of specimens can be obtained from the respiratory system (including sputum, bronchoalveolar lavage, bronchial brushing, fine needle aspiration, and pleural fluid) with different technical preclinical management protocols and different diagnostic yields...
March 15, 2019: Acta Cytologica
Supriya Ghildiyal, Seema Acharya, Brijesh Thakur, Jagdish Rawat, Rajnish Kumar
Background: Cytological evaluation of specimens from respiratory tract is the initial investigation in patients suspected to have pulmonary diseases. The various cytological specimens submitted for analysis include bronchoalveolar lavage, bronchial wash, brush smears, transbronchial needle aspiration, guided fine needle aspiration cytology (FNAC) smears and pleural fluid. Present study was undertaken to study the spectrum of lesions diagnosed by cytomorphological analysis of various cytological specimens...
October 2018: Journal of Cytology
Masashi Mikubo, Masahito Naito, Yoshio Matsui, Kazu Shiomi, Masaaki Ichinoe, Tsutomu Yoshida, Yukitoshi Satoh
BACKGROUND: The association between pleural lavage cytology (PLC) and histologic subtype remains unknown. In this study, we evaluated the effect of a micropapillary pattern (MPP) in lung adenocarcinomas on results of PLC. METHODS: We retrospectively reviewed 600 consecutive patients with surgically resected pulmonary adenocarcinomas and investigated the relationship between PLC status and clinicopathologic factors, including a histologically identified MPP component...
December 2018: Annals of Thoracic Surgery
Anqi Shi, Wang Min, Lai Xiang, Wu Xu, Tao Jiang
The present study aimed to investigate the diagnostic value of automatic DNA image cytometry (DNA-ICM) for diagnosing lung cancer. A total of three different types of samples from 465 cases were included: Bronchoalveolar lavage fluid (BALF), 386 samples; pleural effusion cases, 70 samples; and fine-needle aspiration procedures, 9 samples. Two methods, liquid-based cytology (LBC) and automatic DNA-ICM, were used to assess the samples, and the pathological results of 120/465 cases were reviewed. The results of DNA-ICM were compared with those of LBC and pathology...
July 2018: Oncology Letters
Ronald H L Li, Lynelle R Johnson, Casey Kohen, Fern Tablin
BACKGROUND: Canine neutrophils release neutrophil extracellular traps (NETs) in response to lipopolysaccharide but NETs from clinical septic dogs had not been identified. The primary aim is to describe the methodology of identifying and quantifying neutrophil extracellular traps (NETs) in cytology samples of septic foci in dogs with sepsis using immunofluorescence microscopy. Cytology samples including endotracheal tracheal wash (ETW), bronchoalveolar lavage (BAL), abdominal and pleural effusion collected from 5 dogs (3 septic, 2 non-septic) were fixed, permeabilized and stained for myeloperoxidase (MPO), citrullinated histone H3 (citH3) and cell-free DNA (cfDNA)...
June 27, 2018: BMC Veterinary Research
Jie-Yang Jhuang, Wei-Yu Chen, Shih-Sung Chuang
Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphological and immunophenotypic features of mature tissue histiocytes. As HS may mimic non-Hodgkin lymphoma (NHL) pathologically, before the era of immunohistochemistry, many previously reported cases were misdiagnosed NHL. Up to date, there are only a few reports delineating the cytological features in fine-needle aspiration or bronchoalveolar lavage, but not in the effusion fluid yet. Herein, we report the case of a 61-year-old male with a mediastinal tumor presenting with malignant pleural effusion...
September 2018: Diagnostic Cytopathology
Toru Nakamura, Yoshiro Otsuki, Hidenori Nakamura, Kazuhito Funai
BACKGROUND: There are two issues to be discussed in pleural lavage cytology (PLC) for resected non-small cell lung cancer (NSCLC) whether it should be performed before (pre-PLC) or after (post-PLC) the lung resection and the dose of saline varies widely among the institutions. METHODS: We retrospectively reviewed the clinical records of 466 consecutive patients who underwent a curative resection for NSCLC and received both a pre- and post- PLC using 20 mL of saline from January 2001 to December 2011...
April 5, 2018: Asian Journal of Surgery
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