keyword
https://read.qxmd.com/read/38514360/retrospective-application-of-who-reporting-system-for-lung-cytopathology-with-assessment-of-risk-of-malignancy
#1
JOURNAL ARTICLE
Rachana Meena, Aruna Nambirajan, Anant Mohan, Prabhat Singh Malik, Deepali Jain
INTRODUCTION: The recently introduced World Health Organization (WHO) Reporting System for Lung Cytopathology presents 5 diagnostic categories with corresponding risk of malignancy (ROM) and management protocols. This study uses the system to categorize our institutional respiratory tract cytology specimens, evaluating ROM and diagnostic accuracy for each category. MATERIALS AND METHODS: In a retrospective analysis (May 2020 to August 2021), the following respiratory cytology specimens were classified based on the WHO categories: bronchoalveolar lavage (BAL), bronchial wash/bronchial brushings (BB/BW), endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), fine-needle aspiration cytology (FNAC), sputum, biopsy imprint (BI), and endotracheal wash...
February 23, 2024: Journal of the American Society of Cytopathology
https://read.qxmd.com/read/38436618/can-cell-free-dna-cfdna-in-pleural-lavage-serve-as-a-predictive-and-prognostic-biomarker-among-surgically-treated-stage-i-iii-a-nonsmall-cell-lung-cancer-nsclc-a-pilot-study
#2
JOURNAL ARTICLE
Jyoutishman Saikia, Prabhat S Malik, Sachin Kumar, Deepali Jain, Karan Madan, Sachidanand Jee Bharati, Suryanarayana Deo, Sunil Kumar
BACKGROUND AND OBJECTIVES: The role of cell-free DNA (cfDNA) in operable nonsmall cell lung cancer (NSCLC) is unclear. This study was aimed to evaluate the feasibility for identification of cfDNA in pleural lavage fluid and its correlation with plasma in resectable NSCLCs. METHODS: Consecutively resected NSCLCs were evaluated for cfDNA levels in preoperative plasma (PLS1), intraoperative pleural-lavage (PLV) and postoperative (at 1 month) plasma sample (PLS2). CfDNA was isolated and measured quantitatively by qPCR in a TaqMan probe-detection approach using the human β-actin gene as the amplifying target...
March 4, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38238188/impact-of-pleural-lavage-cytology-positivity-on-early-recurrence-after-surgery-for-non-small-cell-lung-cancer
#3
JOURNAL ARTICLE
José Luis Recuero Díaz, Sonia Gatius Caldero, Joel Rosado Rodríguez, Verónica Caamaño Villaverde, David Gómez de Antonio, Eva Tejerina, Laura Sánchez Moreno, María Martino González, Milagros Moldes Rodríguez, Ihab Abdulkader Nallib, Elena Ramírez Gil, Irene Amat Villegas, Marta Genovés Crespo, Rubén García Ángel, Cora Sampedro Salinas, Santiago Figueroa Almánzar, Amparo Compañ Quilis, Roser Saumench Perramon, Guadalupe González Pont, Íñigo Royo Crespo, Paula Gambó Grasa, José Luis García Fernández, José Antonio Jiménez Heffernan, José Cerón Navarro, Mireia Prieto Rodríguez, José M Porcel
OBJECTIVE: The aim of this study was to elucidate the impact of pleural lavage cytology positivity on early recurrence in patients operated on non-small cell lung cancer (NSCLC). METHODS: This is a multicentre prospective cohort study of 684 patients undergoing an anatomical lung resection for NSCLC between October 2015 and October 2017 at 12 national centres. A pleural lavage was performed before and after lung resection. The association between the different predictors of early recurrence and PLC positivity was performed using univariate and multivariate logistic regression models...
December 18, 2023: Archivos de Bronconeumología
https://read.qxmd.com/read/37395938/intraoperative-rapid-diagnosis-of-pleural-lavage-cytology-in-non-small-cell-lung-cancer
#4
JOURNAL ARTICLE
Kiyomichi Mizuno, Mitsuhiro Isaka, Yukihiro Terada, Hayato Konno, Tetsuya Mizuno, Kiyoshi Tone, Takuya Kawata, Takashi Nakajima, Kazuhito Funai, Yasuhisa Ohde
OBJECTIVE: Positive pleural lavage cytology (PLC +) is a poor prognostic factor for non-small cell lung cancer (NSCLC). However, data on the impact of intraoperative rapid diagnosis of PLC (rPLC) are lacking. Therefore, we evaluated the efficacy of rPLC before resection during surgery. METHODS: A total of 1,838 patients who underwent rPLC for NSCLC between September 2002 and December 2014 were studied retrospectively. We assessed the clinicopathological factors between rPLC findings and the impact on survival of patients with curative resection...
July 3, 2023: General Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/37270329/cytopathology-of-salivary-gland-myoepithelial-carcinoma-a-study-of-13-cases-and-review-of-the-literature
#5
JOURNAL ARTICLE
Prokopios P Argyris, Paul E Wakely
INTRODUCTION: Myoepithelial carcinoma (MECA) is an infrequently recognized salivary gland (SG) neoplasm that commonly develops within a preexisting pleomorphic adenoma (MECA ex PA). Fine-needle aspiration (FNA) biopsy reports of this neoplasm are largely restricted to small series and single case reports. METHODS: Our cytopathology files were searched for examples of SG MECA/MECA ex PA having confirmatory histopathologic verification. Conventional FNA biopsy smears were performed, and exfoliative specimens processed using standard techniques...
May 11, 2023: Journal of the American Society of Cytopathology
https://read.qxmd.com/read/37150913/-pulmonary-adenocarcinoma-in-situ-with-positive-findings-in-pleural-lavage-cytology
#6
JOURNAL ARTICLE
Shinji Nakashima, Toshiyuki Maeda, Hiroki Uchiyama, Takuma Mikami, Shigeki Komatsu, Jyunji Nakazawa, Satoshi Muraki, Taku Sakurada, Eiji Araki
We report a rare case of positive findings in pleural lavage cytology(PLC) in the patient with pulmonary adenocarcinoma in situ (AIS). A 78-year-old woman was presented with a 30 mm pure groundglass nodule (GGN) in the left upper lobe on chest computed tomography (CT). After 2 years follow- up, thoracoscopic surgery was performed to resect the nodule. PLC was performed before pulmonary resection. Histopathological diagnosis was 25 mm AIS. However, PLC showed positive findings of malignant cells. CT examination at 1 year and 6 months postoperatively showed pleural dissemination findings and the patient died of lung cancer at 3 years and 2 months postoperatively...
May 2023: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/36148184/honey-as-a-cytological-fixative-a-comparative-study-with-95-alcohol
#7
JOURNAL ARTICLE
Avinash Priyadarshi, Rupinder Kaur, Roma Issacs
Background Ninety-five percent (95%) ethyl alcohol (ethanol) has been used as a standard cytological fixative but it is expensive, difficult to procure, and has addictive properties. Alternate substitutes like methanol, which give similar results to ethanol, have toxic potential. Honey, a known preservative, is an eco-friendly fixative and is of great value when ethanol is unavailable and economizing on cost is necessary. The present study was done to assess and compare the fixation property and cytomorphological features of smears fixed in 20% honey in comparison to 95% ethyl alcohol and to determine whether the former can be used as an alternative cytological fixative in routine practice...
August 2022: Curēus
https://read.qxmd.com/read/35590372/two-year-intermittent-exposure-of-a-multiwalled-carbon-nanotube-by-intratracheal-instillation-induces-lung-tumors-and-pleural-mesotheliomas-in-f344-rats
#8
JOURNAL ARTICLE
Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, Satoshi Yokota, Norihiro Kobayashi, Makoto Ohnishi, Yuko Goto, Takamasa Numano, Hiroyuki Tsuda, David B Alexander, Jun Kanno, Akihiko Hirose, Akiko Inomata, Dai Nakae
BACKGROUND: A mounting number of studies have been documenting the carcinogenic potential of multiwalled carbon nanotubes (MWCNTs); however, only a few studies have evaluated the pulmonary carcinogenicity of MWCNTs in vivo. A 2-year inhalation study demonstrated that MWNT-7, a widely used MWCNT, was a pulmonary carcinogen in rats. In another 2-year study, rats administered MWNT-7 by intratracheal instillation at the beginning of the experimental period developed pleural mesotheliomas but not lung tumors...
May 19, 2022: Particle and Fibre Toxicology
https://read.qxmd.com/read/35445581/cytopathology-of-the-distant-metastasis-of-papillary-carcinoma-of-thyroid
#9
JOURNAL ARTICLE
Malvika Shastri, Reetu Kundu, Manish Rohilla, Parikshaa Gupta, Nalini Gupta, Radhika Srinivasan, Uma Nahar Saikia, Pranab Dey
AIMS: To describe the cytomorphological features at distant metastatic sites apart from lymph nodes in papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: A total of eight cytology cases from seven patients reported as metastatic papillary carcinoma of thyroid were reviewed including available clinical and radiological details. The details clinical and cytological features were studied. RESULTS: There were a total of five males and two female patients...
August 2022: Diagnostic Cytopathology
https://read.qxmd.com/read/35063028/effect-of-intrabronchial-administration-of-autologous-adipose-derived-mesenchymal-stem-cells-on-severe-equine-asthma
#10
RANDOMIZED CONTROLLED TRIAL
Neža Adamič, Sonja Prpar Mihevc, Rok Blagus, Petra Kramarič, Uroš Krapež, Gregor Majdič, Laurent Viel, Andrew M Hoffman, Dorothee Bienzle, Modest Vengust
BACKGROUND: Severe equine asthma (SEA) is a common chronic respiratory disease and a significant health and well-being problem in horses. Current therapeutic strategies improve pulmonary function and clinical signs in some horses, but in the long-term, return to full athletic function appears to be rare. The aim of this study was to assess the safety and the effect of intrabronchial administration of adipose-derived mesenchymal stem cells (AD-MSC) on pulmonary inflammatory and clinical parameters in horses with SEA...
January 21, 2022: Stem Cell Research & Therapy
https://read.qxmd.com/read/34800224/positive-bag-lavage-cytology-during-thoracoscopic-surgery-for-lung-cancer-is-a-significant-predictor-of-locoregional-recurrence
#11
JOURNAL ARTICLE
Naoya Iwamoto, Junji Ichinose, Rira Hoshi, Hironori Ninomiya, Kohei Hashimoto, Yosuke Matsuura, Masayuki Nakao, Sakae Okumura, Mingyon Mun
OBJECTIVES: Advances in thoracoscopic surgery have made skin incisions smaller, but there are concerns about cancer cell contamination during sample extraction. We performed retrieval bag lavage cytology (BLC) during thoracoscopic surgery to evaluate the risk of cancer dissemination and the prognostic influence of BLC status. METHODS: BLC was investigated in 893 patients who underwent thoracoscopic lobectomy or segmentectomy for lung cancer between 2013 and 2018...
November 20, 2021: General Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/34679625/factors-influencing-concordance-of-pd-l1-expression-between-biopsies-and-cytological-specimens-in-non-small-cell-lung-cancer
#12
JOURNAL ARTICLE
Mohammed S I Mansour, Kim Hejny, Felicia Johansson, Joudy Mufti, Ante Vidis, Ulrich Mager, Annika Dejmek, Tomas Seidal, Hans Brunnström
PD-L1 expression assessed by immunohistochemical staining is used for the selection of immunotherapy in non-small cell lung cancer (NSCLC). Appropriate validation of PD-L1 expression in cytology specimens is important as cytology is often the only diagnostic material in NSCLC. In a previous study comprising two different cohorts of paired biopsies and cytological specimens, we found a fairly good cyto-histological correlation of PD-L1 expression in one, whereas only a moderate correlation was found in the other cohort...
October 18, 2021: Diagnostics
https://read.qxmd.com/read/34507918/empirical-ordering-of-stains-in-cytology-are-we-saving-or-losing
#13
JOURNAL ARTICLE
Melanie Lang-Orsini, Elizabeth M Genega, Kristi Bedrossian, Monika Roychowdhury
INTRODUCTION: Bronchoalveolar lavage (BAL) and body cavity fluids (pleural and peritoneal) have a useful role in the detection of infectious diseases, especially when combined with ancillary stains (Grocott methenamine silver, acid-fast bacilli, Fite, and cytomegalovirus). However, empirical ordering of stains and duplicate testing by concurrent microbiology cultures leads to unnecessary wastage of resources. The aim of our study was to optimize the use of resources. MATERIALS AND METHODS: We performed a retrospective review of all BALs and body cavity fluids from 2016 to 2018 to determine the baseline stain order rate, which was then used in conjunction with clinical information to create a reasonable target for 2019...
November 2021: Journal of the American Society of Cytopathology
https://read.qxmd.com/read/34277307/diffuse-alveolar-hemorrhage-an-unusual-presentation-of-recurrent-malignant-melanoma
#14
Patrick R McKillion, Sanjeev Shrestha, Andrew R Medvec, Amirahwaty Abdullah
Diffuse alveolar hemorrhage (DAH) is a syndrome characterized by bleeding into the alveolar spaces of the lungs, secondary to disruption of the alveolar-capillary basement membrane. While numerous disease processes have been associated with DAH including certain malignancies, to the best of our knowledge, recurrent malignant melanoma has not been previously described in the literature as a cause of DAH. Here, we present a case of a 73-year-old female with a history of malignant melanoma of the left shoulder status post wide local incision two years prior, who presented with complaints of progressive shortness of breath without productive cough or hemoptysis...
July 2021: Curēus
https://read.qxmd.com/read/33739459/short-and-long-term-outcome-in-cats-diagnosed-with-pyothorax-47-cases-2009-2018
#15
JOURNAL ARTICLE
F Krämer, J Rainer, M S Bali
OBJECTIVES: The aims of this retrospective study were to report the short- and long-term outcome in cats treated for pyothorax and to identify prognostic indicators as well as determine recurrence rate. METHODS: Medical records from April 2009 to August 2018 were retrospectively reviewed. Cases were included if a diagnosis of pyothorax was confirmed via cytology and/or culture of pleural fluid. Cats diagnosed with or suspected of having other thoracic diseases and cats with no evidence of pleural effusion were excluded from the study...
March 19, 2021: Journal of Small Animal Practice
https://read.qxmd.com/read/33553367/pulmonary-angiosarcoma-presenting-with-diffuse-alveolar-hemorrhage-a-case-report
#16
Min Yu, Weibin Huang, Yan Wang, Guangsuo Wang, Lingwei Wang, Weihua Tao, Saadia A Faiz, Fung Him Ng, Huiping Li
This study aimed to analyze the diagnosis and treatment of one case of pulmonary angiosarcoma (PPA) retrospectively. The main manifestation of this female patient was cough, hemoptysis and dyspnea. Computed tomography (CT) of the chest revealed multiple small nodules and ground-glass patches in both lungs suggesting of diffuse alveolar hemorrhage (DAH). Laboratory examination revealed decreased hemoglobin and platelet counting, normal coagulation function. Results of rheumatic markers testing including antinuclear antibody (ANA), anti-extractable nuclear antigen antibody (ENA), vasculitis marker, and antiphospholipid antibody were negative...
January 2021: Annals of Translational Medicine
https://read.qxmd.com/read/33439934/how-a-discerning-cytological-examination-can-aid-in-the-diagnosis-of-infectious-diseases-case-reports
#17
JOURNAL ARTICLE
D K Faria, J N de Almeida Júnior, C S Faria, B Durante, B F Falasco, E Terreri Neto, L Antonangelo
Infections caused by uncommon and resistant pathogens in unusual sites have been increasingly reported in medical literature. We describe four cases of rare cytological findings and clinical impact for patients. In the first case, Aspergillus sp and Pneumocystis jirovecii were observed in the bronchoalveolar lavage of a patient with severe systemic lupus. In the second and third cases, we describe the presence of Trichomonas sp and Strongyloides sp larvae in samples of pleural and peritoneal fluid, respectively...
2021: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/33197244/pleural-invasion-epidermal-growth-factor-receptor-mutation-and-carcinoembryonic-antigen-level-affect-pleural-lavage-cytology-positive-status-in-non-small-cell-lung-cancer
#18
JOURNAL ARTICLE
Yusuke Fujibayashi, Hiroyuki Ogawa, Mai Kitazume, Megumi Nishikubo, Yuki Nishioka, Kenji Kimura, Shinya Tane, Yoshitaka Kitamura, Wataru Nishio
OBJECTIVES: Pleural invasion (pl) is strongly associated with the pleural lavage cytology (PLC) status. We analysed tumours with pl and evaluated the relationship between the PLC status and pl. METHODS: We retrospectively reviewed 428 surgically treated patients who had been diagnosed with non-small-cell lung cancer with pl and had their PLC status examined between 2000 and 2016. We investigated the influence of a PLC-positive status on the prognosis and searched for the factors predictive of a PLC-positive status...
April 29, 2021: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/33124609/cytological-analysis-of-bronchoalveolar-lavage-fluid-in-asbestos-exposed-workers
#19
JOURNAL ARTICLE
Pietro Sartorelli, Sveva Indini, Francesco Bianchi, Miriana D'Alessandro, Laura Bergantini, Paolo Cameli, Maria Antonietta Mazzei, Giuseppina Scancarello, Lucio Barabesi, Elena Bargagli
BACKGROUND: Asbestos-related lung diseases are a group of heterogeneous disorders with different pathogenesis and prognosis. Very few studies investigated the BALF cell profile of asbestos exposed workers. The existence of a relationship between bronchoalveolar lavage fluid (BALF) cellular pattern and specific diagnosis and/or asbestos exposure biomarkers would allow the identification of effect biomarkers useful in the follow up of asbestos-exposed workers and in the diagnosis of asbestos-related diseases...
October 31, 2020: La Medicina del Lavoro
https://read.qxmd.com/read/33113114/status-of-pleural-lavage-cytology-in-cases-of-pulmonary-metastasis-a-single-institution-retrospective-study
#20
JOURNAL ARTICLE
Norikazu Kawai, Takeshi Kawaguchi, Tokiko Nakai, Takashi Tojo, Noriyoshi Sawabata, Chiho Ohbayashi, Shigeki Taniguchi
OBJECTIVE: In primary lung cancer surgery, intraoperative pleural lavage cytology (PLC) has been identified as a prognostic marker. However, there have been no reports on PLC for pulmonary metastasectomies. Therefore, the impact of PLC status for patients undergoing pulmonary metastasectomy remains unknown. We aimed to know the incidence and prognostic impact of positive PLC findings in pulmonary metastasectomies. METHODS: We retrospectively reviewed patients undergoing pulmonary metastasectomies between January 2013 and December 2018...
April 2021: General Thoracic and Cardiovascular Surgery
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