Lucia Guerri, Lauren K Dobbs, Daniel A da Silva E Silva, Allen Meyers, Aaron Ge, Lea Lecaj, Caroline Djakuduel, Damien Islek, Dionisio Hipolito, Abdiel Badillo Martinez, Pei-Hong Shen, Cheryl A Marietta, Susanna P Garamszegi, Enrico Capobianco, Zhijie Jiang, Melanie Schwandt, Deborah C Mash, Veronica A Alvarez, David Goldman
BACKGROUND: A salient effect of addictive drugs is to hijack the dopamine reward system, an evolutionarily conserved driver of goal-directed behavior and learning. Reduced dopamine type 2 receptor availability in the striatum is an important pathophysiological mechanism for addiction that is both consequential and causal for other molecular, cellular, and neuronal network differences etiologic for this disorder. Here, we sought to identify gene expression changes attributable to innate low expression of the Drd2 gene in the striatum and specific to striatal indirect medium spiny neurons (iMSNs)...
October 2023: Biol Psychiatry Glob Open Sci