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Carcinoid tumor

Rui Zhang, Yong Zhu, Xiao-Bo Huang, Chris Deng, Min Li, Guang-Shu Shen, Shu-Liang Huang, Shao-Hua Huangfu, Yan-Ni Liu, Chun-Gen Zhou, Ling Wang, Qi Zhang, Youping Deng, Bin Jiang
BACKGROUND: Primary neuroendocrine tumors (NETs) in the presacral region are extremely rare, some of which are caused by other primary tumors or metastatic rectal carcinoids. Nevertheless, cases of NETs have been increasing in recent years. This report describes the first primary neuroendocrine tumor in the presacral region that was found at our hospital within the last five years. CASE SUMMARY: The patient was identified as a 36-year-old woman with a presacral mass and pelvic floor pain...
July 26, 2019: World Journal of Clinical Cases
Josephine Graf, Ulrich-Frank Pape, Henning Jann, Timm Denecke, Ruza Arsenic, Winfried Brenner, Marianne Pavel, Vikas Prasad
AIM: One of the primary prerequisites for peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors (NET) is the presence of somatostatin receptors (SSTR) on NET cells. NET are highly heterogeneous and an individual patient as well as separate metastases can harbor cells with different clones, which influence the SSTR expression on NET cells. With this background we looked into our institutional database to assess the prognostic significance of quality of SSTR expression on SSTR PET/CT imaging in patients treated with at least two cycles of Lu-177 DOTATOC or Lu-177 DOTATATE...
August 14, 2019: European Journal of Nuclear Medicine and Molecular Imaging
Yutaka Shishido, Akihiro Aoyama, Shigeo Hara, Hiroshi Hamakawa, Yutaka Takahashi
BACKGROUND Tumor-to-tumor metastasis is an uncommon phenomenon in which a primary tumor metastasizes into another tumor. CASE REPORT An 81-year-old Asian woman was referred to our hospital for evaluation and treatment of a solid mass in the right middle lung lobe that had rapidly enlarged for 1.5 years compared to that observed over the last 5 years. On computed tomography (CT), the mass was 68×60 mm, and 2 different tumors appeared to exist in the upper portion of the mass. Blood examination findings revealed high serum levels of progastrin-releasing peptide and neuron-specific enolase...
August 15, 2019: American Journal of Case Reports
Mitsutake Yano, Tomomi Katoh, Tetsuya Hamaguchi, Eito Kozawa, Mei Hamada, Koji Nagata, Masanori Yasuda
BACKGROUND: Tumor-to-tumor metastasis (TTM) is a rare but well-documented phenomenon that is defined as metastasis in a histologically distinct tumor. Ovarian mature teratomas (OMTs) can coexist with various cancers by malignant transformation, which may make it difficult to distinguish these from TTM. Herein, we report a case of TTM from appendiceal adenocarcinoma to the OMT, mimicking the malignant transformation of OMT. CASE PRESENTATION: A 67-year-old Japanese woman underwent abdominal total hysterectomy and bilateral salpingo-oophorectomy for an ovarian tumor in another hospital...
August 14, 2019: Diagnostic Pathology
M E Pavel, E Baudin, K E Öberg, J D Hainsworth, M Voi, N Rouyrre, M Peeters, D J Gross, J C Yao
No abstract text is available yet for this article.
August 13, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Takafumi Mie, Takashi Ohta, Takayuki Iwamoto, Rui Mizumoto, Yuki Arimoto, Mayura Toda, Satoshi Shimizu, Shinjiro Yamaguchi, Yoshiki Ito, Hideki Hagiwara
A 42-year-old female developed type 1 diabetes mellitus at the age of 16 years and received insulin therapy. Esophagogastroduodenoscopy revealed an atrophic change localized in the gastric body and a small, protruding gastric lesion. Biopsy revealed that this lesion was gastric neuroendocrine tumor. Hence, the patient underwent en bloc resection by endoscopic submucosal resection with a ligation device. As the patient presented both autoimmune gastritis and type 1 diabetes mellitus, she was diagnosed with type 4 autoimmune polyendocrine syndrome...
2019: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Omar Yusef Kudsi, Fahri Gokcal
Carcinoid tumors are rare neuroendocrine tumors (NETs) found mostly in the gastrointestinal system. The occurrence of NETs in the large intestine according to the location of origin distribute as follows; 54% in the rectum, 20% in the cecum, 7.5% in the sigmoid colon, 5.5% in the rectosigmoid colon and 5% in the ascending colon [1]. A complete cure is usually possible in cases diagnosed and treated early. Extensive lymph node dissection is crucial for colon cancer surgery [2]. To this end, various techniques have been proposed to achieve better oncological results...
August 6, 2019: Colorectal Disease
Daniel Solomon, Eliahu Bekhor, Natasha Leigh, Yash M Maniar, Linsay Totin, Margaret Hoftsedt, Samantha N Aycart, Jacquelyn Carr, Samuel Ballentine, Deepa R Magge, Benjamin J Golas, Reetesh K Pai, Alexandros D Polydorides, David L Bartlett, Daniel M Labow, Haroon A Choudry, Umut Sarpel
BACKGROUND: Low-grade appendiceal mucinous neoplasms (LAMNs) are tumors that often present with widespread mucin in the peritoneal cavity (pseudomyxoma peritonei [PMP]). Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are effective treatment, but no published recommendations exist regarding surveillance. METHODS: Data from prospective databases of patients who underwent CRS-HIPEC from 2001 to 2017 at two high-volume institutions were retrospectively analyzed...
August 5, 2019: Annals of Surgical Oncology
Malgorzata Szolkowska, Ewa Szczepulska-Wojcik, Beata Maksymiuk, Barbara Burakowska, Sebastian Winiarski, Juliusz Gatarek, Piotr Rudzinski, Tadeusz Orlowski, Renata Langfort
Background: This study was an epidemiological analysis of all primary mediastinal neoplasms (PMNs) diagnosed between 2000 and 2016 at the National Tuberculosis and Lung Diseases Research Institute, Poland. Methods: All patients with any mediastinal abnormality were included in the analysis. The patients' age and gender were obtained from the institutional database. Results: From a cohort of 5,108 patients, 3,691 primary mediastinal lesions were found, including 1,005 (19%) PMNs: lymphomas (533, 53% of PMNs), thymomas (215, 21%), neurogenic tumors (NTs) (100, 10%), germ cell tumors (GCTs) (62, 6%), soft tissue tumors (STTs) (47, 5%) and thymic carcinomas/thymic neuroendocrine tumors (TCs/TNETs) (37 in total, 4%)...
June 2019: Journal of Thoracic Disease
Ryan W Day, Yu-Hui Chang, Chee-Chee Stucky, Richard Gray, Barbara Pockaj, Nabil Wasif
BACKGROUND: Histologic subtypes of appendiceal cancer vary in their propensity for metastases to regional lymph nodes (LN). A predictive model would help direct subsequent surgical therapy. METHODS: The National Cancer Database was queried for patients with appendiceal cancer undergoing surgery between 1998 and 2012. Multivariable logistic regression was used to develop a predictive model of LN metastases which was internally validated using Brier score and Area under the Curve (AUC)...
July 29, 2019: Annals of Surgery
Servet Kocaöz, Gülay Turan
Aim: This study aimed to analyze the frequency of carcinoid tumor, the applied treatments to cure it, and the survival periods of the patients thereafter in a city located in the west of Turkey, Balıkesir. Materials and Methods: The data for this study were gathered by the careful retrospective analysis of 6369 files of patients who underwent an appendectomy operation during the time span of January 2011 and December 2017 in Balıkesir Atatürk City Hospital. Results: The results revealed that among the patients who underwent appendectomy, 17 carcinoid tumor cases, 16 of which with combine classic carcinoid and 1 with goblet cell carcinoid, were recorded...
July 2019: Indian Journal of Pathology & Microbiology
Wei Yang, David Pham, Aren Vierra, Sarah Azam, Dorina Gui, John Yoon
Summary: Ectopic ACTH-secreting pulmonary neuroendocrine tumors are rare and account for less than 5% of endogenous Cushing’s syndrome cases. We describe an unusual case of metastatic bronchial carcinoid tumor in a young woman presenting with unprovoked pulmonary emboli, which initially prevented the detection of the primary tumor on imaging. The source of ectopic ACTH was ultimately localized by a Gallium-DOTATATE scan, which demonstrated increased tracer uptake in a right middle lobe lung nodule and multiple liver nodules...
July 26, 2019: Endocrinology, Diabetes & Metabolism Case Reports
Nir Hod, Daniel Levin, Reut Anconina, Benjamin H Taragin, Julia Dudnik, Sophie Lantsberg
Ga-DOTATATE imaging is commonly used for the detection of metastatic disease in neuroendocrine tumors. We present a case of a 69-year-old woman postsurgery for lung carcinoid tumor in which sequential follow-up Ga-DOTATATE PET/CT studies identified focal hepatic uptake that was presumed to represent a liver metastasis. However, correlative imaging with MRI revealed a focal fatty sparing of the liver composed of benign hepatic parenchyma at that area accompanied with diffuse liver steatosis in the background of the "pseudolesion...
July 24, 2019: Clinical Nuclear Medicine
Mauro Cives, Eleonora Pelle', Davide Quaresmini, Barbara Mandriani, Marco Tucci, Franco Silvestris
The treatment landscape of well-differentiated neuroendocrine tumors (NETs) has considerably expanded in recent years, and both somatostatin analogs, radiolabeled somatostatin analogs, everolimus, and sunitinib have been incorporated within the therapeutic armamentarium against these malignancies. Even in the context of multiple treatment options available, cytotoxic chemotherapy plays a pivotal role in the management of pancreatic NETs (panNETs), while its activity in midgut carcinoids and lung NETs is still debated...
July 25, 2019: Current Treatment Options in Oncology
Kartik Viswanathan, Momin T Siddiqui, Alain C Borczuk
INTRODUCTION: Insulinoma-associated protein 1 (INSM1) is an immunohistochemical marker for neuroendocrine differentiation with potentially superior sensitivity and specificity. INSM1 performance in pulmonary cytology cell block material (CB) has not been well established, and large series demonstrating its performance have been few. MATERIALS AND METHODS: Typical and atypical carcinoid, small cell lung carcinoma, and large cell neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma CBs and 563 surgical specimens comprising 17 typical carcinoid, 14 atypical carcinoid, 8 small cell lung carcinoma, 10 large cell neuroendocrine carcinoma, 58 squamous cell carcinoma, 415 adenocarcinoma, and 17 large cell carcinoma cases and 24 other tumor types were immunostained with INSM1, CD56, synaptophysin, and chromogranin A...
June 26, 2019: Journal of the American Society of Cytopathology
Pedro J Davila, Jan C Ortiz-Rosario, Meliza Matinez, Ana C Toro, Jose J Echegaray, Maria Correa-Rivas, Armando L Oliver
Purpose: We report a rare case of a metastatic carcinoid tumor to the right lower lid masquerading as a chalazion. Observations: A 78-year-old Hispanic woman who presented with a 3-month history of a non-resolving chalazion on the right lower lid despite aggressive medical treatment. The patient had a history of noninfectious anterior uveitis and primary hepatic carcinoid tumor that was incidentally diagnosed during the initial uveitis work-up. The right lower eyelid lesion was biopsied and histological and immunopathological analysis revealed a well differentiated neuroendocrine tumor consistent with a carcinoid tumor...
September 2019: American Journal of Ophthalmology Case Reports
E M B P Reuling, C Dickhoff, P W Plaisier, H J Bonjer, J M A Daniels
The treatment of pulmonary carcinoid has changed over the last decades. Although surgical resection is still the gold standard, minimally invasive endobronchial procedures have emerged as a parenchyma sparing alternative for tumors located in the central airways. This review was performed to identify the optimal treatment strategy for pulmonary carcinoid, with a particular focus on the feasibility and outcome of parenchyma sparing techniques versus surgical resection. A systematic review of the literature was carried out using MEDLINE, Embase and the Cochrane databases, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Aura D Herrera-Martínez, Richard A Feelders, Rosanna Van den Dungen, Fadime Dogan-Oruc, Peter M van Koetsveld, Justo P Castaño, Wouter de Herder, Leo J Hofland
<br>Serotonin, a biologically active amine, is related to carcinoid syndrome in functioning neuroendocrine tumors (NETs). Telotristat ethyl is a novel inhibitor of the tryptophan hydroxylase (TPH), a key enzyme in the production of serotonin. While its use in patients with carcinoid syndrome and uncontrolled diarrhea under somatostatin analogs (SSAs) has been recently approved, in vitro data evaluating it effectiveness are lacking. For this reason, we aimed to evaluate the effect of telotristat as monotherapy, and in combination with SSAs, on proliferation and secretion in a NET cell line model...
July 19, 2019: Neuroendocrinology
Wen-Wei Hsu, Tsui-Lien Mao, Chi-Hau Chen
OBJECTIVE: Only a few cases of primary ovarian mucinous carcinoid tumor have been documented in the literature till date. We present a case of primary ovarian mucinous carcinoid tumor, atypical type, and review the reported cases. CASE REPORT: A 33-year-old woman with a left ovarian tumor was diagnosed with primary ovarian mucinous carcinoid tumor, atypical type. She underwent left salpingo-oophorectomy and ipsilateral lymph node dissection. After 5 years, the tumor recurred on the right side, with large para-aortic lymphadenopathy that caused hydronephrosis...
July 2019: Taiwanese Journal of Obstetrics & Gynecology
Shilpa Thakur, Brianna Daley, Joanna Klubo-Gwiezdzinska
Incidence of endocrine cancers is rising every year. Over the last decade, evidence has accumulated that demonstrates the anti-cancer effects of an anti-diabetic drug - metformin - in endocrine malignancies. We performed a literature review utilizing the Pubmed, Medline and databases using the keyword "metformin" plus the following terms: "thyroid cancer," "thyroid nodules," "parathyroid," "hyperparathyroidism," "adrenal adenoma," "Cushing syndrome," "hyperaldosteronism," "adrenocortical cancer," "neuroendocrine tumor (NET)," "pancreatic NET (pNET)," "carcinoid," "pituitary adenoma," "pituitary neuroendocrine tumor (PitNET)", "prolactinoma," "pheochromocytoma/paraganglioma...
July 1, 2019: Journal of Molecular Endocrinology
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