Vasiliki E Georgakopoulou, Eleftherios Zygouris, Christos Nikokiris, Christos Damaskos, Aikaterini Pierrakou, Nikolaos Garmpis, Anna Garmpi, Pagona Sklapani, Aikaterini Aravantinou, Nikolaos Trakas, Jim Janinis, Jubrail Dahabreh
Introduction Lung carcinoid tumors are neuroendocrine neoplasms, less frequent than other lung tumors. They are subdivided into typical carcinoids (TC) and atypical carcinoids (AC), according to the rate of mitosis and the presence of necrosis. Lung carcinoids are often asymptomatic and only discovered incidentally. They may also present with cough, wheezing, asthma, and chronic obstructive pulmonary disease, chest pain, and hemoptysis depending on the location of the tumor and, less commonly, present with carcinoid syndrome...
September 7, 2020: Curēus
Eugeniy Igorevich Zinchenko, Olga Sergeevna Maslak, Vadim Grigorievich Pischik, Aleksandr Dmitrievich Obornev, Aleksandr Igorevich Kovalenko
Pulmonary carcinoids are relatively rare tumors with low metastatic potential. Pleural carcinomatosis of a bronchial carcinoid has only been reported in 4 cases. Due to the rarity of this condition, there are no guidelines for its treatment or management. We report a case of atypical carcinoid with local recurrence and pleural metastases treated by video-assisted thoracoscopic surgery lobectomy and total pleurectomy with photodynamic therapy after non-radical wedge resection.
September 4, 2020: Korean Journal of Thoracic and Cardiovascular Surgery
M Rubino, J Y Scoazec, E Pisa, M Faron, L Spaggiari, J Hadoux, F Spada, D Planchard, C A Cella, S Leboulleux, F De Marinis, M Ducreux, L Lamartina, E Baudin, N Fazio
Highly proliferative lung carcinoids (HPLC) have been recently reported but information about this subset remains scarce. OBJECTIVES: Clinical and pathological data of 630 patients with lung carcinoids (LC) referred to Gustave Roussy Institute (GR) and European Institute of Oncology (IEO) were retrospectively reviewed to select HPLC and analyze their frequency, behavior and compare their outcome to conventional LC with Ki-67 ≤ 20 % and mitotic count (MC)≤10/2 mm2 . MATERIALS AND METHODS: Selection criteria were: diagnosis of LC confirmed by local pathologist, and available clinical and follow-up data...
August 8, 2020: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Jun Wang, Shuai Ren, Yongkang Liu, Kai Guo, Xiao Chen, Zhongqiu Wang, Rong Chen
BACKGROUND Pulmonary carcinoid tumorlets (PCT) are incidental histologic or radiologic discoveries that are localized neuroendocrine tumors whose proliferation is associated with chronic pulmonary inflammatory processes. This study assessed the imaging findings and histological appearances of PCT co-existing with chronic pulmonary inflammatory processes. MATERIAL AND METHODS We performed a retrospective study of 14 patients with incidentally-found PCT with co-existing chronic pulmonary inflammatory processes who underwent preoperative X-rays and CT between 1 January 2003 and 31 December 2012...
September 11, 2020: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Mengzhen Zheng, Tong Li, Yan Li, Tengfei Zhang, Lianfeng Zhang, Wang Ma, Lin Zhou
Introduction: Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare form of neuroendocrine neoplasms (NENs). The purpose of this study was to investigate the characteristics and survival profile of appendiceal MiNENs, with a view of providing robust clinical features of this rare disease. Methods: Patients were selected from the Surveillance, Epidemiology, and End Results database (2004-2016). The prognosis of MiNEN ( n = 315) was compared with other histological subtypes including neuroendocrine tumor (NETs) ( n = 1734), neuroendocrine carcinoma (NECs) ( n = 375), goblet cell carcinoid (GCC) ( n = 968), signet ring cell carcinoma ( n = 463), mucinous adenocarcinoma (MAC) ( n = 2355), and non-mucinous adenocarcinoma (NMAC) ( n = 1187) in the appendix...
2020: Frontiers in Oncology
Piqing Gong, Chunhua Chen, Zhan Wang, Xukun Zhang, Wenxin Hu, Zhiqian Hu, Xinxing Li
The aim of our study was to explore the value of the 8th edition TNM staging system on evaluating the prognosis of colorectal carcinoid. Colorectal carcinoid patients between 1988 and 2015 were selected in the Surveillance, Epidemiology, and End Results Program (SEER) database for analysis. About 4286 patients with colorectal carcinoid tumors were identified, of which were carcinoid tumor NOS (n = 1726), neuroendocrine carcinoma (NEC) (n = 1346) and other carcinoid tumor (OCT) (n = 591). Worsening 10-year CSS rates with increasing N status, M status, and SEER historic stage were demonstrated across all three above groups (all P < ...
September 8, 2020: Cancer Medicine
L Jakubíková
Carcinoids have been classified according to their embryonic origin in the past and are now categorized and classified as neuroendocrine tumors, including low malignant typical carcinoids, moderate malignant atypical carcinoids, and highly malignant large cell neuroendocrine and small cell carcinomas. A typical carcinoid is a previously used term for the current designation of a grade I neuroendocrine tumor, well differentiated, belonging to a group of rare tumors with a good prognosis with metastasis of less than 15% with a five-year survival of more than 90%, rarely producing serotonin...
2020: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Shenghua Dong, Jun Liang, Wenxin Zhai, Zhuang Yu
OBJECTIVE: We aim to develop and validate an effective nomogram prognostic model for patients with typical lung carcinoid tumors using a large patient cohort from the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS: Data from patients with typical lung carcinoid tumors between 2010 and 2015 were selected from the SEER database for retrospective analysis. Univariate and multivariate Cox analysis was performed to clarify independent prognostic factors...
September 2020: American Journal of Clinical Oncology
Kimitoshi Kubo, Noriko Kimura, Masato Suzuoki, Soichiro Matsuda, Momoko Tsuda, Masanori Ohara, Mototsugu Kato
Goblet cell carcinoid (GCC) of the perforated appendix is rare, and its pathological features and prognosis remain poorly described. A 71-year-old woman was admitted to our hospital for right lower abdominal pain, vomiting, and high-grade fever. She was diagnosed with acute appendicitis and underwent emergency laparoscopic appendectomy. Intraoperative examination revealed an enlarged and perforated appendix. Histopathological examination revealed GCC of the appendix with subserosal invasion. She underwent laparoscopic ileocecal resection with lymph node dissection (D3) following appendectomy...
May 2020: Case Reports in Gastroenterology
Patryk Pozowski, Paula Misiak, Kinga Szymańska, Rafał Mazur, Małgorzata Sierpowska, Jurand Silicki, Milena Celmer, Mateusz Łasecki, Aleksander Pawluś, Urszula Zaleska-Dorobisz
BACKGROUND Carcinoid tumor is the most frequent neuroendocrine tumor (NET) that causes liver metastases. One of the best methods to assess this type of pathology is magnetic resonance imaging with hepatocyte-specific contrast media with low molecular weight gadolinium chelate Gd-BOPTA. As these lesions do not contain hepatocytes, they present as hypointense on MRI in comparison with liver tissue which enhances this type of contrast. CASE REPORT In this article, we present a case of a 65-year-old female patient who was admitted to the Emergency Department with abdominal pain...
September 4, 2020: American Journal of Case Reports
Monjur Ahmed
Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence within the last few decades. They contain chromogranin A, synaptophysin and neuron-specific enolase which are necessary for making a diagnosis of neuroendocrine tumor. Ki-67 index and mitotic index correlate with cellular proliferation. Serum chromogranin A is the most commonly used biomarker to assess the bulk of disease and monitor treatment and is raised in both functioning and non-functioning neuroendocrine tumors...
August 15, 2020: World Journal of Gastrointestinal Oncology
Vanessa Oliveira, Gonçalo Videira, Raquel Samões, Paula Carneiro, Esmeralda Neves, Ernestina Santos
INTRODUCTION: Paraneoplastic neurological syndromes (PNS) are immune-mediated diseases that occur in patients with tumors and can be associated with onconeural antibodies. Our aim was to describe our cohort of patients with PNS. METHODS: Retrospective analysis of a cohort of patients followed in a Portuguese tertiary center, with autoantibodies against intracellular antigens from our PNS panel, between 2012 and 2017. RESULTS: Among the 882 patients with suspected PNS (1029 samples), 37 (4...
August 21, 2020: Journal of the Neurological Sciences
Anna Martin, Alycia Wanat-Hawthorne, Aravind Sanjeevaiah, Neelan Doolabh, Ravi V Joshi
No abstract text is available yet for this article.
August 2020: CASE: Cardiovascular Imaging Case Reports
Elizabeth D Marlow, Lisa J Faia, Dafang Wu, Nathan Farley, Sandeep Randhawa
Purpose: Nuclear medicine imaging can provide a noninvasive means of distinguishing inflammatory mass lesions from oncologic intraocular tumors. Observation: We report a case of paraneoplastic ocular sarcoidosis with choroidal mass lesions that was initially concerning for choroidal metastasis of a primary carcinoid tumor. PET CT was utilized with two different tracers to characterize the choroidal mass as being FDG-avid, consistent with a sarcoid-like lesion, and lacking the Gallium (Ga-68) DOTATAE uptake of carcinoid tumor metastases...
December 2020: American Journal of Ophthalmology Case Reports
Khoren Abelian, Omobolaji Ismail Akano, Diana Penha, Erique Guedes-Pinto, Marousa Ntouskou
Mediastinal neuroendocrine tumors (NETs) are very rare. They have been estimated to account for approximately 2%-4% of all anterior mediastinal neoplasms. Carcinoid tumors are a type of NET that can occur in a number of locations. They arise from endocrine amine precursor uptake and decarboxylation cells that can be found in organs such as the lungs. In general, they are slow growing tumors but are nevertheless capable of metastasizing. We present the case of a carcinoid tumor of the anterior mediastinum in a 38-year-old woman presented to our hospital with a 4-month history of worsening breathless and cough...
October 2020: Radiology Case Reports
Alexandra Gangi, Daniel A Anaya
Small bowel neuroendocrine tumors (SB NETs) are increasing in frequency and becoming more common in surgical practice. It is often difficult to make the diagnosis of a SB NET at an early stage, as the primary tumor tends to be small and patients are asymptomatic until there is regional or distant metastasis, when they develop abdominal pain, partial obstruction, or bleeding and/or develop carcinoid syndrome. Despite this advanced presentation at the time of diagnosis, patients with metastatic SB NETs, as compared to other gastrointestinal malignancies, have favorable survival, which can be improved by appropriate surgical interventions...
August 29, 2020: Current Treatment Options in Oncology
Dipesh Uprety, Thorvardur R Halfdanarson, Julian R Molina, Konstantinos Leventakos
Bronchial carcinoids are uncommon tumors accounting for 20 to 30% of all neuroendocrine tumors and about 1-2% of all cancers of pulmonary origin. Bronchial carcinoids are well-differentiated neuroendocrine tumors and have a favorable survival outcome when compared with other subtypes of lung cancers. Treatment of bronchial carcinoids is not simple owing to intricacy of symptom presentation and heterogeneity of disease biology. Successful treatment of patients requires a multimodality approach. Resection is curative in the majority of patients with localized tumors and adjuvant treatment is not routinely recommended...
August 29, 2020: Current Treatment Options in Oncology
Jacob C Balmer, Yana Mikhaylov, David N Lewin, David M Mahvi, E Ramsay Camp
Neurofibromatosis type I (NF1) is an autosomal dominant genetic disorder associated with characteristic skin findings, as well as a fourfold increase in risk of malignancy. NF1 patient malignancies commonly include the central and peripheral nervous system, but these patients are also at high risk of developing gastrointestinal (GI) tumors. While most often these GI tumors are benign upper GI neurofibromas; clinicians should have a high suspicion for malignant tumors, degeneration into a malignant peripheral nerve sheath tumor or less common associated malignancies such as well-differentiated neuroendocrine tumor (formerly carcinoid tumor), when patients present with multiple GI tumors...
August 28, 2020: American Surgeon
(no author information available yet)
No abstract text is available yet for this article.
August 27, 2020: Polish Archives of Internal Medicine
Junmiao Wen, Jiayan Chen, Di Liu, Donglai Chen, Yongbing Chen, Min Fan, Bo Lu
OBJECTIVES: To evaluate the prognostic significance of patterns of distant metastatic organs in metastatic pulmonary neuroendocrine tumors (PNETs). METHODS: 891 metastatic PNETs patients (G1-typical carcinoid, 200; G2-atypical carcinoid, 68; G3-large-cell neuroendocrine carcinoma, 623) diagnosed between 2010 and 2016 were identified. Multivariate analysis was performed using a Cox regression model to identify prognostic factors associated with cancer-specific survival (CSS)...
August 7, 2020: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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