Jian Zhao, Shimiao Wang, Sangdon Han, Sun Hee Kim, Ana Karin Kusnetzow, Julie Nguyen, Elizabeth Rico-Bautista, Hannah Tan, Stephen F Betz, R Scott Struthers, Yunfei Zhu
Nonpeptide sst2 agonists can provide a new treatment option for patients with acromegaly, carcinoid tumors, and neuroendocrine tumors. Our medicinal chemistry efforts have led to the discovery of novel 3,4-dihydroquinazoline-4-carboxamides as sst2 agonists. This class of molecules exhibits excellent human sst2 potency and selectivity against sst1, sst3, sst4 and sst5 receptors. Leading compound 3-(3-chloro-5-methylphenyl)-6-(3-fluoro-2-hydroxyphenyl)-N,7-dimethyl-N-{[(2S)-pyrrolidin-2-yl]methyl}-3,4-dihydroquinazoline-4-carboxamide (28) showed no inhibition of major CYP450 enzymes (2C9, 2C19, 2D6 and 3A4) and weak inhibition of the hERG channel...
September 1, 2020: Bioorganic & Medicinal Chemistry Letters
Nilendu C Purandare, Ameya Puranik, Archi Agrawal, Sneha Shah, Rajiv Kumar, Sabita Jiwnani, George Karimundackal, C S Pramesh, Venkatesh Rangarajan
OBJECTIVE: Purpose of this study was to assess the utility of Ga-DOTA-NOC-PET/computed tomography (CT) (Ga-NOC-PET) in tumor detection, pathological differentiation and baseline staging of pulmonary carcinoids as well as to study its impact on therapeutic decision making. PATIENTS AND METHODS: Patients who underwent a Ga-NOC-PET for initial evaluation of bronchopulmonary carcinoid tumors from August 2014 to December 2019 were included. Detection rate of Ga-NOC-PET for the primary lesion was calculated by visual estimation of tracer uptake as per Krenning score...
July 21, 2020: Nuclear Medicine Communications
Morris Beshay, Federico Gutierrez, Beatrice Ariane Windmöller, Christina Förster, Fritz Mertzlufft
A 27-year-old male patient presented with cough and right-sided, light thoracic pain. His physical appearance showed typical features of gigantism. Subsequently, further diagnostic work-up showed elevated level of growth hormone and a huge tumor of the right lung, identifying a typical pulmonary carcinoid tumor (TPCT). Curative surgery was performed leading to normalization of the elevated growth hormone levels few days after surgery. Two- and five-year follow-up showed no signs of recurrence. Respected to tumor size, we determined the largest TPCT to be reported in medical literature history...
July 28, 2020: General Thoracic and Cardiovascular Surgery
Soobin Kim, Dustin Baldwin, Bernardo Duarte
INTRODUCTION: Appendiceal torsion is a rare phenomenon with only a few reported cases and never in a patient with Ehlers-Danlos syndrome (EDS). We present the first case of appendiceal torsion leading to acute appendicitis in a patient with EDS. PRESENTATION OF CASE: A 36-year-old male with history of musculoskeletal EDS presented with one week of abdominal pain localizing to the right lower quadrant. He was evaluated in the emergency department with a complete set of labs and CT abdomen/pelvis...
June 24, 2020: International Journal of Surgery Case Reports
Abraham Ahmed, Brian J Morse, Rikesh J Makanji, Jamie T Caracciolo, Arthur Parsee
We report a case of a retropubic parasymphyseal cyst in a 69-year-old multiparous female with a protracted history of metastatic small bowel carcinoid (neuroendocrine) tumor. Cysts related to the pubic symphysis are uncommon, and mostly reported in subpubic location. They may be confused with primary vulvar masses, malignant bone tumors or metastatic disease. In our case, encapsulation, lack of solid components or diffusion restriction, communication with the symphysis, lack of activity on Gallium-68-Dotatate PET/CT and signal characteristics on MRI similar to those previously reported in literature for subpubic cysts all aided in eventual diagnosis...
September 2020: Radiology Case Reports
Daria Maccora, Carmelo Caldarella, Martina Leombroni, Valerio De Stefano, Lucia Leccisotti
A 68-year-old woman with a history of multiple myeloma on regular hematological follow-up and with no previous relevant gynecological diseases was found to have an incidental focal uptake by the right ovary at C-methionine PET/CT (C-MET). Transvaginal ultrasound was then performed showing a 2-cm solid right ovarian mass with irregular borders and moderate vascularization at color Doppler examination. Therefore, the patient underwent bilateral salpingectomy, and the final histological results revealed a rare presentation of mature teratoma with insular carcinoid tumor arising from the right ovary...
July 17, 2020: Clinical Nuclear Medicine
Mohid S Khan, Katharina Mellar, Rupert Watts, Isabelle Bocher-Pianka, Abdelali Majdi, Grace Goldstein
INTRODUCTION: Patient surveys of disease burden on daily living rarely explore the impact that patient information sources can have on optimizing care. METHODS: To identify unmet needs/possible solutions for information and support to address the physical, emotional, and informational challenges that patients living with neuroendocrine tumors (NETs) may have, an online survey was conducted among patients recruited by the Carcinoid Cancer Foundation (US), Netzwerk Neuroendokrine Tumoren (NeT) e...
June 2020: Oncology and Therapy
N S Rajaretnam, G Y Meyer-Rochow
Up to 35% of small bowel neuroendocrine tumors (SBNETs) may present with an acute intra-abdominal complication including obstruction, perforation, bleeding or ischemia and may require emergency surgical treatment in centers not normally accustomed to managing patients with neuroendocrine tumors. These patients may have a known diagnosis of SBNET, be suspected as suffering from SBNET or have SBNET diagnosed as an incidental finding on presenting radiology or postoperative pathology. Perioperative priorities include obtaining both clinical and radiological staging with cross-sectional imaging and clinical examination, screening for the presence of carcinoid syndrome and right-sided cardiac disease and assessment of prognosis...
July 21, 2020: World Journal of Surgery
Yoshiyuki Inoue, Hisanaga Horie, Yuko Homma, Ai Sadatomo, Makiko Tahara, Koji Koinuma, Hironori Yamaguchi, Toshiki Mimura, Atsushi Kihara, Alan Kawarai Lefor, Naohiro Sata
BACKGROUND: Goblet cell carcinoid (GCC) is a neuroendocrine tumor usually found in the appendix. GCCs exhibit characteristic findings with mixed endocrine-exocrine features such as staining positive for neuroendocrine markers and producing mucin. The primary GCC of the rectum is exceedingly rare. CASE PRESENTATION: A 77-year-old Japanese male presented with hematochezia. Anal tenderness and a hard mass in the anal canal were found on the digital rectal examination, and colonoscopy was performed...
July 18, 2020: Surgical Case Reports
Mathieu Gauthé, Anne Dierick-Gallet, Thierry Delbot, Léopoldine Bricaire, Jérôme Bertherat, Marie-Odile North, Beatrix Cochand-Priollet, Phillipe Bouchard, Jean-Noël Talbot, Lionel Groussin, Sébastien Gaujoux
BACKGROUND: Primary hyperparathyroidism (HPT1) is the most frequent endocrinopathy in multiple endocrine neoplasia type 1 (MEN1). Its surgical management is challenging. We aimed to describe and compare the imaging findings of parathyroid ultrasound (US), sestaMIBI scintigraphy (sestaMIBI), and 18 F-fluorocholine (FCH) PET/CT in a series of MEN1 patients with HPT1. METHODS: Retrospective analysis of a cohort of MEN1 patients with HPT1 assessed by parathyroid US, sestaMIBI scintigraphy and SPECT/CT, and FCH-PET/CT for potential surgery between 2015 and 2019...
July 17, 2020: World Journal of Surgery
Marina K Baine, Natasha Rekhtman
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive malignancy that is strongly linked to smoking and notoriously difficult to diagnose and treat. Recent molecular data reveal that it represents a biologically heterogeneous group of tumors, characterized by morphologic and genomic diversity that straddles small cell and non-small cell lung carcinomas (NSCLCs), and in a minority of cases atypical carcinoids. This review provides an update on recent molecular and clinical developments in LCNEC with the main focus on practical approach to pathologic diagnosis using illustrative examples of the main differential diagnostic considerations...
June 2020: Translational Lung Cancer Research
Muhammad Umar Hayat Khan, Mohammad Uzair Abdul Rauf, Ayesha Mustafa, Richard Silverman
Lung nodules are often incidentally discovered on lung imaging and can be solitary, which makes them suspicious for tumors, or multiple, which can be suggestive of an infectious process. A bronchial carcinoid is a rare pulmonary neoplasm, representing 1.2% of all primary pulmonary tumors. We report a case of incidentally discovered multiple lung nodules in an asymptomatic human immunodeficiency virus (HIV) patient, which turned out to be a tumor, necessitating the need for keeping a broad differential, a high degree of clinical suspicion, and long-term follow-up for the optimal management of the patient...
June 13, 2020: Curēus
Maria Isabel Del Olmo-García, Maria Angustias Muros, Martín López-de-la-Torre, Marc Agudelo, Pilar Bello, Jose M Soriano, Juan-Francisco Merino-Torres
Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTR) on their cell surface. The first-line pharmacological treatment for inoperable metastatic functioning well-differentiated NETs are somatostatin analogs. On second line, Lu-DOTA-TATE (177 Lu-DOTA0 Tyr 3 octreotate) has shown stabilization of the disease and an increase in progression free survival, as well as effectiveness in controlling symptoms and increasing quality of life. The management of functional NETs before and during LU-DOTA-TATE treatment is specially challenging, as several complications such as severe carcinoid and catecholamine crisis have been described...
July 12, 2020: Journal of Clinical Medicine
Ana Laura Espinosa-de-Los-Monteros, Claudia Ramírez-Rentería, Moisés Mercado
<u>Abstract</u><u> Background and objective </u>: The ectopic ACTH syndrome (EAS) is a heterogeneous condition, caused by neuroendocrine neoplasms (NEN) located in the lungs, thymus or pancreas. Our purpose was to evaluate the long-term outcome of these patients. <u> Design </u>: Retrospective study at a referral center. <u> Methods :</u> The charts of 164 patients with Cushing syndrome, followed at our center from 1993 to 2019 were analyzed. <u> Results </u>: EAS was found in 16 patients (9...
July 13, 2020: Endocrine Practice
Venkata Subramanian Krishnaraju, Swayamjeet Satapathy, Ashwani Sood, Chandan Krushna Das, Debajyoti Chatterjee, Jaya Shukla, Bhagwant Rai Mittal
Primary neuroendocrine tumor of the mediastinum is a relatively rare entity. In metastatic/inoperable disease, therapeutic options are limited to cytotoxic chemotherapy in poorly differentiated tumors and peptide receptor radionuclide therapy in case of well-differentiated tumors. We present the case of a 52-year-old man with mediastinal atypical carcinoid (grade II) neuroendocrine tumor showing mild somatostatin receptor expression and intense FDG avidity with progressive disease on chemotherapy. Chemokine receptor targeted PET/CT with CXCR4 (Ga-CXCR4) showed tracer avidity in tumor sites higher than the physiological sites, which may pave the way for CXCR4-targeted radionuclide therapy in this subgroup of patients...
July 8, 2020: Clinical Nuclear Medicine
Jordan M Cloyd, Jason T Wiseman, Timothy M Pawlik
Pancreatic neuroendocrine tumors (PNET) are a heterogeneous group of neoplasms that vary in their clinical presentation, behavior and prognosis. The most common site of metastasis is the liver. Surgical resection of neuroendocrine liver metastases (NELM) is thought to afford the best long-term outcomes when feasible. Initial preoperative workup should include surveillance for carcinoid syndrome, screening for evidence of liver insufficiency, and performance of imaging specific to neuroendocrine tumors such as a somatostatin receptor positron emission tomography scan...
June 2020: Journal of Gastrointestinal Oncology
Orhun Cig Taskin, Callisia N Clarke, Mert Erkan, Susan Tsai, Douglas B Evans, Volkan Adsay
Significant improvements have taken place in our understanding of classification neuroendocrine neoplasms of the pancreas in the past decade. These are now regarded in three entirely separate categories: (I) neuroendocrine tumors (PanNETs) are by definition well differentiated, the pancreatic counterpart of carcinoids; (II) neuroendocrine carcinomas, which are poorly differentiated (PDNEC), the pancreatic examples of small cell carcinomas or large cell neuroendocrine carcinomas; (III) other neoplasms that have neuroendocrine differentiation or a distinct neuroendocrine component...
June 2020: Journal of Gastrointestinal Oncology
Taro Shimizu, Rama Adikrisna, Ken Shimada, Kozue Uchidate, Keita Fukuda, Ayako Oyama, Masako Ueda, Fumio Goto, Masahiro Suzuki, Takahiro Kawamura
A 69-year-old male presented for an annual medical examination, and his chest X-ray showed an abnormal shadow. He presented to our hospital, and was diagnosed with typical carcinoid tumor of the lung by bronchoscopy. We recommended surgery, however the patient did not agree to the operation. One year later, two masses were detected in the liver. Ultrasound guided biopsy revealed that they were metastases from the atypical carcinoid tumor of the lung. We recommended chemotherapy, but he refused. Six months later, he was admitted to our hospital for symptoms of flushing, fever, watery diarrhea, and palpitations...
2020: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Nina R Sluiter, Jarmila D van der Bilt, Dorothée M R Croll, Menno R Vriens, Ignace H J T de Hingh, Patrick Hemmer, Arend G J Aalbers, Andreas J A Bremers, Wim Ceelen, Andre D'Hoore, Linda J Schoonmade, Veerle Coupé, Henk Verheul, Geert Kazemier, Jurriaan B Tuynman
BACKGROUND: The value of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneally metastasized goblet-cell carcinoids (GCCs) and mixed adenoneuroendocrine carcinomas (MANECs) is currently unclear. We compared outcomes of CRS-HIPEC to surgery alone for peritoneally metastasized GCCs and MANECs. PATIENTS AND METHODS: Two cohorts were obtained from the Netherlands Cancer Registry (n = 569): patients with peritoneally metastasized GCCs and MANECs treated with CRS-HIPEC in Dutch and Belgian centers (n = 45), and patients treated with surgery alone...
January 30, 2020: Clinical Colorectal Cancer
Tomasz Marjanski, Robert Dziedzic, Danush Davoodi, Sofie Josefsson, Wioletta Sawicka, Witold Rzyman
Background: The incidence of lung cancer in the population of patients younger than 50 years of age is relatively low. The aim of this study was to compare the clinical outcomes of patients with early lung cancer onset (ELCO, onset before the age of 50) and late lung cancer onset (LLCO, onset after the age of 50). Methods: We have retrospectively analyzed the prospectively collected data of 1,518 patients with lung cancer treated in a Thoracic Surgery Department in the years 2007-2015...
May 2020: Journal of Thoracic Disease
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