Chun-Liang Yang, Fa-Xi Wang, Jia-Hui Luo, Shan-Jie Rong, Wan-Ying Lu, Qi-Jie Chen, Jun Xiao, Ting Wang, Dan-Ni Song, Jing Liu, Qian Mo, Shuo Li, Yu Chen, Ya-Nan Wang, Yan-Jun Liu, Tong Yan, Wei-Kuan Gu, Shu Zhang, Fei Xiong, Qi-Lin Yu, Zi-Yun Zhang, Ping Yang, Shi-Wei Liu, Decio Eizirik, Ling-Li Dong, Fei Sun, Cong-Yi Wang
Dysregulated T cell activation underpins the immunopathology of rheumatoid arthritis (RA), yet the machineries that orchestrate T cell effector program remain incompletely understood. Herein, we leveraged bulk and single-cell RNA sequencing data from RA patients and validated protein disulfide-isomerase A3 (PDIA3) as a potential therapeutic target. PDIA3 is remarkably upregulated in pathogenic CD4 T cells derived from RA patients and positively correlates with C-reactive protein (CRP) level and disease activity score 28 (DAS28)...
May 30, 2024: Molecular Therapy