Lindsey E Bazzone, Junji Zhu, Michael King, GuanQun Liu, Zhiru Guo, Christopher R MacKay, Pyae P Kyawe, Natasha Qaisar, Joselyn Rojas-Quintero, Caroline A Owen, Abraham L Brass, William McDougall, Christina E Baer, Timothy Cashman, Chinmay M Trivedi, Michaela U Gack, Robert W Finberg, Evelyn A Kurt-Jones
Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis, but the mechanisms are poorly understood. We previously identified A Disintegrin And Metalloproteinase domain 9 (ADAM9) as an important factor in viral pathogenesis. ADAM9 is implicated in a range of human diseases, including inflammatory diseases; however, its role in viral infection is unknown. Here, we demonstrate that mice lacking ADAM9 are more susceptible to encephalomyocarditis virus (EMCV)-induced death and fail to mount a characteristic type I IFN response...
May 16, 2024: Nature Communications