H Salvator, N Mahlaoui, F Suarez, A Marcais, E Longchampt, C Tcherakian, C Givel, A Chabrol, E Caradec, O Lortholary, F Lanternier, C Goyard, L J Couderc, E Catherinot
Chronic Granulomatosis Disease (CGD) is an inherited immune deficiency due to a mutation in the genes coding for the subunits of the NADPH oxidase enzyme that affects the oxidative capacity of phagocytic cells. It is characterized by increased susceptibility to bacterial and fungal infections, particularly Aspergillus, as well as complications associated with hyperinflammation and granulomatous tissue infiltration. There exist two types of frequently encountered pulmonary manifestations: (1) due to their being initially pauci-symptomatic, possibly life-threatening infectious complications are often discovered at a late stage...
January 24, 2024: Revue des Maladies Respiratoires