Yonghao Pan, Jiawei Li, Jianqun Wu, Chengyu Yang, Siying Wu, Kunhua Yang, Xue Yang, Qian Chen, Guibing Fu, Chao Liu
Craniectomy is a lifesaving procedure to alleviate dangerously high intracranial pressure by removing a bone flap from the calvarium. However, the osteointegration of reimplanted bone flap with the existing bone tissue is still a clinical challenge. Hyperbaric oxygen (HBO) therapy has shown efficacy in promoting bone repair and could be a promising treatment for accelerating postoperative recovery. However, the specific cell types that are responsive to HBO treatment are not well understood. In this study, we created a murine model of craniectomy, with reimplantation of the cranial flap after 1 week...
May 15, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society