George Joy, Luis R Lopes, Matthew Webber, Alessandra M Ardissino, James Wilson, Fiona Chan, Iain Pierce, Rebecca K Hughes, Konstantinos Moschonas, Hunain Shiwani, Robert Jamieson, Paula P Velazquez, Ramya Vijayakumar, Erica Dall'Armellina, Peter W Macfarlane, Charlotte Manisty, Peter Kellman, Rhodri H Davies, Maite Tome, Vladan Koncar, Xuyuan Tao, Christoph Guger, Yoram Rudy, Alun D Hughes, Pier D Lambiase, James C Moon, Michele Orini, Gabriella Captur
BACKGROUND: Ventricular arrhythmia in hypertrophic cardiomyopathy (HCM) relates to adverse structural change and genetic status. Cardiovascular magnetic resonance (CMR)-guided electrocardiographic imaging (ECGI) noninvasively maps cardiac structural and electrophysiological (EP) properties. OBJECTIVES: The purpose of this study was to establish whether in subclinical HCM (genotype [G]+ left ventricular hypertrophy [LVH]-), ECGI detects early EP abnormality, and in overt HCM, whether the EP substrate relates to genetic status (G+/G-LVH+) and structural phenotype...
March 19, 2024: Journal of the American College of Cardiology