Nhi T Tran, Tayla R Penny, Kyra Yy Chan, Tanya Tang, Paris C Papagianis, Tara Sepehrizadeh, Lakshmi Nekkanti, Valerie A Zahra, Yen Pham, Tamara Yawno, Ilias Nitsos, Sharmony B Kelly, Alison M Thiel, Michael de Veer, Dhafer M Alahmari, Michael C Fahey, Graham Jenkin, Suzanne L Miller, Robert Galinsky, Graeme R Polglase, Courtney A McDonald
BACKGROUND: Umbilical cord blood (UCB) cells are a promising treatment for preterm brain injury. Access to allogeneic sources of UCB cells offer the potential for early administration to optimise their therapeutic capacities. As preterm infants often require ventilatory support, which can contribute to preterm brain injury, we investigated the efficacy of early UCB cell administration following ventilation to reduce white matter inflammation and injury. METHODS: Preterm fetal sheep (0...
May 8, 2024: Journal of Neuroinflammation