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JOURNAL ARTICLE
Karina Mescouto de Melo, Fabíola Scancetti Tavares, Thales Silva Antunes, Antonio Condino-Neto, Gesmar Rodrigues Silva Segundo, Antônio Carlos Tanajura de Macedo, Alexandre Paz Ferreira, Cláudia França Cavalcante Valente
Background: Autosomal recessive interleukin (IL)-12p40 deficiency is a genetic etiology of Mendelian susceptibility to mycobacterial disease (MSMD). It has been described in ∼50 patients, usually with onset at childhood with Bacille Calmette-Guérin (BCG) and Salmonella infections. Case Presentation: A male patient born to consanguineous parents was diagnosed with presumed lymph node MSMD at the age of 13 years after ocular symptoms. A positive history of inborn error of immunity was present: BCG reaction, skin abscess, and recurrent oral candidiasis...
March 2024: Pediatric Allergy, Immunology, and Pulmonology
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JOURNAL ARTICLE
Wenhui Liu, Wenzhe Zhang, Chen Wang, Jiarun Song, Kaiyue Li, Xia Zhang, Xinyi Wu, Hui Guo
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs), leading to irreversible visual function impairment. Sustained increase in intraocular pressure represents a major risk factor for glaucoma, yet the underlying mechanisms of RGC apoptosis induced by intraocular pressure remains unclear. This study aims to investigate the role of TRPV4 in RGC apoptosis in a rat model of chronic ocular hypertension (COH) and the underlying molecular mechanism. In the COH rat models, we evaluated the visual function, retinal pathological changes and RGC apoptosis...
March 7, 2024: International Immunopharmacology
#23
EDITORIAL
Elisabeth M Messmer
No abstract text is available yet for this article.
March 2024: Ophthalmologie
#24
JOURNAL ARTICLE
Ann Cathrine Larsen, Marie Louise Roed Rasmussen
Vernal keratoconjunctivitis (VKC) is a rare yet severe form of allergic conjunctivitis predominantly affecting children, mainly boys, with a global prevalence and a higher incidence in certain geographical regions. The disease is characterized by seasonal exacerbations. VKC presents with ocular surface inflammation leading to various distressing symptoms such as itching, redness, mucous discharge, and pain. The disease primarily manifests bilaterally, though it may initially appear unilaterally. If left untreated, VKC can result in corneal complications, including shield ulcers and vision impairment, affecting daily activities and psychosocial well-being, especially in children...
March 4, 2024: Ophthalmology and Therapy
#25
JOURNAL ARTICLE
Zhifeng Huang, Aoli Li, Huiqing Zhu, Junxiu Pan, Jun Xiao, Jiang Wu, Yumin Han, Lili Zhong, Xuhui Sun, Lei Wang, Liang Hu, Cuihua Wang, Xingkai Ma, Zaixia Qiao, Min Zhang, Ling Yuan, Xin Liu, Jun Tang, Yue Li, Hong Yu, Zhaobing Zheng, Baoqing Sun
This study is nationwide multicenter epidemiological research, aimed at investigating the distribution changes and seasonal patterns of various airborne allergens among preschool children with allergic rhinitis (AR) in different regions of China, and analyzing the clinical correlation between sensitization to various airborne allergens and AR symptoms in children. Information on children was collected through standard questionnaires, and total IgE (tIgE) and specific IgE (sIgE) for 11 inhalant allergens were tested...
February 27, 2024: Scientific Reports
#26
JOURNAL ARTICLE
Heath Rose, Leonard Bielory
PURPOSE: To better understand the patient journey and challenges in the diagnosis and treatment of patients with vernal keratoconjunctivitis (VKC). METHODS: This qualitative study assessed the experience of caregivers of children with VKC (n = 7) and of clinicians who treat VKC (n = 16) in the United States. The structured interviews were conducted to identify key "pain points", obstacles, and trends on the path to diagnosis. RESULTS: Like an earlier study conducted in the United Kingdom, this study found low awareness of the nature and severity of VKC among U...
February 19, 2024: Journal of Pediatric Ophthalmology and Strabismus
#27
REVIEW
Stefan Kassumeh, Barbara S Brunner, Siegfried G Priglinger, Elisabeth M Messmer
BACKGROUND: In severe and recurrent ocular allergies conventional ophthalmic drugs can reach their limits, especially in chronic forms. The first novel immunomodulators and biologicals are already in clinical use and could provide relief. OBJECTIVE: Based on the immunopathophysiological mechanisms of ocular allergies, possible targets for innovative treatment approaches are presented. An overview of promising new and future immunomodulators and biologicals and their modes of action is also given...
February 16, 2024: Ophthalmologie
#28
JOURNAL ARTICLE
Yang Qin, Weijun Huang, Rui Zheng, Qixing Wang, Qingqing Yu, Yin Li, Kai Wang, Jun Tang
BACKGROUND: The efficacy and safety of the novel immunotherapy method, intra-cervical lymphatic immunotherapy (ICLIT), need to be investigated. Comparing it with subcutaneous immunotherapy (SCIT), we clarified the long-term efficacy and safety of intra-cervical lymphatic immunotherapy on allergic rhinitis (AR), and investigated the improvement of clinical efficacy of the booster injection at 1 year after ICLIT treatment. METHODS: Ninety adult patients with dust mite allergy were randomly divided into 3 groups: 30 in the SCIT group, 30 in the ILCLIT group, and 30 in ICLIT booster group...
February 2024: Clinical and Translational Allergy
#29
JOURNAL ARTICLE
Youssef Abdelmassih, Maxime Makhoul, Mohammad Issa, George Sukkarieh, Daniel Cherfan, Sylvain El-Khoury
AIM: To report on the distribution of eye diseases, aetiologies of severe visual impairment/blindness (SVI/BL) and unmet eye care needs of the Syrian refugee population and the Lebanese host community. METHODS: This retrospective study analysed the data of patients that were examined during the Ayounkon project -an eye health care project offering medical and surgical treatment for Syrian refugees and Lebanese host community in the Bekaa Valley in Lebanon. The project took place in three different primary health care centres and involved cooperation between several NGOs and ophthalmologists working on a voluntary basis...
February 9, 2024: International Ophthalmology
#30
REVIEW
Elisabeth M Messmer, Siegfried G Priglinger, Stefan Kassumeh
BACKGROUND: Vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are complex and rare diseases. Thus, their diagnosis and treatment are often a challenge. OBJECTIVE: Discussion on the epidemiology, new pathogenetic concepts, interesting clinical findings, diagnostic possibilities and new treatment options and their side effects in severe ocular allergies. Analysis of the presentation of VKC in the internet. MATERIAL AND METHODS: Evaluation of recent review articles, original publications, and case reports on the topics of VKC and AKC over the past 5 years...
March 2024: Ophthalmologie
#31
JOURNAL ARTICLE
Bernardo Sousa-Pinto, Arunas Valiulis, Erik Melén, Gerard H Koppelman, Nikolaos G Papadopoulos, Mika Makela, Tari Haahtela, Matteo Bonini, Fulvio Braido, Luisa Brussino, Alvaro A Cruz, Alessandro Fiocchi, Mattia Giovannini, Bilun Gemicioglu, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Violeta Kvedariene, Désirée E Larenas-Linnemann, Renaud Louis, Mario Morais-Almeida, Marek Niedoszytko, Markus Ollert, Oliver Pfaar, Frederico S Regateiro, Graham Roberts, Boleslaw Samolinski, Marine Savouré, Luis Taborda-Barata, Sanna Toppila-Salmi, Maria Teresa Ventura, Marta Vazquez-Ortiz, Rafael José Vieira, Joao A Fonseca, Arzu Yorgancioglu, Torsten Zuberbier, Josep M Anto, Jean Bousquet, Nhân Pham-Thi
BACKGROUND: In allergic rhinitis and asthma, adolescents and young adult patients are likely to differ from older patients. We compared adolescents, young adults and adults on symptoms, control levels, and medication adherence. METHODS: In a cross-sectional study (2015-2022), we assessed European users of the MASK-air mHealth app of three age groups: adolescents (13-18 years), young adults (18-26 years), and adults (>26 years). We compared them on their reported rhinitis and asthma symptoms, use and adherence to rhinitis and asthma treatment and app adherence...
February 2024: Pediatric Allergy and Immunology
#32
REVIEW
Roselie Achten, Judith Thijs, Marlot van der Wal, Chantal van Luijk, Daphne Bakker, Edward Knol, Matthijs van Luin, Mohsin El Amrani, Eveline Delemarre, Ahmed M I Elfiky, Joke de Boer, Femke van Wijk, Marlies de Graaf, Marjolein de Bruin-Weller
Atopic dermatitis (AD) is a chronic inflammatory skin disease for which new targeted therapies are currently available. Due to the increased rates of ocular surface disease (OSD) reported during treatment with these new targeted treatments, more insight into the occurrence and pathomechanism of OSD in moderate-to-severe AD patients is needed. Therefore, this review's first part highlights that most patients with moderate-to-severe AD already have characteristics of OSD before starting targeted treatment. Remarkably, not all AD patients with OSD report ocular symptoms...
February 8, 2024: Clinical and Experimental Allergy
#33
JOURNAL ARTICLE
Zalak Shah, Dipali Purohit, Parul Danayak
PURPOSE: To study the clinical and tomographic characteristics and associations of keratoconus (KC) patients visiting a tertiary eye care hospital. METHODS: This was a cross-sectional, observational study that included 242 newly diagnosed clinical KC patients. Detailed ocular and systemic history, visual complaints, habit of eye rubbing, best spectacle-corrected visual acuity (BSCVA), retinoscopy reflex, detailed slit-lamp examination and tomographic findings, and presence of any ocular and systemic associations were documented for the included patients...
February 5, 2024: Indian Journal of Ophthalmology
#34
JOURNAL ARTICLE
Decoding Therapeutic Applications of Quercetin: Recent Advancements in Nanotechnological Strategies.
Sonam Grewal, Neha Tiwary, Gaurav Malik, Madhukar Garg, Geeta Deswal, Bhawna Chopra, Ajmer Singh Grewal, Ashwani K Dhingra, Kumar Guarve
For centuries, people have used herbal medicine to treat a diversity of health complications and as a natural substance, they have a favourable effect on our health. Herbal ingredients can be utilized as lead molecules in the innovation and development of a new drug. Flavonoids are a class of chemical compounds with diverse phenolic structures, and they are found in a wide variety of foods, including fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. Quercetin is the most prevalent polyphenolic bioflavonoid or flavonoid...
January 17, 2024: Pharmaceutical Nanotechnology
#35
JOURNAL ARTICLE
Kathrin Thormann, Anne-Sophie Lüthi, Felix Deniau, Anja Heider, Simone Cazzaniga, Susanne Radonjic-Hoesli, Mathias Lehmann, Christoph Schlapbach, Elio L Herzog, Marco Kreuzer, Martin S Zinkernagel, Cezmi A Akdis, Denise C Zysset-Burri, Hans-Uwe Simon, Dagmar Simon
BACKGROUND: Dupilumab is used for the treatment of atopic dermatitis (AD). Approximately one third of AD patients develop a dupilumab-associated ocular surface disease (DAOSD), of which the pathomechanism is poorly understood. This study aimed at investigating inflammatory markers in tear fluids of patients on dupilumab therapy. METHODS: Tear fluids were collected from AD patients with DAOSD (ADwDAOSD), AD patients without DAOSD (ADw/oDAOSD), and non-AD patients before and during dupilumab therapy, and analyzed using a specialized proteomic approach quantifying inflammatory markers...
February 5, 2024: Allergy
#36
JOURNAL ARTICLE
Yutaka Omatsu, Yumiko Shimizu, Tomoko Haruki, Yoshitsugu Inoue, Dai Miyazaki
BACKGROUND: Atopic conditions are known to be associated with viral and bacterial infections. The purpose of this study was to determine the relationship between the effects of atopic conditions on the severity and recurrence of ocular infections including herpes simplex virus (HSV). METHODS: This study was performed on 474 consecutive patients with infectious keratitis caused by bacteria, fungus, acanthamoeba, HSV, or varicella-zoster virus. The relationships between the atopic condition and specific infectious pathogens and HSV were determined using real-time PCR...
February 2, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#37
JOURNAL ARTICLE
Maria Cristina Artesani, Sara Urbani, Carla Riccardi, Mariacristina Esposito, Paola De Angelis, Francesca Rea, Renato Tambucci, Monica Malamisura, Luca Buzzonetti, Alessandro Giovanni Fiocchi
Vernal keratoconjunctivitis (VKC) is a bilateral ocular inflammatory disease with a conjunctival and corneal involvement and typical onset during childhood. Eosinophilic esophagitis (EoE) is a chronic disease characterized by eosinophilic inflammation of the mucosa (≥15 eosinophils/HPF) and symptoms of esophageal dysfunction. EoE and VKC are both immune-mediated diseases sharing a similar pathogenetic mechanism and a high association with other allergic diseases. Nevertheless, no data are currently available about their clinical association...
January 2024: World Allergy Organization Journal
#38
JOURNAL ARTICLE
Karolina S Engdahl, Dave C Brodbelt, Carla Cameron, David B Church, Dan G O'Neill
BACKGROUND: The English Cocker Spaniel (ECS) is one of the most popular dog breeds in the UK but information on disorder predisposition and protection is limited. Using anonymised veterinary clinical data from the VetCompass™ Programme, this study aimed to compare disorder predisposition and protection between the ECS and the remaining dogs under primary veterinary care in the UK during 2016. Electronic patient records for random samples of ECS and non-ECS were reviewed. The most common disorders diagnosed during 2016 were extracted and compared using multivariable logistic regression, controlling for confounders...
January 18, 2024: Canine medicine and genetics
#39
JOURNAL ARTICLE
Xue Zhang, Qiang Hu, Bo Jiang, Fang Xie, Zhongyu Zhang, Ali Hafezi-Moghadam, Dawei Sun
BACKGROUND: Retinal ischemia-reperfusion (I/R) serves as a significant contributor to ocular diseases, triggering a cascade of pathological processes. The interplay between neuroinflammation and the apoptosis of retinal ganglion cell (RGC) is a well-explored aspect of retinal I/R-induced tissue damage. Within this intricate landscape, the inflammatory cytokine Interleukin-21 (IL21) emerges as a potent mediator of neuroinflammation with known detrimental effects on neuronal integrity. However, its specific impact on RGC apoptosis in the context of retinal I/R has remains to be uncovered...
January 8, 2024: International Immunopharmacology
#40
JOURNAL ARTICLE
Farah Choulli, Hassan Abdelilah Tafenzi, Faiçal El Hattimy, Mohamed Khaled Choulli, Rhizlane Belbaraka
BACKGROUND: Although the side effects of chemotherapy are frequently described in research studies, there is little evidence on how common they are in everyday clinical care. This study's goal was to assess the most prevalent short-term side effects experienced by patients with localized breast cancer, undergoing chemotherapy based on anthracyclines and taxane-containing treatments, at the medical oncology department of the Mohammed VI University Hospital of Marrakech, Morocco. METHODS: This was a descriptive study...
January 2, 2024: BMC Cancer
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