Mee-Hyun Lee, Do Young Lim, Myoung Ok Kim, Sung-Young Lee, Seung Ho Shin, Jae Young Kim, Sung-Hyun Kim, Dong Joon Kim, Sung Keun Jung, Ke Yao, Joydeb Kumar Kundu, Hye Suk Lee, Cheol-Jung Lee, Sally E Dickinson, David Alberts, G Timothy Bowden, Steven Stratton, Clara Curiel, Janine Einspahr, Ann M Bode, Young-Joon Surh, Yong-Yeon Cho, Zigang Dong
Solar ultraviolet irradiation is an environmental carcinogen that causes skin cancer. Caspase-7 is reportedly expressed at reduced levels in many cancers. The present study was designed to examine the role of caspase-7 in solar-simulated light (SSL)-induced skin cancer and to elucidate its underlying molecular mechanisms. Our study revealed that mice with genetic deficiency of caspase-7 are highly susceptible to SSL-induced skin carcinogenesis. Epidermal hyperplasia, tumor volume and the average number of tumors were significantly increased in caspase-7 knockout (KO) mice compared with SKH1 wild-type mice irradiated with SSL...
November 2015: Carcinogenesis