Septic peritonitis

Zbigniew Tański, Zbigniew Jarząbek, Bartosz Konowalski, Maciej Truszkowski, Jakub Biedrzycki, Bolesław Kuzaka, Piotr Kuzaka
The aim of our study was to evaluate of short-term outcomes of 4210 patients who underwent open abdominal surgery with used either single-layer, absorbable, or continuous sutures. Seromuscular anastomosis were presented (without mucosa). Fluid therapy: GDT and zero-balance GDT were also discussed. Anastomosis leakage developed in 6 patients. They were treated by creating a stoma. Simultaneously, septic shock was treated. Re-anastomoses were performed after some time and after sepsis was suppressed. Results of treatment with use of double-layer sutures, which was is use before 1978, were presented...
August 31, 2019: Polski Przeglad Chirurgiczny
Omer Lerman, Inbar Israeli, Tomer Weingram, Hadas Benzioni-Bar, Josh Milgram, Anna Shipov
OBJECTIVE: To describe acute mesenteric infarction due to suspected Spirocerca lupi aberrant migration in 5 dogs. CASE SERIES SUMMARY: All dogs were large breed, none of which exhibited typical clinical signs associated with spirocercosis. All dogs were eventually diagnosed with septic peritonitis. On exploratory laparotomy, thickening of the jejunal arteries, surrounding mesojejunum, and segmental necrosis were identified. Similar thickening and hematoma formation were found in other regions of the mesentery...
November 2019: Journal of Veterinary Emergency and Critical Care
Şükrü Çolak, Hasan Bektaş
BACKGROUND: A rare cause of acute abdomen or intestinal obstruction, the abdominal cocoon syndrome is also described in the literature as sclerosing peritonitis or sclerosing encapsulating peritonitis. Abdominal cocoon is characterized by the total or partial wrapping of the abdominal organs by a fibrous membrane. Although it is usually observed in young women, the etiology is unknown. The diagnosis is usually made during laparotomy. In this case series, we aimed to present seven patients diagnosed with abdominal cocoon syndrome during operation...
October 2019: Turkish Journal of Trauma & Emergency Surgery: TJTES
Bo Ye, Tianzhu Tao, Andong Zhao, Liyuan Wen, Xiaofei He, Yi Liu, Qiang Fu, Weidong Mi, Jingsheng Lou
Sepsis-associated encephalopathy (SAE) is a poorly understood condition that leads to long-term cognitive impairment and increased mortality in survivors. Recent research revealed that IL-17A/IL-17R might serve as a checkpoint in microglia-mediated neuroinflammation. The present study was designed to determine the specific role of IL-17A-mediated microglia activation in the development of SAE. A mouse model of SAE was induced by cecal ligation and puncture (CLP), and behavior performance was evaluated by the inhibitory avoidance test and the open field test...
2019: Mediators of Inflammation
Stijn Blot, Massimo Antonelli, Kostoula Arvaniti, Koen Blot, Ben Creagh-Brown, Dylan de Lange, Jan De Waele, Mieke Deschepper, Yalim Dikmen, George Dimopoulos, Christian Eckmann, Guy Francois, Massimo Girardis, Despoina Koulenti, Sonia Labeau, Jeffrey Lipman, Fernando Lipovestky, Emilio Maseda, Philippe Montravers, Adam Mikstacki, José-Artur Paiva, Cecilia Pereyra, Jordi Rello, Jean-Francois Timsit, Dirk Vogelaers
PURPOSE: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). METHODS: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection...
October 29, 2019: Intensive Care Medicine
Katherine Maria Scotti, Amy Koenigshof, Loren S H Sri-Jayantha, Michael Kato, Micah Bishop, James W Barr, Medora B Pashmakova
OBJECTIVE: To identify physical exam findings, clinicopathological parameters, time to surgery, empirical antimicrobial use, and culture results that could be associated with outcome in cats with septic peritonitis (SP). DESIGN: Retrospective cohort study of cats from 2002 to 2015. SETTING: Four university teaching hospitals. ANIMALS: Eighty-three cats diagnosed with SP by cytology or culture. INTERVENTIONS: None MEASUREMENTS AND MAIN RESULTS: Fifty-eight cats survived to discharge (69...
October 26, 2019: Journal of Veterinary Emergency and Critical Care
Clara Vigneron, Adrien Mirouse, Hamid Merdji, Christophe Rousseau, Clément Cousin, Fanny Alby-Laurent, Jean-Paul Mira, Jean-Daniel Chiche, Jean-François Llitjos, Frédéric Pène
Sepsis-induced immune dysfunctions are likely to impact on malignant tumor growth. Sequential sepsis-then-cancer models of tumor transplantation in mice recovering from sepsis have shown that the post-septic immunosuppressive environment was able to promote tumor growth. We herein addressed the impact of sepsis on pre-established malignancy in a reverse cancer-then sepsis experimental model. Mice previously inoculated with MCA205 fibrosarcoma cells were subjected to septic challenges by polymicrobial peritonitis induced by cecal ligation and puncture or endotoxinic shock...
2019: Oncoimmunology
Hannah Marshall, Virginia Sinnott-Stutzman, Patty Ewing, Kiko Bracker, Russell Kalis, Roxanna Khorzad
OBJECTIVE: To evaluate bacterial isolates, antimicrobial drug susceptibility, and change in resistance among pre- and post-lavage culture samples in dogs with septic peritonitis. DESIGN: Prospective observational study. SETTING: Private practice referral hospital. ANIMALS: Forty client-owned dogs with confirmed septic peritonitis requiring surgical intervention. INTERVENTIONS: All dogs had perioperative abdominal lavage following source control with 200 to 300 mL/kg 0...
October 21, 2019: Journal of Veterinary Emergency and Critical Care
Sébastien Gibot, Lucie Jolly, Jérémie Lemarié, Kevin Carrasco, Marc Derive, Amir Boufenzer
TREM-1 (Triggering Receptor Expressed on Myeloid cells-1) is an immunoreceptor expressed on neutrophils, monocytes/macrophages, and endothelial cells. It amplifies the inflammatory response driven by Toll-Like Receptors (TLR) engagement. The pharmacological inhibition of TREM-1 confers protection in several pre-clinical models of acute inflammation. In this study, we aimed to investigate the role of TREM-1 in endothelial cells using a sneaking ligand construct (SLC) inhibiting TREM-1 in the endothelium. The SLC was made of 3 modules: an E-selectin targeting domain, a Pseudomonas aeruginosa exotoxin a translocation domain, and a 7 aa peptide (LSKSLVF) that contains the interaction site between TREM-1 and its adaptor protein DAP-12...
2019: Frontiers in Immunology
Andrzej Gryglewski, Piotr Richter, Monika Majewska-Szczepanik, Marian Szczepanik
BACKGROUND: It has previously been shown that appropriate distribution of immune cells between different tissues and organs of the body is required for proper function of the immune system. Our previous work demonstrated that surgical trauma in mice induces γδT lymphocyte migration from peripheral blood to the peritoneal lymphoid organs. These described γδT cells have immunoregulatory activity as they suppress the cell-mediated immune response in vitro. We found a similar phenomenon in patients after different surgical operations...
September 30, 2019: ANZ Journal of Surgery
Qianqian Zhang, Hong Sun, Shougang Zhuang, Na Liu, Xiaowei Bao, Xiandong Liu, Huijuan Ren, Diyu Lv, Zhe Li, Jianwen Bai, Xiaohui Zhou, Lunxian Tang
The function of histone methyltransferase enhancer of zeste homolog 2 (EZH2) in sepsis remains unknown. We reported here that the expression of EZH2 and H3K27me3 was significantly upregulated in the circulation of septic patients, whereas patients who survived presented downregulated the expression of EZH2 on CD14+ monocytes. We further identified increased expression of EZH2 in the circulation, peritoneal fluid, and septic lungs from CLP mice. 3-DZNeP treated CLP mice improved mortality and protected from organ injury...
September 10, 2019: International Immunopharmacology
Kristen N Morrow, Craig M Coopersmith, Mandy L Ford
Sepsis is a major cause of morbidity and mortality worldwide despite numerous attempts to identify effective therapeutics. While some sepsis deaths are attributable to tissue damage caused by inflammation, most mortality is the result of prolonged immunosuppression. Ex vivo , immunosuppression during sepsis is evidenced by a sharp decrease in the production of pro-inflammatory cytokines by T cells and other leukocytes and increased lymphocyte apoptosis. This allows suppressive cytokines to exert a greater inhibitory effect on lymphocytes upon antigen exposure...
2019: Frontiers in Immunology
Anne-Cécile Morvan, Baptiste Hengy, Maïté Garrouste-Orgeas, Stéphane Ruckly, Jean-Marie Forel, Laurent Argaud, Thomas Rimmelé, Jean-Pierre Bedos, Elie Azoulay, Claire Dupuis, Bruno Mourvillier, Carole Schwebel, Jean-François Timsit
INTRODUCTION: Enterococcus species are associated with an increased morbidity in intraabdominal infections (IAI). However, their impact on mortality remains uncertain. Moreover, the influence on outcome of the appropriate or inappropriate status of initial antimicrobial therapy (IAT) is subjected to debate, except in septic shock. The aim of our study was to evaluate whether an IAT that did not cover Enterococcus spp. was associated with 30-day mortality in ICU patients presenting with IAI growing with Enterococcus spp...
September 6, 2019: Critical Care: the Official Journal of the Critical Care Forum
Alena Strelchik, Michelle C Coleman, Valery F Scharf, Regan M Stoneburner, Kelley M Thieman Mankin
OBJECTIVE: To report the intestinal incisional dehiscence rate following enterotomy for foreign body removal in dogs. ANIMALS: 247 client-owned dogs with intestinal foreign bodies treated with enterotomy between November 2001 and September 2017. PROCEDURES: Medical records were reviewed, and data were collected regarding signalment, history, surgery, clinicopathologic findings, hospitalization, intestinal incisional dehiscence, and survival to hospital discharge...
September 15, 2019: Journal of the American Veterinary Medical Association
Başak Göl Serin, Şükran Köse, Osman Yilmaz, Mehmet Yildirim, Ilkay Akbulut, Suheyla Serin Senger, Gülgün Akkoçlu, Gulden Diniz, Süha Serin
BACKGROUND: Intra-abdominal adhesions are still a major problem which is expected to be reduced by the provision of bacterial decontamination. Various antibiotics have been used to prevent the formation of adhesion in the septic abdomen. This study aims to investigate the efficacy of ertapenem in sepsis of rats induced by cecal ligation and puncture. METHODS: Twenty-eight Wistar rats were divided into four groups randomly. In all groups, bacterial peritonitis was created by cecal ligation and puncture method...
August 2019: Turkish Journal of Trauma & Emergency Surgery: TJTES
Joan Tymon-Rosario, Jessica M Atrio, Hyun Ah Yoon, David Erlichman, Veronica Lerner
Background: Previous reports have described cases of abscess formation by Streptococcus constellatus involving the oral cavity, gastrointestinal tract, and septic thrombophlebitis of the right ovarian vein with subsequent bacteremia and septic shock. Ascending infection from the genital tract to the fallopian tubes resulting in peritonitis from Streptococcus constellatus is a rare clinical circumstance where there is minimal information in the literature to guide its diagnosis, management, and expected prognosis...
2019: Case Reports in Obstetrics and Gynecology
Hongmei Tu, Xiaofei Lai, Jiaxi Li, Lili Huang, Yi Liu, Ju Cao
BACKGROUND: Sepsis is a serious syndrome that is caused by an unbalanced host inflammatory response to an infection. The cytokine network plays a pivotal role in the orchestration of inflammatory response during sepsis. IL-26 is an emerging proinflammatory member of the IL-10 cytokine family with multifaceted actions in inflammatory disorders. However, its role in the pathogenesis of sepsis remains unknown. METHODS: Serum IL-26 level was measured and analyzed in 52 septic patients sampled on the day of intensive care unit (ICU) admission, 18 non-septic ICU patient controls, and 30 healthy volunteers...
August 29, 2019: Critical Care: the Official Journal of the Critical Care Forum
Bruno Lopes Correia, Sara E Diniz, Eurico Lopes da Silva, Ricardo Rodrigues-Pinto
PURPOSE: To report and discuss a rare case of septic arthritis of a lumbar facet joint presenting as septic bacterial peritonitis and requiring surgical debridement. METHODS: A 55-year-old man, with a history of intravenous drug usage and hepatitis C, presented to the emergency department with fever, abdominal and lumbar pain. Examination showed ascites. Erythrocyte sedimentation rate and C-reactive protein were elevated. A paracentesis was performed, and a diagnosis of spontaneous bacterial peritonitis was assumed as acute on chronic liver failure...
August 29, 2019: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Sonya C Hansen, Katelyn C Hlusko, Brad M Matz, Lenore M Bacek
OBJECTIVE: To describe the postoperative use of gastrostomy tubes (GT) in dogs with septic peritonitis. A secondary objective was to identify factors associated with GT placement and use that may be related to outcome. DESIGN: Retrospective study. SETTING: University teaching hospital. ANIMALS: Twenty-four dogs diagnosed with septic peritonitis with GT placement at the time of exploratory laparotomy. INTERVENTIONS: None...
August 26, 2019: Journal of Veterinary Emergency and Critical Care
Simona Iacob, Diana Gabriela Iacob
The ecosystem of the gut microbiota consists of diverse intestinal species with multiple metabolic and immunologic activities and it is closely connected with the intestinal epithelia and mucosal immune response, with which it builds a complex barrier against intestinal pathogenic bacteria. The microbiota ensures the integrity of the gut barrier through multiple mechanisms, either by releasing antibacterial molecules (bacteriocins) and anti-inflammatory short-chain fatty acids or by activating essential cell receptors for the immune response...
2019: Frontiers in Microbiology
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