keyword
https://read.qxmd.com/read/38522946/prolonged-duration-of-action-of-suxamethonium-in-pregnant-and-postpartum-patients-a-registry-study
#1
JOURNAL ARTICLE
Helene Dalsten, Vera Crone, Jacob Steinmetz, Christine L Rosager, Lars S Rasmussen, Matias Vested
BACKGROUND: Suxamethonium is hydrolysed by butyrylcholinesterase (BChE) and a low BChE activity can result in a prolonged duration of action of suxamethonium. The BChE activity is reduced during pregnancy and postpartum period by up to 33%. However, it can also be reduced by mutations in the BChE gene. In this study, we assessed BChE activity and mutations in the BChE gene in pregnant and postpartum patients with prolonged duration of action of suxamethonium. It was hypothesised that at least 30% of patients with a low BChE activity did not have a mutation in the BChE gene...
March 24, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38323266/prognostication-and-prediction-of-outcomes-in-patients-with-organophosphorus-and-carbamate-poisoning-a-prospective-cohort-study
#2
JOURNAL ARTICLE
Avanish Jha, Darpanarayan Hazra, Bijesh Yadav, Anand Zachariah, Reginald Alex
BACKGROUND: Organophosphorus (OP) and carbamate poisoning are significant concerns in developing nations. This study evaluates the effectiveness of the ChE check mobile, a cholinesterase-rapid bedside diagnostic test, in the diagnosis and management of OP and carbamate poisoning. MATERIALS AND METHODS: We conducted this prospective observational study, involving patients with OP and carbamate poisoning over 1 year (June 2016 to June 2017) at a single tertiary care center...
February 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38043260/biodegradation-of-urethane-dimethacrylate-based-materials-cad-cam-resin-ceramic-composites-and-its-effect-on-the-adhesion-and-proliferation-of-streptococcus-mutans
#3
JOURNAL ARTICLE
Yiyan Yu, Xinwei Guo, Jiawen Chen, Yuanhang Zhao, Jiazhuo Song, Hamed Alshawwa, Xinying Zou, Hongyan Zhao, Zhimin Zhang
OBJECTIVE: To investigate whether urethane dimethacrylate (UDMA) -based dental restorative materials biodegrade in the presence of Streptococcus mutans (S. mutans) and whether the monomers affect the adhesion and proliferation of S. mutans in turn. METHODS: Cholesterol esterase and pseudocholinesterase-like activities in S. mutans were detected using p-nitrophenyl substrate. Two UDMA-based CAD/CAM resin-ceramic composites, Lava Ultimate (LU) and Vita Enamic (VE), and a light-cured UDMA resin block were co-cultured with S...
November 30, 2023: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/37884182/butyrylcholinesterase-signal-sequence-self-aggregates-and-enhances-amyloid-fibril-formation-in-vitro
#4
JOURNAL ARTICLE
Jacek Jasiecki, Monika Targońska, Anna Janaszak-Jasiecka, Leszek Kalinowski, Krzysztof Waleron, Bartosz Wasąg
Alzheimer's disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ plaques in AD. We have previously found that the BChE substitution in 5'UTR caused an in-frame N-terminal extension of 41 amino acids of the BChE signal peptide. The resultant variant with a 69 amino acid signal peptide, designated N-BChE, could play a role in AD development...
October 24, 2023: Chemico-biological Interactions
https://read.qxmd.com/read/37713081/detection-the-severity-of-organophosphate-intoxication-using-sensitive-serum-biomarkers-s100b-and-amyloid-%C3%AE-a%C3%AE-in-egyptian-subjects
#5
JOURNAL ARTICLE
Mostafa M Elhady, Sara A Adly, Husam A Elshebiny, Said S Moselhy
Organophosphate (OP) is a compound considered the main leading cause of morbidity and mortality from poisoning worldwide. Serum pseudocholinesterase was evaluated as a diagnostic indicator; it cannot be used to monitor therapy or severity of the intoxication. The rationale of the current study was to evaluate sensitivity, specificity, and cut-off values of serum S100B and amyloid β for neurological affection severity. This study was carried out on sixty OP-impaired patients; in addition, 20 normal controls were included...
September 15, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/37651250/alternate-biochemical-markers-in-organophosphate-poisoning
#6
JOURNAL ARTICLE
Austin J Mangaly, Chandni Radhakrishnan
In India, organophosphates are the most widely used pesticides for suicide by poisoning. Early recognition of the diagnosis and its severity will help in achieving a better outcome. In poisoning by organophosphorus compounds, serum acetylcholinesterase (AChE) and pseudocholinesterase are currently widely accepted as biochemical markers for estimating the severity. A wide array of alternate, cheap, and easily available markers are explored in this review and using a combination of these markers may be better in terms of early identification of severe poisoning...
August 2023: Journal of the Association of Physicians of India
https://read.qxmd.com/read/37132509/acetylcholine-structure-based-small-activatable-fluorogenic-probe-for-specific-detection-of-acetylcholinesterase
#7
JOURNAL ARTICLE
Jagpreet S Sidhu, Kalpana Rajendran, Abraham B Mathew, Tabish Iqbal, Deepak K Saini, Debasis Das
Early detection of Alzheimer's disease (AD) is important for taking proper measures against AD pathogenesis. Acetylcholinesterase (AChE) is widely reported to be associated with the pathogenicity of AD. Here, employing the "acetylcholine-mimic" approach, we designed and synthesized a new class of naphthalimide (Naph)-based fluorogenic probes for specific detection of AChE and avoiding interference of butyrylcholinesterase (BuChE), the pseudocholinesterase. We investigated the action of the probes on Electrophorus electricus AChE, and the native human brain AChE that we expressed in Escherichia coli and purified in the active form for the first time...
May 3, 2023: Analytical Chemistry
https://read.qxmd.com/read/36661099/pseudocholinesterase-deficiency-in-ophthalmology-a-systematic-review
#8
REVIEW
Tiffany Cheng, Michael Curley, Anne Barmettler
PURPOSE: Unexpected anesthesia-related complications are among the most feared outcomes of ambulatory surgery. One potential culprit is pseudocholinesterase deficiency, which most commonly presents with protracted apnea, necessitating prolonged mechanical ventilation. We report the first case of pseudocholinesterase deficiency in a Bengali person and the first systematic review of pseudocholinesterase deficiency in ophthalmology. This review analyzed the epidemiology, etiologies, presentation, evaluation, and treatment of pseudocholinesterase deficiency...
January 20, 2023: Orbit
https://read.qxmd.com/read/36652164/biomarkers-of-hepatocellular-synthesis-in-patients-with-decompensated-cirrhosis
#9
JOURNAL ARTICLE
Berivan Gurbuz, Nurdan Guldiken, Philipp Reuken, Lei Fu, Katharina Remih, Christian Preisinger, Radan Brůha, Martin Leníček, Jaromír Petrtýl, Johanna Reissing, Mahmoud Aly, Malin Fromme, Biaohuan Zhou, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Andreas Stallmach, Tony Bruns, Pavel Strnad
BACKGROUND AND AIM: Since hepatocytes produce majority of serum proteins, patients with cirrhosis display substantial alterations in the serum proteome. The aim of the current study was to characterize these changes and to study the prognostic utility of hepatocellular proteins available in routine clinical testing. METHODS: Sera from 29 healthy controls and 43 patients with cirrhosis were subjected to untargeted proteomic analysis. Unsupervised hierarchical clustering was performed with Perseus software and R...
January 18, 2023: Hepatology International
https://read.qxmd.com/read/36623829/diagnostic-value-of-fdg-pet-ct-in-the-diagnostic-work-up-of-inflammation-of-unknown-origin
#10
JOURNAL ARTICLE
Luisa Maria Knappe, Frederik Anton Verburg, Luca Giovanella, Markus Luster, Damiano Librizzi
Introduction The present study aims to evaluate the clinical diagnostic value of FDG-PET/CT in patients with inflammation of unknown origin. Material and methods We retrospectively analyzed data of 130 patients who presented general inflammatory symptoms and/or elevated level of CRP and underwent FDG-PET/CT for the purpose of identifying unknown foci of inflammation. The accuracy of PET/CT findings was assessed against the standard of eventual clinical diagnosis e.g. results of pathology, microbiology or other imaging methods...
January 9, 2023: Nuklearmedizin. Nuclear Medicine
https://read.qxmd.com/read/36551217/pseudocholinesterase-as-a-biomarker-for-untreated-wilson-s-disease
#11
JOURNAL ARTICLE
Harald Hefter, Max Arslan, Theodor S Kruschel, Max Novak, Dietmar Rosenthal, Sven G Meuth, Philipp Albrecht, Christian J Hartmann, Sara Samadzadeh
The aim of this study was to demonstrate that pseudocholinesterase (CHE) serum level is a useful diagnostic biomarker for untreated Wilson's disease (WD). Between 2013 and 2019, about 75 patients were referred to the outpatient department of the University of Düsseldorf with suspected Wilson's disease. In 31 patients with suspected Wilson's disease (WD-SUS-group), WD was excluded by means of investigations other than analysis of blood and urine. A total of 27 parameters of blood and urine in these 31 patients were compared to those of 20 de novo patients with manifest WD (WD-DEF-group), which parameter showed the highest significance level of difference between the WD-DEF-group and the WD-SUS-group...
November 30, 2022: Biomolecules
https://read.qxmd.com/read/36411874/ocular-cyclopentolate-a-mini-review-concerning-its-benefits-and-risks
#12
REVIEW
Homero Contreras-Salinas, Vanessa Orozco-Ceja, María Soledad Romero-López, Mayra Yolanda Barajas-Virgen, Leopoldo Martín Baiza-Durán, Lourdes Yolotzin Rodríguez-Herrera
Cycloplegic and mydriatic agents are essential in ophthalmological clinical practice since they provide the means for diagnosing and treating certain eye conditions. In addition, cyclopentolate has proven to possess certain benefits compared to other available cycloplegics and mydriatics. Still, the incidence of some adverse drug reactions related to this drug, especially in susceptible patients, has created interest in reviewing the literature about the benefits and risks of using cyclopentolate. A literature search was conducted in Medline/PubMed and Google Scholar, focusing on identifying cyclopentolate's benefits and risks; the most important benefit was its usefulness for evaluating refractive errors, especially for hyperopic children, pseudomyopia, anterior uveitis, treatment of childhood myopia, idiopathic vision loss, and during examinations before refractive surgery, with particular advantages compared to other cycloplegics...
2022: Clinical Ophthalmology
https://read.qxmd.com/read/36381386/is-serum-creatine-phosphokinase-level-useful-to-predict-the-severity-of-organophosphate-poisoning
#13
JOURNAL ARTICLE
Subrata Biswas, Ritwik Ghosh, Arpan Mandal, José Lapeña, Dipayan Roy, Julián Benito-León
Background and aim: Organophosphate poisoning is a global health burden due to intentional and occupational exposure, particularly in Asian countries. Patients are usually monitored through serum acetylcholinesterase levels. Still, it is non-specific, does not correlate well with the severity of poisoning, and is not widely available in laboratory settings in developing countries. This study aims to assess serum baseline creatine phosphokinase (CPK) levels as a prognostic biomarker in acute organophosphate poisoning...
September 2022: Medical Research Archives
https://read.qxmd.com/read/36322408/protective-effects-of-biebersteinia-multifida-on-sub-chronic-toxicity-of-dzn-in-male-wistar-rats-biochemical-hematological-and-oxidative-stress-indices
#14
JOURNAL ARTICLE
Fatemeh Esmailpour, Asieh Karimani, Mohammad Heidarpour, Amir Moghaddam Jafari
The protective effect of Biebersteinia Multifida on diazinon-induced toxicity in male Wistar rats was investigated over 8 weeks. Impacts of diazinon (10 mg/kg daily), Biebersteinia Multifida (500 mg/kg daily), and coadministration of them on oxidative stress parameters besides hematological and biochemical indices were assessed in various groups. The gas chromatography-mass spectrometry analysis was performed to identify the antioxidant components of plant extract by comparing the mass spectra and retention indices with those given in the literature...
November 2, 2022: Drug and Chemical Toxicology
https://read.qxmd.com/read/35991195/clinical-epidemiology-and-predictors-of-outcome-in-chlorpyrifos-poisoning-in-farming-and-allied-agricultural-workers-in-east-godavari-andhra-pradesh
#15
JOURNAL ARTICLE
Anand Acharya, Abinash Panda
Background: Chlorpyrifos is the ninth most consumed pesticide for agricultural purposes in India. It is a chlorinated organophosphate that also causes poisoning in non-target species such as humans. There is a scarcity of published literature on chlorpyrifos intoxication in the Indian scenario. Objective: The objective of the study was to find out the clinical epidemiology and factors influencing the outcome of chlorpyrifos poisoning in the farming and allied agricultural workers...
April 2022: Indian Journal of Occupational and Environmental Medicine
https://read.qxmd.com/read/35883545/concurrent-change-in-serum-cholinesterase-activity-and-midregional-proadrennomedullin-level-could-predict-patient-outcome-following-liver-transplantation
#16
JOURNAL ARTICLE
Sebastian O Decker, Albert Krüger, Henryk Wilk, Florian Uhle, Thomas Bruckner, Stefan Hofer, Markus A Weigand, Thorsten Brenner, Aleksandar R Zivkovic
BACKGROUND: After liver transplantation (LTX), patients are susceptible to opportunistic infections resulting in reduced outcomes within the early post-transplantation period. The postoperative monitoring of LTX patients has gained much importance in recent years. However, reliable plasmatic markers predicting 90-day outcomes are still lacking. METHODS: In the post hoc analysis of a prospective, observational study, butyrylcholinesterase (BChE), mid-regional proadrenomedullin (MR-proADM), as well as conventional inflammatory markers (procalcitonin, C-reactive protein) were evaluated in 93 patients at seven consecutive timepoints within the first 28 days following LTX...
July 15, 2022: Biomolecules
https://read.qxmd.com/read/35781444/influence-of-human-and-bacterial-enzymes-on-resin-restorations-a-review
#17
JOURNAL ARTICLE
Mohammed A Jafer, Amnah Aq Qadiri, Naseem A Mtwam, Aeshah H Hakami, Ahlam Am Mowkly, Shilpa Bhandi, Shankargouda Patil
BACKGROUND: Esthetic satisfaction has been a prime concern for patients. This has led to a surge in the development of esthetic restorations and dental composites in the field of restorative dentistry over the past decade. Resins are the most preferred restorative material. However, their failure rate was observed to be high. AIM: This review is aimed for clinician, discussing the influence of human and bacterial enzymes on resin restorations. REVIEW RESULTS: Composite restoration failure is multifactorial with an interplay of mechanical functions such as masticatory forces and abrasion with biological factors such as host modulated and bacterial enzymes...
March 1, 2022: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/35536082/effect-of-virus-inactivation-by-heating-on-routine-clinical-laboratory-indicators-in-serum
#18
JOURNAL ARTICLE
Chanyuan Zhang, Tiebing Liu, Shuli Liu, Guowei Jia, Xuejing Wang
BACKGROUND: Highly infectious viruses such as SARS-CoV-2, MERS-CoV, and Ebola virus represent a threat to clinical laboratory workers. We aimed to investigate how virus inactivation by heating at 60°C for 1 hour affects routine clinical laboratory indicators. METHODS: Each collected serum sample was separated into two aliquots, and various indicators were measured in first aliquot after inactivation by heating at 60°C for 1 hour and in the second after room-temperature incubation for 1 hour...
May 1, 2022: Clinical Laboratory
https://read.qxmd.com/read/35426937/a-prolonged-paralysis-with-succinylcholine-in-pseudocholinesterase-deficiency-an-undesired-effect
#19
JOURNAL ARTICLE
Sameer Acharya, Samjhauta Bhattarai, Isha Shrimanker, Sushilkumar Satish Gupta
No abstract text is available yet for this article.
April 15, 2022: QJM: Monthly Journal of the Association of Physicians
https://read.qxmd.com/read/34639003/butyrylcholinesterase-protein-interactions-in-human-serum
#20
JOURNAL ARTICLE
Jacek Jasiecki, Anna Szczoczarz, Dominik Cysewski, Krzysztof Lewandowski, Piotr Skowron, Krzysztof Waleron, Bartosz Wasąg
Measuring various biochemical and cellular components in the blood is a routine procedure in clinical practice. Human serum contains hundreds of diverse proteins secreted from all cells and tissues in healthy and diseased states. Moreover, some serum proteins have specific strong interactions with other blood components, but most interactions are probably weak and transient. One of the serum proteins is butyrylcholinesterase (BChE), an enzyme existing mainly as a glycosylated soluble tetramer that plays an important role in the metabolism of many drugs...
October 1, 2021: International Journal of Molecular Sciences
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