Jie Zhang, Lei Cao, Lijuan Lyu, Wenqian Qi, Wei Yang, Ruiqing Ren, Chunyu Kao, Yun Zhang, Cheng Zhang, Meng Zhang
Transforming growth factor-β (TGF-β) activated kinase 1 (TAK1), also named mitogen-activated protein kinase 7 (MAPK7), forms a pivotal signaling complex with TAK1-binding proteins (TAB1, TAB2, and TAB3), orchestrating critical biological processes, including immune responses, cell growth, apoptosis, and stress responses. Activation of TAK1 by stimuli, such as tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and Toll-like receptors (TLRs), underscores its central role in cellular signaling...
April 29, 2024: Frontiers in Bioscience (Landmark Edition)