Hong-Mei Li, Ji Hye Jang, Jun-Sub Jung, Jiseon Shin, Chul O Park, Yeon-Ja Kim, Won-Gyun Ahn, Ju-Suk Nam, Chang-Won Hong, Jongho Lee, Yu-Jin Jung, Jiang-Fan Chen, Katya Ravid, H Thomas Lee, Won-Ki Huh, Janusz H Kabarowski, Dong-Keun Song
G2A is a GPCR abundantly expressed in immune cells. G2A-/- mice showed higher lethality, higher plasma cytokines, and an impaired bacterial clearance in response to a murine model of sepsis (cecal ligation and puncture), which were blocked by GdCl3 , an inhibitor of Kupffer cells. Anti-IL-10 Ab reversed the impaired bacterial clearance in G2A-/- mice. Indomethacin effectively blocked both the increased i.p. IL-10 levels and the impaired bacterial clearance, indicating that disturbed PG system is the proximal cause of these phenomena...
December 10, 2018: Journal of Immunology