Jiajian Wang, Caihong Liu, Tingting Wang, Sidi Li, Yunmeng Bai, Fulin Pan, Jiayi Wang, Jing Han, Ruibin Luo, Xing Wan, Haiyan Cui, Yingcai Huang, Mingqi Zheng, Xiaoping Hong, Jian V Zhang, Ruihuan Xu
BACKGROUND: Synovial fibroblasts are critical for maintaining homeostasis in major autoimmune diseases involving joint inflammation, including osteoarthritis and rheumatoid arthritis. However, little is known about the interactions among different cell subtypes and the specific sets of signaling pathways and activities that they trigger. METHODS: Using social network analysis, pattern recognition, and manifold learning approaches, we identified patterns of single-cell communication in OA (osteoarthritis) and RA (rheumatoid arthritis)...
September 11, 2023: Immunology Letters