Shihua Shi, Demei Huang, Yongcan Wu, Caixia Pei, Yilan Wang, Zherui Shen, Sijing Zhao, Nan Jia, Xiaomin Wang, Bonan Chen, Jie Pan, Fei Wang, Zhenxing Wang
Ambient fine particulate matter (PM2.5 ) is considered a leading cause of pathogenic particulate matter induced lung injury. And Salidroside (Sal), the major bioactive constituent isolated from Rhodiola rosea L., has been shown to ameliorate lung injury in various conditions. To uncover the possible therapy for PM2.5 related pulmonary disease, we evaluated the protective role of Sal pre-treatment on PM2.5 induced lung injury in mice by utilizing the survival analysis, hematoxylin and eosin (H&E) staining, lung injury score, lung wet-to-dry weight ratio, enzyme-linked immunosorbent assay (ELISA) kits, immunoblot, immunofluorescence, and transmission electron microscopy (TEM)...
May 24, 2023: Food and Chemical Toxicology