Ryan A Denu, Cissimol P Joseph, Elizabeth S Urquiola, Precious S Byrd, Richard K Yang, Ravin Ratan, Maria Alejandra Zarzour, Anthony P Conley, Dejka M Araujo, Vinod Ravi, Elise F Nassif Haddad, Michael S Nakazawa, Shreyaskumar Patel, Wei-Lien Wang, Alexander J Lazar, Neeta Somaiah
Objective: The vast majority of gastrointestinal stromal tumors (GISTs) are driven by activating mutations in KIT , PDGFRA , or components of the succinate dehydrogenase (SDH) complex ( SDHA , SDHB , SDHC , and SDHD genes). A small fraction of GISTs lack alterations in KIT , PDGFRA , and SDH . We aimed to further characterize the clinical and genomic characteristics of these so-called "triple-negative" GISTs. Methods: We extracted clinical and genomic data from patients seen at MD Anderson Cancer Center with a diagnosis of GIST and available clinical next generation sequencing data to identify "triple-negative" patients...
April 27, 2024: Cancers