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JOURNAL ARTICLE
Aude Belbézier, Thi Thu Thuy Nguyen, Mélanie Arnaud, Bruna Ducotterd, Marie Vangout, Alban Deroux, Catherine Mansard, Françoise Sarrot-Reynauld, Laurence Bouillet
Sjögren's syndrome (SS) is a systemic autoimmune pathology manifested mainly by a dry syndrome, intense asthenia and arthromyalgia. Systemic manifestations may also occur. Since 2019, immunosuppressant agents (IS) or biotherapies are recommended only for patients with systemic involvement. However, before 2019, in some cases, paucisymptomatic patients had been treated with IS/biotherapies, often off-label. Objective : We propose to evaluate the benefit and safety of using IS/biotherapy in patients with SS without systemic involvement...
June 2024: Journal of translational autoimmunity
#2
MULTICENTER STUDY
Grégoire Martin de Frémont, Nathalie Costedoat-Chalumeau, Estibaliz Lazaro, Rakiba Belkhir, Gaëlle Guettrot-Imbert, Nathalie Morel, Gaétane Nocturne, Anna Molto, Tiphaine Goulenok, Elisabeth Diot, Laurent Perard, Nicole Ferreira-Maldent, Maelle Le Besnerais, Nicolas Limal, Nihal Martis, Noémie Abisror, Odile Debouverie, Christophe Richez, Vincent Sobanski, François Maurier, Gaëtan Sauvetre, Hervé Levesque, Marie-Agnès Timsit, Nathalie Tieulié, Pauline Orquevaux, Boris Bienvenu, Matthieu Mahevas, Thomas Papo, Céline Lartigau-Roussin, Elodie Chauvet, Emilie Berthoux, Françoise Sarrot-Reynauld, Loïc Raffray, Marion Couderc, Nicolas Martin Silva, Noémie Jourde-Chiche, Nicolas Belhomme, Thierry Thomas, Vincent Poindron, Viviane Queyrel-Moranne, Juliette Delforge, Camille Le Ray, Emmanuelle Pannier, Xavier Mariette, Véronique Le Guern, Raphaèle Seror
BACKGROUND: Adverse pregnancy outcomes in women with primary Sjögren's syndrome have only been evaluated retrospectively using heterogeneous methods and with contradictory results. We aimed to describe adverse pregnancy, delivery, and birth outcome risks in pregnant women with primary Sjögren's syndrome compared with those of a matched general population in France, and to identify factors predictive of disease flares or adverse pregnancy outcomes. METHODS: We conducted a multicentre, prospective, cohort study in France using the GR2 (Groupe de Recherche sur la Grossesse et les Maladies Rares) registry...
June 2023: Lancet Rheumatology
#3
JOURNAL ARTICLE
Tom Le Voyer, Audrey V Parent, Xian Liu, Axel Cederholm, Adrian Gervais, Jérémie Rosain, Tina Nguyen, Malena Perez Lorenzo, Elze Rackaityte, Darawan Rinchai, Peng Zhang, Lucy Bizien, Gonca Hancioglu, Pascale Ghillani-Dalbin, Jean-Luc Charuel, Quentin Philippot, Mame Sokhna Gueye, Majistor Raj Luxman Maglorius Renkilaraj, Masato Ogishi, Camille Soudée, Mélanie Migaud, Flore Rozenberg, Mana Momenilandi, Quentin Riller, Luisa Imberti, Ottavia M Delmonte, Gabriele Müller, Baerbel Keller, Julio Orrego, William Alexander Franco Gallego, Tamar Rubin, Melike Emiroglu, Nima Parvaneh, Daniel Eriksson, Maribel Aranda-Guillen, David I Berrios, Linda Vong, Constance H Katelaris, Peter Mustillo, Johannes Raedler, Jonathan Bohlen, Jale Bengi Celik, Camila Astudillo, Sarah Winter, Catriona McLean, Aurélien Guffroy, Joseph L DeRisi, David Yu, Corey Miller, Yi Feng, Audrey Guichard, Vivien Béziat, Jacinta Bustamante, Qiang Pan-Hammarström, Yu Zhang, Lindsey B Rosen, Steve M Holland, Marita Bosticardo, Heather Kenney, Riccardo Castagnoli, Charlotte A Slade, Kaan Boztuğ, Nizar Mahlaoui, Sylvain Latour, Roshini S Abraham, Vassilios Lougaris, Fabian Hauck, Anna Sediva, Faranaz Atschekzei, Georgios Sogkas, M Cecilia Poli, Mary A Slatter, Boaz Palterer, Michael D Keller, Alberto Pinzon-Charry, Anna Sullivan, Luke Droney, Daniel Suan, Melanie Wong, Alisa Kane, Hannah Hu, Cindy Ma, Hana Grombiříková, Peter Ciznar, Ilan Dalal, Nathalie Aladjidi, Miguel Hie, Estibaliz Lazaro, Jose Franco, Sevgi Keles, Marion Malphettes, Marlene Pasquet, Maria Elena Maccari, Andrea Meinhardt, Aydan Ikinciogullari, Mohammad Shahrooei, Fatih Celmeli, Patrick Frosk, Christopher C Goodnow, Paul E Gray, Alexandre Belot, Hye Sun Kuehn, Sergio D Rosenzweig, Makoto Miyara, Francesco Licciardi, Amélie Servettaz, Vincent Barlogis, Guillaume Le Guenno, Vera-Maria Herrmann, Taco Kuijpers, Grégoire Ducoux, Françoise Sarrot-Reynauld, Catharina Schuetz, Charlotte Cunningham-Rundles, Frédéric Rieux-Laucat, Stuart G Tangye, Cristina Sobacchi, Rainer Doffinger, Klaus Warnatz, Bodo Grimbacher, Claire Fieschi, Laureline Berteloot, Vanessa L Bryant, Sophie Trouillet Assant, Helen Su, Benedicte Neven, Laurent Abel, Qian Zhang, Bertrand Boisson, Aurélie Cobat, Emmanuelle Jouanguy, Olle Kampe, Paul Bastard, Chaim M Roifman, Nils Landegren, Luigi D Notarangelo, Mark S Anderson, Jean-Laurent Casanova, Anne Puel
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)1,2 , conferring a predisposition to life-threatening COVID-19 pneumonia3 . Here we report that patients with autosomal recessive NIK or RELB deficiency, or a specific type of autosomal-dominant NF-κB2 deficiency, also have neutralizing autoantibodies against type I IFNs and are at higher risk of getting life-threatening COVID-19 pneumonia...
November 2023: Nature
#4
JOURNAL ARTICLE
Benhur Reynauld, Ratheesraj Ratinam, Owen McKay, Daniel Croagh
No abstract text is available yet for this article.
February 11, 2023: Gastrointestinal Endoscopy
#5
JOURNAL ARTICLE
Quentin Riller, Jacques Fourgeaud, Julie Bruneau, Suk See De Ravin, Grace Smith, Mathieu Fusaro, Samy Meriem, Aude Magerus, Marine Luka, Ghaith Abdessalem, Ludovic Lhermitte, Anne Jamet, Emmanuelle Six, Alessandra Magnani, Martin Castelle, Romain Lévy, Mathilde M Lecuit, Benjamin Fournier, Sarah Winter, Michaela Semeraro, Graziella Pinto, Hanène Abid, Nizar Mahlaoui, Nathalie Cheikh, Benoit Florkin, Pierre Frange, Eric Jeziorski, Felipe Suarez, Françoise Sarrot-Reynauld, Dalila Nouar, Dominique Debray, Florence Lacaille, Capucine Picard, Philippe Pérot, Béatrice Regnault, Nicolas Da Rocha, Camille de Cevins, Laure Delage, Brieuc P Pérot, Angélique Vinit, Francesco Carbone, Camille Brunaud, Manon Marchais, Marie-Claude Stolzenberg, Vahid Asnafi, Thierry Molina, Frédéric Rieux-Laucat, Luigi D Notarangelo, Stefania Pittaluga, Jean Philippe Jais, Despina Moshous, Stephane Blanche, Harry Malech, Marc Eloit, Marina Cavazzana, Alain Fischer, Mickaël M Ménager, Bénédicte Neven
BACKGROUND: Allogenic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT) are potentially curative treatments for severe combined immunodeficiency (SCID). Late-onset post-treatment manifestations (such as persistent hepatitis) are not uncommon. OBJECTIVES: To characterize the prevalence and pathophysiology of persistent hepatitis in transplanted SCID patients (SCIDH+) and to evaluate risk factors and treatments. METHODS: We used a variety of techniques (including pathology assessments, metagenomics, single-cell transcriptomics, and cytometry by time of flight) to perform an in-depth study of different tissues from SCIDH+ patients and corresponding asymptomatic similarly transplanted SCID patients (without hepatitis, SCIDH-)...
January 10, 2023: Journal of Allergy and Clinical Immunology
#6
JOURNAL ARTICLE
Morgane Cheminant, Thomas A Fox, Mickael Alligon, Olivier Bouaziz, Bénédicte Neven, Despina Moshous, Stephane Blanche, Aurélien Guffroy, Claire Fieschi, Marion Malphettes, Nicolas Schleinitz, Antoinette Perlat, Jean-François Viallard, Nathalie Dhedin, Francoise Sarrot-Reynauld, Isabelle Durieu, Sebastien Humbert, Fanny Fouyssac, Vincent Barlogis, Ben Carpenter, Rachael E Hough, Arian Dominic John Laurence, Ambroise Marçais, Ronjon Chakraverty, Olivier Hermine, Alain Fischer, Siobhan O Burns, Nizar Mahlaoui, Emma C Morris, Felipe Suarez
Allogeneic hematopoietic stem cell transplantation (alloSCT) is curative for severe inborn errors of immunity (IEI), with recent data suggesting alloSCT in adulthood is safe and effective in selected patients. However, questions remain regarding the indications for and optimal timing of transplant. We retrospectively compared outcomes of transplanted with matched non-transplanted adults with severe IEI. Seventy-nine patients (aged ≥15 years) underwent alloSCT between 2008 and 2018 for IEI, including chronic granulomatous disease (CGD, n=20) and various combined immune deficiencies (CID, n=59)...
August 10, 2022: Blood
#7
RANDOMIZED CONTROLLED TRIAL
Noemie Jourde-Chiche, Nathalie Costedoat-Chalumeau, Karine Baumstarck, Anderson Loundou, Laurence Bouillet, Stéphane Burtey, Valérie Caudwell, Laurent Chiche, Lionel Couzi, Laurent Daniel, Christophe Deligny, Bertrand Dussol, Stanislas Faguer, Pierre Gobert, Guillaume Gondran, Antoine Huart, Aurélie Hummel, Emilie Kalbacher, Adexandre Karras, Marc Lambert, Véronique Le Guern, Ludivine Lebourg, Sandrine Loubière, Hélène Maillard-Lefebvre, François Maurier, Micheline Pha, Viviane Queyrel, Philippe Remy, Françoise Sarrot-Reynauld, David Verhelst, Eric Hachulla, Zahir Amoura, Eric Daugas
OBJECTIVES: Lupus nephritis (LN) is a frequent complication of systemic lupus erythematosus (SLE). Severe (proliferative) forms of LN are treated with induction immunosuppressive therapy (IST), followed by maintenance IST, to target remission and avoid relapses. The optimal duration of maintenance IST is unknown. The WIN-Lupus trial tested whether IST discontinuation after 2‒3 years was non-inferior to IST continuation for two more years in proliferative LN. METHODS: WIN-Lupus was an investigator-initiated multicentre randomised controlled trial...
October 2022: Annals of the Rheumatic Diseases
#8
JOURNAL ARTICLE
Maddalena Larosa, Véronique Le Guern, Gaëlle Guettrot-Imbert, Nathalie Morel, Noémie Abisror, Chafika Morati-Hafsaoui, Pauline Orquevaux, Elisabeth Diot, Andrea Doria, Françoise Sarrot Reynauld, Nicolas Limal, Viviane Queyrel, Odile Souchaud-Debouverie, Laurent Sailler, Maëlle Le Besnerais, Tiphaine Goulenok, Anna Molto, Emmanuelle Pannier-Metzger, Loic Sentilhes, Luc Mouthon, Estibaliz Lazaro, Nathalie Costedoat-Chalumeau
OBJECTIVES: The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis of pregnancies in women with systemic lupus erythematosus (SLE) are unknown. We analysed their impact on maternal flares and adverse pregnancy outcomes (APOs). METHODS: We evaluated all women (≥18 years) with SLE enrolled in the prospective GR2 study with an ongoing singleton pregnancy at 12 weeks (one pregnancy/woman). Several sets of criteria were used to define remission, disease activity, and damage...
January 7, 2022: Rheumatology
#9
JOURNAL ARTICLE
Steffanie Nario, Benhur Reynauld, Helen Blacklaws, Sharon Boden, Rishi Sud, Glenn Hawken, Satbir Singh, Karl Herba, James Panetta, James Pang
Background and Aim: Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection has resulted in high rates of successful disease cure; however, not enough healthcare providers are available to deliver treatment to the population living with chronic HCV. To demonstrate that a nurse practitioner (NP) model of care is non-inferior to specialist gastroenterologist (SG) management of HCV infection, as measured by sustained viral response at 12 weeks (SVR12 ) after initiation of DAA therapy...
June 2021: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
#10
JOURNAL ARTICLE
Ségolène Gendreau, Raphael Porcher, Benjamin Thoreau, Romain Paule, François Maurier, Tiphaine Goulenok, Laure Frumholtz, Charlotte Bernigaud, Saskia Ingen-Housz-Oro, Arsène Mekinian, Alexandra Audemard-Verger, Antoine Gaillet, Laurent Perard, Maxime Samson, Romain Sonneville, Jean-Benoît Arlet, Adrien Mirouse, Jean-Emmanuel Kahn, Julien Charpentier, Éric Hachulla, Aurélie Hummel, Thomas Pires, Pierre-Louis Carron, Cécile-Audrey Durel, Wendy Jourde, Xavier Puechal, Jean-Christophe Lega, Françoise Sarrot-Reynauld, Nathalie Tieulie, Elisabeth Diot, Loïc Guillevin, Benjamin Terrier
BACKGROUND: Gastrointestinal (GI) involvement was described to be a poor prognostic factor in systemic necrotizing vasculitis. Its prognostic significance may vary according to clinical presentation and vasculitis subtype. AIMS: This study investigated risk-factors associated to poor outcome in GI-involvement of vasculitis. METHODS: Patients with systemic vasculitis as defined by the 2012 Chapel Hill Consensus Conference and presenting with GI involvement were retrospectively included...
April 2021: Seminars in Arthritis and Rheumatism
#11
MULTICENTER STUDY
Julie Chezel, Nathalie Costedoat-Chalumeau, Cedric Laouénan, Diane Rouzaud, Camille Chenevier-Gobeaux, Véronique Le Guern, Alexis Mathian, Drifa Belhadi, Sébastien de Almeida Chaves, Pierre Duhaut, Olivier Fain, Lionel Galicier, Pascale Ghillani-Dalbin, Jean Emmanuel Kahn, Nathalie Morel, Laurent Perard, Micheline Pha, Fanny Saidoune, Francoise Sarrot-Reynauld, Olivier Aumaitre, François Chasset, Nicolas Limal, Helene Desmurs-Clavel, Felix Ackermann, Zahir Amoura, Thomas Papo, Karim Sacre
OBJECTIVE: Identification of biological markers able to better stratify cardiovascular risks in SLE patients is needed. We aimed to determine whether serum cardiac troponin T (cTnT) levels measured with a highly sensitive assay [high sensitivity cTnT (HS-cTnT)] may predict cardiovascular events (CVEs) in SLE. METHOD: All SLE patients included between 2007 and 2010 in the randomized, double-blind, placebo-controlled, multicentre PLUS trial were screened. Patients with no past history of CVE at inclusion and a follow-up period of >20 months were analysed...
March 2, 2021: Rheumatology
#12
JOURNAL ARTICLE
Aude Belbézier, Alban Deroux, Françoise Sarrot-Reynauld, Barbara Colombe, Annick Bosseray, Claire Wintenberger, Perrine Dumanoir, Maxime Lugosi, Isabelle Boccon-Gibod, Vincent Leroy, Maxime Maignan, Roselyne Collomb-Muret, Damien Viglino, Mathieu Vaillant, Lorella Minotti, Emeline Lagrange, Olivier Epaulard, Chantal Dumestre-Perard, Sébastien Lhomme, Julien Lupo, Sylvie Larrat, Patrice Morand, Carole Schwebel, Antoine Vilotitch, Jean-Luc Bosson, Laurence Bouillet
INTRODUCTION: Hepatitis E virus (HEV) infection has been reported to be associated with neurological disorders. However, the real prevalence of acute hepatitis E in those diseases is still unknown. We determined the prevalence of anti-HEV IgM antibody in a population with acute non-traumatic, non-metabolic, non-vascular neurological injury. METHOD: A registry was created in Grenoble Hospital University from 2014 to 2018 to collect data on patients with acute (<3 months) non-traumatic, non-metabolic, non-vascular neurological injuries...
July 2020: Journal of Infection and Public Health
#13
JOURNAL ARTICLE
Hélène Coignard-Biehler, Nizar Mahlaoui, Benoit Pilmis, Vincent Barlogis, Pauline Brosselin, Nathalie De Vergnes, Marianne Debré, Marion Malphettes, Pierre Frange, Emilie Catherinot, Isabelle Pellier, Isabelle Durieu, Antoinette Perlat, Bruno Royer, Alain Le Quellec, Eric Jeziorski, Alain Fischer, Olivier Lortholary, Laurent Aaron, Daniel Adoue, Claire Aguilar, Nathalie Aladjidi, Alexandre Alcais, Zahir Amoura, Philippe Arlet, Corinne Armari-Alla, Brigitte Bader-Meunier, Sophie Bayart, Yves Bertrand, Boris Bienvenu, Stéphane Blanche, Damien Bodet, Bernard Bonnotte, Raphaël Borie, Patrick Boutard, Claire Briandet, Jean-Paul Brion, Jacques Brouard, Sarah Cohen-Beaussant, Laurence Costes, Louis-Jean Couderc, Pierre Cougoul, Virginie Courteille, Geneviève de Saint Basile, Catherine Devoldere, Anne Deville, Jean Donadieu, Eric Dore, Fabienne Dulieu, Christine Edan, Natacha Entz-Werle, Claire Fieschi, Amandine Forestier, Fanny Fouyssac, Vincent Gajdos, Lionel Galicier, Virginie Gandemer, Martine Gardembas, Catherine Gaud, Gaelle Guillerm, Eric Hachulla, Mohamed Hamidou, Olivier Hermine, Cyrille Hoarau, Sébastien Humbert, Arnaud Jaccard, Serge Jacquot, Jean-Philippe Jais, Roland Jaussaud, Pierre-Yves Jeandel, Kamila Kebaili, Anne-Sophie Korganow, Olivier Lambotte, Fanny Lanternier, Claire Larroche, Anne-Sophie Lascaux, Emmanuelle Le Moigne, Vincent Le Moing, Yvon Lebranchu, Marc Lecuit, Guillaume Lefevre, Richard Lemal, Valérie Li Thiao Te, Aude Marie-Cardine, Nicolas Martin Silva, Agathe Masseau, Christian Massot, Françoise Mazingue, Etienne Merlin, Gérard Michel, Frédéric Millot, Béatrice Monlibert, Fabrice Monpoux, Despina Moshous, Luc Mouthon, Martine Munzer, Bénédicte Neven, Raphaëlle Nove-Josserand, Eric Oksenhendler, Marie Ouachée-Chardin, Caroline Oudot, Anne Pagnier, Jean-Louis Pasquali, Marlène Pasquet, Yves Perel, Capucine Picard, Christophe Piguet, Dominique Plantaz, Johan Provot, Pierre Quartier, Frédéric Rieux-Laucat, Pascal Roblot, Pierre-Marie Roger, Pierre-Simon Rohrlich, Hervé Rubie, Valéry Salle, Françoise Sarrot-Reynauld, Amélie Servettaz, Jean-Louis Stephan, Nicolas Schleinitz, Felipe Suarez, Laure Swiader, Sophie Taque, Caroline Thomas, Olivier Tournilhac, Caroline Thumerelle, François Tron, Jean-Pierre Vannier, Jean-François Viallard
PURPOSE: Patients with primary immunodeficiency (PID) are at risk of serious complications. However, data on the incidence and causes of emergency hospital admissions are scarce. The primary objective of the present study was to describe emergency hospital admissions among patients with PID, with a view to identifying "at-risk" patient profiles. METHODS: We performed a prospective observational 12-month multicenter study in France via the CEREDIH network of regional PID reference centers from November 2010 to October 2011...
August 10, 2019: Journal of Clinical Immunology
#14
JOURNAL ARTICLE
Joëlle Khourieh, Geetha Rao, Tanwir Habib, Danielle T Avery, Alain Lefèvre-Utile, Marie-Olivia Chandesris, Aziz Belkadi, Maya Chrabieh, Hanan Alwaseem, Virginie Grandin, Françoise Sarrot-Reynauld, Agathe Sénéchal, Olivier Lortholary, Xiao-Fei Kong, Stéphanie Boisson-Dupuis, Capucine Picard, Anne Puel, Vivien Béziat, Qian Zhang, Laurent Abel, Henrik Molina, Nico Marr, Stuart G Tangye, Jean-Laurent Casanova, Bertrand Boisson
Heterozygous in-frame mutations in coding regions of human STAT3 underlie the only known autosomal dominant form of hyper IgE syndrome (AD HIES). About 5% of familial cases remain unexplained. The mutant proteins are loss-of-function and dominant-negative when tested following overproduction in recipient cells. However, the production of mutant proteins has not been detected and quantified in the cells of heterozygous patients. We report a deep intronic heterozygous STAT3 mutation, c.1282-89C>T, in 7 relatives with AD HIES...
August 13, 2019: Proceedings of the National Academy of Sciences of the United States of America
#15
JOURNAL ARTICLE
Aude Belbezier, Françoise Sarrot-Reynauld, Frédéric Thony, Florence Tahon, Olivier Heck, Laurence Bouillet
A 62-year-old woman presented with hemithoracic anesthesia and acute abdominal pain following a violent psychological stress. Magnetic resonance imaging showed a thoracic hematoma with arachnoiditis of the spinal cord. Tomography revealed a typical aspect of segmental arterial mediolysis with multiple aneurysms and stenoses of the splanchnic arteries, confirmed by abdominal arteriography. There was no argument for hereditary, traumatic, atherosclerotic, infectious, or inflammatory arterial disease. Segmental arterial mediolysis was diagnosed on the basis of the radiologic data and probably involved both medullary and splanchnic arteries...
March 2017: Journal of Vascular Surgery Cases and Innovative Techniques
#16
COMPARATIVE STUDY
Sophie Colliard, Noémie Jourde-Chiche, Giovanna Clavarino, Françoise Sarrot-Reynauld, Evelyne Gout, Alban Deroux, Mélanie Fougere, Nathalie Bardin, Laurence Bouillet, Jean-Yves Cesbron, Nicole M Thielens, Chantal Dumestre-Pérard
OBJECTIVE: Systemic lupus erythematosus (SLE) is a multisystem inflammatory disease characterized by the production of various autoantibodies. The aim of this study was to investigate the presence of anti-ficolin-2 antibodies in SLE patients and to evaluate the association between the levels of these autoantibodies, clinical manifestations, and disease activity. METHODS: This is a comparative study using a cohort of 165 SLE patients and 48 healthy subjects. SLE patients were further divided into 2 groups (low disease activity [SLE Disease Activity Index (SLEDAI) score ≤4, n = 88] and high disease activity [SLEDAI score >4, n = 77])...
August 2018: Arthritis Care & Research
#17
JOURNAL ARTICLE
Bruno Revol, Laura Bickert, Françoise Sarrot-Reynauld, Benoit Allenet
Patients have to be informed about the risks and benefits of medicinal products derived from human plasma. No study has examined the patient's perspective yet. Our objective was to assess perceived benefits and risks of immunoglobulins administration from the patient's point of view. Thirty-four patients receiving subcutaneous or intravenous immunoglobulins for chronic disorders at a single university hospital were asked to complete a survey. Although the level of comfort was high, the results revealed variable and incomplete knowledge, in particular about the nature of the treatment...
December 2017: Thérapie
#18
MULTICENTER STUDY
Valentine Heidelberger, Saskia Ingen-Housz-Oro, Alicia Marquet, Matthieu Mahevas, Didier Bessis, Laurence Bouillet, Frédéric Caux, Catherine Chapelon-Abric, Sébastien Debarbieux, Emmanuel Delaporte, Anne-Bénédicte Duval-Modeste, Olivier Fain, Pascal Joly, Sylvain Marchand-Adam, Jean-Benoît Monfort, Nicolas Noël, Thierry Passeron, Marc Ruivard, Françoise Sarrot-Reynauld, Denis Verrot, Diane Bouvry, Laurence Fardet, Olivier Chosidow, Pascal Sève, Dominique Valeyre
Importance: Evidence for the long-term efficacy and safety of anti-tumor necrosis factor α agents (anti-TNF) in treating cutaneous sarcoidosis is lacking. Objective: To determine the efficacy and safety of anti-TNF in treating cutaneous sarcoidosis in a large observational study. Design, Setting, and Participants: STAT (Sarcoidosis Treated with Anti-TNF) is a French retrospective and prospective multicenter observational database that receives data from teaching hospitals and referral centers, as well as several pneumology, dermatology, and internal medicine departments...
July 1, 2017: JAMA Dermatology
#19
MULTICENTER STUDY
Yvan Jamilloux, Fleur Cohen-Aubart, Catherine Chapelon-Abric, Delphine Maucort-Boulch, Alicia Marquet, Laurent Pérard, Laurence Bouillet, Alban Deroux, Sébastien Abad, Philip Bielefeld, Diane Bouvry, Marc André, Nicolas Noel, Boris Bienvenu, Alice Proux, Sandra Vukusic, Bahram Bodaghi, Françoise Sarrot-Reynauld, Jean Iwaz, Zahir Amoura, Christiane Broussolle, Patrice Cacoub, David Saadoun, Dominique Valeyre, Pascal Sève
INTRODUCTION: The off-label use of TNF antagonists in refractory sarcoidosis is increasingly reported but data on their efficacy and safety are still insufficient. OBJECTIVE: To report on efficacy and safety of TNF antagonists in severe and refractory sarcoidosis. METHODS: Examination of retrospective demographic, clinical, therapeutic, and adverse event data on 132 sarcoidosis patients (58% women; mean (min-max) age = 45.5 (14-78) years) given TNF antagonists (mainly infliximab, 91%) and investigation of response-linked factors...
October 2017: Seminars in Arthritis and Rheumatism
#20
MULTICENTER STUDY
C Comarmond, P Jego, C Veyssier-Belot, I Marie, A Mekinian, A Elmaleh-Sachs, G Leroux, D Saadoun, E Oziol, T Fraisse, H Hyvernat, M-F Thiercein-Legrand, F Sarrot-Reynauld, N Ferreira-Maldent, M de Menthon, C Goujard, D Khau, Y Nguen, S Monnier, A Michon, B Castel, O Decaux, J-C Piette, P Cacoub
Objective To study the outcome of patients with antiphospholipid syndrome (APS) after oral anticoagulant treatment cessation. Methods We performed a retrospective study of patients with APS experiencing cessation of oral anticoagulant and enrolled in a French multicentre observational cohort between January 2014 and January 2016. The main outcome was the occurrence of recurrent thrombotic event after oral anticoagulation cessation. Results Forty four APS patients interrupted oral anticoagulation. The median age was 43 (27-56) years...
October 2017: Lupus
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