Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Annie Wing-Tung Lee, Iain Chi-Fung Ng, Evelyn Yin-Kwan Wong, Ivan Tak-Fai Wong, Rebecca Po-Po Sze, Kit-Yu Chan, Tsz-Yan So, Zhipeng Zhang, Sharon Ka-Yee Fung, Sally Choi-Ying Wong, Wing-Yin Tam, Hiu-Yin Lao, Lam-Kwong Lee, Jake Siu-Lun Leung, Chloe Toi-Mei Chan, Timothy Ting-Leung Ng, Jiaying Zhang, Franklin Wang-Ngai Chow, Polly Hang-Mei Leung, Gilman Kit-Hang Siu
Foodborne pathogens, particularly antimicrobial-resistant (AMR) bacteria, remain a significant threat to global health. Given the limitations of conventional culture-based approaches, which are limited in scope and time-consuming, metagenomic sequencing of food products emerges as a promising solution. This method provides a fast and comprehensive way to detect the presence of pathogenic microbes and antimicrobial resistance genes (ARGs). Notably, nanopore long-read sequencing provides more accurate bacterial taxonomic classification in comparison to short-read sequencing...
August 2024: Food Microbiology
#42
JOURNAL ARTICLE
Mark A Caudell, Carmen Castillo, Lucas F Santos, Laura Grajeda, Juan Carlos Romero, Maria Renee Lopez, Sylvia Omulo, Mariangeli Freitas Ning, Guy H Palmer, Douglas R Call, Celia Cordon-Rosales, Rachel M Smith, Carolyn T A Herzig, Ashley Styczynski, Brooke M Ramay
OBJECTIVES: The spread of extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) and carbapenem-resistant Enterobacterales (CRE) has resulted in increased morbidity, mortality, and health care costs worldwide. To identify the factors associated with ESCrE and CRE colonization within hospitals, we enrolled hospitalized patients at a regional hospital located in Guatemala. METHODS: Stool samples were collected from randomly selected patients using a cross-sectional study design (March-September, 2021), and samples were tested for the presence of ESCrE and CRE...
June 2024: IJID Reg
#43
JOURNAL ARTICLE
Abera A Kitaba, Zelalem T Bonger, Degefu Beyene, Zeleke Ayenew, Estifanos Tsige, Tesfa Addis Kefale, Yonas Mekonnen, Dejenie S Teklu, Elias Seyoum, Abebe A Negeri
BACKGROUND: Clinicians rely on local antimicrobial resistance pattern data to guide empiric treatment for seriously ill patients when culture and antimicrobial susceptibility testing results are not immediately available. OBJECTIVE: This study aimed to analyse 5-year trends in antimicrobial resistance profiles of Escherichia coli and Klebsiella pneumoniae isolates. METHODS: Bacteriology reports from 2017 to 2021 at the Ethiopian Public Health Institute were analysed retrospectively...
2024: African Journal of Laboratory Medicine
#44
JOURNAL ARTICLE
Erwin Hadi Chandra, Tom Ch Adriani, Ahmadi Alwi, Mulawardi, Nyityasmono Tri Nugroho, Dewi Yusuf
Objective : Hemodialysis (HD) catheter-related bloodstream infections (CRBSIs) are a major complication of long-/short-term catheter. Material and Methods : Patients with HD CRBSIs were identified, and their blood was taken and sent to clinical pathology for culture and sensitivity testing. The inclusion criteria were adults with end-stage renal disease who required urgent HD access in the presence of a central venous catheter (CVC) infection. Results : The most common isolates among the patients with CRBSIs were gram-positive microorganisms (57...
March 25, 2024: Annals of Vascular Diseases
#45
JOURNAL ARTICLE
Yue Jiang, Huilin Yang, Zhen-Yu Wang, Da-Chuan Lin, Xinan Jiao, Yunlong Hu, Jing Wang
OBJECTIVE: Salmonella enterica serovar Kentucky ST198 has emerged as a global threat to humans. In this study, we aimed to characterize the prolonged carriage of ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing S . Kentucky ST198 in a single patient with inflammatory bowel disease (IBD). METHODS: Three S . Kentucky strains were collected from a single patient with IBD on 11th January, 23rd January, and 8th February, 2022, respectively...
2024: Infection and Drug Resistance
#46
JOURNAL ARTICLE
Zhenhua Ji, Miaomiao Jian, Xuan Su, Yingyi Pan, Yi Duan, Weijie Ma, Lei Zhong, Jiaru Yang, Jieqin Song, Xinya Wu, Li Gao, Weijiang Ma, Jing Kong, Bingxue Li, Jinjing Chen, Meixiao Liu, Yuxin Fan, Li Peng, Yan Dong, Fukai Bao, Aihua Liu
BACKGROUND: Leptospirosis, an important zoonotic bacterial disease, commonly affects resource-poor populations and results in significant morbidity and mortality worldwide. The value of antibiotics in leptospirosis remains unclear, as evidenced by the conflicting opinions published. METHODS: We conducted a search in the PubMed, Web of Science, and Cochrane Library databases for studies. These studies included clinical trials and retrospective studies that evaluated the efficacy or safety of antibiotics for leptospirosis treatment...
April 16, 2024: Systematic Reviews
#47
JOURNAL ARTICLE
Misheck Shawa, Atmika Paudel, Herman Chambaro, Harvey Kamboyi, Ruth Nakazwe, Luke Alutuli, Tuvshinzaya Zorigt, Taona Sinyawa, Mulemba Samutela, Joseph Chizimu, Manyando Simbotwe, Kyoko Hayashida, Naganori Nao, Masahiro Kajihara, Yoshikazu Furuta, Yasuhiko Suzuki, Hirofumi Sawa, Bernard Hang'ombe, Hideaki Higashi
Increased antimicrobial resistance (AMR) among bacteria underscores the need to strengthen AMR surveillance and promote data-based prescribing. To evaluate trends and associations between antimicrobial usage (AMU) and AMR, we explored a dataset of 34,672 bacterial isolates collected between 2015 and 2020 from clinical samples at the University Teaching Hospital (UTH) in Lusaka, Zambia. The most frequently isolated species were Escherichia coli (4,986/34,672; 14.4%), Staphylococcus aureus (3,941/34,672; 11.4%), and Klebsiella pneumoniae (3,796/34,672; 10...
2024: PloS One
#48
JOURNAL ARTICLE
Ki Tae Kwon, Yoonjung Kim, Shin-Woo Kim, Hyun-Ha Chang, Soyoon Hwang, Sohyun Bae, Eunkyung Nam
BACKGROUND: Nationwide research on the association between carbapenem-resistant Enterobacterales (CREs) and antibiotic use is limited. METHODS: This nested case-control study analyzed Korean National Health Insurance claims data from April 2017 to April 2019. Based on the occurrence of CRE, hospitalized patients aged ≥ 18 years were classified into CRE (cases) and control groups. Propensity scores based on age, sex, modified Charlson comorbidity score, insurance type, long-term care facility, intensive care unit stay, and acquisition of vancomycin-resistant Enterococci were used to match the case and control groups (1:3)...
April 15, 2024: Journal of Korean Medical Science
#49
JOURNAL ARTICLE
Antimicrobial resistance prediction by clinical metagenomics in pediatric severe pneumonia patients.
Mingyu Gan, Yanyan Zhang, Gangfeng Yan, Yixue Wang, Guoping Lu, Bingbing Wu, Weiming Chen, Wenhao Zhou
BACKGROUND: Antimicrobial resistance (AMR) is a major threat to children's health, particularly in respiratory infections. Accurate identification of pathogens and AMR is crucial for targeted antibiotic treatment. Metagenomic next-generation sequencing (mNGS) shows promise in directly detecting microorganisms and resistance genes in clinical samples. However, the accuracy of AMR prediction through mNGS testing needs further investigation for practical clinical decision-making. METHODS: We aimed to evaluate the performance of mNGS in predicting AMR for severe pneumonia in pediatric patients...
April 15, 2024: Annals of Clinical Microbiology and Antimicrobials
#50
JOURNAL ARTICLE
Roxana Zamudio, Patrick Boerlin, Michael R Mulvey, Marisa Haenni, Racha Beyrouthy, Jean-Yves Madec, Stefan Schwarz, Ashley Cormier, Gabhan Chalmers, Richard Bonnet, George G Zhanel, Heike Kaspar, Alison E Mather
BACKGROUND: Extended-spectrum cephalosporins (ESCs) are third and fourth generation cephalosporin antimicrobials used in humans and animals to treat infections due to multidrug-resistant (MDR) bacteria. Resistance to ESCs (ESC-R) in Enterobacterales is predominantly due to the production of extended-spectrum β-lactamases (ESBLs) and plasmid-mediated AmpC β-lactamases (AmpCs). The dynamics of ESBLs and AmpCs are changing across countries and host species, the result of global transmission of ESC-R genes...
April 11, 2024: EBioMedicine
#51
JOURNAL ARTICLE
Chenxi Gao, Yiying She, Miaomiao Luo, Zhijiao Yue, Yixiang Jiang, Lulu Hu, Rui Cai, Min Jiang, Shuang Wu, Xiaolu Shi, Yinghui Li, Yaqun Qiu, Qinghua Hu
OBJECTIVE: To understand the prevalence, genetic characteristics and drug resistance features of Salmonella Kentucky ST314 in Shenzhen. METHODS: Whole genome sequencing of 14 strains of Salmonella Kentucky ST314 collected from 2010-2021 by the Foodborne Disease Surveillance Network of Shenzhen Center for Disease Control and Prevention for phylogenetic evolutionary analysis, drug resistance gene and plasmid detection; drug susceptibility experiments were performed by micro-broth dilution method...
March 2024: Wei Sheng Yan Jiu, Journal of Hygiene Research
#52
REVIEW
Eyob Hirpa Tola
Listeriosis is an important foodborne zoonotic disease affecting humans and animals in Ethiopia. This review aims to synthesize the epidemiology, prevalence, distribution, and antimicrobial resistance of Listeria species in the country. The literature reveals a widespread occurrence of Listeria infection in humans, animals, and food products, with an average prevalence of 21.6% for Listeria species and 6.9% for L. monocytogenes . Three sequence types (STs) of L. monocytogenes (2, 145, and 18) and twelve STs of L...
2024: Veterinary Medicine
#53
JOURNAL ARTICLE
Chongyang Wu, Li Xiong, Quanfeng Liao, Weili Zhang, Yuling Xiao, Yi Xie
BACKGROUND: Elizabethkingia is emerging as an opportunistic pathogen in humans. The aim of this study was to investigate the clinical epidemiology, antimicrobial susceptibility, virulence factors, and genome features of Elizabethkingia spp. METHODS: Clinical data from 71 patients who were diagnosed with Elizabethkingia-induced pneumonia and bacteremia between August 2019 and September 2021 were analyzed. Whole-genome sequencing was performed on seven isolates, and the results were compared with a dataset of 83 available Elizabethkingia genomes...
April 10, 2024: Annals of Clinical Microbiology and Antimicrobials
#54
JOURNAL ARTICLE
Shem K Blackley, Jay Lawrence, Addison Blevins, Caroline Howell, Charles C Butts, Nathan M Polite, Thomas J Capasso, Andrew C Bright, Kayla A Hall, Andrew N Haiflich, Ashley Y Williams, Christopher M Kinnard, Maryann I Mbaka, Jonathon P Audia, Jon D Simmons, Yannleei L Lee
BACKGROUND: Infection is a common cause of mortality within intensive care units (ICUs). Antibiotic resistance patterns and culture data are used to create antibiograms. Knowledge of antibiograms facilitates guiding empiric therapies and reduces mortality. Most major hospitals utilize data collection to create hospital-wide antibiograms. Previous studies have shown significant differences in susceptibility patterns between hospital wards and ICUs. We hypothesize that institutional or combined ICU antibiograms are inadequate to account for differences in susceptibility for patients in individual ICUs...
April 10, 2024: American Surgeon
#55
JOURNAL ARTICLE
Fangjun Liu, Qunhuan Kou, Hongyuan Li, Yangzhi Cao, Meng Chen, Xin Meng, Yinyong Zhang, Ting Wang, Hui Wang, Dan Zhang, Yushe Yang
Cefiderocol is the first approved catechol-conjugated cephalosporin against multidrug-resistant Gram-negative bacteria, while its application was limited by poor chemical stability associated with the pyrrolidinium linker, moderate potency against Klebsiella pneumoniae and Acinetobacter baumannii , intricate procedures for salt preparation, and potential hypersensitivity. To address these issues, a series of novel catechol-conjugated derivatives were designed, synthesized, and evaluated. Extensive structure-activity relationships and structure-metabolism relationships (SMR) were conducted, leading to the discovery of a promising compound 86b (Code no...
April 10, 2024: Journal of Medicinal Chemistry
#56
JOURNAL ARTICLE
Ruthika S Patil, Pradeep Onteru, Janmajay Jena, Chapala Shashank, Humera Siddiqua, Hiral A Parikh, Heena Dixit Tiwari
INTRODUCTION: The onset and maintenance of disease can be significantly influenced by the colonization of the mouth cavity by pathogenic microorganisms or by an imbalance of the physiological microbiome. Hence, in the current study, various commonly used antibiotics have been tested for their antibacterial and antifungal activity. MATERIALS AND METHODS: The current research was performed as an in vitro study. The commonly used antibiotics Augmentin (CV), Ceftriaxone-Cephalosporin (CF), and Linezolid were tested for the microorganisms, lactobacillus, and Escherichia coli ...
February 2024: Journal of Pharmacy & Bioallied Sciences
#57
JOURNAL ARTICLE
Bo-Gyeong Jeong, Myeong-Yeon Kim, Chang-Sook Jeong, Hackwon Do, Jisub Hwang, Jun Hyuck Lee, Sun-Shin Cha
Stenotrophomonas spp. intrinsically resistant to many β-lactam antibiotics are found throughout the environment. CESS-1 identified in Stenotrophomonas sp. KCTC 12332 is an uncharacterized class A β-lactamase. Here, CESS-1 was revealed to display hydrolytic activities toward penicillins (penicillin G and ampicillin) and cephalosporins (cephalexin, cefaclor, and cefotaxime), while its activity toward carbapenems (imipenem and meropenem) was negligible. Although cefaclor, cephalexin, and ampicillin have similar structures with identical R1 side chains, the catalytic parameters of CESS-1 toward the three β-lactam antibiotics were distinct...
April 6, 2024: International Journal of Antimicrobial Agents
#58
JOURNAL ARTICLE
Semiha Çelik Ekinci, Ercan Yenilmez, Gülfem Akengin Öcal, Meliha Çağla Sönmezer, Arzu Tarakçı, Cemanur Aygün, Damla Akdağ, Derya Seyman, Cansu Aşık, Esra Zerdali, Fatma Yılmaz Karadağ, Şafak Kaya, Mehmet Çelik, Şeyma Çifci, İlknur Esen Yıldız, Fatma Çölkesen, Fethiye Akgül, Özlem Aldemir, Merve Bozdağ, Deniz Özer, Lokman Hızmalı, Esra Canbolat Ünlü, Deniz Gür Altunay, Ahmet Şahin, Gülten Ünlü, Ayşe Eda Gençalioğlu, Sema Tekin Şahin, Yeliz Özdemir, Sibel Ünlü, Sarp Singil, Jale Altıntaş, Sinem Akkaya Işık, Özlem Gül, Nazan Tuna, Sümeyra Şimşek, Müge Özgüler, Pınar Elbir Kılıç, Mehmet Emirhan Işık, Ayşe Karakuş, Kazım Kıratlı, Ahmet Cem Yardımcı, Serkan Volkan, Yıldız Olçar, Yasemin Çakır, Nermin Özer Yılmaz, Serhat Karaayvaz, Ayşe Batırel, Zeynep Cansu Duran, Hüseyin Kemal Raşa, Şükran Köse
Background: Surgical antimicrobial prophylaxis (SAP) is the peri-operative administration of antimicrobial agents. Compliance rates vary worldwide from 15% to 84.3%, with studies in Turkey not exceeding 35%. The aim of this multicenter study was to determine the rate of appropriate antibiotic class, timing, and duration as well as discharge prescriptions in Turkey. Thus, we aimed to determine the rate of full compliance with SAP procedures in our country Patients and Methods: This multicenter, prospective, observational, descriptive study was conducted in 47 hospitals from 28 provinces in seven different regions of Turkey...
April 2024: Surgical Infections
#59
JOURNAL ARTICLE
Ana Abad-Fau, Eloisa Sevilla, Ainara Oro, Inmaculada Martín-Burriel, Bernardino Moreno, Mariano Morales, Rosa Bolea
Escherichia coli ( E. coli ) is a pathogen frequently isolated in cases of urinary tract infections (UTIs) in both humans and dogs and evidence exists that dogs are reservoirs for human infections. In addition, E. coli is associated to increasing antimicrobial resistance rates. This study focuses on the analysis of antimicrobial resistance and the presence of selected virulence genes in E. coli isolates from a Spanish dog population suffering from UTI. This collection of isolates showed an extremely high level of phenotypic resistance to 1st-3rd generation cephalosporins, followed by penicillins, fluoroquinolones and amphenicols...
2024: Frontiers in Veterinary Science
#60
JOURNAL ARTICLE
Rita Fernandes, Raquel Abreu, Isa Serrano, Roger Such, Encarnación Garcia-Vila, Sandy Quirós, Eva Cunha, Luís Tavares, Manuela Oliveira
This study aimed to characterize the antimicrobial resistance (AMR) and virulence profiles of 67 Escherichia coli isolates obtained from faecal samples of 77 wild mammals from 19 different species, admitted in two rescue and rehabilitation centers in Costa Rica. It was possible to classify 48% (n = 32) of the isolates as multidrug-resistant, and while the highest resistance levels were found towards commonly prescribed antimicrobials, resistance to fluoroquinolones and third generation cephalosporins were also observed...
April 5, 2024: Scientific Reports
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
