Birgit Kalb, Ingo Marenholz, Alexander Csn Jeanrenaud, Lara Meixner, Aleix Arnau-Soler, Oscar D Rosillo-Salazar, Ahla Ghauri, Penelope Cibin, Katharina Blümchen, Rupert Schlags, Gesine Hansen, Jürgen Seidenberg, Thomas Keil, Susanne Lau, Bodo Niggemann, Kirsten Beyer, Young-Ae Lee
BACKGROUND: A genetic defect in the epidermal barrier protein filaggrin plays a major role in the etiology of eczema and associated allergic airways diseases. However, it is still controversial to what extend loss-of-function (LOF) mutations in the filaggrin gene (FLG) contribute to the development and persistence of food allergies. OBJECTIVE: We tested association of FLG LOF mutations with allergic reactions to diverse foods and investigated their potential effect on the persistence of early food allergies...
June 14, 2022: Journal of Allergy and Clinical Immunology