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Cancer AND herbs | Page 2

Kai-Ching Tay, Loh Teng-Hern Tan, Chim Kei Chan, Sok Lai Hong, Kok-Gan Chan, Wei Hsum Yap, Priyia Pusparajah, Learn-Han Lee, Bey-Hing Goh
Cancer, a complex yet common disease, is caused by uncontrolled cell division and abnormal cell growth due to a variety of gene mutations. Seeking effective treatments for cancer is a major research focus, as the incidence of cancer is on the rise and drug resistance to existing anti-cancer drugs is major concern. Natural products have the potential to yield unique molecules and combinations of substances that may be effective against cancer with relatively low toxicity/better side effect profile compared to standard anticancer therapy...
2019: Frontiers in Pharmacology
Hua Gong, Weihua Chen, Lanhua Mi, Dan Wang, Youkang Zhao, Chao Yu, Aiguang Zhao
Context: Bladder cancer, which has high recurrence, is one of the most deadly cancers in the world. Astragalus propinquus Schischkin (Fabaceae) and Sagittaria sagittifolia L. (Alismataceae) are important herbs reported to be effective in cancer therapy. Objective: The efficacy of QCSL (Qici Sanling decoction) in bladder cancer treatment was examined. Materials and methods: T24 cells were injected into the flanks of nude mice and the mice were randomly divided into five groups: control; 20 mg/kg XAV-939 (an inhibitor of the WNT/β-catenin pathway); QCSL (100, 200, or 400 mg/kg)...
December 2019: Pharmaceutical Biology
Suleman Abid, Padmanaban Mohanan, Lalitha Kaliraj, Jin Kyu Park, Jong Chan Ahn, Deok Chun Yang
Gynostemma pentaphyllum is a traditional oriental medicinal herb used as tea since ancient time. Among Gynostemma species, G. pentaphyllum has more active chemical components and better therapeutic effect. It is used to cure depression, diabetes, anxiety, hyperlipidemia, fatigue, immunity, cancer, and oxidative stress. Overexploitation of G. pentaphyllum for its medicinal benefits has been on a rise, due to which they are adulterated or mistakenly identified with other members of Gynostemma species. Hence, we used chloroplast universal regions such as ycf3, accD, petD, psbB and their polymorphism to distinguish G...
August 7, 2019: Fitoterapia
Chao Huang, Xiu-Lian Wang, Fang-Fang Qi, Zuo-Liang Pang
Tumour-associated fibroblasts (TAFs) mediate the differentiation of adjacent stromal cells. Berberine (BBR), a monomer of traditional Chinese herbs, exhibits a potent therapeutic effect against cancer. However, the effects of BBR on the differentiation of normal colonic epithelial cells induced by TAFs have not been determined. In the present study, we selected the TAF-like myofibroblast cell line CCD-18Co. CCD-18Co-derived conditioned medium (CM) and co-culture induced epithelial-mesenchymal transition (EMT) changes in colonic epithelial HCoEpiC cells with decreased E-cadherin and increased vimentin and α-SMA expression...
August 9, 2019: Journal of Cell Communication and Signaling
Junlin He, Si Yu, Chuanjie Guo, Lu Tan, Xiaominting Song, Miao Wang, Jing Wu, Yuling Long, Daoyin Gong, Ruoqi Zhang, Zhixing Cao, Yuzhi Li, Cheng Peng
Paris polyphylla. is a traditional medicinal herb that has long been used to prevent cancer in many Asian countries. Polyphyllin I (PPI), an important bioactive constituent of Paris polyphylla, has been found to exhibit a wide variety of anticancer activities in many types of cancer cells. However, the effects of PPI on human gastric carcinoma cells and its mechanism of action remain unclear. In this study, we examined the effective anti-gastric carcinoma activity of PPI and its underlying mechanism of action in HGC-27 cells...
September 2019: Biomedicine & Pharmacotherapy
Zhaoqing Zheng, Man Wu, Juan Zhang, Wenwei Fu, Naihan Xu, Yuanzhi Lao, Lan Lin, Hongxi Xu
The complexity and multi-target feature of natural compounds have made it difficult to elucidate their mechanism of action (MoA), which hindered the development of lead anticancer compounds to some extent. In this study, we applied RNA-Seq and GSEA transcriptome analysis to rapidly and efficiently evaluate the anticancer mechanisms of neobractatin (NBT), a caged prenylxanthone isolated from the Chinese herb Garcinia bracteata . We found that NBT exerted anti-proliferative effect on various cancer cells and caused both G1/S and G2/M arrest in synchronized cancer cells through its effects on the expression of E2F1 and GADD45α...
2019: Frontiers in Oncology
Hanyuan Shen, Zhipeng Qu, Yuka Harata-Lee, Thazin Nwe Aung, Jian Cui, Wei Wang, R Daniel Kortschak, David L Adelson
Herbal compatibility is the knowledge of which herbs to combine in traditional Chinese medicine (TCM) formulations. The lack of understanding of herbal compatibility is one of the key problems for the application and popularization of TCM in western society. Because of the chemical complexity of herbal medicines, it is simpler to begin to conduct compatibility research based on herbs rather than component plant secondary metabolites. We have used transcriptome analysis to explore the effects and interactions of two plant extracts (Kushen and Baituling) combined in Compound Kushen Injection (CKI)...
2019: Frontiers in Oncology
Fenglian Wu, Jun Zhu, Guoliang Li, Jiaxin Wang, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Qingfu Zhang
Siberian ginseng , perennial herb belongs to Araliaceae family used in traditional medicines to treat hypertension, thrombus, inflammation and cancer. In the present study, we biosynthesized goldnanoparticles using Siberian ginseng aqeous extract in a cost effective manner. The synthesized Siberian ginseng gold nanoparticle (SG-GNPs) were characterized using UV-Vis spec, HR-TEM, XRD, FTIR, SAED analysis. UV-Vis spectroscopic analysis showed a surface Plasmon resonance peak at 538 nm which does not reduce till 30 days of incubation...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Shu Dong, Zhimin Ding, Hao Zhang, Qiwen Chen
Objective: To identify prognostic biomarkers and drugs that target them in colon adenocarcinoma (COAD) based on the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. Methods: The TCGA dataset was used to identify the top 50 upregulated differentially expressed genes (DEGs), and Gene Expression Omnibus profiles were used for validation. Survival analyses were conducted with the TCGA dataset using the RTCGAToolbox package in the R software environment. Drugs targeting the candidate prognostic biomarkers were searched in the DrugBank and herbal databases...
January 2019: Integrative Cancer Therapies
Shian-Ren Lin, Chia-Hsiang Chang, Che-Fang Hsu, May-Jwan Tsai, Henrich Cheng, Max K Leong, Ping-Jyun Sung, Jian-Chyi Chen, Ching-Feng Weng
Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural-based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e...
August 1, 2019: British Journal of Pharmacology
Mette Borre, Gitte Aarøe Dam, Henning Grønbaek
Background: Biologically based complementary medicines (BB-CMs) are popular in patients with cancer. However, there are only limited data for BB-CMs in patients with neuroendocrine tumors (NET). We aimed to identify the prevalence and type of BB-CM use and the association to the nutritional risk score (NRS-2002) in NET patients. Methods: We performed a cross-sectional questionnaire study in NET outpatients at the Department of Hepatology and Gastroenterology at Aarhus University Hospital. The nutritional risk was determined by the NRS-2002...
August 1, 2019: Scandinavian Journal of Gastroenterology
Ye Wang, Zhiling Zhu
Introduction: Oridonin, which is isolated from the Chinese herb Rabdosia rubescens, has been reported to exhibit an anti-tumorous effect on different cancers. In this study, we investigated the molecular mechanism by which oridonin suppresses human ovarian cancer. Material and methods: The inhibition of oridonin on cell proliferation was assessed by CCK8 assay. Cell cycle and apoptosis were analyzed by flow cytometry, staining with propidium iodide (PI) or annexin-V/PI respectively...
July 2019: Archives of Medical Science: AMS
Xi-Lin Ouyang, Feng Qin, Ri-Zhen Huang, Dong Liang, Chun-Gu Wang, Heng-Shan Wang, Zhi-Xin Liao
BACKGROUND: Non-Small-Cell Lung Cancer (NSCLC) is the most-frequent cause of cancer death, and novel chemotherapeutic drugs for treating NSCLC are urgently needed. 2α, 3α, 23-trihydroxy-13α, 27-cyclours-11-en-28-oic acid (euscaphic acid G) is a new hexacyclic triterpene acid isolated by our group from Glechoma longituba (Nakai) Kupr. However, the underlying mechanisms responsible for the anticancer effects of hexacyclic triterpene acid have not been elucidated. PURPOSE: In the present work, we evaluated growth inhibitory effect of the new isolated hexacyclic triterpene acid and explored the underlying molecular mechanisms...
July 20, 2019: Phytomedicine
Zahra Amirghofran, Narjes Shekofteh, Mehri Ghafourian, Neda Khosravi, Kurosh Kalantar, Saeed Malek-Hosseini
BACKGROUND: Immunomodulatory materials from natural herbs and the characterization of their immune enhancement<br />effects may have tremendous potential as cancer treatment. The aim of the present study was to investigate the<br />apoptosis-inducing activities of Euphorbia hebecarpa Boiss and Euphorbia petiolata Banks & Sol. plant extracts and<br />their effects on cytokine secretion by lymphocytes. MATERIALS AND METHODS: We assessed the apoptosis-inducing<br />effect of the plants' hexane extracts on previously determined sensitive cell lines (HeLa for E...
July 1, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Yi Zhao, Bingtao Li, Gaoyu Wang, Shuchao Ge, Ximing Lan, Guoliang Xu, Hongning Liu
Dendrobium officinale is a herb in traditional Chinese medicine where D. officinale polysaccharides (DOP) are the main active ingredient. This study aimed at evaluating DOP efficiency at inhibiting 1-Methyl-2-nitro-1-nitrosoguanidine (MNNG) induced precancerous lesions of gastric cancer (PLGC) in rats through the Wnt/b-catenin pathway and analyzing the variations of serum endogenous metabolites. PLGC was established in male Sprague-Dawley (SD) rats by administering 150 μg/mL MNNG in drinking water for 7 months and giving 0...
July 23, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Qinglin Li, Xiaoxuan Fu, Xinyang Ge, Feng Tao, Ping Huang, Minghua Ge, Hongchuan Jin
Polygonum perfoliatum L. belongs to the genus Polygonaceae and has a long history to be used as a Chinese medicinal herb to reduce swelling, control body temperature, and promote detoxification. However, its anticancer activity and mechanisms of action have not been evaluated yet. In the present study, we used several cell lines and xenograft models from different cancers to demonstrate the broad-spectrum anticancer activity of P. perfoliatum L as well as its underlying mechanisms of action in vitro and in vivo ...
2019: Frontiers in Oncology
Liang Fang, Fang Zhao, Stephen Iwanowycz, Junfeng Wang, Sophia Yin, Yuzhen Wang, Daping Fan
Emodin is a Chinese herb-derived compound that exhibits a variety of pharmacological benefits. Although emodin has been shown to inhibit growth of cancer cells, its antineoplastic function is incompletely understood. CD155 is a member of poliovirus receptor-related (PRR) family of adhesion molecules; it is constitutively expressed on many tumor cell lines and tissues and has diverse functions. CD155 has been reported to mediate activation of T cells via CD226 or inhibition of T cells via T-cell immunoreceptor with Ig and ITIM domains (TIGIT)...
July 17, 2019: International Immunopharmacology
Huang Li, Zijun Lai, Hong Yang, Jun Peng, Youqin Chen, Jiumao Lin
Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies worldwide. For patients diagnosed with the presence of metastatic disease, surgery is not suitable for the majority of them. Lymphangiogenesis is a key factor during cancer metastasis and is regulated by vascular endothelial growth factor C (VEGF‑C). Hedyotis diffusa Willd. (HDW) is a Chinese herb of the Rubiaceae family that reportedly inhibits tumor metastasis. However, its underlying anticancer mechanisms have not yet been elucidated...
July 5, 2019: Oncology Reports
Li Liu, Jingyan Fan, Guihai Ai, Jie Liu, Ning Luo, Caixia Li, Zhongping Cheng
BACKGROUND: Berberine (BBR), a compound extracted from a variety of medicinal herbs, has been shown multiple pharmacological effects against cancer cells of different origins. Cisplatin (DDP) is known as an effective chemotherapeutic agent against cancer by inducing DNA damage and cell apoptosis. However, the effect of the combined used of BBR and DDP on cell necroptosis in ovarian cancer has not been reported. METHODS: OVCAR3 and three patient-derived primary ovarian cancer cell lines (POCCLs) were chosen as the experimental objects...
July 18, 2019: Biological Research
Zhengshang Ruan, Lei Niu, Li Han, Rongrong Ren, Zhenyu Xu, Wenwen Dong, Lai Jiang
Tanshinones are a class of abietane diterpene compounds extracted from Salvia miltiorrhiza , and have been used for medical purposes in traditional Chinese medicinal practices. This herb has been used in the treatment of chronic obstructive pulmonary disease (COPD), breast cancer and inflammatory disorders. This study examined the anti-inflammatory properties of tanshinones. In addition, lipid-soluble compounds which were specific to Tanshinone class were also highlighted, out of which two compounds, dihydrotanshinone I and cryptotanshinone were selected with the aim of creating a new research perspective in order to further elucidate the mechanisms of the pathogenesis of inflammatory diseases...
August 2019: Experimental and Therapeutic Medicine
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