keyword
https://read.qxmd.com/read/38476474/tissue-engineering-scaffolds-loaded-with-a-variety-of-plant-extracts-novel-model-in-breast-cancer-therapy
#21
REVIEW
Reyhaneh Azhari Rad, Yasaman Naghdi, Mobina Majidi Jamalabadi, Sima Masoumi, Leila Rezakhani, Morteza Alizadeh
Despite recent improvements in detecting and managing breast cancer (BC), it continues to be a major worldwide health concern that annually affects millions of people. Exploring the anti-BC potentials of natural compounds has received a lot of scientific attention due to their multi-target mode of action and good safety profiles because of these unmet needs. Drugs made from herbs are secure and have a lot fewer negative effects than those made from synthetic materials. Early stage patients benefit from breast-conserving surgery, but the risk of local recurrence remains, necessitating implanted scaffolds...
2024: Breast Cancer: Basic and Clinical Research
https://read.qxmd.com/read/38472833/quantitative-nmr-spectrometry-of-phenylpropanoids-including-isoeugenol-in-herbs-spices-and-essential-oils
#22
JOURNAL ARTICLE
Pascal Fabry, Sandra Weber, Jan Teipel, Elke Richling, Stephan G Walch, Dirk W Lachenmeier
Isoeugenol (2-methoxy-4-(1-propenyl)phenol) has been recently classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). This study conducted an analysis of isoeugenol in common herbs and spices, including basil, cinnamon, ginger, and nutmeg, using 1 H nuclear magnetic resonance (NMR) spectrometry. Additionally, over 1300 coffee samples were analysed by 1 H-NMR for isoeugenol, but it was not detected in any of the analysed samples. Various essential oils, including nutmeg, basil, clove, sweet flag, and ylang-ylang oils, were examined for isoeugenol content...
February 27, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38466979/effectiveness-of-chinese-herbal-medicine-as-a-complementary-treatment-for-neutropenia-prevention-and-immunity-modulation-during-chemotherapy-in-patients-with-breast-cancer-protocol-for-a-real-world-pragmatic-clinical-trial
#23
JOURNAL ARTICLE
Kai-Hung Wang, Hsuan-Shu Shen, Sung-Chao Chu, Tso-Fu Wang, Ching-Wei Lin, Wei-Han Huang, Yi-Feng Wu, Ching-Chun Ho, Cheng-Yoong Pang, Chi-Cheng Li
BACKGROUND: In recent years, advancements in cancer treatment have enabled cancer cell inhibition, leading to improved patient outcomes. However, the side effects of chemotherapy, especially leukopenia, impact patients' ability to tolerate their treatments and affect their quality of life. Traditional Chinese medicine is thought to provide complementary cancer treatment to improve the quality of life and prolong survival time among patients with cancer. OBJECTIVE: This study aims to evaluate the effectiveness of Chinese herbal medicine (CHM) as a complementary treatment for neutropenia prevention and immunity modulation during chemotherapy in patients with breast cancer...
March 11, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38463777/antitumour-mechanisms-of-traditional-chinese-medicine-elicited-by-regulating-tumour-associated-macrophages-in-solid-tumour-microenvironments
#24
REVIEW
Jiamin Gao, Weishan Tan, Luyun Yuan, Haoyue Wang, Junkai Wen, Kexiang Sun, Xin Chen, Shuyun Wang, Wanli Deng
Tumour-associated macrophages (TAMs), particularly M2-TAMs, constitute the largest proportion of immune cells in the solid tumour microenvironment, playing a crucial role in tumour progression and correlating with poor prognosis. TAMs promote the proliferation, invasion, and metastasis of tumour cells by remodelling the extracellular matrix, inhibiting immunity, promoting immune escape and tumour angiogenesis, and affecting cell metabolism. Traditional Chinese medicine (TCM) has been used clinically in China for millennia...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38462913/integration-of-network-pharmacology-and-experimental-validation-to-explore-jixueteng-yinyanghuo-herb-pair-alleviate-cisplatin-induced-myelosuppression
#25
JOURNAL ARTICLE
Yi Liu, Shuying Dai, Yixiao Xu, Yuying Xiang, Yao Zhang, Zeting Xu, Lin Sun, Gao-Chen-Xi Zhang, Qijin Shu
Jixueteng, the vine of the bush Spatholobus suberectus Dunn., is widely used to treat irregular menstruation and arthralgia. Yinyanghuo, the aboveground part of the plant Epimedium brevicornum Maxim., has the function of warming the kidney to invigorate yang. This research aimed to investigate the effects and mechanisms of the Jixueteng and Yinyanghuo herbal pair (JYHP) on cisplatin-induced myelosuppression in a mice model. Firstly, ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) screened 15 effective compounds of JYHP decoction...
2024: Integrative Cancer Therapies
https://read.qxmd.com/read/38462407/herbal-compounds-as-promising-therapeutic-agents-in-precision-medicine-strategies-for-cancer-a-systematic-review
#26
REVIEW
Bizhar Ahmed Tayeb, Ikhwan Yuda Kusuma, Alaa A M Osman, Renáta Minorics
BACKGROUND: The field of personalized medicine has gained increasing attention in cancer care, with the aim of tailoring treatment strategies to individual patients for improved outcomes. Herbal medicine, with its long-standing historical use and extensive bioactive compounds, offers a rich source of potential treatments for various diseases, including cancer. OBJECTIVE: To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer diseases...
February 28, 2024: Journal of Integrative Medicine
https://read.qxmd.com/read/38461683/therapeutic-effects-and-molecular-mechanisms-of-quercetin-in-gynecological-disorders
#27
REVIEW
Xian Jian, Chen Shi, Weichen Luo, Liyuan Zhou, Lili Jiang, Kuiran Liu
Quercetin is a representative flavonoid that is widely present in fruits, herbs, and vegetables. It is also an important active core component in traditional Chinese medicines. As an important flavonoid, quercetin has various properties and exerts antioxidant, anti-inflammatory, and cardioprotective effects. The public interest in quercetin is increasing, and quercetin has been used to prevent or treat numerous of diseases, such as polycystic ovary syndrome (PCOS), cancer, autoimmune diseases and chronic cardiovascular diseases, in clinical experiments and animal studies due to its powerful antioxidant properties and minimal side effects...
March 8, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38460574/chemometric-profiling-and-anti-arthritic-activity-of-aerial-parts-of-glinus-oppositifolius-l-aug-dc
#28
JOURNAL ARTICLE
Chandan Das, Goutam Ghosh, Goutam Rath, Debajyoti Das, Biswakanth Kar, Deepak Pradhan, Vineet Kumar Rai, Tushar Kanti Rajwar, Jitu Halder, Priyanka Dash
ETHNOPHARMACOLOGICAL RELEVANCE: Glinus oppositifolius (L.) Aug. DC. belongs to the family Molluginaceae, an annual prostrate herb traditionally used to treat inflammations, arthritis, malarial, wounds, fevers, diarrhoea, cancer, stomach discomfort, jaundice, and intestinal parasites. However, the anti-arthritic activity of the aerial part has still not been reported. AIM OF THE STUDY: To investigate the antioxidant and anti-arthritic activity of G. oppositifolius in Complete Freund's Adjuvant (CFA) induced rats...
March 7, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38459947/potential-bioactive-compound-and-hub-gene-identification-of-endometrial-carcinoma-using-systems-biology
#29
JOURNAL ARTICLE
Shanmugapriya Rishikesan, Parthiban Brindhadevi, Rajakumari K, N Srinath, M Balamugundhan
Endometrial carcinoma is a frequent cancer of the female genital tract. Endometrial carcinoma accounts for 97% of all uterine malignancies and 3 % of sarcomas that develop from the endometrium's glands. Endometrial cancer is frequently found in its early stages since most women quickly report postmenopausal vaginal hemorrhage. The need for more advanced medications to improve survival in such situations is still unfulfilled. As a result, there is growing interest in employing an herbal treatment to treat endometriosis, which seems to be an effective strategy...
March 9, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38459935/a-network-pharmacological-approach-for-the-identification-of-potential-therapeutic-targets-of-brahmi-nei-a-complex-traditional-siddha-formulation
#30
JOURNAL ARTICLE
Agnes Preethy H, Yanamandram Balasubramanian Venkatakrishnan, Vigneshwar Ramakrishnan, Uma Maheswari Krishnan
Brahmi Nei (BN), a traditional Indian polyherbal formulation has been described in classical texts for the treatment of anxiety and depression, as well as to fortify the immune system. The individual herbs of BN have been used for treatment of wide range of disorders including cognition, inflammation, skin ailments and cancer etc., This diverse basket of therapeutic activity suggests that BN may possess therapeutic benefits to other disorders. So, the present study aims to identify the potential therapeutic targets of BN using a network pharmacological approach to comprehend the multi target action of its multiple phytoconstituents...
March 9, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38456489/%C3%AE-%C3%A2-phellandrene-enhances-the-apoptosis-of-ht%C3%A2-29-cells-induced-by-5%C3%A2-fluorouracil-by-modulating-the-mitochondria%C3%A2-dependent-pathway
#31
JOURNAL ARTICLE
Anita Caroline Susanto, Laksmi Hartajanie, Chih-Chung Wu
α‑Phellandrene (α‑PA), a natural constituent of herbs, inhibits cancer cell viability and proliferation. 5‑Fluorouracil (5‑FU) is a frequently utilized chemotherapeutic medicine for the treatment of colon cancer, which works by triggering cancer cell apoptosis. The present study examined how the combination of α‑PA and 5‑FU affects the suppression of human colon cancer cells by promoting apoptosis. The impact of this treatment on cell viability, apoptosis, and the expression levels of Bcl‑2 family members, caspase family members and mitochondria‑related molecules in HT‑29 cells was assessed by the MTT assay, immunocytochemistry, western blotting and quantitative PCR...
April 2024: Oncology Reports
https://read.qxmd.com/read/38452697/paris-polyphylla-ethanol-extract-and-polyphyllin-i-ameliorate-adenomyosis-by-inhibiting-epithelial-mesenchymal-transition
#32
JOURNAL ARTICLE
Ya-Xin Shi, Li Xu, Xin Wang, Ke-Ke Zhang, Cheng-Yuan Zhang, Hong-Yun Liu, Ping-Ping Ding, Wei Shi, Zhi-Yong Liu
BACKGROUND: The active ingredients of the Chinese medical herb Paris polyphylla, P. polyphylla ethanol extract (PPE) and polyphyllin I (PPI), potentially inhibit epithelial-mesenchymal transition (EMT) in tumors. However, the roles of these ingredients in inhibiting EMT in adenomyosis (AM) remain to be explored. PURPOSE: The primary goal of the study was to uncover the underlying molecular processes through which PPE and PPI suppress EMT in AM, alongside assessing the safety profiles of these substances...
February 22, 2024: Phytomedicine
https://read.qxmd.com/read/38445504/review-of-herbal-medicinal-plants-used-in-the-management-of-cancers-in-the-east-africa-region-from-2019-to-2023
#33
REVIEW
Ali Kudamba, Josephine N Kasolo, Godfrey S Bbosa, Allan Lugaajju, Henry Wabinga, Hussein M Kafeero, Jamilu E Ssenku, Shaban O Alemu, Abdul Walusansa, Nixon Niyonzima, Haruna Muwonge
BACKGROUND: In the East African region, herbal plants are essential in the treatment and control of cancer. Given the diverse ecological and cultural makeup of the regional states, it is likely that different ethnic groups will use the same or different plants for the same or different diseases. However, since 2019, this has not been compiled into a single study. PURPOSE: The study aimed to compile and record the medicinal plants utilized in East Africa from April 2019 to June 2023 to treat various cancer types...
2024: Integrative Cancer Therapies
https://read.qxmd.com/read/38444945/a-comprehensive-review-of-the-anticancer-effects-of-decursin
#34
REVIEW
Yueming Chu, Qiang Yuan, Hangyu Jiang, Liang Wu, Yutao Xie, Xiaofen Zhang, Lin Li
Cancer is a globally complex disease with a plethora of genetic, physiological, metabolic, and environmental variations. With the increasing resistance to current anticancer drugs, efforts have been made to develop effective cancer treatments. Currently, natural products are considered promising cancer therapeutic agents due to their potent anticancer activity and low intrinsic toxicity. Decursin, a coumarin analog mainly derived from the roots of the medicinal plant Angelica sinensis , has a wide range of biological activities, including anti-inflammatory, antioxidant, neuroprotective, and especially anticancer activities...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38442431/intranasal-delivery-of-herbal-medicine-for-disease-treatment-a-systematic-review
#35
REVIEW
Khoa Nguyen Tran, Ji-Hye Kwon, Min-Kyung Kim, Nhi Phuc Khanh Nguyen, In-Jun Yang
BACKGROUND: Intranasal administration has been adopted in traditional medicine to facilitate access to the bloodstream and central nervous system (CNS). In modern medicine, nasal drug delivery systems are valuable for disease treatment because of their noninvasiveness, good absorption, and fast-acting effects. OBJECTIVE: This study aimed to systematically organize preclinical and clinical studies on intranasal herbal medicines to highlight their potential in drug development...
February 28, 2024: Phytomedicine
https://read.qxmd.com/read/38441023/ginsenoside-rg3-a-review-of-its-anticancer-mechanisms-and-potential-therapeutic-applications
#36
JOURNAL ARTICLE
Lei Wu, Lin Bai, Wenshu Dai, Yaping Wu, Pengjun Xi, Lily Zheng, Jie Zhang
BACKGROUND: Traditional Chinese Medicine (TCM) has a long history of treating various diseases and is increasingly being recognized as a complementary therapy for cancer. A promising natural compound extracted from the Chinese herb ginseng is ginsenoside Rg3, which has demonstrated significant anticancer effects. It has been tested in a variety of cancers and tumors and has proven to be effective in suppressing cancer. OBJECTIVE: This work covers various aspects of the role of ginsenoside Rg3 in cancer treatment, including its biological functions, key pathways, epigenetics, and potential for combination therapies, all of which have been extensively researched and elucidated...
March 4, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38437959/ursolic-acid-alleviates-paclitaxel-induced-peripheral-neuropathy-through-ppar%C3%AE-activation
#37
JOURNAL ARTICLE
Yulian Yang, Zhongzheng He, Shuangchan Wu
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) reduces the overall quality of life and leads to interruption of chemotherapy. Ursolic acid, a triterpenoid naturally which presents in fruit peels and in many herbs and spices, can function as a peroxisome proliferator-activated receptor γ (PPARγ) agonist, and has been widely used as an herbal medicine with a wide spectrum of pharmacological activities, including anti-cancer, anti-inflammatory and neuroprotective effect...
March 2, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38432577/network-pharmacology-analysis-molecular-docking-integrated-experimental-verification-reveal-%C3%AE-sitosterol-as-the-active-anti-nsclc-ingredient-of-polygonatum-cyrtonema-hua-by-suppression-of-pi3k-akt-hif-1%C3%AE-signaling-pathway
#38
JOURNAL ARTICLE
Wen Cao, Fangwei Yuan, Tongyan Liu, Rong Yin
ETHNOPHARMACOLOGICAL RELEVANCE: Polygonatum cyrtonema Hua (Huangjing) is a Chinese herb that is considered by ancient Chinese healers to have the effect of nourishing yin and moisturizing the lungs. It is clinically used to treat diseases of the pulmonary system, including non-small cell lung cancer. However, the precise active components and underlying mechanisms of Huangjing in the context of treating NSCLC remain uncertain. AIM OF THE STUDY: This study aimed to explore the active components and mechanisms of Huangjing for the treatment of NSCLC by means of data mining, network pharmacology, and in vitro and vivo experiments...
March 1, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38428661/predicting-the-mechanism-of-action-of-yqyyjd-prescription-in-the-treatment-of-non-small-cell-lung-cancer-using-transcriptomics-analysis
#39
JOURNAL ARTICLE
Yinan Yin, Yichao Wang, Chengyan Wang, Yilu Zhang, Ao Qi, Jiajun Song, Ling Xu, Wenxiao Yang, Lijing Jiao
ETHNOPHARMACOLOGICAL RELEVANCE: The efficacy of the herbal formula Yiqi Yangyin Jiedu (YQYYJD) in the treatment of advanced lung cancer has been reported in clinical trials. However, the key anti-lung cancer herbs and molecular mechanisms underlying its inhibition of lung cancer are not well-understood. AIM OF THE STUDY: To identify the key anti-lung cancer herbs in the YQYYJD formula and investigate their therapeutic effect and potential mechanism of action in non-small cell lung cancer (NSCLC) using transcriptomics and bioinformatics techniques...
February 28, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38428659/exploring-the-mechanism-of-erteng-sanjie-capsule-in-treating-gastric-and-colorectal-cancers-via-network-pharmacology-and-in-vivo-validation
#40
JOURNAL ARTICLE
Wencui Zhang, Ying Wang, Han Yu, Zengcai Jin, Yuyao Yuan, Likun Liu, Jing Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: The Erteng-Sanjie capsule (ETSJC) has therapeutic effects against gastric cancer (GC) and colorectal cancer (CRC). However, its underlying pharmacological mechanism remains unclear. AIM OF THE STUDY: To explore the pharmacological mechanism of ETSJC against GC and CRC via network pharmacology and in-vivo validation. MATERIALS AND METHODS: Data on the ingredients of ETSJC were obtained from the TCMSP and HERB databases...
February 28, 2024: Journal of Ethnopharmacology
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