Francesca Bai, Valeria Bono, Lidia Borghi, Federica Bonazza, Camilla Falcinella, Virginia Vitaletti, Federica Miraglia, Mattia Trunfio, Andrea Calcagno, Jessica Cusato, Elena Vegni, Antonella D'arminio Monforte, Giulia Marchetti
BACKGROUND: HIV-associated neurocognitive disorders (HAND) still affects persons living with HIV (PLWH) and their pathogenesis isn't completely understood. We aimed to explore the association between plasma and CSF markers of blood-brain barrier (BBB) impairment and HAND in untreated PLWH. DESIGN: Cross-sectional study. METHODS: We enrolled untreated PLWH, who underwent blood exams and lumbar puncture to measure inflammation (IL-15, TNF-α), BBB damage (zonulin and tight junction proteins, TJs: occludin, claudin-5) and endothelial adhesion molecules (VCAM-1, ICAM-1)...
May 3, 2024: AIDS