Emilia Alors-Pérez, Ricardo Blázquez-Encinas, María Trinidad Moreno-Montilla, Víctor García-Vioque, Juan Manuel Jiménez-Vacas, Andrea Mafficini, Iranzu González-Borja, Claudio Luchini, Juan M Sánchez-Hidalgo, Marina E Sánchez-Frías, Sergio Pedraza-Arevalo, Antonio Romero-Ruiz, Rita T Lawlor, Antonio Viúdez, Manuel D Gahete, Aldo Scarpa, Álvaro Arjona-Sánchez, Raúl M Luque, Alejandro Ibáñez-Costa, Justo P Castaño
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, characterized by late diagnosis and poor treatment response. Surgery is the only curative approach, only available to early-diagnosed patients. Current therapies have limited effects, cause severe toxicities, and minimally improve overall survival. Understanding of splicing machinery alterations in PDAC remains incomplete. Here, we comprehensively examined 59 splicing machinery components, uncovering dysregulation in pre-mRNA processing factor 8 (PRPF8) and RNA-binding motif protein X-linked (RBMX)...
May 24, 2024: Molecular Oncology