keyword
https://read.qxmd.com/read/38653539/impact-of-age-comorbidities-and-relevant-changes-on-surveillance-strategy-of-intraductal-papillary-mucinous-neoplasms-a-competing-risk-analysis
#41
JOURNAL ARTICLE
Stefano Crippa, Giovanni Marchegiani, Giulio Belfiori, Paola Vittoria Maria Rancoita, Tommaso Pollini, Anna Burelli, Laura Apadula, Maria Giovanna Scarale, Davide Socci, Marco Biancotto, Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso, Roberto Salvia, Massimo Falconi
OBJECTIVE: Cost-effectiveness of surveillance for branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) is debated. We combined different categories of risks of IPMN progression and of IPMN-unrelated mortality to improve surveillance strategies. DESIGN: Retrospective analysis of 926 presumed BD-IPMNs lacking worrisome features (WFs)/high-risk stigmata (HRS) under surveillance. Charlson Comorbidity Index (CACI) defined the severity of comorbidities. IPMN relevant changes included development of WF/HRS, pancreatectomy or death for IPMN or pancreatic cancer...
April 23, 2024: Gut
https://read.qxmd.com/read/38652392/statewide-survey-of-primary-care-and-subspecialty-providers-on-hepatocellular-carcinoma-risk-stratification-and-surveillance-practices
#42
JOURNAL ARTICLE
Andrew M Moon, Rachel M Swier, Lindsay M Lane, A Sidney Barritt, Hanna K Sanoff, Andrew F Olshan, Stephanie B Wheeler, George N Ioannou, Nicole J Kim, Scott Hagan, Philip Vutien, Thad Benefield, Louise M Henderson
BACKGROUND: Hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis is associated with improved survival. Provision of HCC surveillance is low in the US, particularly in primary care settings. AIMS: To evaluate current hepatitis C virus (HCV) and HCC surveillance practices and physician attitudes regarding HCC risk-stratification among primary care and subspecialty providers. METHODS: Using the Tailored Design Method, we delivered a 34-item online survey to 7654 North Carolina-licensed internal/family medicine or gastroenterology/hepatology physicians and advanced practice providers in 2022...
April 23, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38642272/the-role-of-the-gut-microbiome-in-health-and-disease-in-the-elderly
#43
REVIEW
Lea Ann Chen, Kaitlyn Boyle
PURPOSE OF REVIEW: Growing evidence supports the contribution of age in the composition and function of the gut microbiome, with specific findings associated with health in old age and longevity. RECENT FINDINGS: Current studies have associated certain microbiota, such as Butyricimonas, Akkermansia, and Odoribacter, with healthy aging and the ability to survive into extreme old age. Furthermore, emerging clinical and pre-clinical research have shown promising mechanisms for restoring a healthy microbiome in elderly populations through various interventions such as fecal microbiota transplant (FMT), dietary interventions, and exercise programs...
April 20, 2024: Current Gastroenterology Reports
https://read.qxmd.com/read/38639680/american-society-for-gastrointestinal-endoscopy-european-society-of-gastrointestinal-endoscopy-guideline-on-primary-endoscopic-bariatric-and-metabolic-therapies-for-adults-with-obesity
#44
Pichamol Jirapinyo, Alia Hadefi, Christopher C Thompson, Árpád V Patai, Rahul Pannala, Stefan K Goelder, Vladimir Kushnir, Marc Barthet, Caroline M Apovian, Ivo Boskoski, Christopher G Chapman, Paul Davidson, Gianfranco Donatelli, Vivek Kumbhari, Bu Hayee, Janelle Esker, Tomas Hucl, Aurora D Pryor, Roberta Maselli, Allison R Schulman, Francois Pattou, Shira Zelber-Sagi, Paul A Bain, Valérie Durieux, Konstantinos Triantafyllou, Nirav Thosani, Vincent Huberty, Shelby Sullivan
This joint ASGE-ESGE guideline provides an evidence-based summary and recommendations regarding the role of endoscopic bariatric and metabolic therapies (EBMTs) in the management of obesity. The document was developed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. It evaluates the efficacy and safety of EBMT devices and procedures that currently have CE mark or FDA-clearance/approval, or that had been approved within five years of document development. The guideline suggests the use of EBMTs plus lifestyle modification in patients with a BMI of ≥ 30 kg/m2 , or with a BMI of 27...
April 16, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38639679/consensus-statements-on-the-current-landscape-of-artificial-intelligence-applications-in-endoscopy-addressing-roadblocks-and-advancing-artificial-intelligence-in-gastroenterology
#45
Sravanthi Parasa, Tyler Berzin, Cadman Leggett, Seth Gross, Alessandro Repici, Omer F Ahmad, Austin Chiang, Nayantara Coelho-Prabhu, Jonathan Cohen, Evelien Dekker, Rajesh N Keswani, Charles E Kahn, Cesare Hassan, Nicholas Petrick, Peter Mountney, Jonathan Ng, Michael Riegler, Yuichi Mori, Yutaka Saito, Shyam Thakkar, Irving Waxman, Michael Bradley Wallace, Prateek Sharma
BACKGROUND AND AIMS: The American Society for Gastrointestinal Endoscopy (ASGE) AI Task Force along with experts in endoscopy, technology space, regulatory authorities, and other medical subspecialties initiated a consensus process that analyzed the current literature, highlighted potential areas, and outlined the necessary research in artificial intelligence (AI) to allow a clearer understanding of AI as it pertains to endoscopy currently. METHODS: A modified Delphi process was used to develop these consensus statements...
April 16, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38638082/endoscopic-application-of-magnetic-compression-anastomosis-a-review
#46
REVIEW
Guo Zhang, Zheng Liang, Guiping Zhao, Shutian Zhang
Magnetic compression anastomosis (MCA) is a new method that provides sutureless passage construction for tubular organs. Due to the high recurrence rate of conventional endoscopic treatment and the high morbidity and mortality of surgical procedures, the MCA technique shows promise. The aim of this review is to comprehensively examine the literature related to the use of MCA in different gastrointestinal diseases over the past few years, categorizing them according to the anastomotic site and describing in detail the various methods of magnet delivery and the clinical outcomes of MCA...
April 18, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38637963/progression-of-the-fib-4-index-among-patients-with-chronic-hcv-infection-and-early-liver-disease
#47
JOURNAL ARTICLE
Lisette A P Krassenburg, Raoel Maan, Amy Puenpatom, Nicole S Erler, Christoph Welsch, Stijn van Hees, Orlando Cerrhoci, Johannes Vermehren, Robert J de Knegt, Bettina E Hansen, Stefan Zeuzem, Thomas Vanwolleghem, Harry L A Janssen, Robert A de Man, Jordan J Feld, Adriaan J van der Meer
BACKGROUND AND AIMS: Historical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed to assess liver disease progression according to the non-invasive Fibrosis-4 (FIB-4) index in patients with chronic HCV and early disease. METHODS AND RESULTS: Patients diagnosed with chronic HCV and FIB-4 <3.25 from four international liver clinics were included in a retrospective cohort study...
December 7, 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/38637458/women-in-gastroenterology-what-is-the-current-situation-results-of-an-italian-national-survey
#48
JOURNAL ARTICLE
Ludovica Venezia, Nunzia Labarile, Roberta Maselli, Antonio Benedetti, Bruno Annibale, Maria Caterina Parodi, Marco Soncini, Fabiana Zingone
BACKGROUND: Many women grow up dreaming of becoming doctors, preferring specialties that allow more focus on time outside the hospital and on family life. Nowadays, specialties, like gastroenterology, have still a significant gender gap. METHODS: Based on this known discrepancy, a web-based questionnaire was designed by the Young Component of the Scientific Committee of the Federation of Italian Scientific Societies of Digestive Diseases 2023 (FISMAD) to examine the current situation of female gastroenterologists in Italy...
April 18, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38637454/early-versus-standard-initiation-of-terlipressin-for-acute-kidney-injury-in-aclf-a-randomized-controlled-trial-eterli-study
#49
JOURNAL ARTICLE
Ankur Jindal, Hitesh Singh, Guresh Kumar, Vinod Arora, Manoj Kumar Sharma, Rakhi Maiwall, V Rajan, Harsh Vardhan Tewathia, Chitranshu Vasishtha, Shiv Kumar Sarin
BACKGROUND AND AIMS: Terlipressin infusion is effective in hepatorenal syndrome (HRS-AKI). However, its efficacy for HRS-AKI resolution in acute-on-chronic liver failure (ACLF) patients has been suboptimal. Progression of AKI is rapid in ACLF. We investigated whether early initiation of terlipressin(eTerli) can improve response rates. METHODS: Consecutive ACLF patients with stage II/III AKI despite albumin resuscitation (40 g) were randomized to receive terlipressin at 2 mg/24 h plus albumin at 12 h (ET, n = 35) or at 48 h as standard therapy (ST, n = 35)...
April 18, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38634559/visceral-adipose-tissue-reduction-measured-by-deep-neural-network-architecture-improved-reflux-esophagitis-endoscopic-grade
#50
JOURNAL ARTICLE
Yoo Min Han, Jeong Hee Yoon, Seokha Yoo, Su Jin Chung, Jeong Min Lee, Ji Min Choi, Eun Hyo Jin, Ji Yeon Seo
BACKGROUND AND AIMS: Visceral obesity is a risk factor for reflux esophagitis (RE). We investigated the risk of RE according to visceral adipose tissue (VAT) measured by deep neural network architecture using computed tomography and evaluated the longitudinal association between abdominal adipose tissue changes and the disease course of RE. METHODS: Individuals receiving health checkups who underwent esophagogastroduodenoscopy (EGD) and abdominal computed tomography (CT) at Seoul National University Healthcare System Gangnam Center between 2015 and 2016 were included...
April 18, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38632832/reproductive-functions-and-pregnancy-outcome-in-female-patients-with-celiac-disease
#51
JOURNAL ARTICLE
Shubham Prasad, Priyanka Singh, Alka Singh, Wajiha Mehtab, Simple Rajput, Sana Dang, Ashish Chauhan, Mahendra Singh Rajput, Garima Kachhawa, Soumya Jagannath, Vineet Ahuja, Govind K Makharia
BACKGROUND AND AIM: Abnormalities in the reproductive functions are often ignored while evaluating a patient with celiac disease (CeD). We evaluated the entire reproductive functions in female patients with CeD. METHODS: In a case control study between 2020 and 2021 using detailed questionnaire, we evaluated reproductive functions (age at menarche, menstrual pattern, fertility, pregnancy outcome and menopause) in biopsy-proven female patients with CeD of age >10 years...
April 17, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38631839/defining-predictors-of-responsiveness-to-advanced-therapies-in-crohn-s-disease-and-ulcerative-colitis-protocol-for-the-ibd-response-and-nested-cd-metaresponse-prospective-multicentre-observational-cohort-study-in-precision-medicine
#52
JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631807/management-of-hepatorenal-syndrome-and-associated-outcomes-a-systematic-reviews
#53
REVIEW
Jamshid Roozbeh, Shahrokh Ezzatzadegan Jahromi, Mohamad Hossein Rezazadeh, Anahid Hamidianjahromi, Leila Malekmakan
BACKGROUND: Hepatorenal syndrome (HRS), a multiorgan condition of acute kidney injury, is seen in advanced liver disease. This study aims to evaluate the current treatment for HRS. METHODS: The authors searched PubMed, Scopus and Google Scholar literature. After quality assessment, 31 studies were included in this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology and the population, intervention, comparison and outcome scheme were used...
April 17, 2024: BMJ Open Gastroenterology
https://read.qxmd.com/read/38631318/analysis-of-the-characteristics-of-coexisting-lesions-in-colorectal-cancer-patients-in-an-international-study-a-subgroup-analysis-of-the-atlas-trial
#54
JOURNAL ARTICLE
Naohisa Yoshida, Sho Suzuki, Ken Inoue, Satimai Aniwan, Han-Mo Chiu, Kannikar Laohavichitra, Sakkarin Chirapongsathorn, Takeshi Yamamura, Chen-Ya Kuo, Tiing Leong Ang, Takahito Takezawa, Rungsun Rerknimitr, Hideki Ishikawa
INTRODUCTION: We investigated coexisting lesion types in patients with invasive colorectal cancer (CRC) in a multinational study for comprehending the adenoma-carcinoma and serrated pathway about the development of CRC. METHODS: We retrospectively reviewed 3050 patients enrolled in the international randomized controlled trial (ATLAS study) to evaluate the colorectal polyp detection performance of image-enhanced endoscopy in 11 institutions in four Asian countries/regions...
April 17, 2024: Digestion
https://read.qxmd.com/read/38630422/capsules-for-the-diagnosis-and-treatment-of-gastrointestinal-motility-disorders-a-game-changer
#55
REVIEW
Irene Sonu, Sun Jung Oh, Satish S C Rao
PURPOSE OF REVIEW: Over the last few decades, there have been remarkable strides in endoscopy and radiological imaging that have advanced gastroenterology. However, the management of neurogastroenterological disorders has lagged behind, in part handicapped by the use of catheter-based manometry that is both non-physiological and uncomfortable. The advent of capsule technology has been a game changer for both diagnostic and therapeutic applications. RECENT FINDINGS: Here, we discuss several capsule devices that are available or under investigation...
April 17, 2024: Current Gastroenterology Reports
https://read.qxmd.com/read/38629327/an-abdominal-vibration-combined-with-walking-exercise-avcwe-program-for-older-patients-with-constipation-development-and-feasibility-study
#56
JOURNAL ARTICLE
Yuan-Yuan Zhang, Ramoo Vimala, Ping Lei Chui, Ida Normiha Hilmi
BACKGROUND: Older patients with constipation are at higher risk for inadequate bowel preparation, but there are currently no targeted strategies. This study aims to develop an abdominal vibration combined with walking exercise (AVCWE) program and assess its feasibility among older patients with constipation. METHODS: Phase I: Using the Delphi technique, eight experts across three professional fields were consulted to develop the AVCWE program. The experts evaluated and provided recommendations on demonstration videos and detailed descriptions of the preliminary protocol...
April 17, 2024: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/38629308/current-status-of-preoperative-endoscopic-biliary-drainage-for-distal-and-hilar-biliary-obstruction
#57
REVIEW
Hirotoshi Ishiwatari, Junya Sato, Hiroki Sakamoto, Takuya Doi, Hiroyuki Ono
The purpose of preoperative biliary drainage (PBD) is to reduce complications during the perioperative period. The extrahepatic bile duct comprises distal and hilar bile ducts and assessing the need for PBD must be considered separately for each duct, as surgical procedures and morbidities vary. The representative disease-causing distal bile duct obstruction is pancreatic cancer. A randomized controlled trial has revealed that PBD carries the risk of recurrent cholangitis and pancreatitis before surgery, thus eliminating the need for PBD when early surgery is feasible...
April 17, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/38628397/current-advances-and-future-directions-in-combined-hepatocellular-and-cholangiocarcinoma
#58
REVIEW
Yu-Zhu Zhang, Yu-Chen Liu, Tong Su, Jiang-Nan Shi, Yi Huang, Bo Liang
The low incidence of combined hepatocellular cholangiocarcinoma (cHCC-CCA) is an important factor limiting research progression. Our study extensively included nearly three decades of relevant literature and assembled the most comprehensive database comprising 5,742 patients with cHCC-CCA. We summarized the characteristics, tumor markers, and clinical features of these patients. Additionally, we present the evolution of cHCC-CCA classification and explain the underlying rationale for these classification standards...
2024: Gastroenterology Report
https://read.qxmd.com/read/38627920/validation-of-gpt-4-for-clinical-event-classification-a-comparative-analysis-with-icd-codes-and-human-reviewers
#59
JOURNAL ARTICLE
Yichen Wang, Yuting Huang, Induja R Nimma, Songhan Pang, Maoyin Pang, Tao Cui, Vivek Kumbhari
BACKGROUND AND AIM: Effective clinical event classification is essential for clinical research and quality improvement. The validation of artificial intelligence (AI) models like Generative Pre-trained Transformer 4 (GPT-4) for this task and comparison with conventional methods remains unexplored. METHODS: We evaluated the performance of the GPT-4 model for classifying gastrointestinal (GI) bleeding episodes from 200 medical discharge summaries and compared the results with human review and an International Classification of Diseases (ICD) code-based system...
April 16, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38626060/the-role-of-the-fibroblast-in-barrett-s-esophagus-and-esophageal-adenocarcinoma
#60
JOURNAL ARTICLE
Huili Zhu, Ramon U Jin
PURPOSE OF REVIEW: Barrett's esophagus (BE) is the number one risk factor for developing esophageal adenocarcinoma (EAC), a deadly cancer with limited treatment options that has been increasing in incidence in the US. In this report, we discuss current studies on the role of mesenchyme and cancer-associated fibroblasts (CAFs) in BE and EAC, and we highlight translational prospects of targeting these cells. RECENT FINDINGS: New insights through studies using single-cell RNA sequencing (sc-RNA seq) have revealed an important emerging role of the mesenchyme in developmental signaling and cancer initiation...
April 12, 2024: Current Opinion in Gastroenterology
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