Yuanji Dai, Min Zhang, Xiaoyu Liu, Ting Sun, Wenqi Qi, Wei Ding, Zhe Chen, Ping Zhang, Ruirui Liu, Huimin Chen, Siyan Chen, Yuzhen Wang, Yingying Yue, Nannan Song, Weiwei Wang, Haihong Jia, Zhongrui Ma, Cuiling Li, Qixin Chen, Bingqing Li
The intestinal pathogen Salmonella enterica rapidly enters the bloodstream after the invasion of intestinal epithelial cells, but how Salmonella breaks through the gut-vascular barrier is largely unknown. Here, we report that Salmonella enters the bloodstream through intestinal CX3CR1+ macrophages during early infection. Mechanistically, Salmonella induces the migration/invasion properties of macrophages in a manner dependent on host cell actin and on the pathogen effector SteC. SteC recruits host myosin light chain protein Myl12a and phosphorylates its Ser19 and Thr20 residues...
March 25, 2024: EMBO Journal