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REVIEW
Tadatsugu Morimoto, Yu Toda, Michiyuki Hakozaki, Permsak Paholpak, Kazuyuki Watanabe, Kinshi Kato, Masatsugu Tsukamoto, Hirohito Hirata, Yoichi Kaneuchi, Yasunori Tome, Satomi Nagamine, Kotaro Nishida, Hiroo Katsuya, Yoshihiro Matsumoto, Koji Otani, Masaaki Mawatari, Takuya Nikaido
Despite the recent advances in cancer treatment, the incidence of patients with spinal metastases continues to grow along with the total number of cancer patients. Spinal metastases can significantly impair activities of daily living (ADL) and quality of life (QOL), compared with other types of bone metastases, as they are characterized with severe pain and paralysis caused by skeletal-related events. Reduced ADL can also lead to treatment limitations as certain anticancer agents and radiation therapy are not compatible treatments; thus, leading to a shorter life expectancy...
2024: Frontiers in Oncology
#2
REVIEW
Lee M Jeys, Joachim Thorkildsen, Vineet Kurisunkal, Ajay Puri, Pietro Ruggieri, Matthew T Houdek, Richard A Boyle, Walid Ebeid, Eduardo Botello, Guy V Morris, Minna K Laitinen, Adesegun Abudu, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Jose I Albergo, John Alexander, Bugra Alpan, Ahmed Aoude, Apichat Asavamongkolkul, William Aston, Thomas Baad-Hansen, Tessa Balach, Joseph Benevenia, Peter Bergh, Nicholas Bernthal, Odion Binitie, Michele Boffano, Jos Bramer, Harriet Branford White, Bernadette Brennan, Jorge Cabrolier, Jose A Calvo Haro, Domenico A Campanacci, Rodrigo Cardoso, Richard Carey Smith, Nicolas Casales Fresnga, Jose M Casanova, Oscar Ceballos, Chung M Chan, Yang-Guk Chung, Miguel A Clara-Altamirano, Gillian Cribb, Solomon Dadia, Dietmar Dammerer, Marieke de Vaal, Javier Delgado Obando, Shaneel Deo, Claudia Di Bella, Davide M Donati, Makoto Endo, Levent Eralp, Bulent Erol, Scott Evans, Will Eward, Fabrice Fiorenza, Joao Freitas, Philipp T Funovics, Marcos Galli Serra, Michelle Ghert, Kanishka Ghosh, Luis C Gomez Mier, Jesus Gomez Vallejo, Anthony Griffin, Ashish Gulia, Maurice Guzman, Jendrik Hardes, John Healey, Adriana Hernandez, Asle Hesla, Chindanai Hongsaprabhas, Francis Hornicek, Keith Hosking, Shintaro Iwata, Jake Jagiello, Luke Johnson, Andy Johnston, Min Joo, Paul Jutte, Bilal Kapanci, Zeeshan Khan, Hiroshi Kobayashi, Yehuda Kollender, Sebastian Koob, Daniel Kotrych, Louis-Romee Le Nail, Pawel Legosz, Burkhard Lehner, Andreas Leithner, Valerae Lewis, Peng Lin, Francisco Linares, Santiago Lozano Calderon, Ashish Mahendra, Ferdiansyah Mahyudin, Eric Mascard, Jean-Camille Mattei, Louise McCullough, Manuel R Medellin Rincon, Rhidian Morgan-Jones, Diego J Moriel Garcesco, Sophie Mottard, Robert Nakayama, Prashant Narhari, Gary O'Toole, Oliveira Vania, André Olivier, Mohamed Omar, Eduardo Ortiz-Cruz, Harzem Ozger, Korhan Ozkan, Emanuela Palmerini, Panayiotis Papagelopoulos, Michael Parry, Sam Patton, Michael M Petersen, Gerard Powell, Mark Puhaindran, Anand Raja, Raja B Rajasekaran, Lauris Repsa, Mickael Ropars, Andrea Sambri, Thomas Schubert, Ahmad Shehadeh, Geoffrey Siegel, Scott Sommerville, Andre Spiguel, Jonathan Stevenson, Gwen Sys, Thomas Temple, Frank Traub, Hiroyuki Tsuchiya, Juan Valencia, Michel Van de Sande, Gualter Vaz, Roberto Velez Villa, Oleg Vyrva, Hazem Wafa, Wan I Wan Faisham Numan, Edward Wang, David Warnock, Joel Werier, Kwok-Chuen Wong, Yamamoto Norio, Ye Zhaoming, Suraya Zainul Abidin, Tomas Zamora, Juan P Zumarraga, Ghaith Abou-Nouar, Carsten Gebert, R L Randall
Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and complications. Therefore, consensus on its day-to-day treatment decisions is needed. In January 2024, the Birmingham Orthopaedic Oncology Meeting (BOOM) attempted to gain global consensus from 300 delegates from over 50 countries. The meeting focused on these critical areas and aimed to generate consensus statements based on evidence amalgamation and expert opinion from diverse geographical regions...
May 1, 2024: Bone & Joint Journal
#3
Christopher D Liao, Zachary Erlichman, Georgios Georgakis, Fazel Khan, Aleksandra Krajewski
BACKGROUND: Aneurysmal bone cysts (ABCs) are aggressive, expansile, and locally destructive vascular lesions. The exact etiology of ABCs is currently unknown and hypothesized to be related to vascular malformations or disruption of osseous vascularity. To date, there have been no reports describing the development of pubic ABCs following penile inversion vaginoplasty (PIV). METHODS: This report describes the development of a pubic ABC in a transgender patient who had previously undergone PIV, possibly indicating a very rare complication of this gender-affirming operation...
2024: Eplasty
#4
JOURNAL ARTICLE
Shivang Shukla, Abhijeet Ashok Salunke, Maharshi Trivedi, Keval Patel, Shivam Pandya, Ritesh Suthar, Tarun Reddy, Kanika Kapoor, Poojitha Yala, Geetha Krishna, Nandlal Bharwani, Shashank Pandya
BACKGROUND: Ewing's sarcoma is highly aggressive bone tumor having predilection for younger age groups with t (11,22) translocation, recombines the FLI-1 and EWS genes on chromosome 22. This disease requires multi-disciplinary treatment withneo-adjuvant chemotherapy followed by surgery or radiotherapy and adjuvant chemotherapy. This study was aimed to assess the demographic distribution, clinical behaviour and oncological outcome of Ewings Sarcoma involving upper extremity. METHODS: From 2015 to 2022, 45 patients of upper extremity Ewing's sarcoma underwent treatment at a territory cancer centre...
March 2024: Journal of Orthopaedics
#5
REVIEW
Alina-Simona Bereanu, Bogdan Ioan Vintilă, Rareș Bereanu, Ioana Roxana Codru, Adrian Hașegan, Ciprian Olteanu, Vicențiu Săceleanu, Mihai Sava
The worldwide increase of multidrug-resistant Gram-negative bacteria is a global threat. The emergence and global spread of Klebsiella pneumoniae carbapenemase- (KPC-) producing Klebsiella pneumoniae represent a particular concern. This pathogen has increased resistance and abilities to persist in human reservoirs, in hospital environments, on medical devices, and to generate biofilms. Mortality related to this microorganism is high among immunosuppressed oncological patients and those with multiple hospitalizations and an extended stay in intensive care...
March 28, 2024: Microorganisms
#6
REVIEW
Christoph Theil, Sebastian Bockholt, Georg Gosheger, Ralf Dieckmann, Jan Schwarze, Martin Schulze, Jan Puetzler, Burkhard Moellenbeck
Periprosthetic joint infection is a feared complication after the megaprosthetic reconstruction of oncologic and non-oncologic bone defects of including the knee or hip joint. Due to the relative rarity of these procedures, however, optimal management is debatable. Considering the expanding use of megaprostheses in revision arthroplasty and the high revision burden in orthopedic oncology, the risk of PJI is likely to increase over the coming years. In this non-systematic review article, we present and discuss current management options and the associated results focusing on studies from the last 15 years and studies from dedicated centers or study groups...
March 31, 2024: Medicina
#7
REVIEW
Francesco Onorato, Virginia Masoni, Luca Gagliardi, Luca Costanzo Comba, Fabrizio Rivera
Periprosthetic joint infections (PJIs) are one of the most worrying complications orthopedic surgeons could face; thus, methods to prevent them are evolving. Apart from systemic antibiotics, targeted strategies such as local antimicrobial coatings applied to prosthetics have been introduced. This narrative review aims to provide an overview of the main antimicrobial coatings available in arthroplasty orthopedic surgery practice. The search was performed on the PubMed, Web of Science, SCOPUS, and EMBASE databases, focusing on antimicrobial-coated devices used in clinical practice in the arthroplasty world...
March 30, 2024: Medicina
#8
JOURNAL ARTICLE
Vivek Ajit Singh, Vinesh Sandhu, Choo Tze Yong, Nor Faissal Yasin
INTRODUCTION: The foot is a complex structure composed of several tissues, each of which can be the origin of the proliferation and development of the tumour. Most lesions about the foot are reactive or inflammatory, but some are true neoplasms. METHOD: This is a retrospective analysis of 4997 patient records treated in the Orthopaedic Oncology Unit of University Malaya Medical Centre, Malaysia, between 1 January 2010 to 31 December 2020. Demographic data of 195 patients with foot tumours were analysed out of 4997 neoplasm patients...
2024: Journal of Orthopaedic Surgery
#9
JOURNAL ARTICLE
Hai V Le, Yashar Javidan, Safdar N Khan, Eric O Klineberg
Anterior cervical spine surgery (ACSS) is a surgical intervention widely used for a myriad of indications including degenerative, oncologic, inflammatory, traumatic, and congenital spinal conditions. A primary concern for surgeons performing ACSS is the postoperative development of oropharyngeal dysphagia. Current literature reports a wide incidence of this complication ranging from 1 to 79%. Dysphagia after ACSS is multifactorial, with common risk factors being prolonged duration of operation, revision surgeries, multilevel surgeries, and use of recombinant human bone morphogenetic protein-2...
April 18, 2024: Journal of the American Academy of Orthopaedic Surgeons
#10
JOURNAL ARTICLE
S Velázquez-Rodríguez, M A Clara-Altamirano, D Y García-Ortega, A R Lizcano-Suárez, H Martínez-Said, V Villavicencio-Valencia, M Cuellar-Hubbe
INTRODUCTION: reconstruction of large bone defects using modular knee arthroplasty (MKA) presents a significant challenge in terms of functionality. The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients. MATERIAL AND METHODS: a retrospective cohort study was conducted, including patients with a diagnosis of musculoskeletal tumor in the distal femur or proximal tibia, who underwent MKA between January 1, 2010, and December 31, 2021...
2024: Acta Ortopédica Mexicana
#11
James P Waters, Sydney Horenstein, Austin Egger, Parker Johnsen, Tae Won Kim
Multidisciplinary team collaboration in the diagnosis of rare tumors such as parosteal lipoma is highly important, especially when suspicious of malignancy. The use of radiological and physical examinations is imperative to monitor recurrence and quality of life.
April 2024: Clinical Case Reports
#12
COMPARATIVE STUDY
Xin Hu, Yang Wen, Minxun Lu, Yi Luo, Yong Zhou, Xiao Yang, Chongqi Tu, Li Min
BACKGROUND: Debates persist over optimal pelvic girdle reconstruction after acetabular tumor resection, with surgeons grappling between modular and 3D-printed hemipelvic endoprostheses. We hypothesize superior outcomes with 3D-printed versions, yet scarce comparative research exists. This study fills the gap, examining biomechanics and clinical results retrospectively. METHODS: From February 2017 to June 2021, we retrospectively assessed 32 patients undergoing en bloc resection for malignant periacetabular tumors at a single institution...
April 23, 2024: Journal of Orthopaedic Surgery and Research
#13
Takaki Kitamura, Tomonori Shigemura, Yohei Yamamoto, Yasuaki Murata
Metastatic pelvic tumors pose a significant challenge in oncologic orthopedics due to their complex management and the high potential for postoperative complications. This case study discusses a 75-year-old male with a sacral stress fracture following a type 3 internal hemipelvectomy for a metastatic lesion from gastric cancer in the left pubic bone. Initial conservative treatments failed to yield satisfactory improvement, leading to surgical intervention. Open reduction and internal fixation with an iliosacral screw, despite complications, significantly alleviated pain and improved mobility...
March 2024: Curēus
#14
JOURNAL ARTICLE
L Andreani, E Ipponi, G Varchetta, A D Ruinato, S De-Franco, F R Campo, A D'Arienzo
INTRODUCTION: Periprosthetic joint infection (PJI) represents a serious burden in orthopaedic oncology. Through the years, several local expedients have been proposed to minimise the risk of periprosthetic infection. In this study, we report our outcomes using topical vancomycin powder (VP) with the aim to prevent PJIs. MATERIALS AND METHODS: Fifty oncological cases treated with massive bone resection and the implant of a megaprosthesis were included in our study...
March 2024: Malaysian Orthopaedic Journal
#15
JOURNAL ARTICLE
Y H Ng, Y C Chai, N Mazli, N F Jaafar, S Ibrahim
INTRODUCTION: To describe the duration of survival among bone tumour patients with endoprosthesis reconstruction and to determine frequency of implant failure, revision of surgery, and amputation after endoprosthesis reconstruction. MATERIALS AND METHODS: A retrospective cross-sectional review of all patients with either primary bone tumour or secondary bone metastases treated with en bloc resection and endoprosthesis reconstruction from January 2008 to December 2020...
March 2024: Malaysian Orthopaedic Journal
#16
REVIEW
Zhensheng Lin, Yuhe Wei, Huazhe Yang
As a primary malignant bone cancer, osteosarcoma (OS) poses a great threat to human health and is still a huge challenge for clinicians. At present, surgical resection is the main treatment strategy for OS. However, surgical intervention will result in a large bone defect, and some tumor cells remaining around the excised bone tissue often lead to the recurrence and metastasis of OS. Biomedical Mg-based materials have been widely employed as orthopedic implants in bone defect reconstruction, and, especially, they can eradicate the residual OS cells due to the antitumor activities of their degradation products...
June 2024: APL Bioengineering
#17
JOURNAL ARTICLE
Wael Mohamed Safwat Sadek, Ibrahim Khairy Fayed Elshamly, Moustafa Saladin Mohammed Salem, Wessam Gamal AbouSenna, Emad Ebeid, Walid Atef Ebeid
BACKGROUND: Osteosarcoma is the most common primary bone malignancy in skeletally immature patients. The proximal humerus is the third most common site of osteosarcoma. The literature shows a paucity of published data concerning the outcome of proximal humerus osteosarcoma managed by limb salvage. The purpose of this study was to answer the following questions: (1) do patients with proximal humerus osteosarcoma managed by limb salvage and neoadjuvant chemotherapy show good functional and oncological outcomes, and (2) are there any prognostic factors that are associated with better oncological and functional outcomes? MATERIALS AND METHODS: The study was a retrospective case series study assessing the overall outcome of 34 patients with proximal humerus osteosarcoma...
April 18, 2024: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
#18
JOURNAL ARTICLE
Zachary C Lum, Dylon P Collins, Stanley Dennison, Lohitha Guntupalli, Soham Choudhary, Augustine M Saiz, Robert L Randall
Introduction Artificial intelligence (AI) models using large language models (LLMs) and non-specific domains have gained attention for their innovative information processing. As AI advances, it's essential to regularly evaluate these tools' competency to maintain high standards, prevent errors or biases, and avoid flawed reasoning or misinformation that could harm patients or spread inaccuracies. Our study aimed to determine the performance of Chat Generative Pre-trained Transformer (ChatGPT) by OpenAI and Google BARD (BARD) in orthopedic surgery, assess performance based on question types, contrast performance between different AIs and compare AI performance to orthopedic residents...
March 2024: Curēus
#19
REVIEW
Svetlana Piatnitskaia, Guzel Rafikova, Azat Bilyalov, Svyatoslav Chugunov, Iskander Akhatov, Valentin Pavlov, Julia Kzhyshkowska
The increasing use of medical implants in various areas of medicine, particularly in orthopedic surgery, oncology, cardiology and dentistry, displayed the limitations in long-term integration of available biomaterials. The effective functioning and successful integration of implants requires not only technical excellence of materials but also consideration of the dynamics of biomaterial interaction with the immune system throughout the entire duration of implant use. The acute as well as long-term decisions about the efficiency of implant integration are done by local resident tissue macrophages and monocyte-derived macrophages that start to be recruited during tissue damage, when implant is installed, and are continuously recruited during the healing phase...
2024: Frontiers in Immunology
#20
JOURNAL ARTICLE
David Le, Kelsey Martin, Sean C Clark, Devyn Ruso, Alex Hoyen, Krystal Hunter, Tae Won B Kim
The purpose of this study was to identify trends in the use of functional outcome measures within orthopedic oncology. The search engine, PubMed, was reviewed for all articles over an 11-year period from 2011 to 2021 from five major journals that publish in the field of orthopedic oncology. The functional outcome measures used in the articles were recorded along with study date, study design, clinical topic/pathology, and level of evidence. Out of 5968 musculoskeletal tumor-focused articles reviewed, 293 (4...
April 5, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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