R Sahoo, V Chittibabu, G Patil, S Rao, S Thakur, G Dhondalay, A J Kulkarni, A Banerjee, B S Ajaikumar, A Korlimarla, A Nargund, R N Niti, K S Gopinath, Shilpa Prabhudesai, R M Raghavendra
p53 Mutations and over expression have been shown to predict treatment response in head and neck cancer patients. Failure of organ sparing therapy has been attributed to cisplatin and radiotherapy resistance in carcinoma of the larynx patients. In this study, we evaluate the relationships between p53 over expression/mutations, bcl(2) expression and ploidy status in a retrospective cohort of responder and non-responder carcinoma of the larynx patients. Tissue samples from 22 patients with histopathologically confirmed carcinoma of the larynx and matched for age, stage, node status and treatment regimen, were analysed from our tissue biorepository...
December 2009: Oral Oncology