keyword
https://read.qxmd.com/read/33482226/adult-glut3-homozygous-null-mice-survive-to-demonstrate-neural-excitability-and-altered-neurobehavioral-responses-reminiscent-of-neurodevelopmental-disorders
#1
Bo-Chul Shin, Carlos Cepeda, Mason Eghbali, Shin Yun Byun, Michael S Levine, Sherin U Devaskar
Since GLUT3 is vital for fueling neurotransmission, we examined in-vivo the adult phenotype carrying the conditional homozygous glut3 gene mutation (KO) in glutamate-excitatory neurons. These KO mice demonstrated sex-specific differences in brain and body weights (p = 0.0001 and p = 0.01 each) with reduced GLUT3 protein in cerebral cortices and brain stem (p = 0.005). In patch clamp studies the glut3 KO mice displayed a shorter latency to and enhanced paroxysmal activity (p = 0.01 and p = 0...
January 19, 2021: Experimental Neurology
https://read.qxmd.com/read/33481009/multi-omics-analyses-of-cognitive-traits-and-psychiatric-disorders-highlights-brain-dependent-mechanisms
#2
Roxanna Korologou-Linden, Genevieve M Leyden, Caroline L Relton, Rebecca C Richmond, Tom G Richardson
Integrating findings from genome-wide association studies with molecular datasets can develop insight into the underlying functional mechanisms responsible for trait-associated genetic variants. We have applied the principles of Mendelian randomization (MR) to investigate whether brain-derived gene expression (n = 1194) may be responsible for mediating the effect of genetic variants on eight cognitive and psychological outcomes (attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, bipolar disorder, depression, intelligence, insomnia, neuroticism and schizophrenia)...
January 22, 2021: Human Molecular Genetics
https://read.qxmd.com/read/33480483/intrusive-destructive-behaviors-novel-behavioral-presentations-of-patients-with-co-occurring-tourette-syndrome-obsessive-compulsive-disorder-and-attention-deficit-hyperactivity-disorder
#3
Erica Greenberg, Aldis H Petriceks, Theodore A Stern
The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry...
January 21, 2021: Primary Care Companion to CNS Disorders
https://read.qxmd.com/read/33480319/brief-report-evaluation-of-working-memory-deficits-in-children-with-adhd-using-the-nih-list-sorting-working-memory-task
#4
Morgan L Jusko, Joseph S Raiker, Mileini Campez, Jessica N Smith, Whitney D Fosco, Leonel Horta, Kelcey Little, Kisbel Espinal, Gabriela Sanchez, Aaron T Mattfeld, Elizabeth M Gnagy, Andrew R Greiner, Erika K Coles, William E Pelham
Variability in working memory (WM) task selection likely contributes to heterogeneity in effect size estimates of deficiencies in youth with attention-deficit/hyperactivity disorder (ADHD). This has resulted in the development of brief, easy to administer assessments such as the NIH List Sorting Working Memory (LSWM) task from the NIH Cognitive Toolbox in hopes of standardizing measurement of this construct. Unfortunately, substantial questions persist regarding the specific constructs being evaluated by this task (e...
January 22, 2021: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://read.qxmd.com/read/33480309/the-relation-between-symptoms-of-adhd-and-symptoms-of-eating-disorders-in-university-students
#5
Jessica Baraskewich, Emma A Climie
There is evidence to suggest an association between Attention-Deficit/Hyperactivity Disorder (ADHD) and eating disorders (EDs). As those with subclinical symptoms of ADHD or ED often experience impairment, this cross-sectional study examined the relationship between ADHD symptoms and ED symptoms in a predominately subclinical undergraduate population. Students ( n  = 133; 80% female) completed questionnaires measuring ADHD and ED symptomatology. The relation between overall ADHD symptoms and ED symptoms was examined using linear regression; findings indicated that higher ADHD symptoms significantly predicted higher ED symptoms...
January 22, 2021: Journal of General Psychology
https://read.qxmd.com/read/33480179/changing-parenting-style-between-two-generations-and-its-impacts-on-the-severity-of-behavioral-and-emotional-symptoms
#6
Sareh Ghorbani, Banafsheh Gharraee, Fariba Hosseini, Zahra Maghami Sharif, Asma Aghebati
OBJECTIVE: The purpose of this study is to compare the perceived parenting dimensions in mothers and their daughters (differences between two generations), and study the relationship between these dimensions and the severity of daughters' behavioral and emotional symptoms. MATERIALS AND METHODS: 300 participants (150 daughters with their mothers) participated in this study. They responded to the perceived parenting styles questionnaire (PSQ), and mothers were additionally asked to answer the child symptoms inventory-4 (CSI-4)...
January 22, 2021: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://read.qxmd.com/read/33479512/association-of-gray-matter-volumes-with-general-and-specific-dimensions-of-psychopathology-in-children
#7
E Leighton Durham, Hee Jung Jeong, Tyler M Moore, Randolph M Dupont, Carlos Cardenas-Iniguez, Zaixu Cui, Farrah E Stone, Marc G Berman, Benjamin B Lahey, Antonia N Kaczkurkin
Childhood is an important time for the manifestation of psychopathology. Psychopathology is characterized by considerable comorbidity which is mirrored in the underlying neural correlates of psychopathology. Both common and dissociable variations in brain volume have been found across multiple mental disorders in adult and youth samples. However, the majority of these studies used samples with broad age ranges which may obscure developmental differences. The current study examines associations between regional gray matter volumes (GMV) and psychopathology in a large sample of children with a narrowly defined age range...
January 21, 2021: Neuropsychopharmacology
https://read.qxmd.com/read/33479511/functional-connectivity-during-frustration-a-preliminary-study-of-predictive-modeling-of-irritability-in-youth
#8
Dustin Scheinost, Javid Dadashkarimi, Emily S Finn, Caroline G Wambach, Caroline MacGillivray, Alexandra L Roule, Tara A Niendam, Daniel S Pine, Melissa A Brotman, Ellen Leibenluft, Wan-Ling Tseng
Irritability cuts across many pediatric disorders and is a common presenting complaint in child psychiatry; however, its neural mechanisms remain unclear. One core pathophysiological deficit of irritability is aberrant responses to frustrative nonreward. Here, we conducted a preliminary fMRI study to examine the ability of functional connectivity during frustrative nonreward to predict irritability in a transdiagnostic sample. This study included 69 youths (mean age = 14.55 years) with varying levels of irritability across diagnostic groups: disruptive mood dysregulation disorder (n = 20), attention-deficit/hyperactivity disorder (n = 14), anxiety disorder (n = 12), and controls (n = 23)...
January 21, 2021: Neuropsychopharmacology
https://read.qxmd.com/read/33479212/integrative-analysis-of-genome-wide-association-studies-identifies-novel-loci-associated-with-neuropsychiatric-disorders
#9
Xueming Yao, Joseph T Glessner, Junyi Li, Xiaohui Qi, Xiaoyuan Hou, Chonggui Zhu, Xiaoge Li, Michael E March, Liu Yang, Frank D Mentch, Heather S Hain, Xinyi Meng, Qianghua Xia, Hakon Hakonarson, Jin Li
Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major depressive disorder (MDD) share common clinical presentations, suggesting etiologic overlap. A substantial proportion of SNP-based heritability for neuropsychiatric disorders is attributable to genetic components, and genome-wide association studies (GWASs) focusing on individual diseases have identified multiple genetic loci shared between these diseases...
January 21, 2021: Translational Psychiatry
https://read.qxmd.com/read/33479207/maternal-acute-and-chronic-inflammation-in-pregnancy-is-associated-with-common-neurodevelopmental-disorders-a-systematic-review
#10
Velda X Han, Shrujna Patel, Hannah F Jones, Timothy C Nielsen, Shekeeb S Mohammad, Markus J Hofer, Wendy Gold, Fabienne Brilot, Samantha J Lain, Natasha Nassar, Russell C Dale
Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA), triggered by both acute and systemic chronic inflammation, is hypothesized to be one of the mechanisms implicated in the pathogenesis of neurodevelopmental disorders (NDD). Although there is substantial preclinical evidence to support the MIA hypothesis, the human evidence is disparate...
January 21, 2021: Translational Psychiatry
https://read.qxmd.com/read/33479201/brain-dynamics-the-temporal-variability-of-connectivity-and-differences-in-schizophrenia-and-adhd
#11
Edmund T Rolls, Wei Cheng, Jianfeng Feng
We describe advances in the understanding of brain dynamics that are important for understanding the operation of the cerebral cortex in health and disease. In data from 1017 participants from the Human Connectome Project, we show that early visual and connected areas have low temporal variability of their functional connectivity. We show that a low temporal variability of the connectivity of cortical areas is related to high mean functional connectivity between those areas, and provide an account of how these dynamics arise...
January 21, 2021: Translational Psychiatry
https://read.qxmd.com/read/33478559/predicting-the-number-of-article-citations-in-the-field-of-attention-deficit-hyperactivity-disorder-adhd-with-the-100-top-cited-articles-since-2014-a-bibliometric-analysis
#12
Chien-Ho Lin, Tsair-Wei Chien, Yu-Hua Yan
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children or early adolescents with an estimated worldwide prevalence of 7.2%. Numerous articles related to ADHD have been published in the literature. However, which articles had ultimate influence is still unknown, and what factors affect the number of article citations remains unclear as well. This bibliometric analysis (1) visualizes the prominent entities with 1 picture using the top 100 most-cited articles, and (2) investigates whether medical subject headings (i...
January 21, 2021: Annals of General Psychiatry
https://read.qxmd.com/read/33477503/stress-immune-biomarkers-in-saliva-among-children-with-adhd-status
#13
Anna Krahel, Elzbieta Paszynska, Agnieszka Slopien, Maria Gawriolek, Justyna Otulakowska-Skrzynska, Szymon Rzatowski, Amadeusz Hernik, Tomasz Hanć, Ewa Bryl, Paula Szczesniewska, Karolina Bilska, Joanna Duda, Marta Tyszkiewicz-Nwafor, Monika Dmitrzak-Weglarz
Background . This cross-sectional study aimed to evaluate stress and immune biomarkers in saliva samples of attention-deficit/hyperactivity disorder ADHD compared to healthy non-ADHD children. Material and methods . A total of 132 children under 11 years old (8.5 ± 1.1) enrolled in a cross-sectional study: with confirmed ADHD (n = 60) and healthy controls (n = 72). The clinical evaluation included physical measurements (height, waist, hip circumference, body weight, body mass index BMI, BMI z-score) and unstimulated saliva collection and measurements of free cortisol, salivary alpha-amylase (sAA), and secreted immunoglobulins (sIgA, IgG, and IgM) with quantitative assay (ELISA) analysis...
January 18, 2021: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/33476697/a-study-on-resting-eeg-effective-connectivity-difference-before-and-after-neurofeedback-for-children-with-adhd
#14
Shanshan Wang, Dujuan Zhang, Bei Fang, Xingping Liu, Guoli Yan, Guanghong Sui, Qingwei Huang, Ling Sun, Suogang Wang
Altered functional networks in attention deficit/hyperactivity disorder (ADHD) have been frequently reported, but effective connectivity has hardly been studied. Especially the differences of effective connectivity in children with ADHD after receiving neurofeedback (NF) training have been merely reported. Therefore, this study aimed to explore the effective networks of ADHD and the positive influence of NF on the effective networks. Electroencephalogram (EEG) data were recorded from 22 children with ADHD (including data from children pretraining and posttraining) and 15 age-matched healthy controls during an eyes-closed resting state...
January 18, 2021: Neuroscience
https://read.qxmd.com/read/33476640/therapeutic-potential-of-targeting-g-protein-gated-inwardly-rectifying-potassium-girk-channels-in-the-central-nervous-system
#15
REVIEW
Danko Jeremic, Irene Sanchez-Rodriguez, Lydia Jimenez-Diaz, Juan D Navarro-Lopez
G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for maintaining resting membrane potential, cell excitability and inhibitory neurotransmission. Coupled to numerous G protein-coupled receptors (GPCRs), they mediate the effects of many neurotransmitters, neuromodulators and hormones contributing to the general homeostasis and particular synaptic plasticity processes, learning, memory and pain signaling. A growing number of behavioral and genetic studies suggest a critical role for the appropriate functioning of the central nervous system, as well as their involvement in many neurologic and psychiatric conditions, such as neurodegenerative diseases, mood disorders, attention deficit hyperactivity disorder, schizophrenia, epilepsy, alcoholism and drug addiction...
January 18, 2021: Pharmacology & Therapeutics
https://read.qxmd.com/read/33476302/a-grm7-mutation-associated-with-developmental-delay-reduces-mglu7-expression-and-produces-neurological-phenotypes
#16
Nicole M Fisher, Aqeela AlHashim, Aditi B Buch, Hana Badivuku, Manar M Samman, Kelly M Weiss, Gabriela I Cestero, Mark D Does, Jerri M Rook, Craig W Lindsley, P Jeffrey Conn, Rocco G Gogliotti, Colleen M Niswender
The metabotropic glutamate receptor 7 (mGlu7) is a G protein-coupled receptor that has been recently linked to neurodevelopmental disorders. This association is supported by the identification of GRM7 variants in patients with autism spectrum disorder, attention deficit hyperactivity disorder, and severe developmental delay. One GRM7 mutation previously reported in two patients results in a single amino acid change, I154T, within the mGlu7 ligand-binding domain. Here, we report two new patients with this mutation who present with severe developmental delay and epilepsy...
January 21, 2021: JCI Insight
https://read.qxmd.com/read/33476173/central-autonomic-regulation-assessed-by-pupillary-light-reflex-is-impaired-in-children-with-attention-deficit-hyperactivity-disorder
#17
A Hamrakova, I Ondrejka, N Sekaninova, L Bona Olexova, Z Visnovcova, D Cesnekova, I Hrtanek, M Oppa, P Hutka, I Tonhajzerova
It is assumed that the Attention Deficit Hyperactivity Disorder is associated with the central autonomic dysregulation, however, the studies are rare. Analysis of pupillary light reflex represents a non-invasive tool to provide information related to the central autonomic regulation; thus, we aimed to evaluate potential disturbances in the central autonomic integrity using pupillary light reflex examination in Attention Deficit Hyperactivity Disorder. We have examined 20 children with Attention Deficit Hyperactivity Disorder (10 boys, 13...
January 21, 2021: Physiological Research
https://read.qxmd.com/read/33475395/an-evaluation-of-the-effect-of-methylphenidate-on-working-memory-time-perception-and-choice-impulsivity-in-children-with-adhd
#18
Mileini Campez, Joseph S Raiker, Kelcey Little, Amy R Altszuler, Brittany M Merrill, Fiona L Macphee, Elizabeth M Gnagy, Andrew R Greiner, Erica D Musser, Erika K Coles, William E Pelham
Individuals with Attention-Deficit Hyperactivity Disorder (ADHD) consistently exhibit a stronger preference for immediate rewards than for larger rewards available following a delay on tasks measuring choice impulsivity (CI). Despite this, however, there remains a dearth of studies examining the impact of stimulant treatment on CI as well as associated higher order (e.g., working memory [WM]) and perceptual (e.g., time perception) cognitive processes. The present study examines the effect of osmotic release oral system methylphenidate (OROS-MPH) on CI, WM and time perception processes as well as the relation among these processes before and after taking a regimen of OROS-MPH...
January 21, 2021: Experimental and Clinical Psychopharmacology
https://read.qxmd.com/read/33475025/self-esteem-and-clinical-features-in-a-clinical-sample-of-children-with-adhd-and-social-anxiety-disorder
#19
Fahri Çelebi, Dilek Ünal
OBJECTIVE: In this study, we aimed to investigate self-esteem and clinical features in clinically referred children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and comorbid Social Anxiety Disorder (SAD) and compare these to children and adolescents without SAD. METHODS: One hundred and twenty child and adolescent drug-naïve outpatients (6-15 years of age) with a primary diagnosis of ADHD were included. Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), was used to evaluate ADHD and comorbidities...
January 21, 2021: Nordic Journal of Psychiatry
https://read.qxmd.com/read/33474652/overview-of-capice-childhood-and-adolescence-psychopathology-unravelling-the-complex-etiology-by-a-large-interdisciplinary-collaboration-in-europe-an-eu-marie-sk%C3%A5-odowska-curie-international-training-network
#20
Hema Sekhar Reddy Rajula, Mirko Manchia, Kratika Agarwal, Wonuola A Akingbuwa, Andrea G Allegrini, Elizabeth Diemer, Sabrina Doering, Elis Haan, Eshim S Jami, Ville Karhunen, Marica Leone, Laura Schellhas, Ashley Thompson, Stéphanie M van den Berg, Sarah E Bergen, Ralf Kuja-Halkola, Anke R Hammerschlag, Marjo Riitta Järvelin, Amy Leval, Paul Lichtenstein, Sebastian Lundstrom, Matteo Mauri, Marcus R Munafò, David Myers, Robert Plomin, Kaili Rimfeld, Henning Tiemeier, Eivind Ystrom, Vassilios Fanos, Meike Bartels, Christel M Middeldorp
The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) is a European Union (EU) funded training network aimed at investigating the causes of individual differences in common childhood and adolescent psychopathology, especially depression, anxiety, and attention deficit hyperactivity disorder...
January 20, 2021: European Child & Adolescent Psychiatry
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