Yan Yu, Wenqiu Xu, Sufen Zhang, Suihua Feng, Feng Feng, Junshang Dai, Xiao Zhang, Peirun Tian, Shunyao Wang, Zhiguang Zhao, Wenrui Zhao, Liping Guan, Zhixu Qiu, Jianguo Zhang, Huanhuan Peng, Jiawei Lin, Qun Zhang, Weiping Chen, Huahua Li, Qiang Zhao, Gefei Xiao, Zhongzhe Li, Shihao Zhou, Can Peng, Zhen Xu, Jingjing Zhang, Rui Zhang, Xiaohong He, Hua Li, Jia Li, Xiaohong Ruan, Lijian Zhao, Jun He
BACKGROUND: Preeclampsia (PE) is a pregnancy complication defined by new onset hypertension and proteinuria or other maternal organ damage after 20 weeks of gestation. Although non-invasive prenatal testing (NIPT) has been widely used to detect fetal chromosomal abnormalities during pregnancy, its performance in combination with maternal risk factors to screen for PE has not been extensively validated. Our aim was to develop and validate classifiers that predict early- or late-onset PE using the maternal plasma cell-free DNA (cfDNA) profile and clinical risk factors...
2024: Frontiers in Medicine