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JOURNAL ARTICLE
Robert Tamai, Lillian Dawit, Patrick Lee, Okeefe L Simmons, Li Ding, Liyun Yuan
BACKGROUND: Obesity and metabolic syndrome (MetS) have been implicated as rising risk factors for the development of colorectal cancers. A rapid increase in the prevalence of obesity and severe obesity among Hispanic patients in the United States may present substantially increased risk for advanced colorectal neoplasia in this population. Currently, there is very little research in this area. AIMS: We sought to identify metabolic risk factors for advanced adenomas (AA) in Hispanic Americans...
February 16, 2024: Digestive Diseases and Sciences
#22
JOURNAL ARTICLE
Haowen Tian, William Lee, Yuli Li, Morris J Dweck, Angel Mendoza, Patrick G Harran, K N Houk
Octafluorocyclopentene (OFCP) has found utility as a polyelectrophile in substitution cascades that form complex macrocyclic compounds. The Harran group synthesis of macrocyclic polypeptides depends on OFCP as a linker, combining with four different nucleophilic units of a polypeptide. We report a computational investigation of the origins of OFCP reactivity and a rationale for controlled mono-, di-, tri-, and tetrasubstitution of fluoride ions by heteroatomic nucleophiles. The roles of inductive, negative hyperconjugative, and resonance electron-donation by fluoride substituents are explored for the reaction of OFCP, less-fluorinated analogues, and common electrophilic alkenes with several different nucleophiles...
February 14, 2024: Journal of the American Chemical Society
#23
JOURNAL ARTICLE
Angel Yuk Yan Chan, Jeffrey Wen Wei Chang, Gary Shun Pan Cheung, Prasanna Neelakantan, Chengfei Zhang, Angeline Hui Cheng Lee
OBJECTIVES: The aim of this research was to compare the penetration ability of calcium silicate-based sealers (iRoot SP and TotalFill BC HiFlow) and an epoxy resin-based sealer (AH Plus) into the lateral canals using the single-cone (SC) or continuous wave compaction (CW) obturation techniques. METHODS: Ninety single-rooted human teeth received canal instrumentation and diaphanisation before artificial lateral canals were created at 3 different root levels. The specimens were randomly allocated into 6 groups based on the combination of obturation technique and sealer used...
February 12, 2024: International Dental Journal
#24
Joshua A Hill, Michael J Martens, Jo-Anne H Young, Kavita Bhavsar, Jianqun Kou, Min Chen, Lik Wee Lee, Aliyah Baluch, Madhav V Dhodapkar, Ryotaro Nakamura, Kristin Peyton, Dianna S Howard, Uroosa Ibrahim, Zainab Shahid, Paul Armistead, Peter Westervelt, John McCarty, Joseph McGuirk, Mehdi Hamadani, Susan DeWolf, Kinga Hosszu, Elad Sharon, Ashley Spahn, Amir A Toor, Stephanie Waldvogel, Lee M Greenberger, Jeffery J Auletta, Mary M Horowitz, Marcie L Riches, Miguel-Angel Perales
BACKGROUND: The optimal timing of vaccination with SARS-CoV-2 vaccines after cellular therapy is incompletely understood. OBJECTIVE: To describe humoral and cellular responses after SARS-CoV-2 vaccination initiated <4 months versus 4-12 months after cellular therapy. DESIGN: Multicenter prospective observational study. SETTING: 34 centers in the United States. PARTICIPANTS: 466 allogeneic hematopoietic cell transplant (HCT; n=231), autologous HCT (n=170), or chimeric antigen receptor T cell (CAR-T cell) therapy (n=65) recipients enrolled between April 2021 and June 2022...
January 25, 2024: medRxiv
#25
JOURNAL ARTICLE
Ryan Lee, Neeraj Sood, Chun Nok Lam, Jennifer B Unger
INTRODUCTION: The U.S. Food and Drug Administration (FDA) approved the updated 2023-2024 COVID-19 vaccines by Pfizer-BioNTech and Moderna on September 11, 2023. Despite the Centers for Disease Control and Prevention (CDC)'s recommendation that everyone 6 months and older receive the updated COVID-19 vaccine, the general public's intentions to receive the new 2023-2024 vaccine are unknown. METHODS: Intentions to receive the new COVID-19 vaccine and the demographic predictors of those intentions were assessed from a survey of adult residents, ages 18 and older, of Los Angeles County, California conducted in October 2023...
February 9, 2024: American Journal of Preventive Medicine
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JOURNAL ARTICLE
Marc Boubnovski Martell, Kristofer Linton-Reid, Sumeet Hindocha, Mitchell Chen, Paula Moreno, Marina Álvarez-Benito, Ángel Salvatierra, Richard Lee, Joram M Posma, Marco A Calzado, Eric O Aboagye
The rich chemical information from tissue metabolomics provides a powerful means to elaborate tissue physiology or tumor characteristics at cellular and tumor microenvironment levels. However, the process of obtaining such information requires invasive biopsies, is costly, and can delay clinical patient management. Conversely, computed tomography (CT) is a clinical standard of care but does not intuitively harbor histological or prognostic information. Furthermore, the ability to embed metabolome information into CT to subsequently use the learned representation for classification or prognosis has yet to be described...
February 3, 2024: NPJ Precision Oncology
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RANDOMIZED CONTROLLED TRIAL
Yoon-Koo Kang, Min-Hee Ryu, Maria Di Bartolomeo, Ian Chau, Harry Yoon, Jong Gwang Kim, Keun-Wook Lee, Sang Chul Oh, Atsuo Takashima, Anna Kryzhanivska, Yee Chao, Ludovic Evesque, Michael Schenker, Arlo McGinn, Yufan Zhao, Jennifer Lee, Lucjan Wyrwicz, Narikazu Boku
BACKGROUND: Rivoceranib is an oral, selective tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2. ANGEL (NCT03042611) was a global, randomized, double-blinded, placebo-controlled, phase 3 study evaluating rivoceranib as 3rd-line or ≥4th-line therapy in patients with advanced/metastatic gastric or gastroesophageal junction (GEJ) cancer. METHODS: Patients had failed ≥2 lines of chemotherapy and were randomized 2:1 to rivoceranib 700 mg once daily or placebo with best supportive care...
March 2024: Gastric Cancer
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REVIEW
Luis A Marín-Castañeda, Armando Armas-Salazar, Jimena González-Salido, Fátima X Cid-Rodriguez, Ángel Lee, José D Carrillo-Ruiz
Significant progress has been made in Stereotactic and Functional Neurosurgery (SFN) within Latin America (LATAM), which can be attributed to the rapid advancements in technology and a growing pool of expertise. However, despite the growing importance of this field, a comprehensive scientometric analysis of LATAM contributions is still lacking. The aim of this study is to shed light on the top-cited articles in the field authored by LATAM researchers. A search of the Scopus database was performed using specific keywords in the field of SFN to retrieve the top 100 most cited articles...
January 25, 2024: World Neurosurgery
#29
JOURNAL ARTICLE
Matthew D Galsky, Xiangnan Guan, Deepali Rishipathak, Aaron S Rapaport, Hesham M Shehata, Romain Banchereau, Kobe Yuen, Eugene Varfolomeev, Ruozhen Hu, Chia-Jung Han, Haocheng Li, Yuxin Liang, Domagoj Vucic, Li Wang, Jun Zhu, Haocheng Yu, Rebecca H Herbst, Emma Hajaj, Evgeny Kiner, Aristotelis Bamias, Maria De Santis, Ian D Davis, José Ángel Arranz, Eiji Kikuchi, Sandrine Bernhard, Patrick Williams, Chooi Lee, Ira Mellman, Shomyseh Sanjabi, Robert Johnston, Peter C Black, Enrique Grande, Sanjeev Mariathasan
In metastatic urothelial cancer (mUC), cisplatin versus carboplatin leads to durable disease control in a subset of patients. The IMvigor130 trial reveals more favorable effects with atezolizumab combined with gemcitabine and cisplatin (GemCis) versus gemcitabine and carboplatin (GemCarbo). This study investigates the immunomodulatory effects of cisplatin as a potential explanation for these observations. Our findings indicate that improved outcomes with GemCis versus GemCarbo are primarily observed in patients with pretreatment tumors exhibiting features of restrained adaptive immunity...
February 20, 2024: Cell reports medicine
#30
REVIEW
Min Yi Sum, Charmaine Tsz Wing Wong, Sin Ting Chu, Angel Li, Athena Hoi Ting Lee, Eric Yu Hai Chen, Sherry Kit Wa Chan
PURPOSE: This study aimed to meta-analysis the level of internalised stigma experienced by individuals with psychosis worldwide, and the impact of cultural differences, economic status of the studied regions and duration of illness on their levels of internalised stigma. Clinical and individual level factors associated with internalised stigma and stigma resistance were also systematically reviewed. METHODS: A systematic search of keywords on two scholarly databases were conducted...
January 26, 2024: International Journal of Social Psychiatry
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JOURNAL ARTICLE
Jayanthi Nagappan, Siew-Eng Ooi, Kuang-Lim Chan, Faizun Kadri, Zain Nurazah, Mohd Amin Ab Halim, Lee Pei Lee Angel, Shamala Sundram, Chiew-Foan Chin, Sean T May, Eng Ti Leslie Low
BACKGROUND: Ganoderma boninense is a phytopathogen of oil palm, causing basal and upper stem rot diseases. METHODS: The genome sequence was used as a reference to study gene expression during growth in a starved carbon (C) and nitrogen (N) environment with minimal sugar and sawdust as initial energy sources. This study was conducted to mimic possible limitations of the C-N nutrient sources during the growth of G. boninense in oil palm plantations. RESULTS: Genome sequencing of an isolate collected from a palm tree in West Malaysia generated an assembly of 67...
January 25, 2024: Molecular Biology Reports
#32
JOURNAL ARTICLE
Yifan V Mao, Elena G Hughes, David Steinmetz, Samantha Troob, Jiyoon Kim, Chi-Hong Tseng, Gregory A Fishbein, Dipti P Sajed, Masha J Livhits, Michael W Yeh, Denise Lee, Trevor E Angell, James X Wu
IMPORTANCE: Standard treatment for patients with medullary thyroid cancer (MTC) consists of total thyroidectomy with central neck dissection, but the rationale for bilateral surgery in patients with unilateral disease on ultrasonography remains unclear. OBJECTIVE: To determine the presence of occult contralateral disease (lesions not seen on preoperative ultrasonography) in patients with MTC as a rationale for total thyroidectomy. DESIGN, SETTING, AND PARTICIPANTS: This multi-institutional, retrospective cohort study was conducted from September 1998 to April 2022 in academic medical centers and included patients with MTC who underwent thyroidectomy with preoperative imaging...
January 25, 2024: JAMA Otolaryngology—Head & Neck Surgery
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JOURNAL ARTICLE
Sharib Ali, Noha Ghatwary, Debesh Jha, Ece Isik-Polat, Gorkem Polat, Chen Yang, Wuyang Li, Adrian Galdran, Miguel-Ángel González Ballester, Vajira Thambawita, Steven Hicks, Sahadev Poudel, Sang-Woong Lee, Ziyi Jin, Tianyuan Gan, ChengHui Yu, JiangPeng Yan, Doyeob Yeo, Hyunseok Lee, Nikhil Kumar Tomar, Mahmood Haithami, Amr Ahmed, Michael A Riegler, Christian Daul, Pål Halvorsen, Jens Rittscher, Osama E Salem, Dominique Lamarque, Renato Cannizzaro, Stefano Realdon, Thomas de Lange, James E East
Polyps are well-known cancer precursors identified by colonoscopy. However, variability in their size, appearance, and location makes the detection of polyps challenging. Moreover, colonoscopy surveillance and removal of polyps are highly operator-dependent procedures and occur in a highly complex organ topology. There exists a high missed detection rate and incomplete removal of colonic polyps. To assist in clinical procedures and reduce missed rates, automated methods for detecting and segmenting polyps using machine learning have been achieved in past years...
January 23, 2024: Scientific Reports
#34
JOURNAL ARTICLE
TingFang Lee, Joel S Schuman, Maria de Los Angeles Ramos Cadena, Yan Zhang, Gadi Wollstein, Jiyuan Hu
PURPOSE: Broken stick analysis is a widely used approach for detecting unknown breakpoints where the association between measurements is nonlinear. We propose LIMBARE, an advanced linear mixed-effects breakpoint analysis with robust estimation, especially designed for longitudinal ophthalmic studies. LIMBARE accommodates repeated measurements from both eyes and over time, and it effectively addresses the presence of outliers. METHODS: The model setup of LIMBARE and the computing algorithm for point and confidence interval estimates of the breakpoint were introduced...
January 2, 2024: Translational Vision Science & Technology
#35
JOURNAL ARTICLE
Katrina Dimaano, Millicent Croman, Stefania Montero, Isabela Sandigo-Saballos, Manuel Orellana, Nikhil Chervu, Beverley A Petrie, Hanjoo Lee
BACKGROUND: Primary care physicians (PCP) play a key role in offering colorectal cancer (CRC) screenings, particularly amongst underserved populations. Given potential delays in or omission of CRC screening in the absence of a PCP, we aimed to determine stage of CRC at diagnosis in an underserved population. METHODS: A retrospective chart review was conducted at two Los Angeles County safety-net hospitals. Inclusion criteria were a CRC diagnosis between 2018 and 2021 and age between 50 and 75 years at diagnosis time...
January 2024: Surgery open science
#36
JOURNAL ARTICLE
Burak Kocak, Tugba Akinci D'Antonoli, Nathaniel Mercaldo, Angel Alberich-Bayarri, Bettina Baessler, Ilaria Ambrosini, Anna E Andreychenko, Spyridon Bakas, Regina G H Beets-Tan, Keno Bressem, Irene Buvat, Roberto Cannella, Luca Alessandro Cappellini, Armando Ugo Cavallo, Leonid L Chepelev, Linda Chi Hang Chu, Aydin Demircioglu, Nandita M deSouza, Matthias Dietzel, Salvatore Claudio Fanni, Andrey Fedorov, Laure S Fournier, Valentina Giannini, Rossano Girometti, Kevin B W Groot Lipman, Georgios Kalarakis, Brendan S Kelly, Michail E Klontzas, Dow-Mu Koh, Elmar Kotter, Ho Yun Lee, Mario Maas, Luis Marti-Bonmati, Henning Müller, Nancy Obuchowski, Fanny Orlhac, Nikolaos Papanikolaou, Ekaterina Petrash, Elisabeth Pfaehler, Daniel Pinto Dos Santos, Andrea Ponsiglione, Sebastià Sabater, Francesco Sardanelli, Philipp Seeböck, Nanna M Sijtsema, Arnaldo Stanzione, Alberto Traverso, Lorenzo Ugga, Martin Vallières, Lisanne V van Dijk, Joost J M van Griethuysen, Robbert W van Hamersvelt, Peter van Ooijen, Federica Vernuccio, Alan Wang, Stuart Williams, Jan Witowski, Zhongyi Zhang, Alex Zwanenburg, Renato Cuocolo
PURPOSE: To propose a new quality scoring tool, METhodological RadiomICs Score (METRICS), to assess and improve research quality of radiomics studies. METHODS: We conducted an online modified Delphi study with a group of international experts. It was performed in three consecutive stages: Stage#1, item preparation; Stage#2, panel discussion among EuSoMII Auditing Group members to identify the items to be voted; and Stage#3, four rounds of the modified Delphi exercise by panelists to determine the items eligible for the METRICS and their weights...
January 17, 2024: Insights Into Imaging
#37
JOURNAL ARTICLE
Sung Yong Park, Gina Faraci, Kevin Ganesh, Michael P Dubé, Ha Youn Lee
BACKGROUND: Tackling HIV drug resistance is one of major challenges for ending AIDS epidemic, but the elevated expense of cutting-edge genomics hampers the advancement of HIV genotype testing for clinical care. METHODS: We developed a HIV genotype testing pipeline that centers on a cost-efficient portable Nanopore sequencer. Accuracy verification was conducted through comparison with parallel data obtained via fixed-site Pacbio sequencing. Our complete pol-gene sequencing strategy coupled with portable high-throughput sequencing was applied to identify drug resistance mutations across 58 samples sourced from the ART-treated Los Angeles General Medical Center Rand Schrader Clinic (LARSC) cohort (7 samples from 7 individuals) and the ART-naïve Center for HIV/AIDS Vaccine Immunology (CHAVI) cohort (51 samples from 38 individuals)...
January 9, 2024: Journal of Clinical Virology
#38
JOURNAL ARTICLE
Adeline M Nyamathi, Benissa E Salem, Lillian Gelberg, Dana Rose Garfin, Kate Wolitsky-Taylor, Sanghyuk S Shin, Zhaoxia Yu, Angela Hudson, Kartik Yadav, Richard Clarke, Mitra Alikhani, Emily van Cise, Darlene Lee
People experiencing homelessness report increased exposure to traumatic life events and higher rates of depression, anxiety, and post-traumatic stress disorder as compared with the general population. Heart rate variability-biofeedback (HRV-BF) has been shown to decrease symptoms of stress, anxiety, depression, and PTSD. However, HRV-BF has not been tested with the most vulnerable of populations, homeless adults. The purpose of this randomized controlled trial was to compare the effectiveness of an HRV-BF intervention versus a Health Promotion (HP) active control intervention focused on improving mental health symptoms among homeless adults...
December 26, 2023: Stress and Health: Journal of the International Society for the Investigation of Stress
#39
JOURNAL ARTICLE
Fernando Ramos, María Lourdes Hermosín, Marta Fuertes-Núñez, Pilar Martínez, Carlos Rodriguez-Medina, Manuel Barrios, Francisco Ibáñez, Teresa Bernal, Maria Teresa Olave, Miguel Ángel Álvarez, María Vahí, Teresa Caballero-Velázquez, Bernardo González, Albert Altés, Lorena García, Pascual Fernández, María Antonia Durán, Rocío López, Montserrat Rafel, Josefina Serrano
Acute myeloid leukemia has a poor prognosis in older adults, and its management is often unclear due to its underrepresentation in clinical trials. Both overall survival (OS) and health-related quality-of-life (HRQoL) are key outcomes in this population, and patient-reported outcomes may contribute to patient stratification and treatment assignment. This prospective study included 138 consecutive patients treated in daily practice with the currently available non-targeted therapies (intensive chemotherapy [IC], attenuated chemotherapy [AC], hypomethylating agents [HMA], or palliative care [PC])...
November 28, 2023: Journal of Personalized Medicine
#40
REVIEW
Angela T H Kwan, Khaled Al-Kassimi, Jacob S Portnoff, Gurkaran Singh, Mehrshad Hanafimosalman, Marija Tesla, Nima Gharibi, Tiffany Ni, Ziji Guo, Davaine J N Sonfack, Julia Martyniuk, Saman Arfaie, Mohammad Sadegh Mashayekhi, Mohammad Mofatteh, Richie Jeremian, Kevin Ho, Luis Rafael Moscote-Salazar, Ángel Lee, Muhammad Youshay Jawad, Felicia Ceban, Kayla M Teopiz, Rodrigo B Mansur, Roger Ho, Joshua D Rosenblat, Bing Cao, Taeho Greg Rhee, Roger S McIntyre
Neurological manifestations have been widely reported in adults with COVID-19, yet the extent of involvement among the pediatric population is currently poorly characterized. The objective of our systematic review is to evaluate the association of SARS-CoV-2 infection with neurological symptoms and neuroimaging manifestations in the pediatric population. A literature search of Cochrane Library; EBSCO CINAHL; Global Index Medicus; OVID AMED, Embase, Medline, PsychINFO; and Scopus was conducted in accordance with the Peer Review of Electronic Search Strategies form (October 1, 2019 to March 15, 2022)...
December 11, 2023: Journal of Psychiatric Research
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