Sana Rehman, Arsalan Nadeem, Umar Akram, Abeer Sarwar, Ammara Quraishi, Hina Siddiqui, Muhammad Abdullah Javed Malik, Mehreen Nabi, Ihtisham Ul Haq, Andrew Cho, Ishan Mazumdar, Minsoo Kim, Kevin Chen, Sadra Sepehri, Richard Wang, Aneri B Balar, Dhairya A Lakhani, Vivek S Yedavalli
Ischemic stroke poses a significant global health challenge, necessitating ongoing exploration of its pathophysiology and treatment strategies. This comprehensive review integrates various aspects of ischemic stroke research, emphasizing crucial mechanisms, therapeutic approaches, and the role of clinical imaging in disease management. It discusses the multifaceted role of Netrin-1, highlighting its potential in promoting neurovascular repair and mitigating post-stroke neurological decline. It also examines the impact of blood-brain barrier permeability on stroke outcomes and explores alternative therapeutic targets such as statins and sphingosine-1-phosphate signaling...
April 7, 2024: Biomedicines