Sulemon Chaudhry, Yojiro Kato, Joshua Weiner, Paula Alonso-Guallart, Sam Baker, David C Woodland, Jay H Lefkowitch, Raimon Duran-Struuck, Hugo P Sondermeijer, Jonah Zitsman, Mallory L Sears, Anette Wu, Brian Karolewski, Philipp J Houck, Mercedes Martinez, Tomoaki Kato, Megan Sykes, Adam D Griesemer
BACKGROUND: Although short-term outcomes for liver transplantation have improved, patient and graft survivals are limited by infection, cancer and other complications of immunosuppression. Rapid induction of tolerance after liver transplantation would decrease these complications, improving survival and quality of life. Tolerance to kidneys, but not thoracic organs or islets, has been achieved in nonhuman primates and humans through the induction of transient donor chimerism. Since the liver is considered to be tolerogenic, we tested the hypothesis that the renal transplant transient chimerism protocol would induce liver tolerance...
April 6, 2020: Transplantation