Mohammad Hossein Khosravi, Mélanie Louras, Géraldine Martens, Jean-François Kaux, Aurore Thibaut, Nicolas Lejeune
BACKGROUND: In the context of managing persistent post-concussive symptoms (PPCS), existing treatments like pharmacotherapy, cognitive behavioral therapy, and physical rehabilitation show only moderate effectiveness. The emergence of neuromodulation techniques in PPCS management has led to debates regarding optimal stimulation parameters and their overall efficacy. METHODS: this scoping review involved a comprehensive search of PubMed and ScienceDirect databases, focusing on controlled studies examining the therapeutic potential of non-invasive brain stimulation (NIBS) techniques in adults with PPCS...
February 17, 2024: Biomedicines
Ioannis Mavroudis, Alin Ciobica, Ioana Miruna Balmus, Vasile Burlui, Laura Romila, Alin Iordache
Mild traumatic brain injury (mTBI) accounts for most TBI cases, the leading cause of morbidity and mortality worldwide. Despite its high incidence, mTBI pathophysiology remains largely unknown. Recent studies have shown that the inflammatory response is activated early after mTBI and can persist for several weeks or months. However, limited evidence on the utility of inflammatory biomarkers as predictors of clinical outcomes in mTBI has been previously provided. Thus, this systematic review and meta-analysis aims to provide an overview of the current knowledge on the role of inflammation in the pathogenesis of mTBI and the potential of some inflammatory biomolecules as biomarkers of mTBI...
January 26, 2024: Biomedicines
Jacob R Powell, Xiaopeng Zong, Joshua M Weinstein, Stephen M DeLellis, Shawn F Kane, Gary E Means, Jason P Mihalik
Mild traumatic brain injury (mTBI) and occupational blast exposure in military Service Members may lead to impaired brain waste clearance which increases neurological disease risk. Perivascular spaces (PVS) are a key part of the glymphatic system which supports brain waste clearance, preferentially during sleep. Visible PVS on clinical magnetic resonance imaging have been previously observed in patients with neurodegenerative diseases and animal neurotrauma models. The purpose of this study was to determine associations between PVS morphological characteristics, military career stage, and mTBI history in Special Operations Forces (SOF) Soldiers...
February 23, 2024: Annals of Biomedical Engineering
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No abstract text is available yet for this article.
February 2024: American Family Physician
Connor McKee, Mark Matthews, Alan Rankin, Chris Bleakley
Background: Concussion examination is based primarily on clinical evaluation and symptomatic reporting. Pupillary light reflex (PLR) metrics may provide an objective physiological marker to inform concussion diagnosis and recovery, but few studies have assessed PLR, and normative data are lacking, particularly for adolescents. Aim: To capture PLR data in adolescent rugby players and examine the effects of concussion history and biological sex. Design: Cross-sectional. Methods: Male and female adolescent rugby union players aged 16 to 18 years were recruited at the start of the 2022-2023 playing season...
February 11, 2024: Sports
Elani A Bykowski, Jamie N Petersson, Sean P Dukelow, Chester Ho, Chantel T Debert, Tony Montina, Gerlinde A S Metz
Metabolomic biomarkers hold promise in aiding the diagnosis and prognostication of traumatic brain injury. In Canada, over 165,000 individuals annually suffer from a traumatic brain injury (TBI), making it one of the most prevalent neurological conditions. In this pilot investigation, we examined blood-derived biomarkers as proxy measures that can provide an objective approach to TBI diagnosis and monitoring. Using a 1 H nuclear magnetic resonance (NMR)-based quantitative metabolic profiling approach, this study determined whether (1) blood-derived metabolites change during recovery in male participants with mild to severe TBI; (2) biological pathway analysis reflects mechanisms that mediate neural damage/repair throughout TBI recovery; and (3) changes in metabolites correlate to initial injury severity...
February 2, 2024: Metabolites
Veerle Lubbers, Dirk Van den Hoven, Joukje van der Naalt, Korné Jellema, Crispijn Van den Brand, Barbra Backus
Around 16% of patients with mild traumatic brain injury (mTBI) develop a post-concussion syndrome (PCS) with persistent physical, neurological and behavioural complaints. PCS has a great impact on a patient's quality of life, often decreases the ability to return to work, and henceforth has a great economic impact. Recent studies suggest that early treatment can greatly improve prognosis and prevent long-term effects in these patients. However, early recognition of patients at high risk of PCS remains difficult...
February 23, 2024: Journal of Neurotrauma
Brandon Macknofsky, Clyde K Fomunung, Shimron Brown, Jessica V Baran, Alessia C Lavin, Vani Sabesan
BACKGROUND: There has been little focus on concussions in youth lacrosse players in the United States. PURPOSE: To provide a descriptive analysis of the epidemiology and incidence of concussions in youth lacrosse and compare the results with well-documented analyses of concussions in youth American football. STUDY DESIGN: Descriptive epidemiology study. METHODS: Data on concussions in pediatric patients playing lacrosse from 2006 to 2019 were collected using the National Electronic Injury Surveillance System (NEISS)...
February 2024: Orthopaedic Journal of Sports Medicine
Anne K Galgon, Rebecca A Bliss
OBJECTIVE: The recent publication of the Physical Therapy Evaluation and Treatment After Concussion Clinical Practice Guideline is intended to assist clinicians in their decision making specific to evaluation and intervention. Clinical practice guidelines are supported by best available evidence, though it is unknown what other factors drive clinical decision making in the realm of concussion management. The purpose of this study was to explore factors related to the process of clinical decision making of experienced physical therapists who treat individuals with concussion...
February 22, 2024: Physical Therapy
Adam Biard, Prabakar Vaittinada Ayar, Alhassane Diallo, Maryame Gatineau-Sailliant, Clémence Lefevre, Mélanie Cogne, Philippe Azouvi, Thierry Faillot, Philippe Decq, Matthieu Faillot
BACKGROUND: Previous studies suggest an association between Post-concussion syndrome (PCS) and depression, both highly prevalent after mTBI. OBJECTIVE: To assess the prevalence and risk-factors of depression among patients with PCS 1 month after mTBI. METHODS: We prospectively screened 372 mTBI patients admitted in two academic Emergency Departments between 2017 and 2019. One month after mTBI, we administered the Rivermead Post-concussion symptoms Questionnaire (RPQ) and the Patient Health Questionnaire (PHQ-9) questionnaires over the telephone...
February 22, 2024: Brain Injury
Julia Rybkina, Nithin Jacob, Brenda Colella, David Gold, Donna E Stewart, Lesley A Ruttan, Liesel-Ann C Meusel, Mary P McAndrews, Susan Abbey, Robin Green
Post-acute sequelae of SARS-COV-2 (PASC) is growing in prevalence, and involves symptoms originating from the central neurological, cardiovascular, respiratory, gastrointestinal, autonomic nervous, or immune systems. There are non-specific symptoms such as fatigue, headaches, and brain fog, which cannot be ascribed to a single system. PASC places a notable strain on our healthcare system, which is already laden with a large number of acute-COVID-19 patients. Furthermore, it impedes social, academic and vocational functioning, and impacts family life, relationships, and work/financial life...
2024: Frontiers in Public Health
Stephen L Aita, Rohan Muchintala, Advith Suresh, Suraj Patel, Benjamin Schuler, Jonathan D Lichtenstein
BACKGROUND: Considering the multifaceted consequences of improperly managed sport-related concussions (SRCs) in American football, identifying efficacious prevention measures for enhancing player safety is crucial. PURPOSE: To investigate the association of primary prevention measures (no-tackle practices and using a mobile tackling dummy in practice) with the frequency of SRCs within college football programs in the United States. STUDY DESIGN: Descriptive epidemiology study...
February 2024: Orthopaedic Journal of Sports Medicine
Pritam Dutta
BACKGROUND: To compare the pupillary dynamics using an iPhone-based pupillometry technique in subjects with sports concussion with photosensitivity and aged-matched controls. METHODS: Fifty subjects with sports concussion were compared with 50 aged-matched healthy controls. Athletes with persistent concussive symptoms for 1 year or more after the initial injury were included. All the subjects underwent a Post-Concussion Symptom Scale (PCSS) administration followed by pupillary dynamics measurement using an iPhone-based application (Reflex-Pro PLR analyzer)...
February 21, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Anna E Boone, Casey Perry, Whitney L Henderson
IMPORTANCE: Some people experience persistent symptoms after a concussion that greatly affect occupational performance. OBJECTIVE: To evaluate the feasibility and preliminary effect of metacognitive strategy training in a sample of adults with postconcussive symptoms. DESIGN: Single-group, prospective design. SETTING: University research laboratory. PARTICIPANTS: Adults with persistent concussive symptoms affecting function (N = 14)...
March 1, 2024: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Anna E Boone, Whitney L Henderson, Sepideh Zenoozi
IMPORTANCE: Little is known about how and to what extent persistent concussive symptoms affect occupational performance in adults. OBJECTIVE: To evaluate the impact of persistent postconcussive symptoms on occupational performance. DESIGN: A cross-sectional study design was used in which the occupational performance needs of adults with persistent concussion symptoms were identified by a trained occupational therapist via semistructured interview...
March 1, 2024: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Thomas A Buckley, Scott W Passalugo, Caitlin A Gallo, Barry Bodt, Kelsey M Evans, Barry A Munkasy
OBJECTIVE: The purpose of this study was to assess changes in concussion knowledge and attitudes amongst incoming intercollegiate student-athletes over the course of a decade (2010-2012 vs 2021-2023). METHODS: There were 592 student-athletes from 2 cohorts (2010-2012, 2021-2023) who completed the Rosenbaum Concussion Knowledge and Attitudes Survey (ROCKaS) questionnaire which is comprised of a concussion knowledge index (CKI, 0-24) and attitude index (CAI, 15-75) with higher scores reflecting better performance...
February 18, 2024: Brain Injury
Eric O Ingram, Justin E Karr
Objective: Investigate whether a four-factor model of post-concussion symptoms (i.e. cognitive, physical, affective, and sleep-arousal) aids in identifying student-athletes with persistent concerns not reflected by a total symptom score. Method: Collegiate student-athletes ( N  = 32,066) from the Concussion Assessment Research and Education consortium completed the Sport Concussion Assessment Tool, 3rd edition Symptom Evaluation at baseline and two post-injury follow-ups (i.e. beginning RTP and 6-month)...
February 18, 2024: Clinical Neuropsychologist
Thomas W McAllister, Rachel Kenny, Jaroslaw Harezlak, Jody Harland, Michael A McCrea, Paul Pasquina, Steven P Broglio
Objective : The goal of this study was to characterize normative scores for the Brief Symptom Inventory (BSI-18) in collegiate athletes to inform decision making about the need for psychological health services in this group. Methods : Collegiate student-athletes ( N  = 20,034) from 25 universities completed the BSI-18 at their preseason baseline assessment. A subgroup ( n  = 5,387) underwent multiple baseline assessments. Global Severity Index (GSI) scores were compared to community norms and across multiple timepoints...
February 18, 2024: Clinical Neuropsychologist
Heena R Manglani, Brenda C Lovette, Victoria A Grunberg, Jesse Frieder, Ana-Maria Vranceanu, Jonathan Greenberg
OBJECTIVE: To assess psychosocial treatment preferences and factors that may impact treatment participation among young adults with a recent concussion and co-occurring anxiety. DESIGN: In-depth semi-structured individual qualitative interviews, followed by thematic analysis using a hybrid deductive-inductive approach. SETTING: Academic medical center in the US Northeast. PARTICIPANTS: Seventeen young adults (18-24) who sustained a concussion within the past 3-10 weeks and reported at least mild anxiety (≥5 on the General Anxiety Disorder-7 questionnaire)...
February 16, 2024: Archives of Physical Medicine and Rehabilitation
Julia C Nahman, Cody Staples, Lauren N Irwin Harper, Luis Ahumada, Mohamed Rehman, Sarah Irani, P Patrick Mularoni, Danielle M Ransom
OBJECTIVE: This study aimed to explore the relation between resilience, emotional changes following injury, and recovery duration in sport-related concussion. METHODS: Thirty-one high school student-athletes (ages 14-18) with sports-related injuries (concussion, n  = 17 orthopedic injury, n  = 14) were recruited from a pediatric sports medicine clinic. Participants completed self-report resilience ratings and self- and parent-reported post-concussion symptoms as part of a neuropsychological test battery...
February 17, 2024: Applied Neuropsychology. Child
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