Anna Gard, Evgenios N Kornaropoulos, Maria Portnova-Wernersson, Ia Rorsman, Kaj Blennow, Henrik Zetterberg, Yelverton Tegner, Alessandro De Maio, Karin Markenroth Bloch, Isabella Björkman-Burtscher, Helene Pessah, Markus Nilsson, Niklas Marklund
Sports-related concussions may cause white matter injuries and persistent post-concussive symptoms (PPCS). We hypothesized that athletes with PPCS would have neurocognitive impairments and white matter abnormalities which could be revealed by advanced neuroimaging using ultra-high field strength diffusion tensor (DTI) and diffusion kurtosis (DKI) imaging metrics and cerebrospinal fluid (CSF) biomarkers. A cohort of athletes with PPCS of a severity limiting the ability to work/study and participate in sport school and/or social activities for ≥ 6 months completed 7T MRI (morphological T1-weighed volumetry, DTI and DKI), extensive neuropsychological testing, symptom rating and CSF biomarker sampling...
March 13, 2024: Journal of Neurotrauma