Annalise E Miner, Jenna R Groh, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Henrik Zetterberg, Kaj Blennow, Elaine Peskind, Nicholas J Ashton, Charles E Gaudet, Brett Martin, Joseph N Palmisano, Sarah J Banks, William B Barr, Jennifer V Wethe, Robert C Cantu, David W Dodick, Douglas I Katz, Jesse Mez, Suzan van Amerongen, Jeffrey L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern, Michael L Alosco
INTRODUCTION: Blood-based biomarkers offer a promising approach for the detection of neuropathologies from repetitive head impacts (RHI). We evaluated plasma biomarkers of amyloid, tau, neurodegeneration, and inflammation in former football players. METHODS: The sample included 180 former football players and 60 asymptomatic, unexposed male participants (aged 45-74). Plasma assays were conducted for beta-amyloid (Aβ) 40, Aβ42, hyper-phosphorylated tau (p-tau) 181+231, total tau (t-tau), neurofilament light (NfL), glial fibrillary acidic protein (GFAP), interleukin-6 (IL-6), Aβ42/p-tau181 and Aβ42/Aβ40 ratios...
October 1, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association